Norbert O Reich

Norbert O Reich

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Norbert O Reich

Norbert O Reich

Publications by authors named "Norbert O Reich"

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The R882H substitution in the human DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.

J Biol Chem 2019 Nov 22;294(48):18207-18219. Epub 2019 Oct 22.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510

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http://dx.doi.org/10.1074/jbc.RA119.010827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885622PMC
November 2019

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site.

Nat Commun 2019 10 10;10(1):4600. Epub 2019 Oct 10.

Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-019-12498-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787082PMC
October 2019

Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.

Apoptosis 2019 06;24(5-6):529-537

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.

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http://dx.doi.org/10.1007/s10495-019-01531-1DOI Listing
June 2019

Integrated rate laws for processive and distributive enzymatic turnover.

J Chem Phys 2019 Jun;150(24):244120

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://aip.scitation.org/doi/10.1063/1.5097576
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http://dx.doi.org/10.1063/1.5097576DOI Listing
June 2019

The highly specific, cell cycle-regulated methyltransferase from relies on a novel DNA recognition mechanism.

J Biol Chem 2018 12 15;293(49):19038-19046. Epub 2018 Oct 15.

From the Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106.

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http://dx.doi.org/10.1074/jbc.RA118.005212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295719PMC
December 2018

Light-Triggered Genome Editing: Cre Recombinase Mediated Gene Editing with Near-Infrared Light.

Small 2018 07 2;14(30):e1800543. Epub 2018 Jul 2.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.

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http://doi.wiley.com/10.1002/smll.201800543
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http://dx.doi.org/10.1002/smll.201800543DOI Listing
July 2018

Specificity versus Processivity in the Sequential Modification of DNA: A Study of DNA Adenine Methyltransferase.

J Phys Chem B 2018 01 10;122(3):1112-1120. Epub 2018 Jan 10.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/acs.jpcb.7b10349DOI Listing
January 2018

Caulobacter crescentus Cell Cycle-Regulated DNA Methyltransferase Uses a Novel Mechanism for Substrate Recognition.

Biochemistry 2017 08 18;56(30):3913-3922. Epub 2017 Jul 18.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00378DOI Listing
August 2017

Affinity-Based Assembly of Peptides on Plasmonic Nanoparticles Delivered Intracellularly with Light Activated Control.

Bioconjug Chem 2017 07 19;28(7):1816-1820. Epub 2017 Jun 19.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00276DOI Listing
July 2017

Light-Patterned RNA Interference of 3D-Cultured Human Embryonic Stem Cells.

Adv Mater 2016 Dec 27;28(48):10732-10737. Epub 2016 Oct 27.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.

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http://dx.doi.org/10.1002/adma.201603318DOI Listing
December 2016

Mechanisms of Protein Translocation on DNA Are Differentially Responsive to Water Activity.

Biochemistry 2016 Dec 5;55(50):6957-6960. Epub 2016 Dec 5.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00872DOI Listing
December 2016

Rational Manipulation of DNA Methylation by Using Isotopically Reinforced Cytosine.

Chembiochem 2016 11 30;17(21):2018-2021. Epub 2016 Sep 30.

Retrotope, Inc., 4300 El Camino Real, Suite 201, Los Altos, CA, 94022, USA.

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http://doi.wiley.com/10.1002/cbic.201600393
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http://dx.doi.org/10.1002/cbic.201600393DOI Listing
November 2016

Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles.

Chem Commun (Camb) 2015 Dec;51(100):17692-5

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106-9510 USA.

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http://dx.doi.org/10.1039/c5cc07989fDOI Listing
December 2015

Extracting enzyme processivity from kinetic assays.

J Chem Phys 2015 Dec;143(22):224115

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1063/1.4937155DOI Listing
December 2015

Modular plasmonic nanocarriers for efficient and targeted delivery of cancer-therapeutic siRNA.

Nano Lett 2014 6;14(4):2046-51. Epub 2014 Mar 6.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/nl500214eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985716PMC
October 2015

Light-activated RNA interference in human embryonic stem cells.

Biomaterials 2015 Sep 10;63:70-9. Epub 2015 Jun 10.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.06.006DOI Listing
September 2015

De novo DNA methyltransferase DNMT3A: Regulation of oligomeric state and mechanism of action in response to pH changes.

Biochim Biophys Acta 2015 Jun 11;1850(6):1131-9. Epub 2015 Feb 11.

