Publications by authors named "Nissim Benvenisty"

99Publications

Mapping Gene Circuits Essential for Germ Layer Differentiation via Loss-of-Function Screens in Haploid Human Embryonic Stem Cells.

Cell Stem Cell 2020 Oct 30;27(4):679-691.e6. Epub 2020 Jul 30.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.06.023DOI Listing
October 2020

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation.

Stem Cell Reports 2020 Jun 9. Epub 2020 Jun 9.

The Azrieli Center for Stem Cells and Genetic Research, The Hebrew University, Jerusalem, Israel; Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.05.014DOI Listing
June 2020

The essentiality landscape of cell cycle related genes in human pluripotent and cancer cells.

Cell Div 2019 23;14:15. Epub 2019 Dec 23.

2Department of Genetics, Institute of Life Sciences, The Hebrew University, Givat-Ram, 9190401 Jerusalem, Israel.

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http://dx.doi.org/10.1186/s13008-019-0058-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927170PMC
December 2019

Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells.

Cell Stem Cell 2019 Oct 19;25(4):456-461. Epub 2019 Sep 19.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus - Givat Ram, Jerusalem, Israel, 9190401. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.09.001DOI Listing
October 2019

Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells.

Cell Stem Cell 2019 09;25(3):419-432.e9

Department of Obstetrics and Gynecology and Columbia University Fertility Center, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA; Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.06.013DOI Listing
September 2019

Defining Human Pluripotency.

Cell Stem Cell 2019 07;25(1):9-22

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, Edmond J. Safra Campus - Givat Ram, the Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.06.010DOI Listing
July 2019

Epigenetic aberrations in human pluripotent stem cells.

EMBO J 2019 06 14;38(12). Epub 2019 May 14.

Department of Genetics, The Azrieli Center for Stem Cells and Genetic Research, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel

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http://dx.doi.org/10.15252/embj.2018101033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576196PMC
June 2019

Global Characterization of X Chromosome Inactivation in Human Pluripotent Stem Cells.

Cell Rep 2019 04;27(1):20-29.e3

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.019DOI Listing
April 2019

FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo.

Cell Rep 2019 03;26(10):2531-2539.e4

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.026DOI Listing
March 2019

Genome-wide Screen for Culture Adaptation and Tumorigenicity-Related Genes in Human Pluripotent Stem Cells.

iScience 2019 Jan 3;11:398-408. Epub 2019 Jan 3.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183026
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http://dx.doi.org/10.1016/j.isci.2018.12.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348297PMC
January 2019

Mice from Same-Sex Parents: CRISPRing Out the Barriers for Unisexual Reproduction.

Cell Stem Cell 2018 11;23(5):625-627

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.012DOI Listing
November 2018

Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs.

Stem Cell Res 2018 08 26;31:16-26. Epub 2018 Jun 26.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.06.013DOI Listing
August 2018

Defining essential genes for human pluripotent stem cells by CRISPR-Cas9 screening in haploid cells.

Nat Cell Biol 2018 05 16;20(5):610-619. Epub 2018 Apr 16.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://www.nature.com/articles/s41556-018-0088-1
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http://dx.doi.org/10.1038/s41556-018-0088-1DOI Listing
May 2018

Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells.

PLoS Genet 2017 Aug 24;13(8):e1006979. Epub 2017 Aug 24.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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https://dx.plos.org/10.1371/journal.pgen.1006979
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http://dx.doi.org/10.1371/journal.pgen.1006979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587343PMC
August 2017

Haploidy in Humans: An Evolutionary and Developmental Perspective.

Dev Cell 2017 06;41(6):581-589

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.04.019DOI Listing
June 2017

Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome.

Int J Dev Biol 2017 ;61(3-4-5):285-292

Department of Developmental Biology and Cancer Research, Hebrew University, Jerusalem.

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http://www.intjdevbiol.com/paper.php?doi=170022hc
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http://dx.doi.org/10.1387/ijdb.170022hcDOI Listing
June 2018

Large-Scale Analysis of Loss of Imprinting in Human Pluripotent Stem Cells.

Cell Rep 2017 05;19(5):957-968

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.020DOI Listing
May 2017

Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells.

Stem Cell Reports 2017 05 6;8(5):1354-1365. Epub 2017 Apr 6.

The Azrieli Center for Stem Cells and Genetic Research, Institute of Life Sciences, The Hebrew University of Jerusalem, Givat-Ram, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425613PMC
May 2017

Stem cells: Aspiring to naivety.

Nature 2016 12 30;540(7632):211-212. Epub 2016 Nov 30.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/nature20484DOI Listing
December 2016

Human pluripotent stem cells in modeling human disorders: the case of fragile X syndrome.

Regen Med 2017 01 30;12(1):53-68. Epub 2016 Nov 30.

The Azrieli Center for Stem Cells & Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.2217/rme-2016-0100DOI Listing
January 2017

Haploid Human Embryonic Stem Cells: Half the Genome, Double the Value.

Cell Stem Cell 2016 11;19(5):569-572

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.009DOI Listing
November 2016

Efficient Generation of Viral and Integration-Free Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes.

Curr Protoc Stem Cell Biol 2016 Nov;39(1):2D.18.1-2D.18.28

Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience, David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.1002/cpsc.19DOI Listing
November 2016

Identification and propagation of haploid human pluripotent stem cells.

Nat Protoc 2016 Nov 20;11(11):2274-2286. Epub 2016 Oct 20.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nprot.2016.145DOI Listing
November 2016

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation.

