Pieter Vader

Pieter Vader

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Pieter Vader

Pieter Vader

Publications by authors named "Pieter Vader"

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32Publications

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Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression.

Front Immunol 2018 30;9:738. Epub 2018 Apr 30.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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April 2018

Preparation and Isolation of siRNA-Loaded Extracellular Vesicles.

Methods Mol Biol 2017 ;1545:197-204

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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February 2018

Interaction of Extracellular Vesicles with Endothelial Cells Under Physiological Flow Conditions.

Methods Mol Biol 2017 ;1545:205-213

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584, CX, The Netherlands.

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February 2018

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach.

Nanoscale 2018 Feb;10(5):2413-2426

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.

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February 2018

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis.

J Control Release 2017 Nov 14;266:100-108. Epub 2017 Sep 14.

Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. Electronic address:

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November 2017

Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation.

Nanomedicine 2017 Aug 30;13(6):2061-2065. Epub 2017 Mar 30.

Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

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August 2017

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles.

Mol Ther 2017 07 6;25(7):1580-1587. Epub 2017 Apr 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, UK; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands. Electronic address:

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July 2017

Microbubbles-Assisted Ultrasound Triggers the Release of Extracellular Vesicles.

Int J Mol Sci 2017 Jul 25;18(8). Epub 2017 Jul 25.

Imaging Division, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherland.

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July 2017

Extracellular vesicles for drug delivery.

Adv Drug Deliv Rev 2016 11 27;106(Pt A):148-156. Epub 2016 Feb 27.

Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Electronic address:

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November 2016

Cetuximab treatment alters the content of extracellular vesicles released from tumor cells.

Nanomedicine (Lond) 2016 Apr 16;11(8):881-90. Epub 2016 Mar 16.

Department of Clinical Chemistry & Haematology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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April 2016

Cells release subpopulations of exosomes with distinct molecular and biological properties.

Sci Rep 2016 Mar 2;6:22519. Epub 2016 Mar 2.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, United Kingdom.

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March 2016

Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting.

J Extracell Vesicles 2016 14;5:31053. Epub 2016 Mar 14.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands;

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March 2016

Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles.

J Extracell Vesicles 2015 27;4:26883. Epub 2015 May 27.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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May 2015

Extracellular vesicles as drug delivery systems: lessons from the liposome field.

J Control Release 2014 Dec 2;195:72-85. Epub 2014 Aug 2.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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December 2014

Extracellular vesicles: emerging targets for cancer therapy.

Trends Mol Med 2014 Jul 3;20(7):385-93. Epub 2014 Apr 3.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3QX, UK. Electronic address:

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July 2014

New considerations in the preparation of nucleic acid-loaded extracellular vesicles.

Ther Deliv 2014 Feb;5(2):105-7

Department of Clinical Chemistry & Haematology, University Medical Center Utrecht, Utrecht, The Netherlands and Department of Physiology, Anatomy & Genetics, Le Gros Clark Building, Room 231, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.

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February 2014

Extracellular microRNAs are dynamic non-vesicular biomarkers of muscle turnover.

Nucleic Acids Res 2013 Nov 14;41(20):9500-13. Epub 2013 Aug 14.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA, Dubowitz Neuromuscular Centre, UCL Institute of Child Health, 30 Guildford Street, London, WC1N 1EH, UK and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

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November 2013

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles.

J Control Release 2013 Nov 29;172(1):229-238. Epub 2013 Aug 29.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. Electronic address:

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November 2013

Exosome mimetics: a novel class of drug delivery systems.

Int J Nanomedicine 2012 16;7:1525-41. Epub 2012 Mar 16.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.

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September 2012

Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery.

J Control Release 2012 Jul 25;161(2):635-44. Epub 2011 Nov 25.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.

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July 2012

Physicochemical and biological evaluation of siRNA polyplexes based on PEGylated Poly(amido amine)s.

Pharm Res 2012 Feb 11;29(2):352-61. Epub 2011 Aug 11.

Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508, TB, Utrecht, The Netherlands.

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February 2012

Disulfide-based poly(amido amine)s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity.

Pharm Res 2011 May 23;28(5):1013-22. Epub 2010 Dec 23.

Department of Pharmaceutics Z-513, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.

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May 2011

A method for quantifying cellular uptake of fluorescently labeled siRNA.

J Control Release 2010 Nov 30;148(1):106-109. Epub 2010 Jun 30.

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands. Electronic address:

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November 2010

Probing the membrane interface-interacting proteome using photoactivatable lipid cross-linkers.

J Proteome Res 2007 May 22;6(5):1951-62. Epub 2007 Mar 22.

Department Biochemistry of Membranes, Bijvoet Center for Biomolecular Research and Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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May 2007