Interdepartmental Program in Biomolecular Science & Engineering, University of California, Santa Barbara, CA 93106-9510, United States; Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA 93106-9510, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2015.02.003DOI Listing
June 2015

DNA adenine methyltransferase facilitated diffusion is enhanced by protein-DNA "roadblock" complexes that induce DNA looping.

Biochemistry 2015 Apr 25;54(13):2181-92. Epub 2015 Mar 25.

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/bi501344rDOI Listing
April 2015

Targeted intracellular delivery of proteins with spatial and temporal control.

Mol Pharm 2015 Feb 23;12(2):600-9. Epub 2014 Dec 23.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/mp500675pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319691PMC
February 2015

Distinct facilitated diffusion mechanisms by E. coli Type II restriction endonucleases.

Biochemistry 2014 Nov 6;53(45):7028-37. Epub 2014 Nov 6.

Department of Chemistry and Biochemistry, University of California at Santa Barbara , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/bi501110rDOI Listing
November 2014

Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near-Infra-Red Light.

Part Part Syst Charact 2014 Nov 14;31(11):1158-1167. Epub 2014 Jul 14.

Chemical Engineering and Material Science, University of Minnesota, Minneapolis, MN 55455.

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http://dx.doi.org/10.1002/ppsc.201400035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695930PMC
November 2014

DNA looping provides for "intersegmental hopping" by proteins: a mechanism for long-range site localization.

J Mol Biol 2014 Oct 15;426(21):3539-52. Epub 2014 Aug 15.

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Building 557, Room 1432, Santa Barbara, CA 93106-9510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.08.002DOI Listing
October 2014

Etchable plasmonic nanoparticle probes to image and quantify cellular internalization.

Nat Mater 2014 Sep 8;13(9):904-11. Epub 2014 Jun 8.

1] Cancer Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA [2] Center for Nanomedicine and Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://www.nature.com/articles/nmat3982
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http://dx.doi.org/10.1038/nmat3982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141013PMC
September 2014

Enzyme-promoted base flipping controls DNA methylation fidelity.

Biochemistry 2013 Mar 27;52(10):1677-85. Epub 2013 Feb 27.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.

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http://dx.doi.org/10.1021/bi3012912DOI Listing
March 2013

Distal structural elements coordinate a conserved base flipping network.

Biochemistry 2013 Mar 27;52(10):1669-76. Epub 2013 Feb 27.

Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106-9510, United States.

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http://dx.doi.org/10.1021/bi301284fDOI Listing
March 2013

STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition.

Nucleic Acids Res 2013 Jan 24;41(2):754-63. Epub 2012 Nov 24.

Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1093/nar/gks1085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553987PMC
January 2013

Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation.

J Biol Chem 2012 Sep 21;287(37):30941-51. Epub 2012 Jun 21.

Interdepartmental Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1074/jbc.M112.366625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438927PMC
September 2012

RNA modulation of the human DNA methyltransferase 3A.

Nucleic Acids Res 2012 Sep 22;40(17):8550-7. Epub 2012 Jun 22.

Interdepartmental Program in Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1093/nar/gks537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458530PMC
September 2012

Molecular drivers of base flipping during sequence-specific DNA methylation.

Chembiochem 2012 Jul 22;13(11):1574-7. Epub 2012 Jun 22.

Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1002/cbic.201200104DOI Listing
July 2012

Robust SERS enhancement factor statistics using rotational correlation spectroscopy.

Nano Lett 2012 Jun 7;12(6):2912-7. Epub 2012 May 7.

Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.

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http://dx.doi.org/10.1021/nl3005447DOI Listing
June 2012

Proximal recognition sites facilitate intrasite hopping by DNA adenine methyltransferase: mechanistic exploration of epigenetic gene regulation.

J Biol Chem 2012 Jun 7;287(27):22873-81. Epub 2012 May 7.

Department of Chemistry and Biochemistry University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1074/jbc.M111.332502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391122PMC
June 2012

A new strategy for detection and development of tractable telomerase inhibitors.

J Med Chem 2012 Apr 10;55(8):3678-86. Epub 2012 Apr 10.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1021/jm201191dDOI Listing
April 2012

Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation.

J Biol Chem 2011 Dec 6;286(48):41479-88. Epub 2011 Oct 6.

Interdepartmental Program in Biomolecular Science & Engineering, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1074/jbc.M111.284687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308859PMC
December 2011

Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14.

Nucleic Acids Res 2011 Sep 21;39(17):7641-55. Epub 2011 Jun 21.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1093/nar/gkr475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177210PMC
September 2011

Transcription factor beacons for the quantitative detection of DNA binding activity.

