Publications by authors named "Pedro Miguel Lacal"

32 Publications

Targeting Tumor-Associated Macrophages to Increase the Efficacy of Immune Checkpoint Inhibitors: A Glimpse into Novel Therapeutic Approaches for Metastatic Melanoma.

Cancers (Basel) 2020 Nov 17;12(11). Epub 2020 Nov 17.

Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

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November 2020

PDIA3 Expression in Glioblastoma Modulates Macrophage/Microglia Pro-Tumor Activation.

Int J Mol Sci 2020 Nov 3;21(21). Epub 2020 Nov 3.

Dipartimento di Bioetica e Sicurezza, Sezione di Farmacologia-Catholic University Medical School, 00168 Rome, Italy.

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November 2020

Approaching coronavirus disease 2019: Mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2.

Biochem Pharmacol 2020 10 23;180:114169. Epub 2020 Jul 23.

Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy. Electronic address:

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October 2020

Role of VEGFs/VEGFR-1 Signaling and its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models.

Int J Mol Sci 2020 Feb 18;21(4). Epub 2020 Feb 18.

Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

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February 2020

Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors.

Pharmacol Res 2018 10 28;136:97-107. Epub 2018 Aug 28.

Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. Electronic address:

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October 2018

Poly(ADP-ribose) polymerase inhibitor olaparib hampers placental growth factor-driven activation of myelomonocytic cells.

Oncol Rep 2018 May 5;39(5):2261-2269. Epub 2018 Mar 5.

Department of Systems Medicine, University of Rome 'Tor Vergata', I‑00133 Rome, Italy.

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May 2018

The Anti-Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody D16F7 Inhibits Glioma Growth and Angiogenesis In Vivo.

J Pharmacol Exp Ther 2018 01 12;364(1):77-86. Epub 2017 Oct 12.

Departments of Systems Medicine (M.G.A., L.T., C.C., G.G.) and Experimental Medicine and Surgery (E.B., M.S.), University of Rome Tor Vergata, Rome, Italy; and Laboratory of Molecular Oncology, "Istituto Dermopatico dell'Immacolata"-Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy (F.R., P.M.L.)

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January 2018

Challenging resistance mechanisms to therapies for metastatic melanoma.

Trends Pharmacol Sci 2013 Dec 7;34(12):656-66. Epub 2013 Nov 7.

Department of System Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.

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December 2013

Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness.

Oncol Rep 2013 Dec 10;30(6):2887-96. Epub 2013 Oct 10.

Laboratory of Molecular Oncology, 'Istituto Dermopatico dell'Immacolata'- IRCCS, Rome, Italy.

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December 2013

Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion.

J Pharmacol Exp Ther 2013 Oct 26;347(1):164-72. Epub 2013 Jul 26.

Laboratory of Molecular Oncology, "Istituto Dermopatico dell'Immacolata-IRCCS," Rome, Italy (P.M.L., F.R.); Department of Medicine, University of Perugia, Perugia, Italy (M.G.P., R.B., S.R., G.M., C.R., G.N.); and Department of System Medicine, University of Rome "Tor Vergata," Rome, Italy (A.M., G.G.).

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October 2013

Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.

Am J Pathol 2006 Oct;169(4):1167-82

Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy.

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October 2006

An autocrine loop directed by the vascular endothelial growth factor promotes invasiveness of human melanoma cells.

Int J Oncol 2005 Dec;27(6):1625-32

Laboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata-IRCCS, I-00167 Rome, Italy.

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December 2005