Outi Vaarala

Outi Vaarala

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Outi Vaarala

Publications by authors named "Outi Vaarala"

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Exposure to sewage water and the development of allergic manifestations in Finnish children.

Pediatr Allergy Immunol 2019 Sep 28;30(6):598-603. Epub 2019 Jun 28.

Clinicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/pai.13090DOI Listing
September 2019

Dynamics of IFN-β Responses During Respiratory Viral Infection: Insights for Therapeutic Strategies.

Am J Respir Crit Care Med 2019 Aug 28. Epub 2019 Aug 28.

University of Southampton, Faculty of Medicine, Clinical & Experimental Sciences, Southampton, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1164/rccm.201901-0214OCDOI Listing
August 2019

Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients.

J Allergy Clin Immunol 2019 Jul 4;144(1):61-69.e7. Epub 2019 Feb 4.

Respiratory, Inflammation and Autoimmunity, Biotech IMED Unit, AstraZeneca, Gothenburg, Sweden.

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http://dx.doi.org/10.1016/j.jaci.2019.01.027DOI Listing
July 2019

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

J Allergy Clin Immunol 2019 Jun 13. Epub 2019 Jun 13.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.003DOI Listing
June 2019

Immunomodulatory effects of antipsychotic treatment on gene expression in first-episode psychosis.

J Psychiatr Res 2019 Feb 10;109:18-26. Epub 2018 Nov 10.

Mental Health Unit, National Institute for Health and Welfare, P.O. Box 30, FI-00271, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jpsychires.2018.11.008DOI Listing
February 2019

No evidence of the role of early chemical exposure in the development of β-cell autoimmunity.

Environ Sci Pollut Res Int 2019 Jan 13;26(2):1370-1378. Epub 2018 Nov 13.

Scientific Laboratory, Clinicum, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland.

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http://link.springer.com/10.1007/s11356-018-3659-6
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http://dx.doi.org/10.1007/s11356-018-3659-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331740PMC
January 2019

Bronchial extracellular matrix from COPD patients induces altered gene expression in repopulated primary human bronchial epithelial cells.

Sci Rep 2018 02 22;8(1):3502. Epub 2018 Feb 22.

Bioscience Regeneration Department, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

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http://dx.doi.org/10.1038/s41598-018-21727-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823945PMC
February 2018

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial.

Gastroenterology 2017 10 5;153(4):961-970.e3. Epub 2017 Jul 5.

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.06.049DOI Listing
October 2017

Rotavirus Vaccination and the Risk of Celiac Disease or Type 1 Diabetes in Finnish Children at Early Life.

Pediatr Infect Dis J 2017 07;36(7):674-675

From the *Institute of Clinical Medicine, University of Helsinki, and †Department of Health Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1097/INF.0000000000001600DOI Listing
July 2017

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity.

Diabetologia 2017 07 4;60(7):1223-1233. Epub 2017 May 4.

Department of Public Health Solutions, National Institute for Health and Welfare, PO Box 30, FI-00271, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00125-017-4280-9DOI Listing
July 2017

ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk.

J Allergy Clin Immunol 2016 06 12;137(6):1699-1706.e13. Epub 2016 Jan 12.

Institute for Laboratory Medicine, Pathobiochemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany; Comprehensive Biomaterial Bank Marburg, CBBMR, Medical Faculty, Philipps University of Marburg, Marburg, Germany.

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http://dx.doi.org/10.1016/j.jaci.2015.10.042DOI Listing
June 2016

Similar Antibody Levels in 3-Year-Old Children Vaccinated Against Measles, Mumps, and Rubella at the Age of 12 Months or 18 Months.

J Infect Dis 2016 06 9;213(12):2005-13. Epub 2016 Feb 9.

Department of Health Protection, National Institute for Health and Welfare.

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http://dx.doi.org/10.1093/infdis/jiw058DOI Listing
June 2016

Altered Fecal Microbiota in Paediatric Inflammatory Bowel Disease.

J Crohns Colitis 2015 Dec 7;9(12):1088-95. Epub 2015 Sep 7.

VTT Technical Research Centre of Finland, Espoo, Finland.

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http://dx.doi.org/10.1093/ecco-jcc/jjv147DOI Listing
December 2015

Autoantibodies against ganglioside GM3 are associated with narcolepsy-cataplexy developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus.

J Autoimmun 2015 Sep 27;63:68-75. Epub 2015 Jul 27.

Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland; Research Program Unit, Immunobiology, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2015.07.006DOI Listing
September 2015

[Narcolepsy as an autoimmune disease].

Duodecim 2015 ;131(12):1153-60

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September 2015

The increased risk for autoimmune diseases in patients with eating disorders.

PLoS One 2014 22;9(8):e104845. Epub 2014 Aug 22.

Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104845PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141740PMC
May 2015

Antibodies to deamidated gliadin peptide in diagnosis of celiac disease in children.

J Pediatr Gastroenterol Nutr 2015 May;60(5):626-31

*Department of Clinical Microbiology †Department of Pediatrics, University of Eastern Finland ‡Department of Pediatrics and Adolescent Medicine, University of Turku, Turku §A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio ||Department of Pediatrics, University of Oulu and Oulu University Hospital, Oulu ¶Children's Hospital, University of Helsinki, Helsinki #Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland.

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http://www.naspghan.org/files/documents/pdfs/cme/jpgn/Antibo
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http://dx.doi.org/10.1097/MPG.0000000000000666DOI Listing
May 2015

Infections in infants fed formula supplemented with bovine milk fat globule membranes.

J Pediatr Gastroenterol Nutr 2015 Mar;60(3):384-9

*Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden †Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland ‡Department of Nutrition, University of California, Davis.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MPG.0000000000000624DOI Listing
March 2015

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Cell Host Microbe 2015 Feb 5;17(2):260-73. Epub 2015 Feb 5.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689191PMC
February 2015

Consumption of unprocessed cow's milk protects infants from common respiratory infections.

J Allergy Clin Immunol 2015 Jan 19;135(1):56-62. Epub 2014 Oct 19.

Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.

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http://dx.doi.org/10.1016/j.jaci.2014.08.044DOI Listing
January 2015

Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans.

J Immunol 2015 Jan 5;194(1):68-75. Epub 2014 Dec 5.

Children's Hospital, University of Helsinki and Helsinki University Central Hospital, 00281 Helsinki, Finland; Respiratory, Inflammatory and Autoimmune Diseases, Innovative Medicine, AstraZeneca, 43183 Mölndal, Sweden

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1401653
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http://dx.doi.org/10.4049/jimmunol.1401653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273995PMC
January 2015

Heterogeneity in diabetes-associated autoantibodies and susceptibility to Type 1 diabetes: lessons for disease prevention.

Expert Rev Endocrinol Metab 2015 Jan 31;10(1):25-34. Epub 2014 Aug 31.

g 7 Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1586/17446651.2015.955474DOI Listing
January 2015

Lactose inhibits regulatory T-cell-mediated suppression of effector T-cell interferon-γ and IL-17 production.

Br J Nutr 2014 Dec 21;112(11):1819-25. Epub 2014 Oct 21.

Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare,Haartmaninkatu 8,FI-00290Helsinki,Finland.

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http://dx.doi.org/10.1017/S0007114514001998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239808PMC
December 2014

Does autoreactivity have a role in narcolepsy?

Lancet Neurol 2014 Nov;13(11):1072-1073

Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland; Respiratory, Inflammatory and Autoimmune Diseases, Innovative Medicine, AstraZeneca, Mölndal, Sweden.

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http://dx.doi.org/10.1016/S1474-4422(14)70168-1DOI Listing
November 2014

Dendritic cells from Crohn's disease patients show aberrant STAT1 and STAT3 signaling.

PLoS One 2013 7;8(8):e70738. Epub 2013 Aug 7.

Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070738PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737363PMC
August 2014

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.

Lancet Neurol 2014 Jun;13(6):600-13

Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1016/S1474-4422(14)70075-4DOI Listing
June 2014

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals.

Nutr Metab (Lond) 2014 13;11:28. Epub 2014 Jun 13.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum, Helsinki, Finland ; Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, Helsinki, Finland ; Diabetes & Obesity Research Program, Research Program's Unit, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1743-7075-11-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067102PMC
June 2014

Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease.

Scand J Gastroenterol 2014 Feb 10;49(2):145-56. Epub 2013 Dec 10.

Department of Clinical and Experimental Medicine, Division of Paediatrics, Faculty of Health Sciences, Linköping University , Linköping , Sweden.

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http://www.tandfonline.com/doi/full/10.3109/00365521.2013.86
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http://dx.doi.org/10.3109/00365521.2013.863966DOI Listing
February 2014

Gut microbiota and type 1 diabetes.