J Am Chem Soc 2011 Sep 12;133(35):13836-9. Epub 2011 Aug 12.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106, United States.

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http://dx.doi.org/10.1021/ja204775kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866037PMC
September 2011

Determinants of precatalytic conformational transitions in the DNA cytosine methyltransferase M.HhaI.

Biochemistry 2011 Mar 10;50(9):1465-73. Epub 2011 Feb 10.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, United States.

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http://dx.doi.org/10.1021/bi101446gDOI Listing
March 2011

The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.

J Biol Chem 2010 Sep 14;285(38):29091-100. Epub 2010 Jul 14.

Interdepartmental Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1074/jbc.M110.142513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937940PMC
September 2010

Identification of a second DNA binding site in human DNA methyltransferase 3A by substrate inhibition and domain deletion.

Arch Biochem Biophys 2010 Jun 17;498(1):13-22. Epub 2010 Mar 17.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106-9510, USA.

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http://dx.doi.org/10.1016/j.abb.2010.03.007DOI Listing
June 2010

Fabrication of Ag@SiO(2)@Y(2)O(3):Er nanostructures for bioimaging: tuning of the upconversion fluorescence with silver nanoparticles.

J Am Chem Soc 2010 Mar;132(9):2850-1

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1021/ja909108xDOI Listing
March 2010

Mapping local pH in live cells using encapsulated fluorescent SERS nanotags.

Small 2010 Mar;6(5):618-22

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1002/smll.200901893DOI Listing
March 2010

Cell-targeted self-assembled DNA nanostructures.

J Am Chem Soc 2009 Oct;131(40):14237-9

Biomolecular Science and Engineering Program, University of California-Santa Barbara, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/ja9015638DOI Listing
October 2009

Coupling sequence-specific recognition to DNA modification.

J Biol Chem 2009 Aug 4;284(34):22690-6. Epub 2009 Jun 4.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1074/jbc.M109.015966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755677PMC
August 2009

The recognition pathway for the DNA cytosine methyltransferase M.HhaI.

Biochemistry 2009 Aug;48(33):7807-16

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/bi900502gDOI Listing
August 2009

Escherichia coli DNA adenine methyltransferase: intrasite processivity and substrate-induced dimerization and activation.

Biochemistry 2009 Aug;48(31):7399-410

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/bi9008006DOI Listing
August 2009

Escherichia coli DNA adenine methyltransferase: the structural basis of processive catalysis and indirect read-out.

J Biol Chem 2009 Jul 5;284(27):18390-400. Epub 2009 May 5.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1074/jbc.M109.005876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709375PMC
July 2009

Tracking transcription factor complexes on DNA using total internal reflectance fluorescence protein binding microarrays.

Nucleic Acids Res 2009 Jul 31;37(13):e94. Epub 2009 May 31.

Department of Biomolecular Science & Engineering, University of California, Santa Barbara, CA, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkp424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715255PMC
July 2009

Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates.

ACS Nano 2009 Jul 15;3(7):2007-15. Epub 2009 Jun 15.

Department of Chemistry and Biochemistry.

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http://dx.doi.org/10.1021/nn900469qDOI Listing
July 2009

Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins.

Anal Chem 2009 Feb;81(4):1608-14

Dipartimento di Scienze e Tecnologie Chimiche, Universita di Roma Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.

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http://dx.doi.org/10.1021/ac802365xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692654PMC
February 2009

Self-assembly of DNA arrays into multilayer stacks.

Langmuir 2009 Jan;25(2):1091-6

Department of Chemistry and Biochemistry, Biomolecular Science and Engineering Program, University of California - Santa Barbara, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/la801306jDOI Listing
January 2009

The early expressed HIV-1 genes regulate DNMT1 expression.

Epigenetics 2008 May-Jun;3(3):149-56. Epub 2008 May 31.

Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.4161/epi.3.3.6372DOI Listing
October 2008

Competitive Lrp and Dam assembly at the pap regulatory region: implications for mechanisms of epigenetic regulation.

J Mol Biol 2008 Oct 6;383(1):92-105. Epub 2008 Aug 6.

Program in Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.07.086DOI Listing
October 2008

Modulation of Escherichia coli DNA methyltransferase activity by biologically derived GATC-flanking sequences.

J Biol Chem 2008 Jul 23;283(29):20106-16. Epub 2008 May 23.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1074/jbc.M802502200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459302PMC
July 2008

Molecular scale architecture: engineered three- and four-way junctions.

Bioconjug Chem 2008 Feb 11;19(2):470-5. Epub 2007 Dec 11.

