Publications by authors named "Peng Xiang"

359 Publications

Pollution-Derived Br Boosts Oxidation Power of the Coastal Atmosphere.

Environ Sci Technol 2022 Aug 10. Epub 2022 Aug 10.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hong Kong SAR 999077, China.

The bromine atom (Br) has been known to destroy ozone (O) and accelerate the deposition of toxic mercury (Hg). However, its abundance and sources outside the polar regions are not well-known. Here, we report significant levels of molecular bromine (Br)─a producer of Br─observed at a coastal site in Hong Kong, with an average noontime mixing ratio of 5 ppt. Given the short lifetime of Br (∼1 min at noon), this finding reveals a large Br daytime source. On the basis of laboratory and field evidence, we show that the observed daytime Br is generated by the photodissociation of particulate nitrate (NO) and that the reactive uptake of dinitrogen pentoxide (NO) on aerosols is an important nighttime source. Model-calculated Br concentrations are comparable with that of the OH radical─the primary oxidant in the troposphere, accounting for 24% of the oxidation of isoprene, a 13% increase in net O production, and a nearly 10-fold increase in the production rate of toxic Hg. Our findings reveal that reactive bromines play a larger role in the atmospheric chemistry and air quality of polluted coastal and maritime areas than previously thought. Our results also suggest that tightening the control of emissions of two conventional pollutants (NO and SO)─thereby decreasing the levels of nitrate and aerosol acidity─would alleviate halogen radical production and its adverse impact on air quality.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.est.2c02434DOI Listing
August 2022

Host Species Influence the Gut Microbiota of Endemic Cold-Water Fish in Upper Yangtze River.

Front Microbiol 2022 18;13:906299. Epub 2022 Jul 18.

Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.

The fish gut microbiome plays an important role in nutrition absorption and energy metabolism. Studying the gut microbes of cold-water fish is important to understand the dietary adaptation strategies in extreme environments. In this study, the gut samples of (SW, herbivorous), (SK, omnivorous), and (PP, carnivorous) in the upper Yangtze River were collected, and we sequenced 16S rRNA amplicon to study the potential relationship between gut microbes and host species. The results showed that gut microbial composition and diversity were significantly different between the three cold-water fishes. These fishes had different key taxa in their gut microbes, including bacteria involved in the breakdown of food (e.g., , , and 10). The highest alpha diversity indices (e.g., Chao 1 index) were identified in the herbivore (SW), followed by the carnivore (PP), and the lowest in the omnivore (SK). Non-metric multidimensional scaling (NMDS) results revealed that the gut microbial community of these species was different between host species. The neutral community model (NCM) showed that the microbial community structure of SW was shaped by stochastic processes, and the highest species dispersal was found in SW, followed by PP, and the lowest in SK. The results of niche breadth agreed with these findings. Our results demonstrated that host species influenced the gut microbiome composition, diversity, and microbial community assembly processes of the three cold-water fishes. These findings implied that the variation of gut microbiome composition and function plays a key role in digesting and absorbing nutrients from different foods in cold-water fish.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2022.906299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339683PMC
July 2022

Comparative Mitogenomic Analysis Reveals Intraspecific, Interspecific Variations and Genetic Diversity of Medical Fungus .

J Fungi (Basel) 2022 Jul 26;8(8). Epub 2022 Jul 26.

Biotechnology and Nuclear Technology Research Institute, Sichuan Academy of Agricultural Sciences, 106 # Shizishan Rd., Chengdu 610061, China.

species are widely distributed in the world with high diversity. Some species are considered to be pathogenic fungi while others are used as traditional medicine in Asia. In this study, we sequenced and assembled four complete mitogenomes, including s118, s37, s62, and s74. The sizes of the four mitogenomes ranged from 50,603 to 73,416 bp. All specimens had a full set of core protein-coding genes (PCGs), and the gene of species was detected to be under positive or relaxed selection. We found that the non-conserved PCGs, which encode RNA polymerases, DNA polymerases, homing endonucleases, and unknown functional proteins, are dynamic within and between species. Introns were thought to be the main contributing factor in mitogenome size variation (< 0.01). Frequent intron loss/gain events were detected within and between species. The mitogenome of s26 gained intron P637 in the gene compared with the other two mitogenomes. In addition, some rare introns in were detected in distinct Basidiomycetes, indicating potential gene transfer events. Comparative mitogenomic analysis revealed that gene arrangements also varied within and between mitogenomes. Using maximum likelihood and Bayesian inference methods with a combined mitochondrial gene dataset, phylogenetic analyses generated identical, well-supported tree topologies for 71 species. This study reveals intraspecific and interspecific variations of the mitogenomes, which promotes the understanding of the origin, evolution, and genetic diversity of species.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/jof8080781DOI Listing
July 2022

Recent Developments in Surface-Enhanced Raman Spectroscopy and Its Application in Food Analysis: Alcoholic Beverages as an Example.

Foods 2022 Jul 21;11(14). Epub 2022 Jul 21.

Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.