Authors:
Outi Vaarala

Rev Diabet Stud 2012 28;9(4):251-9. Epub 2012 Dec 28.

Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1900/RDS.2012.9.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740694PMC
January 2014

Human intestinal microbiota and type 1 diabetes.

Authors:
Outi Vaarala

Curr Diab Rep 2013 Oct;13(5):601-7

Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Haartmaninkatu 8, 00290, Helsinki, Finland,

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http://dx.doi.org/10.1007/s11892-013-0409-5DOI Listing
October 2013

Interleukin-17 immunity in pediatric Crohn disease and ulcerative colitis.

J Pediatr Gastroenterol Nutr 2013 Sep;57(3):287-92

Department of Vaccination and Immune Protection, Immune Response Unit, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1097/MPG.0b013e3182979252DOI Listing
September 2013

Inflammatory response and IgE sensitization at early age.

Pediatr Allergy Immunol 2013 Jun 11;24(4):395-401. Epub 2013 Apr 11.

Department of Environmental Health, National Institute for Health and Welfare, Kuopio, Finland.

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http://dx.doi.org/10.1111/pai.12072DOI Listing
June 2013

Impaired intestinal tolerance in the absence of a functional complement system.

J Allergy Clin Immunol 2013 Apr 23;131(4):1167-75. Epub 2012 Oct 23.

Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jaci.2012.09.004DOI Listing
April 2013

Fecal microbiota composition differs between children with β-cell autoimmunity and those without.

Diabetes 2013 Apr 28;62(4):1238-44. Epub 2012 Dec 28.

Department of Medical Microbiology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.2337/db12-0526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609581PMC
April 2013

Altered phenotype of peripheral blood dendritic cells in pediatric type 1 diabetes.

Diabetes Care 2012 Nov 11;35(11):2303-10. Epub 2012 Jul 11.

Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.2337/dc11-2460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476907PMC
November 2012

Expansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes.

Pediatr Diabetes 2012 Aug 15;13(5):400-7. Epub 2012 Feb 15.

Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://doi.wiley.com/10.1111/j.1399-5448.2012.00852.x
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http://dx.doi.org/10.1111/j.1399-5448.2012.00852.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225542PMC
August 2012

In Crohn's Disease, Anti-TNF-α Treatment Changes the Balance between Mucosal IL-17, FOXP3, and CD4 Cells.

ISRN Gastroenterol 2012 14;2012:505432. Epub 2012 Jun 14.

Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Haartmaninkatu 8, 00290 Helsinki, Finland.

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http://dx.doi.org/10.5402/2012/505432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384926PMC
August 2012

Early human enterovirus infections in healthy Swedish children participating in the PRODIA pilot study.

J Med Virol 2012 Jun;84(6):923-30

Intestinal Viruses Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1002/jmv.23284DOI Listing
June 2012

Is the origin of type 1 diabetes in the gut?

Authors:
Outi Vaarala

Immunol Cell Biol 2012 Mar 31;90(3):271-6. Epub 2012 Jan 31.

Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1038/icb.2011.115DOI Listing
March 2012

Diabetes: Should we treat infection or inflammation to prevent T2DM?

Nat Rev Endocrinol 2012 Mar 20;8(6):323-5. Epub 2012 Mar 20.

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http://dx.doi.org/10.1038/nrendo.2012.31DOI Listing
March 2012

No evidence for activation of T(H)1 or T(H)17 pathways in unstimulated peripheral blood mononuclear cells from children with β-cell autoimmunity or T1D.

J Inflamm Res 2008 1;1:11-7. Epub 2008 Sep 1.

Linköping University, Faculty of Health Sciences, Department of Clinical and Experimental Medicine, Division of Pediatrics and Diabetes Research Center, Linköping, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218718PMC
November 2011

Asthma and allergic symptoms and type 1 diabetes-related autoantibodies in 2.5-yr-old children.

Pediatr Diabetes 2011 Nov 6;12(7):604-10. Epub 2011 Apr 6.

Division of Cardiovascular Medicine, Department of Medical and Health Sciences Faculty of Health Sciences, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1111/j.1399-5448.2011.00758.xDOI Listing
November 2011

The gut as a regulator of early inflammation in type 1 diabetes.

Authors:
Outi Vaarala

Curr Opin Endocrinol Diabetes Obes 2011 Aug;18(4):241-7

Immune Response Unit, Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland.