Department of Chemistry and Biochemistry, University of California at Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/bc700270kDOI Listing
February 2008

Enzyme-directed positioning of nanoparticles on large DNA templates.

Bioconjug Chem 2008 Feb 19;19(2):476-9. Epub 2007 Dec 19.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/bc700275hDOI Listing
February 2008

Facile synthesis of naphthoquinone spiroketals by diastereoselective oxidative [3 + 2] cycloaddition.

Org Lett 2007 Dec 29;9(26):5537-40. Epub 2007 Nov 29.

Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/ol702450dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430727PMC
December 2007

AdoMet-dependent methyl-transfer: Glu119 is essential for DNA C5-cytosine methyltransferase M.HhaI.

J Mol Biol 2007 Nov 19;373(5):1157-68. Epub 2007 Aug 19.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.08.009DOI Listing
November 2007

Specific and sensitive detection of nucleic acids and RNases using gold nanoparticle-RNA-fluorescent dye conjugates.

Chem Commun (Camb) 2007 Nov 19(42):4342-4. Epub 2007 Sep 19.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1039/b710306aDOI Listing
November 2007

Detection of sequence-specific protein-DNA interactions via surface enhanced resonance Raman scattering.

J Am Chem Soc 2007 Nov 7;129(47):14572-3. Epub 2007 Nov 7.

Department of Chemistry and Biochemistry, The University of California Santa Barbara, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/ja0767837DOI Listing
November 2007

S-adenosyl-L-methionine-dependent methyl transfer: observable precatalytic intermediates during DNA cytosine methylation.

Biochemistry 2007 Jul 7;46(30):8766-75. Epub 2007 Jul 7.

Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/bi7005948DOI Listing
July 2007

The role of high affinity non-specific DNA binding by Lrp in transcriptional regulation and DNA organization.

J Mol Biol 2007 Jun 18;369(5):1307-17. Epub 2007 Apr 18.

Program in Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.04.023DOI Listing
June 2007

Long-range structural and dynamical changes induced by cofactor binding in DNA methyltransferase M.HhaI.

Biochemistry 2007 Jun 25;46(24):7261-8. Epub 2007 May 25.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/bi602662eDOI Listing
June 2007

Chemically patterned microspheres for controlled nanoparticle assembly in the construction of SERS hot spots.

J Am Chem Soc 2007 Jun 1;129(25):7760-1. Epub 2007 Jun 1.

University of California at Santa Barbara, Department of Chemistry and Biochemistry, Santa Barbara, California 93106-9510, USA.

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http://dx.doi.org/10.1021/ja072533eDOI Listing
June 2007

A heterogeneous PNA-based SERS method for DNA detection.

J Am Chem Soc 2007 May 24;129(19):6086-7. Epub 2007 Apr 24.

Department of Chemistry and Biochemistry, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1021/ja0705184DOI Listing
May 2007

Determinants of sequence-specific DNA methylation: target recognition and catalysis are coupled in M.HhaI.

Biochemistry 2006 Dec;45(51):15563-72

Department of Chemistry and Biochemistry and Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106-9510.

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http://dx.doi.org/10.1021/bi061414tDOI Listing
December 2006

Conformational transitions as determinants of specificity for the DNA methyltransferase EcoRI.

J Biol Chem 2006 Sep 15;281(37):26821-31. Epub 2006 Jul 15.

Program in Biomolecular Science and Engineering, Department of Chemistry and Biochemistry, University of California, Santa Barbara 93106-9510, USA.

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http://dx.doi.org/10.1074/jbc.M603388200DOI Listing
September 2006

Engineered extrahelical base destabilization enhances sequence discrimination of DNA methyltransferase M.HhaI.

J Mol Biol 2006 Sep 21;362(2):334-46. Epub 2006 Jul 21.

Program in Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.07.031DOI Listing
September 2006

The role of Arg165 towards base flipping, base stabilization and catalysis in M.HhaI.

J Mol Biol 2006 Sep 22;362(3):516-27. Epub 2006 Jul 22.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.07.030DOI Listing
September 2006

Selective inhibitors of bacterial DNA adenine methyltransferases.

J Biomol Screen 2006 Aug 7;11(5):497-510. Epub 2006 Jun 7.

EpiGenX Pharmaceuticals, Pacific Technology Center, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1177/1087057106287933DOI Listing
August 2006

GATC flanking sequences regulate Dam activity: evidence for how Dam specificity may influence pap expression.

J Mol Biol 2006 Jan 18;355(3):459-72. Epub 2005 Nov 18.