Surface-enhanced Raman spectroscopy (SERS) is an emerging technology that combines Raman spectroscopy and nanotechnology with great potential. This technology can accurately characterize molecular adsorption behavior and molecular structure. Moreover, it can provide rapid and sensitive detection of molecules and trace substances. In practical application, SERS has the advantages of portability, no need for sample pretreatment, rapid analysis, high sensitivity, and 'fingerprint' recognition. Thus, it has great potential in food safety detection. Alcoholic beverages have a long history of production in the world. Currently, a variety of popular products have been developed. With the continuous development of the alcoholic beverage industry, simple, on-site, and sensitive detection methods are necessary. In this paper, the basic principle, development history, and research progress of SERS are summarized. In view of the chemical composition, the beneficial and toxic components of alcoholic beverages and the practical application of SERS in alcoholic beverage analysis are reviewed. The feasibility and future development of SERS are also summarized and prospected. This review provides data and reference for the future development of SERS technology and its application in food analysis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/foods11142165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316878PMC
July 2022

miR-8485 alleviates the injury of cardiomyocytes through TP53INP1.

J Biochem Mol Toxicol 2022 Jul 25:e23159. Epub 2022 Jul 25.

Department of Cardiology, The Second Affiliated Hospital (Jiande Branch), Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

MicroRNAs (miRNAs) feature prominently in regulating the progression of chronic heart failure (CHF). This study was performed to investigate the role of miR-8485 in the injury of cardiomyocytes and CHF. It was found that miR-8485 level was markedly reduced in the plasma of CHF patients, compared with the healthy controls. H O treatment increased tumor necrosis factor-α, interleukin (IL)-6, and IL-1β levels, inhibited the viability of human adult ventricular cardiomyocyte cell line AC16, and increased the apoptosis, while miR-8485 overexpression reversed these effects. Tumor protein p53 inducible nuclear protein 1 (TP53INP1) was identified as a downstream target of miR-8485, and TP53INP1 overexpression weakened the effects of miR-8485 on cell viability, apoptosis, as well as inflammatory responses. Our data suggest that miR-8485 attenuates the injury of cardiomyocytes by targeting TP53INP1, suggesting it is a protective factor against CHF.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbt.23159DOI Listing
July 2022

The COVID-19 Pandemic and Overall Wellbeing: Mediating Role of Virtual Reality Fitness for Physical-Psychological Health and Physical Activity.

Psychol Res Behav Manag 2022 13;15:1741-1756. Epub 2022 Jul 13.

School of Education, Soochow University, Suzhou, People's Republic of China.

Background: Virtual reality applications are made for various objectives such as business, entertainment, education, and healthcare. Anxiety, phobias, distress, disordered eating, drug addiction, panic disorder, post-traumatic stress disorder, schizophrenia, bipolar disorder, psychosis, depression, and autism spectrum disorders may benefit from virtual reality-based approaches. The 2019 coronavirus (COVID-19) pandemic has impacted the way we live, enjoy, study, sport, and socialize significantly. Virtual reality fitness technology gained much attention during the COVID-19 preventive measures time.

Objective: The present study explores the role of virtual reality fitness in improving overall wellbeing during the COVID-19 pandemic home isolation period in terms of physical-psychological health and physical activity.

Methods: A total of 2300 individuals were recruited using the snowball sampling technique to participate in the study. The primary data were collected using an anonymous web-based survey. SPSS-23 and Smart-PLS 3.2.9 software were used to analyze the data.

Results: The direct path coefficient analysis of the study constructs show that virtual reality fitness has (preventive measures -> virtual reality fitness -> overall wellbeing, preventive measures -> virtual reality fitness -> physical exercise, and preventive measures -> virtual reality fitness -> physical health) profound effects on the research participants' mental and physical wellbeing of the study participants while indirect mediation analysis shows that virtual reality fitness has (preventive measures -> virtual reality fitness ->overall wellbeing, preventive measures -> virtual reality fitness -> physical exercise, preventive measures -> virtual reality fitness ->physical health) significant impacts.

Conclusion: Our study results concluded that house exercises through virtual reality fitness are a good substitute for public gyms and private group fitness programs during the first pandemic wave for physical-psychological and overall wellbeing. Virtual reality fitness technology can alleviate many of the challenges brought on by the epidemic, resulting in increased utilization.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/PRBM.S369020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289576PMC
July 2022

Intrinsic parameter-free calibration of FPP using a ray phase mapping model.

Opt Lett 2022 Jul;47(14):3564-3567

This Letter presents a ray phase mapping model (RPM) for fringe projection profilometry (FPP) that avoids calibrating intrinsic parameters. The novelty of the RPM, to the best of our knowledge, is the ability to characterize the imaging system with independent rays for each pixel, and to associate the rays with the projected phase in the illumination field for efficient 3D mapping, which avoids complex imaging-specific modeling about lens layout and distortion. Two loss functions are constructed to flexibly optimize camera ray parameters and mapping coefficients, respectively. As a universal approach, it has the potential to calibrate different types of FPP systems with high accuracy. Experiments on wide-angle lens FPP, telecentric lens FPP, and micro-electromechanical system (MEMS)-based FPP are carried out to verify the feasibility of the proposed method.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.462504DOI Listing
July 2022

MRTF-A alleviates myocardial ischemia reperfusion injury by inhibiting the inflammatory response and inducing autophagy.

Mol Cell Biochem 2022 Jul 12. Epub 2022 Jul 12.

Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, China.