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http://dx.doi.org/10.1097/MED.0b013e3283488218DOI Listing
August 2011

A functional complement system is required for normal T helper cell differentiation.

Immunobiology 2011 Jun 27;216(6):737-43. Epub 2010 Oct 27.

Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S017129851000192
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http://dx.doi.org/10.1016/j.imbio.2010.10.004DOI Listing
June 2011

The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease.

Scand J Gastroenterol 2011 May 3;46(5):538-49. Epub 2011 Feb 3.

Division of Paediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.

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http://liu.diva-portal.org/smash/get/diva2:413607/FULLTEXT01
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http://www.tandfonline.com/doi/full/10.3109/00365521.2011.55
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http://dx.doi.org/10.3109/00365521.2011.551888DOI Listing
May 2011

Serum immune-activation potency and response to anti-TNF-α therapy in Crohn's disease.

World J Gastroenterol 2010 Dec;16(46):5845-51

Division of Gastroenterology, Hospital for Children and Adolescents and Helsinki University Central Hospital, University of Helsinki, Helsinki, FIN-00029, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001976PMC
http://dx.doi.org/10.3748/wjg.v16.i46.5845DOI Listing
December 2010

IL-17 immunity in human type 1 diabetes.

J Immunol 2010 Aug 30;185(3):1959-67. Epub 2010 Jun 30.

Immune Response Unit, National Institute for Health and Welfare, Helsinki, Finland.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1000788
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http://dx.doi.org/10.4049/jimmunol.1000788DOI Listing
August 2010

Combined T regulatory cell and Th2 expression profile identifies children with cow's milk allergy.

Clin Immunol 2010 Jul 15;136(1):16-20. Epub 2010 Mar 15.

Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.clim.2010.02.011DOI Listing
July 2010

Environmental factors and primary prevention in type 1 diabetes.

Pediatr Endocrinol Diabetes Metab 2009 ;15(4):227-32

Immunogenetics Laboratory, University of Turku, Turku, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225540PMC
June 2010

Human leukocyte antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 haplotypes are associated with humoral responses to early food allergens in children.

Int Arch Allergy Immunol 2010 16;152(2):169-77. Epub 2009 Dec 16.

Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1159/000265538DOI Listing
June 2010

Infiltration of Foxp3- and Toll-like receptor-4-positive cells in the intestines of children with food allergy.

J Pediatr Gastroenterol Nutr 2010 Apr;50(4):367-76

Hospital for Children and Adolescents, University of Helsinki, Finland.

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https://insights.ovid.com/crossref?an=00005176-900000000-996
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http://dx.doi.org/10.1097/MPG.0b013e3181cd2636DOI Listing
April 2010

New means to monitor the effect of glucocorticoid therapy in children.

World J Gastroenterol 2010 Mar;16(9):1104-9

Division of Gastroenterology, Hospital for Children and Adolescents, University of Helsinki, Box 281, Helsinki, FIN-00029, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835787PMC
http://dx.doi.org/10.3748/wjg.v16.i9.1104DOI Listing
March 2010

Activation of T cells in preterm infants with respiratory distress syndrome.

Neonatology 2009 26;96(4):248-58. Epub 2009 May 26.

Department of Pediatrics, Kanta-Hame Central Hospital, Hameenlinna, Finland.

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http://dx.doi.org/10.1159/000220764DOI Listing
January 2010

Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.

J Autoimmun 2009 Sep 26;33(2):155-64. Epub 2009 May 26.

Immunogenetics Laboratory, University of Turku, MediCity, BioCity 4th Floor, Turku, Finland.

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http://dx.doi.org/10.1016/j.jaut.2009.04.003DOI Listing
September 2009

Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus.

Scand J Gastroenterol 2009 ;44(4):422-30

Department of Immunology, Institute of General and Molecular Pathology, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1080/00365520802624177DOI Listing
June 2009

Breastfeeding stimulates total and cow's milk-specific salivary IgA in infants.

Pediatr Allergy Immunol 2009 May;20(3):295-8

Laboratory for Immunobiology, National Public Health Institute, Mannerheimintie166, Helsinki FIN-00300, Finland.

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http://dx.doi.org/10.1111/j.1399-3038.2008.00776.xDOI Listing
May 2009

Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes.

Diabetes Metab Res Rev 2008 Nov-Dec;24(8):635-41

Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

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http://doi.wiley.com/10.1002/dmrr.904
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http://dx.doi.org/10.1002/dmrr.904DOI Listing
February 2009

Lipopolysaccharide-induced immune responses in relation to the TLR4(Asp299Gly) gene polymorphism.

