Publications by authors named "Pimolvan Tappayuthpijarn"

3 Publications

  • Page 1 of 1

Acetylcholinesterase inhibitory activity of Thai traditional nootropic remedy and its herbal ingredients.

J Med Assoc Thai 2011 Dec;94 Suppl 7:S183-9

Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathumtani, Thailand.

The incidence of Alzheimer disease (AD) is increasing every year in accordance with the increasing of elderly population and could pose significant health problems in the future. The use of medicinal plants as an alternative prevention or even for a possible treatment of the AD is, therefore, becoming an interesting research issue. Acetylcholinesterase (AChE) inhibitors are well-known drugs commonly used in the treatment of AD. The aim of the present study was to screen for AChE inhibitory activity of the Thai traditional nootropic recipe and its herbal ingredients. The results showed that ethanolic extracts of four out of twenty-five herbs i.e. Stephania pierrei Diels. Kaempfera parviflora Wall. ex Baker, Stephania venosa (Blume) Spreng, Piper nigrum L at 0.1 mg/mL showed % AChE inhibition of 89, 64, 59, 50; the IC50 were 6, 21, 29, 30 microg/mL respectively. The other herbs as well as combination of the whole recipe had no synergistic inhibitory effect on AChE activity. However some plants revealed antioxidant activity. More research should have be performed on this local wisdom remedy to verify the uses in scientific term.
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December 2011

Using 6-gingerol content and gene mapping for identification of two types of ginger used in Thai traditional medicine.

J Med Assoc Thai 2012 Jan;95 Suppl 1:S135-41

Department of Applied Thai Traditional Medicine, Faculty of medicine, Thammasat University, Rungsit Campus, Klongluang, Pathumthani, Thailand.

Background: Two species of ginger were used in Thai traditional medicine as Zingiber officinale Roscoe and Zingiber ligulatum Roxb.

Objective: To investigate for identification two types of ginger by morphological and microscopic characters, DNA profiles, and determination of 6-gingerol content by HPLC.

Material And Method: Fresh rhizomes of two gingers, their ages more than one year were collected from 12 sources in 4 parts of Thailand. The fresh leaves were also collected for studying DNA profile by amplified fragment length polymorphism (AFLP) method.

Results: The morphological characters of two types of gingers were almost corresponded to AFLP patterns and they were identified as Z officinale Rocs. and Z. ligulatum Roxb. Microscopic examinations of dried rhizomes from the both species showed the same pattern. By means of HPLC and TLC methods, 6-gingerol content was found only in Z. officanale in range of 2.58-17.04% but disappeared in Z. ligulatum.

Conclusion: Determination of 6-gingerol content by HPLC or TLC pattern can be used to identified two types of ginger used in Thai Traditional Medicine.
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January 2012

The efficacy of Thai capsaicin in management of overactive bladder and hypersensitive bladder.

J Med Assoc Thai 2003 Sep;86(9):861-7

Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

This paper has been generated to provide information on the effectiveness of capsaicin treatment among patients with overactive or hypersensitive bladder. The evaluation process required approximately 14 (overactive bladder) and 11 (hypersensitive bladder and primary detrusor instability) participants who received capsaicin intravesically. The solution consisted of capsaicin (concentration = 1 mM/L) diluted in 30 per cent ethanol solution 100 ml. All participants went through at least 1 urodynamic test 1 month before and after receiving capsaicin intravesical instillation. The capsaicin treatment for overactive and hypersensitive bladders was very effective. On the average, (overactive bladder) participants' voiding needs decreased from 16.5 +/- 4.8 times/day to 8.6 +/- 2.5 times/day, leakage from 9.7 +/- 8.1 times/day to 2.4 +/- 4.3 times/day, bladder capacity from 160.1 +/- 123.3 ml to 236.9 +/- 146.1 ml, and detrusor contraction from 71.1 +/- 29.2 cm/H2O to 57.3 +/- 27.2 cm/H2O. On average, (hypersensitive bladder and primary detrusor instability) participants' voiding needs decreased from (Day time) 19.45 +/- 17.99 times to 12.00 +/- 8.91 times/day, (Night time) 7.09 +/- 6.03 times to 4.09 +/- 3.8 times, bladder capacity from 197.40 +/- 156.06 ml to 323.45 +/- 129.46 ml, and detrusor contraction from 32.64 +/- 22.77 cm/H2O to 36.64 +/- 19.22 cm/H2O. Capsaicin efficiency was rated very high for both overactive and hypersensitive bladder and primary detrusor instability. In Thailand, it has been possible to produce capsaicin using local chili supplies, thus the price of the drug itself is very economical. When considering the efficiency and the inexpensive cost of capsaicin, this treatment would be another great alternative for overactive and hypersensitive bladder cure.
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September 2003