Myocardin-related transcription factor A (MRTF-A) has an inhibitory effect on myocardial infarction; however, the mechanism is not clear. This study reveals the mechanism by which MRTF-A regulates autophagy to alleviate myocardial infarct-mediated inflammation, and the effect of silent information regulator 1 (SIRT1) on the myocardial protective effect of MRTF-A was also verified. MRTF-A significantly decreased cardiac damage induced by myocardial ischemia. In addition, MRTF-A decreased NLRP3 inflammasome activity, and significantly increased the expression of autophagy protein in myocardial ischemia tissue. Lipopolysaccharide (LPS) and 3-methyladenine (3-MA) eliminated the protective effects of MRTF-A. Furthermore, simultaneous overexpression of MRTF-A and SIRT1 effectively reduced the injury caused by myocardial ischemia; this was associated with downregulation of inflammatory factor proteins and when upregulation of autophagy-related proteins. Inhibition of SIRT1 activity partially suppressed these MRTF-A-induced cardioprotective effects. SIRT1 has a synergistic effect with MRTF-A to inhibit myocardial ischemia injury through reducing the inflammation response and inducing autophagy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-022-04510-4DOI Listing
July 2022

Fitness Apps, Live Streaming Workout Classes, and Virtual Reality Fitness for Physical Activity During the COVID-19 Lockdown: An Empirical Study.

Front Public Health 2022 22;10:852311. Epub 2022 Jun 22.

College of Physical Education and Sports, Soochow University, Suzhou, China.

Background: Physical activity is an essential need of the human body that helps improve the physical fitness of an individual and creates a positive impact on overall wellbeing. Smartphone applications play an essential role in providing several benefits to consumers by offering various capabilities in terms of health and fitness.COVID-19 preventive measures shut down public places, and people cannot go to the gym and parks for physical activity. Smart applications for physical activity are an effective way to keep active while staying at home.

Objective: The objective of the present study was to assess the mediating role of the e-platforms physical activity among the Chinese people in China during the COVID-19 lockdown.

Method: The participants in this study were Chinese citizens living in home isolation during the early stages of the epidemic in China. The primary data was collected via an online survey using a convenience sample strategy in accordance with the study purpose. The collected data were cleaned by using the SPSS-25 statistical software. SmartPLS 3.0 software was used to investigate the suggested study framework utilizing the structural equation modeling technique.

Results: Descriptive statistics shows that the ratio of gender includes 49% ( = 2,626) male and 51% females in the entire sample. SEM results show that all hypotheses (H1: β = 0.497, = 43.068, = <0.001; H2: β = 0.498, = 41.078, = <0.001; H3: β = 0.498, = 41.078, = <0.001; H4: β = 0.471, = 39.103, = <0.001; H5: β = 0.468, = 42.633, = <0.001; H6: β = 0.251, = 11.212, = <0.001; H7: β = 0.367, = 16.032, = <0.001; H8: β = 0.170, = 13.750, = <0.001; H9: β = 0.125, = 10.604, = <0.001; H10: β = 0.173, = 14.842, = <0.001) were statistically confirmed.

Conclusion: In COVID-19, when there are limited physical activity resources, smart applications play an essential role as an alternative to gyms and change people's perspective regarding the adoption of health and fitness. Smart applications have made exercise and physical activity accessible and convenient to adopt.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpubh.2022.852311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9257108PMC
June 2022

Enhanced electrochemical performance of the cobalt chloride carbonate hydroxide hydrate via micromorphology and phase transformation.

J Colloid Interface Sci 2022 Jun 28;626:506-514. Epub 2022 Jun 28.

Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, Hubei 443002, PR China. Electronic address:

Micromorphology and conductivity are two vital factors for the practical capacitance of the electrode materials for supercapacitors. In this work, a novel two-step electrochemical activation method involving a cyclic voltammetry (CV) treatment within 0-0.7 V followed by a CV treatment within -1.2-0 V is explored to induce the micromorphology and phase transformation of the cobalt chloride carbonate hydroxide hydrate (CCCH) nanoneedle arrays. The first-step activation transforms the CCCH to Co(OH) and then the reversible transformation between Co(OH) and CoOOH generates plenty of pores in the sample, thereby increasing the specific capacitance from 0.54 to 1.74 F cm at the current density of 10 mA cm. The second-step activation inducing the reversible transformation between Co(OH) and Co not only endows the final sample with a nanosheets-assembled fasciculate structure but also decreases the internal resistance via generating Co in the final sample (CCCH-P75N50). Consequently, the CCCH-P75N50 shows a high specific capacitance of 3.83 F cm at the current density of 10 mA cm. Besides, the aqueous asymmetric supercapacitor assembled with CCCH-P75N50 and commercial conductive carbon cloth (CC) delivers a high energy density of 2.75 mWh cm at a power density of 37.5 mW cm. This work provides a novel, facile and promising method to optimize the micromorphology and conductivity of Co-based electrodes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2022.06.140DOI Listing
June 2022

Chinese Baijiu: The Perfect Works of Microorganisms.

Front Microbiol 2022 16;13:919044. Epub 2022 Jun 16.

Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu, China.

Chinese Baijiu is one of the famous distilled liquor series with unique flavors in the world. Under the open environment, Chinese Baijiu was produced by two solid-state fermentation processes: jiuqu making and baijiu making. Chinese Baijiu can be divided into different types according to the production area, production process, starter type, and product flavor. Chinese Baijiu contains rich flavor components, such as esters and organic acids. The formation of these flavor substances is inseparable from the metabolism and interaction of different microorganisms, and thus, microorganisms play a leading role in the fermentation process of Chinese Baijiu. Bacteria, yeasts, and molds are the microorganisms involved in the brewing process of Chinese Baijiu, and they originate from various sources, such as the production environment, production workers, and jiuqu. This article reviews the typical flavor substances of different types of Chinese Baijiu, the types of microorganisms involved in the brewing process, and their functions. Methods that use microbial technology to enhance the flavor of baijiu, and for detecting flavor substances in baijiu were also introduced. This review systematically summarizes the role and application of Chinese Baijiu flavor components and microorganisms in baijiu brewing and provides data support for understanding Chinese Baijiu and further improving its quality.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2022.919044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245514PMC
June 2022

Primary Kaposi's Sarcoma of the Nasal Cavity: Clinical Experience and Review of the Literature.