Clin Vaccine Immunol 2008 Dec 15;15(12):1878-83. Epub 2008 Oct 15.

Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, SE-58185 Linköping, Sweden.

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http://dx.doi.org/10.1128/CVI.00241-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593161PMC
December 2008

Leaking gut in type 1 diabetes.

Authors:
Outi Vaarala

Curr Opin Gastroenterol 2008 Nov;24(6):701-6

Laboratory for Immunobiology, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.1097/MOG.0b013e32830e6d98DOI Listing
November 2008

Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood.

Pediatr Diabetes 2008 Oct 21;9(5):434-41. Epub 2008 May 21.

Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/j.1399-5448.2008.00413.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225539PMC
October 2008

The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.

Diabetes 2008 Oct;57(10):2555-62

Laboratory for Immunobiology, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db08-03
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http://dx.doi.org/10.2337/db08-0331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551660PMC
October 2008

GAD treatment and insulin secretion in recent-onset type 1 diabetes.

N Engl J Med 2008 Oct 8;359(18):1909-20. Epub 2008 Oct 8.

Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1056/NEJMoa0804328DOI Listing
October 2008

IL-23/IL-17 immunity as a hallmark of Crohn's disease.

Inflamm Bowel Dis 2008 Sep;14(9):1175-84

Laboratory for Immunobiology, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.1002/ibd.20475DOI Listing
September 2008

Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study.

Pediatr Diabetes 2008 Jun 5;9(3 Pt 1):182-90. Epub 2008 Mar 5.

Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1111/j.1399-5448.2008.00369.xDOI Listing
June 2008

Pre and probiotics in the prevention and treatment of food allergy.

Curr Opin Allergy Clin Immunol 2008 Jun;8(3):243-8

Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1097/ACI.0b013e3282ffb134DOI Listing
June 2008

Effect of Lactobacillus rhamnosus GG on rBet v1 and rMal d1 specific IgA in the saliva of patients with birch pollen allergy.

Ann Allergy Asthma Immunol 2008 Apr;100(4):338-42

National Public Health Institute, Laboratory for Immunobiology, Helsinki, Finland.

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http://dx.doi.org/10.1016/S1081-1206(10)60596-0DOI Listing
April 2008

Increased activation of GATA-3, IL-2 and IL-5 of cord blood mononuclear cells in infants with IgE sensitization.

Pediatr Allergy Immunol 2008 Mar 25;19(2):132-9. Epub 2007 Jul 25.

The Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/j.1399-3038.2007.00593.xDOI Listing
March 2008

Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice.

J Pharmacol Exp Ther 2007 Oct 17;323(1):180-5. Epub 2007 Jul 17.

Department of Medical Cell Biology, Biomedicum, P.O. Box 571, SE-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1124/jpet.107.122655DOI Listing
October 2007

Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population.

Br J Nutr 2007 Jan;97(1):111-6

Department of Molecular and Clinical Medicine, Linköpings Universitet, Sweden.

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http://dx.doi.org/10.1017/S0007114507210189DOI Listing
January 2007

Insulin treatment in patients with type 1 diabetes induces upregulation of regulatory T-cell markers in peripheral blood mononuclear cells stimulated with insulin in vitro.

Diabetes 2006 Dec;55(12):3446-54

National Public Health Institute, Department of Viral Diseases and Immunology, Laboratory for Immunology, Mannerheimintie 166, 00300 Helsinki, Finland.

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http://dx.doi.org/10.2337/db06-0132DOI Listing
December 2006

Is it dietary insulin?

Authors:
Outi Vaarala

Ann N Y Acad Sci 2006 Oct;1079:350-9

Laboratory for Immunobiology, Department of Viral Disease and Immunology, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland.

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http://www.researchgate.net/profile/Outi_Vaarala/publication
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http://doi.wiley.com/10.1196/annals.1375.054
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http://dx.doi.org/10.1196/annals.1375.054DOI Listing
October 2006

Probiotics for the prevention of beta cell autoimmunity in children at genetic risk of type 1 diabetes--the PRODIA study.

Ann N Y Acad Sci 2006 Oct;1079:360-4

Centre of Clinical Experimental Research, Division of Pediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden.

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http://dx.doi.org/10.1196/annals.1375.055DOI Listing
October 2006