Program in Biomolecular Science and Engineering and the Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.11.003DOI Listing
January 2006

Gold nanoparticle decoration of DNA on silicon.

Langmuir 2005 Nov;21(23):10699-701

Department of Chemistry and Biochemistry, Biomolecular Science and Engineering Program, University of California, Santa Barbara, 93106-9510, USA.

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http://dx.doi.org/10.1021/la0515367DOI Listing
November 2005

Mechanism of allosteric regulation of Dnmt1's processivity.

Biochemistry 2005 Nov;44(45):14977-88

Department of Chemistry and Biochemistry and Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1021/bi050988fDOI Listing
November 2005

Controlled spacing of cationic gold nanoparticles by nanocrown RNA.

J Am Chem Soc 2005 Aug;127(34):11886-7

Department of Chemistry and Biochemistry, University of California - Santa Barbara, 93106-9510, USA.

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http://dx.doi.org/10.1021/ja051144mDOI Listing
August 2005

DNA cytosine C5 methyltransferase Dnmt1: catalysis-dependent release of allosteric inhibition.

Biochemistry 2005 Jul;44(27):9472-85

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1021/bi050295zDOI Listing
July 2005

DNA methylation modulates Salmonella enterica serovar Typhimurium virulence in Caenorhabditis elegans.

FEMS Microbiol Lett 2005 Apr;245(1):53-9

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.femsle.2005.02.030DOI Listing
April 2005

Statistical coevolution analysis and molecular dynamics: identification of amino acid pairs essential for catalysis.

Proc Natl Acad Sci U S A 2005 Jan 18;102(4):994-9. Epub 2005 Jan 18.

Department of Chemistry, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1073/pnas.0409128102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545822PMC
January 2005

The mechanism of target base attack in DNA cytosine carbon 5 methylation.

Biochemistry 2004 Sep;43(36):11460-73

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1021/bi0496743DOI Listing
September 2004

Simultaneous DNA binding, bending, and base flipping: evidence for a novel M.EcoRI methyltransferase-DNA complex.

J Biol Chem 2004 Aug 20;279(35):37049-60. Epub 2004 Jun 20.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1074/jbc.M404573200DOI Listing
August 2004

Simultaneous DNA binding and bending by EcoRV endonuclease observed by real-time fluorescence.

Biochemistry 2003 Dec;42(49):14375-85

Department of Chemistry and Biochemistry and Interdepartmental Program in Biomolecular Science and Engineering, University of California at Santa Barbara, 93106-9510, USA.

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http://dx.doi.org/10.1021/bi035520wDOI Listing
December 2003

Bacteriophage T4Dam (DNA-(adenine-N6)-methyltransferase): evidence for two distinct stages of methylation under single turnover conditions.

J Biol Chem 2003 Oct 30;278(43):41749-55. Epub 2003 Jul 30.

Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo 630559, Novosibirsk Region, Russia.

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http://dx.doi.org/10.1074/jbc.M306397200DOI Listing
October 2003

Murine DNA cytosine C(5)-methyltransferase: in vitro studies of de novo methylation spreading.

Biochem Biophys Res Commun 2003 Oct;310(1):209-14

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1016/j.bbrc.2003.08.138DOI Listing
October 2003

DNA (cytosine-N4-)- and -(adenine-N6-)-methyltransferases have different kinetic mechanisms but the same reaction route. A comparison of M.BamHI and T4 Dam.

J Biol Chem 2003 May 20;278(18):15713-9. Epub 2003 Feb 20.

Institute of Molecular Biology, State Research Center of Virology and Biotechnology "Vector," Koltsovo, Novosibirsk Region, 630559 Russia.

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http://dx.doi.org/10.1074/jbc.M213213200DOI Listing
May 2003

A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase.

J Biol Chem 2003 Mar 10;278(10):8238-43. Epub 2002 Dec 10.

Department of Chemistry and Biochemistry and Program in Biochemistry and Molecular Biology, University of California, Santa Barbara 93106, USA.

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http://dx.doi.org/10.1074/jbc.M209839200DOI Listing
March 2003

Functional analysis of BamHI DNA cytosine-N4 methyltransferase.

J Mol Biol 2003 Jan;325(4):711-20

Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, CA 93106-9510, USA.

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http://dx.doi.org/10.1016/s0022-2836(02)01282-2DOI Listing
January 2003

Enzymatic manipulation of DNA-nanomaterial constructs.

J Am Chem Soc 2002 Jul;124(26):7644-5

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1021/ja025971oDOI Listing
July 2002