Ear Nose Throat J 2022 Jun 27:1455613221111734. Epub 2022 Jun 27.

Department of Otorhinolaryngology, 74654Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.

Kaposi's sarcoma (KS) is a vascular sarcoma derived from vascular endothelial cells and presents with multiple lesions. It mainly appears on the skin and oral mucosa, usually in the face, oral mucosa, and genitals. Very few cases of primary lesions in the nasal cavity have been reported. It is often difficult to diagnose only by imaging examination. Here, we describe a case of KS in a patient who was human immunodeficiency virus (HIV)-negative, in which the primary sites were the nasal mucosa and nasal septum. A diagnosis was made according to the patient's clinical presentation, physical examination, laboratory examination, imaging examination, and histopathological results. We used surgical resection combined with chemotherapy, with 6 months' postoperative follow-up without recurrence. We reviewed the relevant literature to identify similar cases and summarize the findings reported on this rare manifestation of KS. We recommend that, where possible, antiviral therapy such as interferon, and regular review should continue, to improve the survival rate and patients' quality of life.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/01455613221111734DOI Listing
June 2022

Metabolic pathway-based molecular subtyping of colon cancer reveals clinical immunotherapy potential and prognosis.

J Cancer Res Clin Oncol 2022 Jun 22. Epub 2022 Jun 22.

Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.

Purpose: Colon cancer presents challenges to clinical diagnosis and management due to its high heterogeneity. For more efficient and convenient diagnosis and treatment of colon cancer, we are committed to characterizing the molecular features of colon cancer by pioneering a classification system based on metabolic pathways.

Methods: Based on the 113 metabolic pathways and genes collected in the previous stage, we scored and filtered the metabolic pathways of each sample in the training set by ssGSEA, and obtained 16 metabolic pathways related to colon cancer recurrence. In consistent clustering of training set samples with recurrence-related metabolic pathway scores, we identified two robust molecular subtypes of colon cancer (MC1 and MC2). Furthermore, we performed multi-angle analysis on the survival differences of subtypes, metabolic characteristics, clinical characteristics, functional enrichment, immune infiltration, differences with other subtypes, stemness indices, TIDE prediction, and drug sensitivity, and finally constructed colon cancer prognostic model.

Results: The results showed that the MC1 subtype had a poor prognosis based on higher immune activity and immune checkpoint gene expression. The MC2 subtype is associated with high metabolic activity and low expression of immune checkpoint genes and a better prognosis. The MC2 subtype was more responsive to PD-L1 immunotherapy than the MC1 subclass. However, we did not observe significant differences in tumor mutational burden between the two.

Conclusion: Two molecular subtypes of colon cancer based on metabolic pathways have distinct immune signatures. Constructing prognostic models based on subtype differential genes provides valuable reference for personalized therapy targeting unique tumor metabolic signatures.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-022-04070-6DOI Listing
June 2022

Highly Durable and Efficient Ni-FeO/FeNi Electrocatalysts Synthesized by a Facile Combustion-Based Method for Overall Water Splitting with Large Current Densities.

ACS Appl Mater Interfaces 2022 Jun 10;14(24):27842-27853. Epub 2022 Jun 10.

Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong 515063, P. R. China.

Ni-/Fe-based materials are promising electrocatalysts for the oxygen evolution reaction (OER) but usually are not suitable for the hydrogen evolution reaction (HER). Herein, a durable and bifunctional catalyst consisting of Ni-FeO and FeNi is prepared on nickel foam (Ni-FeO/FeNi/NF) by solution combustion and subsequent calcination to accomplish efficient alkaline water splitting. Density functional theory (DFT) calculation shows that the high HER activity is attributed to the strong electronic coupling effects between FeO and FeNi in the Janus nanoparticles by modulating Δ and electronic states. Consequently, small overpotentials (η) of 71 and 272 mV in HER and 269 and 405 mV in OER yield current densities () of 50 and 1000 mA cm, respectively. The catalyst shows outstanding stability for 280 and 200 h in HER and OER at a of ∼50 mA cm. Also, the robustness and mechanical stability of the electrode at an elevated of ∼500 mA cm are excellent. Moreover, Ni-FeO/FeNi/NF shows excellent water splitting activities as a bifunctional catalyst as exemplified by of 50 and 500 mA cm at cell voltages of 1.58 and 1.80 V, respectively. The Ni-FeO/FeNi/NF structure synthesized by the novel, simple, and scalable strategy has large potential in commercial water electrolysis, and the combustion method holds great promise in the fabrication of thin-film electrodes for different applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.2c04562DOI Listing
June 2022

All-Optical Parametric-Resonance Magnetometer Based on He Atomic Alignment.

Sensors (Basel) 2022 May 31;22(11). Epub 2022 May 31.

State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Electronics, Center for Quantum Information Technology, Peking University, Beijing 100871, China.

