Paul J Tacken

Paul J Tacken

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Paul J Tacken

Paul J Tacken

Publications by authors named "Paul J Tacken"

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27Publications

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ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation.

Molecules 2019 May 12;24(9). Epub 2019 May 12.

Department of Tumor Immunology, Radboud Insititute for Molecular Life Sciences, Radboud University Medical Center, Postbox 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.3390/molecules24091825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540027PMC
May 2019

Controlled release of antigen and Toll-like receptor ligands from PLGA nanoparticles enhances immunogenicity.

Nanomedicine (Lond) 2017 Mar 9;12(5):491-510. Epub 2017 Feb 9.

Department of Tumor Immunology, Radboud Insititute for Molecular Life Sciences, Radboud University Medical Center, Postbox 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.2217/nnm-2016-0295DOI Listing
March 2017

Tracking targeted bimodal nanovaccines: immune responses and routing in cells, tissue, and whole organism.

Mol Pharm 2014 Dec 24;11(12):4299-313. Epub 2014 Oct 24.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/mp400717rDOI Listing
December 2014

Targeting dendritic cells--why bother?

Blood 2013 Apr 6;121(15):2836-44. Epub 2013 Feb 6.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1182/blood-2012-09-452078DOI Listing
April 2013

Targeting nanoparticles to dendritic cells for immunotherapy.

Methods Enzymol 2012 ;509:143-63

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/B978-0-12-391858-1.00008-3DOI Listing
August 2012

Antibodies and carbohydrate ligands binding to DC-SIGN differentially modulate receptor trafficking.

Eur J Immunol 2012 Aug;42(8):1989-98

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/eji.201142258DOI Listing
August 2012

Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN.

Biomaterials 2012 Jun 10;33(16):4229-39. Epub 2012 Mar 10.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.biomaterials.2012.02.036DOI Listing
June 2012

The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.

Blood 2012 Mar 10;119(10):2284-92. Epub 2012 Jan 10.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-08-373944DOI Listing
March 2012

Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity.

Blood 2011 Dec 3;118(26):6836-44. Epub 2011 Oct 3.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-07-367615DOI Listing
December 2011

The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells.

Biomaterials 2011 Oct 2;32(28):6791-803. Epub 2011 Jul 2.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S014296121100504
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http://dx.doi.org/10.1016/j.biomaterials.2011.04.082DOI Listing
October 2011

Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.

Blood 2011 Oct 22;118(15):4111-9. Epub 2011 Aug 22.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-04-34
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http://dx.doi.org/10.1182/blood-2011-04-346957DOI Listing
October 2011

Multimodal imaging of nanovaccine carriers targeted to human dendritic cells.

Mol Pharm 2011 Apr 16;8(2):520-31. Epub 2011 Mar 16.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/mp100356kDOI Listing
April 2011

DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells.

Eur J Immunol 2011 Apr 17;41(4):1014-23. Epub 2011 Mar 17.

Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1002/eji.201040790
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http://dx.doi.org/10.1002/eji.201040790DOI Listing
April 2011

Targeted antigen delivery and activation of dendritic cells in vivo: steps towards cost effective vaccines.

Semin Immunol 2011 Feb 26;23(1):12-20. Epub 2011 Jan 26.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Postbox 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.smim.2011.01.001DOI Listing
February 2011

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro.

J Control Release 2010 Jun 13;144(2):118-26. Epub 2010 Feb 13.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016836591000121
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http://dx.doi.org/10.1016/j.jconrel.2010.02.013DOI Listing
June 2010

Human plasmacytoid dendritic cells phagocytose, process, and present exogenous particulate antigen.

J Immunol 2010 Apr 19;184(8):4276-83. Epub 2010 Mar 19.

Department of Tumor Immunology, , Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.0903286DOI Listing
April 2010

No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation.

J Immunol 2008 Jun;180(11):7687-96

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.180.11.7687DOI Listing
June 2008

Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.

Blood 2008 Apr 7;111(8):4245-53. Epub 2008 Feb 7.

Department of Tumor Immunology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2007-03-081398DOI Listing
April 2008

Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting.

Nat Rev Immunol 2007 Oct;7(10):790-802

Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Tumour Immunology, Postbox 9101, Nijmegen, 6500HB, Netherlands.

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http://etumaster.icmv.free.fr/Cours/3.5/Biblio%20%C3%A9tudia
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http://www.nature.com/doifinder/10.1038/nri2173
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http://dx.doi.org/10.1038/nri2173DOI Listing
October 2007

Relevance of DC-SIGN in DC-induced T cell proliferation.

J Leukoc Biol 2007 Mar 29;81(3):729-40. Epub 2006 Nov 29.

Department of Tumor Immunology, NCMLS 278, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26/28, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1189/jlb.0606414DOI Listing
March 2007

Targeting antigens to dendritic cells in vivo.

Immunobiology 2006 7;211(6-8):599-608. Epub 2006 Jul 7.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.imbio.2006.05.021DOI Listing
December 2006

Monocyte CD64 or CD89 targeting by surfactant protein D/anti-Fc receptor mediates bacterial uptake.

Immunology 2006 Apr;117(4):494-501

Department of Biochemistry and Cell Biology, Graduate School of Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

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http://doi.wiley.com/10.1111/j.1365-2567.2006.02324.x
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http://dx.doi.org/10.1111/j.1365-2567.2006.02324.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782248PMC
April 2006

Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus.

Am J Physiol Lung Cell Mol Physiol 2005 Oct 10;289(4):L606-16. Epub 2005 Jun 10.

Dept. of Medicine, Boston University School of Medicine, MA 02118, USA.

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http://dx.doi.org/10.1152/ajplung.00130.2005DOI Listing
October 2005

Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody.

Blood 2005 Aug 5;106(4):1278-85. Epub 2005 May 5.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2005-01-0318DOI Listing
August 2005

Effective targeting of pathogens to neutrophils via chimeric surfactant protein D/anti-CD89 protein.

J Immunol 2004 Apr;172(8):4934-40

Department of Biochemistry and Cell Biology, Graduate School of Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.172.8.4934DOI Listing
April 2004

VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area.

Atherosclerosis 2002 May;162(1):103-10

Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9503, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/s0021-9150(01)00697-9DOI Listing
May 2002