Publications by authors named "Olcay Dilken"

5 Publications

  • Page 1 of 1

Effects of Hemoadsorption with Cytosorb during Severe Rhabdomyolysis: Reply to the Letter to the Editor of Daum and Colleagues.

Blood Purif 2021 3;50(2):273-274. Epub 2020 Sep 3.

Department of Intensive Care, Erasmus Medical Centre, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1159/000509898DOI Listing
September 2020

Assessment of sublingual microcirculation in critically ill patients: consensus and debate.

Ann Transl Med 2020 Jun;8(12):793

Department of Intensive Care Med, Laboratory of Translational Intensive Care Med, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

The main concern in shock and resuscitation is whether the microcirculation can carry adequate oxygen to the tissues and remove waste. Identification of an intact coherence between macro- and microcirculation during states of shock and resuscitation shows a functioning regulatory mechanism. However, loss of hemodynamic coherence between the macro and microcirculation can be encountered frequently in sepsis, cardiogenic shock, or any hemodynamically compromised patient. This loss of hemodynamic coherence results in an improvement in macrohemodynamic parameters following resuscitation without a parallel improvement in microcirculation resulting in tissue hypoxia and tissue compromise. Hand-held vital microscopes (HVMs) can visualize the microcirculation and help to diagnose the nature of microcirculatory shock. Although treatment with the sole aim of recruiting the microcirculation is as yet not realized, interventions can be tailored to the needs of the patient while monitoring sublingual microcirculation. With the help of the newly introduced software, called MicroTools, we believe sublingual microcirculation monitoring and diagnosis will be an essential point-of-care tool in managing shock patients.
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http://dx.doi.org/10.21037/atm.2020.03.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333125PMC
June 2020

Use of Spironolactone in SARS-CoV-2 ARDS Patients.

Turk J Anaesthesiol Reanim 2020 Jun 30;48(3):254-255. Epub 2020 Apr 30.

Department of Intensive Care, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey.

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http://dx.doi.org/10.5152/TJAR.2020.569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279869PMC
June 2020

Successful Reduction of Creatine Kinase and Myoglobin Levels in Severe Rhabdomyolysis Using Extracorporeal Blood Purification (CytoSorb®).

Blood Purif 2020 28;49(6):743-747. Epub 2020 Feb 28.

Department of Intensive Care, Erasmus Medical Centre, University Medical Center, Rotterdam, The Netherlands.

Rhabdomyolysis, if severe, can lead to acute kidney injury (AKI). Myoglobin is an iron and oxygen-binding protein that is freely filtered by the glomerulus. Precipitation of myoglobin in the nephrons' distal parts is responsible for tubular damage with AKI as a consequence. Extracorporeal clearance of myoglobin is conventionally attempted by the use of continuous renal replacement therapy (CRRT) with high cut-off dialysis membranes to limit the extent of the damage. We describe a case of a 56-year-old man with traumatic crush injury and a persistent source of muscle ischaemia unresponsive to high dose CRRT with EMiC-2 filter. Due to therapy failure, he was subsequently treated with the addition of a haemoadsorber (CytoSorb®) to the circuit. This reduced myoglobin and creatine kinase levels successfully despite ongoing tissue ischaemia. However, CytoSorb® was not enough to maintain microcirculatory perfusion, resulting in the eventual demise of the patient due to severity of the injury. Our report indicates that myoglobin was efficiently removed with CytoSorb® following exchange with the conventional high cut-off filter in continuous venovenous haemodialysis in severe traumatic rhabdomyolysis.
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http://dx.doi.org/10.1159/000505899DOI Listing
February 2020

ICU Utilization for Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease Receiving Noninvasive Ventilation. Seeking Answers to the Questions of Utilization: Does Perception Reflect Reality?

Crit Care Med 2019 08;47(8):e725-e726

Pulmonary, Critical Care and Sleep Section, West Lost Angeles VA Healthcare Center (111Q), David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Intensive Care, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, Turkey Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain.

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http://dx.doi.org/10.1097/CCM.0000000000003798DOI Listing
August 2019