Parametric-resonance magnetometer is a high-sensitivity quantum sensor characterized by applying the non-resonant radio-frequency (RF) fields to the atomic ensemble. The RF fields lead to crosstalk in the multi-sensor design, thus disturbing the magnetic-field measurement results. We propose an optically modulated alignment-based 4He parametric-resonance magnetometer. By using the fictitious field generated by the modulated light shift, parametric resonance is realized, and crosstalk caused by the magnetic RF field is prevented. The relative intensity noise of the lasers is suppressed to optimize the sensitivity of the magnetometer. Our magnetometer experimentally demonstrates a magnetic-field noise floor of 130 fT/Hz1/2 in both open- and closed-loop operations and has the potential to reach 70 fT/Hz1/2 when compared with the optimized magnetic RF scheme. It provides near-zero magnetic-field measurements with a 2 kHz bandwidth at room temperature, which is useful for high-bandwidth measurements in biomagnetic applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/s22114184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185463PMC
May 2022

Comparison of the Biological Characteristics and Molecular Mechanisms of Fludioxonil-Resistant Isolates of from Tomato in Liaoning Province of China.

Plant Dis 2022 Jul 9;106(7):1959-1970. Epub 2022 Jun 9.

Institute of Plant Protection, Liaoning Academy of Agricultural Sciences, Shenyang 110161, People's Republic of China.

is a common filamentous phytopathogen that causes serious pre- and postharvest losses worldwide. The phenylpyrrole fungicide fludioxonil has been reported to have high activity against and has been applied to control gray mold in tomato. A total of 206 isolates were collected from tomato greenhouses in Liaoning Province, China, in 2016 and 2017, and sensitivity to fludioxonil was demonstrated by discriminatory concentrations. One highly fludioxonil-resistant isolate, 5 medium-fludioxonil-resistance isolates, and 23 low-fludioxonil-resistance isolates were detected in the field. The fludioxonil-resistant isolates were less fit than the sensitive isolates and presented reduced sporulation, pathogenicity, and mycelial growth and hypersensitivity to osmotic stress, even though sclerotium production had no connection with resistance. Positive cross-resistance was observed between fludioxonil and the dicarboximide fungicides procymidone and iprodione but not between fludioxonil and the fungicides boscalid, fluopyram, fluazinam, and pyrimethanil. Sequence alignment of the gene indicated that the observed sensitivity was identical to that of B05.10 and the low-resistance mutant had two types of mutations, F127S+I365N and A1259T. The medium-resistance mutants had only one type of mutation linked with the 3-aa mutant Q369P+N373S+A1259T, and the highly resistant mutant had a 3-aa mutation with I365S+N373S+A1259T. Molecular docking illustrated that all the resistant isolates showed less affinity than the sensitive isolates with fludioxonil.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1094/PDIS-07-21-1446-REDOI Listing
July 2022

Periostin Attenuates Cyclophosphamide-induced Bladder Injury by Promoting Urothelial Stem Cell Proliferation and Macrophage Polarization.

Stem Cells Transl Med 2022 06;11(6):659-673

Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Interstitial cystitis (IC) is a bladder syndrome of unclear etiology with no generally accepted treatment. Growing evidence suggest that periostin (POSTN) is an important homeostatic component in the tissue repair and regeneration in adulthood, but its function in urinary bladder regeneration is still unknown. Here we investigate whether POSTN is involved in bladder tissue repair in a cyclophosphamide (CYP)-induced interstitial cystitis model. POSTN is primarily expressed in bladder stroma (detrusor smooth muscle and lamina propria) and upregulated in response to CYP-induced injury. POSTN deficiency resulted in more severe hematuria, aggravated edema of the bladder, and delayed umbrella cell recovery. Besides, less proliferative urothelial cells (labeled by pHH3, Ki67, and EdU) and lower expression of Krt14 (a urothelial stem cell marker) were detected in POSTN-/- mice post CYP exposure, indicating a limited urothelial regeneration. Further investigations revealed that POSTN could induce Wnt4 upregulation and activate AKT signaling, which together activates β-catenin signaling to drive urothelial stem cell proliferation. In addition, POSTN can promote resident macrophage proliferation and polarization to a pro-regenerative (M2) phenotype, which favors urothelial regeneration. Furthermore, we generated injectable P-GelMA granular hydrogel as a biomaterial carrier to deliver recombinant POSTN into the bladder, which could increase urothelial stem cells number, decrease umbrella cells exfoliation, and hence alleviate hematuria in a CYP-induced interstitial cystitis model. In summary, our findings identify a pivotal role of POSTN in bladder urothelial regeneration and suggest that intravesical biomaterials-assisted POSTN delivery may be an efficacious treatment for interstitial cystitis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/stcltm/szac025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216508PMC
June 2022

Phosphate mining activities affect crop rhizosphere fungal communities.

Sci Total Environ 2022 Sep 24;838(Pt 2):156196. Epub 2022 May 24.

Biotechnology and Nuclear Technology Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu, Sichuan, China. Electronic address:

Phosphate mining releases heavy metals into the surrounding environment. In this study, the effects of phosphate mining on rhizosphere soil fungi in surrounding crops, including Lactuca sativa var. angustata, Glycine max (L.) Merr., and Triticum aestivum L., were assessed. Phosphate mining significantly reduced the crop rhizosphere fungal diversity (P < 0.05). The relative abundances of Fusarium and Epicoccum increased in mining rhizosphere soil compared with the baseline. Beta diversity analysis indicated that phosphate mining led to the differentiation of fungal community structure in plant rhizospheres. Guild analysis indicated that different plant rhizosphere fungi developed various guilds in response to phosphate mining stress. Nine fungi were isolated from soil samples, with solubilization index values ranging from 1.1 to 2.5. Two efficient phosphate solubilizers, Epicoccum nigrum and Fusarium verticillioides, were enriched in phosphate mining rhizosphere soil samples. The dissolution kinetics of inorganic phosphorus and alkaline phosphatase activity assay showed strong phosphorus dissolution ability of the isolated fungi. Penicillium aculeatum, Trichoderma harzianum, Chaetomium globosum, and F. verticillioides showed strong tolerance to multiple heavy metals. This study furthers our understanding of how rhizosphere fungal ecology is affected by phosphate mining and provides important resources for the remediation of phosphate mining soil pollution.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2022.156196DOI Listing
September 2022

Case Report: Rabies Vaccine-Induced Thrombotic Thrombocytopenic Purpura in a Patient With Systemic Lupus Erythematosus.

Front Immunol 2022 25;13:851316. Epub 2022 Apr 25.

Department of Rheumatology and Immunology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangdong, China.

For patients with autoimmune diseases, vaccination is controversial. The use of vaccination in patients with autoimmune diseases is controversial. There are many reports of secondary thrombotic thrombocytopenic purpura cases after various vaccinations. Thrombotic thrombocytopenic purpura is a rare thrombotic microangiopathy characterized by microvascular pathological hemolytic anemia, severe thrombocytopenia, and ischemic organ damage with a very high fatality rate. We report a case of thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus after rabies vaccination. She developed gastrointestinal bleeding nearly a month after the vaccination. Laboratory tests confirmed a severe deficiency of ADAMTS13 and the presence of ADAMTS13 autoantibodies. Through early identification of thrombotic thrombocytopenic purpura, immunosuppressive therapy, and plasma exchange treatment, the patient was saved from danger. This case suggests that attenuated vaccines may also have unexpected adverse effects in patients with long-term use of immunosuppressive drugs and autoimmune diseases. To our knowledge, this is the first case report of thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus secondary to rabies vaccination.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2022.851316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9085745PMC
May 2022

Bacteroides ovatus-mediated CD27 MAIT cell activation is associated with obesity-related T2D progression.

Cell Mol Immunol 2022 Jul 11;19(7):791-804. Epub 2022 May 11.

Department of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

Type 2 diabetes (T2D) is highly associated with obesity. However, the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune disorder. Mucosal-associated invariant T (MAIT) cells, which are innate-like T cells that recognize bacterial metabolites, have been reported to be altered in obese people and to lead to metabolic dysfunction during obesity. By studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D, we found an elevation in CD27-negative (CD27) MAIT cells producing a high level of IL-17 under T2D obese conditions, which could be positively correlated with impaired glucose metabolism in obese people. We further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell abnormalities. Specifically, accumulation of the bacterial strain Bacteroides ovatus in the peripheral blood drove IL-17-producing CD27 MAIT cell expansion and could be associated with T2D risk in obese individuals. Overall, these results suggest that an aberrant gut microbiota-immune axis in obese people may drive or exacerbate T2D. Importantly, CD27 MAIT cell subsets and Bacteroides ovatus could represent targets for novel interventional strategies. Our findings extend current knowledge regarding the clinical relevance of body mass index (BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41423-022-00871-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243016PMC
July 2022

Laser-frequency stabilization with differential single-beam saturated absorption spectroscopy of He atoms.

Rev Sci Instrum 2022 Apr;93(4):043001

State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Electronics, and Center for Quantum Information Technology, Peking University, Beijing 100871, China.

Differential single-beam saturated-absorption spectroscopy (DSSAS) is proposed to stabilize lasing frequency and suppress Doppler-broadened background and common-mode optical noise. The spectral first-derivative demodulated signal of metastable He4 atoms is used as an error signal to stabilize a fiber laser around 1083 nm. Experimental results show that, compared with existing non-DSSAS frequency stabilization, DSSAS stabilization produces better stability and lower fluctuations, especially for frequency-noise-corrupted lasers. In DSSAS stabilization, for data acquired over 7000 s, the root mean square frequency fluctuation of the fiber laser is 16.4 kHz, and the frequency stability described by the modified Allan deviation is 4.1 × 10 at 100 s. Even for a defective laser with poor frequency stability, the proposed scheme demonstrates experimentally high capability of noise suppression and reduces the frequency fluctuations by two orders of magnitude. Given its simplicity and compact design, frequency stabilization by DSSAS is promising for quantum-sensor applications, such as atomic magnetometers, atomic gyroscopes, and atomic clocks.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1063/5.0084605DOI Listing
April 2022

Dictionary-based compressive Fourier ptychography.

Opt Lett 2022 May;47(9):2314-2317

Fourier ptychography (FP) provides an alternative scheme for improving the spatial bandwidth product with limited device. However, an angle-variation illumination is necessary to realize scanning imaging in the Fourier plane, which dramatically restricts the imaging speed and detection efficiency. In this paper, we propose a multiplexing and compressible FP scheme based on the structured illuminations and compressive sensing technique. Half of the LEDs are lighted together to reduce the exposure time; meanwhile, a learned dictionary is employed to reduce the sampling times. In addition, spectral independent illumination is proposed to retrieve color information from monochrome samplings. We experimentally verify that the proposed method can effectively reduce the sampling time with limited resolution loss.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.450852DOI Listing
May 2022

A novel risk score model based on five angiogenesis-related long non-coding RNAs for bladder urothelial carcinoma.

Cancer Cell Int 2022 Apr 19;22(1):157. Epub 2022 Apr 19.

Department of Urology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

Background: Tumour angiogenesis is an independent risk factor for bladder urothelial carcinoma (BUC) progression, but viable and promising antiangiogenic targets are understudied. Emerging evidence suggests that long non-coding RNAs (lncRNAs) play prominent role in the tumour microenvironment and tumour angiogenesis.

Methods: The clinical data of BUC patients were obtained from TCGA database and clinical specimens of 138 BUC patients. Univariate and multivariate COX regression analyses were used to identify survival-related ARLNRs (sARLNRs) from The Molecular Signatures Database v4.0. Fisher's exact probability method was used to detect the correlations between sARLNRs levels and clinicopathological characteristics. A chain of experiments including FACS, qPCR, immunohistochemistry, tube formation, migration and invasion assays, combining with co-culture models, were utilized to validate the clinical significance and angiogenetic correlation of sARLNRs.

Results: Five sARLNRs were employed to establish an angiogenesis-related risk score model, by which patients in the low-risk group obtained better overall survival than those in the high-risk group. The expression of AC005625.1 and AC008760.1 was significantly related to ECs percentage, tumour size and muscle invasion status. Besides, AC005625.1 and AC008760.1 expressed lower in BUC cell lines and tumour tissues than that in normal urothelial cells and adjacent normal tissues, with much lower levels in more advanced T stages. A prominently higher proportion of ECs was detected in tumour tissues with lower expression of AC005625.1 and AC008760.1. In the co-culture models, we found that knockdown of AC005625.1 and AC008760.1 in BUC cells increased the tube formation, migration and invasion abilities of HUVEC. The expression levels of CD31, VEGF-A, VIMENTIN and N-CADHERIN were also enhanced in HUVEC cells co-cultured with siR-AC005625.1 and siR-AC008760.1-treated T24 cells.

Conclusion: In the study, we identify five sARLNRs and validate their clinical significance, angiogenesis correlation and prognosis-predictive values in BUC. These findings may provide a new perspective and some promising antiangiogenic targets for clinical diagnosis and treatment strategies of BUC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12935-022-02575-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019982PMC
April 2022

LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1.

Adv Sci (Weinh) 2022 05 10;9(16):e2103135. Epub 2022 Apr 10.

Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong, 250012, China.

Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in the nucleus and is resistant to antiviral agents. Identification of host factors involved in cccDNA transcriptional regulation is expected to prove a new venue for HBV therapy. Recent evidence suggests the involvement of long noncoding RNAs (lncRNAs) in mediating the interaction of host factors with various viruses, however, lncRNAs that HBV targets and represses cccDNA transcription have not been fully elucidated. Here, the authors identified LINC01431 as a novel host restriction factor for HBV transcription. Mechanically, LINC01431 competitively bound with type I protein arginine methyltransferase (PRMT1) to block the HBx-mediated PRMT1 ubiquitination and degradation. Consequently, LINC01431 increased the occupancy of PRMT1 on cccDNA, leading to enhanced H4R3me2a modification and reduced acetylation of cccDNA-bound histones, thereby repressing cccDNA transcription. In turn, to facilitate viral replication, HBV transcriptionally repressed LINC01431 expression by HBx-mediated repression of transcription factor Zinc fingers and homeoboxes 2 (ZHX2). Collectively, the study demonstrates LINC01431 as a novel epigenetic regulator of cccDNA minichromosome and highlights a feedback loop of HBx-LINC01431-PRMT1 in HBV replication, which provides potential therapeutic targets for HBV treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/advs.202103135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165498PMC
May 2022

Single-shot noninvasive imaging through scattering medium under white-light illumination.

Opt Lett 2022 Apr;47(7):1754-1757

We experimentally investigate image reconstruction through a scattering medium under white-light illumination. To solve the inverse problem of noninvasive scattering imaging, a modified iterative algorithm is employed with an interpretable constraint on the optical transfer function (OTF). As a result, a sparse and real object can be retrieved whether it is illuminated with a narrowband or broadband light. Compared with the well-known speckle correlation technique (SCT), the proposed method requires no restrictions on the speckle autocorrelation and shows a potential advantage in scattering imaging.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.453923DOI Listing
April 2022

Large DOF microscopic fringe projection profilometry with a coaxial light-field structure.

Opt Express 2022 Feb;30(5):8015-8026

Fringe projection profilometry (FPP) has been widely researched for three-dimensional (3D) microscopic measurement during recent decades. Nevertheless, some disadvantages arising from the limited depth of field and occlusion still exist and need to be further addressed. In this paper, light field imaging is introduced for microscopic fringe projection profilometry (MFPP) to obtain a larger depth of field. Meanwhile, this system is built with a coaxial structure to reduce occlusion, where the principle of triangulation is no longer applicable. In this situation, the depth information is estimated based on the epipolar plane image (EPI) of light field. In order to make a quantitative measurement, a metric calibration method which establishes the mapping between the slope of the line feature in EPI and the depth information is proposed for this system. Finally, a group of experiments demonstrate that the proposed LF-MFPP system can work well for depth estimation with a large DOF and reduced occlusion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.452361DOI Listing
February 2022

Divergent oxidative dearomatization coupling reactions to construct polycyclic cyclohexadienones.

Chem Commun (Camb) 2022 Mar 31;58(27):4348-4351. Epub 2022 Mar 31.

Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.

Highly selective divergent oxidative dearomatization coupling reactions, in which the chemoselectivity is controlled by catalysts and bases, are reported herein. Three different kinds of polycyclic cyclohexadienones are produced from the same reactants (41 examples, 85-99% yield). Our method marks a novel copper- and palladium-catalyzed C-H oxidative dearomatization of phenolic derivatives.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d2cc00183gDOI Listing
March 2022

PMP-Net++: Point Cloud Completion by Transformer-Enhanced Multi-step Point Moving Paths.

IEEE Trans Pattern Anal Mach Intell 2022 Mar 15;PP. Epub 2022 Mar 15.

Point cloud completion concerns to predict missing part for incomplete 3D shapes. A common strategy is to generate complete shape according to incomplete input. However, unordered nature of point clouds will degrade generation of high-quality 3D shapes, as detailed topology and structure of unordered points are hard to be captured during the generative process using an extracted latent code. We address this problem by formulating completion as point cloud deformation process. Specifically, we design a novel neural network, named PMP-Net++, to mimic behavior of an earth mover. It moves each point of incomplete input to obtain a complete point cloud, where total distance of point moving paths (PMPs) should be the shortest. Therefore, PMP-Net++ predicts unique PMP for each point according to constraint of point moving distances. The network learns a strict and unique correspondence on point-level, and thus improves quality of predicted complete shape. Moreover, since moving points heavily relies on per-point features learned by network, we further introduce a transformer-enhanced representation learning network, which significantly improves completion performance of PMP-Net++. We conduct comprehensive experiments in shape completion, and further explore application on point cloud up-sampling, which demonstrate non-trivial improvement of PMP-Net++ over state-of-the-art point cloud completion/up-sampling methods.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TPAMI.2022.3159003DOI Listing
March 2022

Early environmental enrichment for autism spectrum disorder Fmr1 mice models has positive behavioral and molecular effects.

Exp Neurol 2022 06 5;352:114033. Epub 2022 Mar 5.

Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China. Electronic address:

Autism spectrum disorder is a complex neurodevelopmental condition with genetic and phenotypic heterogeneity characterized by hallmark impairments in social functioning and repetitive behaviors. Fragile X syndrome (FXS), the leading single-gene form of autism spectrum disorder, is the most common form of inherited intellectual disability. Environmental enrichment has been shown to improve several aspects of brain development and affect histopathological, cognitive, and behavioral outcomes. However, the optimal time window to initiate it and improve cognitive and emotional development is largely unexplored. In the current study, we determined the longitudinal trends of BDNF-TrkB expression and dendritic development in FXS mice. Additionally, FXS mice were housed in an enriched environment when they showed significantly different BDNF-TrkB pathways and the phenotype of dendritic spines on postnatal day 10 (P10) until P60. The environmental enrichment delayed and attenuated some neurological alterations in FXS mice and prevented the development of cognitive and anxiety-related abnormalities and repetitive stereotyped behaviors. The correlation between neurotrophin-related pathways and multiple autistic-like behaviors was confirmed. Transcriptional profiling indicates that environmental enrichment increases the differences in the prefrontal cortex and hippocampal gene expression associated with the neural system and behavioral development. Our results provide novel evidence on the usefulness of early intervention for neurodevelopmental disorders as a strategy to facilitate positive effects on neural development and behaviors by acting on the BDNF/TrkB-PLCγ1-CaMKII pathway.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2022.114033DOI Listing
June 2022

A Concomitant Cancer Diagnosis Is Associated With Poor Cardiovascular Outcomes Among Acute Myocardial Infarction Patients.

Front Cardiovasc Med 2022 17;9:758324. Epub 2022 Feb 17.

Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Background And Aims: With the increasing coexistence of cardiovascular disease and cancer in contemporary clinical practice, studies on the outcomes in acute myocardial infarction (AMI) patients with cancer has not been systematically investigated. This study sought to investigated the effect of coexisting cancer on the treatment and clinical outcomes among AMI patients.

Methods: We retrospectively integrated and analyzed cardiovascular data of 6,607 AMI patients between June 2016 and December 2019. Patients with cancer were compared with pair-matched cancer-naive patients. Cox proportional hazards models were constructed to compare the differences in outcomes.

Results: Of 6,607 patients, 2.3% ( = 150) had been diagnosed with cancer. Patients with cancer were older (70.3 ± 10.0 vs. 63.9 ± 11.5 years, < 0.001) and had a higher burden of comorbidities. Moreover, patients with cancer tended to receive clopidogrel (52.0 vs. 40.0%, = 0.004) rather than ticagrelor (45.6 vs. 58.2%, = 0.003) than those without cancer. After pairwise matching, patients with cancer were less likely to undergo in-hospital percutaneous coronary intervention (61.3 vs. 70.0%, = 0.055). And after 3-year follow-up, the cumulative incidence of cardiovascular death (14.0 vs. 8.3%; adjusted HR, 1.93; 95% CI, 1.11-3.39; = 0.021) among patients with cancer was significantly higher than that among the matched controls, a similar pattern was observed for the composite outcome of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke (16.0 vs. 10.3%; adjusted HR, 1.98; 95% CI, 1.21-3.26; = 0.007). Moreover, patients with a historical cancer diagnosis within 5 years had a higher risk of cardiovascular ischemic events.

Conclusions: AMI patients with a concomitant diagnosis of cancer tended to be treated with conservative therapies and were at substantially higher risk for adverse cardiovascular outcomes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcvm.2022.758324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891500PMC
February 2022
-->