Stem Cell Reports 2016 10 8;7(4):777-786. Epub 2016 Sep 8.

Department of Genetics, The Azrieli Center for Stem Cells and Genetic Research, Institute of Life Sciences, The Hebrew University, Givat-Ram, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063584PMC
October 2016

Chromosomal Instability and Molecular Defects in Induced Pluripotent Stem Cells from Nijmegen Breakage Syndrome Patients.

Cell Rep 2016 08 18;16(9):2499-511. Epub 2016 Aug 18.

Department of Genetics, Institute of Life Sciences, The Hebrew University, Givat-Ram, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.071DOI Listing
August 2016

Efficient Generation of Viral and Integration-Free Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes.

Curr Protoc Stem Cell Biol 2016 08 17;38:2D.18.1-2D.18.27. Epub 2016 Aug 17.

Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience, David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087818PMC
http://dx.doi.org/10.1002/cpsc.11DOI Listing
August 2016

Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq.

Nat Commun 2016 07 7;7:12144. Epub 2016 Jul 7.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/ncomms12144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941052PMC
July 2016

Policy: Global standards for stem-cell research.

Nature 2016 05;533(7603):311-3

Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA, and a member of the steering committee of the International Society for Stem Cell Research's Guidelines Task Force.

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http://dx.doi.org/10.1038/533311aDOI Listing
May 2016

Derivation and differentiation of haploid human embryonic stem cells.

Nature 2016 Apr 16;532(7597):107-11. Epub 2016 Mar 16.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/nature17408DOI Listing
April 2016

Pluripotent stem cells in disease modelling and drug discovery.

Nat Rev Mol Cell Biol 2016 Mar 28;17(3):170-82. Epub 2016 Jan 28.

The Azrieli Center for Stem Cells and Genetic Research, Institute of Life Sciences, Hebrew University of Jerusalem, Givat-Ram, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/nrm.2015.27DOI Listing
March 2016

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects.

Cell Stem Cell 2016 Feb 5;18(2):253-61. Epub 2015 Dec 5.

Department of Genetics, The Hebrew University, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.11.003DOI Listing
February 2016

Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons.

Cell Rep 2015 Oct 1;13(2):234-41. Epub 2015 Oct 1.

Department of Physiology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.084DOI Listing
October 2015

Hallmarks of pluripotency.

Nature 2015 Sep;525(7570):469-78

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15515DOI Listing
September 2015

rsPSCs: A new type of pluripotent stem cells.

Cell Res 2015 Aug 16;25(8):889-90. Epub 2015 Jun 16.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://www.nature.com/articles/cr201573
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http://dx.doi.org/10.1038/cr.2015.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528053PMC
August 2015

TeratoScore: Assessing the Differentiation Potential of Human Pluripotent Stem Cells by Quantitative Expression Analysis of Teratomas.

Stem Cell Reports 2015 Jun;4(6):967-74

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471824PMC
June 2015

Differentiation of human parthenogenetic pluripotent stem cells reveals multiple tissue- and isoform-specific imprinted transcripts.

Cell Rep 2015 Apr 2;11(2):308-20. Epub 2015 Apr 2.

Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Institute of Life Sciences, Edmond J. Safra Campus-Givat Ram, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)00292-2.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471500292
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http://dx.doi.org/10.1016/j.celrep.2015.03.023DOI Listing
April 2015

Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors.

Cell Stem Cell 2014 Nov 6;15(5):634-42. Epub 2014 Nov 6.

The New York Stem Cell Foundation Research Institute, New York, NY 10032, USA; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.002DOI Listing
November 2014

Molecular mechanisms regulating the defects in fragile X syndrome neurons derived from human pluripotent stem cells.

Stem Cell Reports 2015 Jan 4;4(1):37-46. Epub 2014 Dec 4.

Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Institute of Life Sciences, The Hebrew University, Givat-Ram, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297868PMC
January 2015

Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.

Cell Stem Cell 2014 Dec;15(6):687-91

Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909140046
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http://dx.doi.org/10.1016/j.stem.2014.10.018DOI Listing
December 2014

Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.

Stem Cells 2015 Mar;33(3):1013-9

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://doi.wiley.com/10.1002/stem.1888
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http://dx.doi.org/10.1002/stem.1888DOI Listing
March 2015

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.

Nat Commun 2014 Sep 8;5:4825. Epub 2014 Sep 8.

1] Department of Biomedical Sciences and Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1038/ncomms5825DOI Listing
September 2014

Sex-dependent gene expression in human pluripotent stem cells.

Cell Rep 2014 Aug 7;8(4):923-32. Epub 2014 Aug 7.

Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.013DOI Listing
August 2014

Aberrant DNA methylation in ES cells.

PLoS One 2014 22;9(5):e96090. Epub 2014 May 22.

Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096090PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031077PMC
June 2015

The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome.

Nat Genet 2014 Jun 11;46(6):551-7. Epub 2014 May 11.

Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/ng.2968DOI Listing
June 2014

Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors.

J Mol Cell Biol 2014 Jun 27;6(3):267-9. Epub 2014 Mar 27.

Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel

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http://dx.doi.org/10.1093/jmcb/mju012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055828PMC
June 2014

Chemical ablation of tumor-initiating human pluripotent stem cells.

Nat Protoc 2014 Mar 27;9(3):729-40. Epub 2014 Feb 27.

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nprot.2014.050DOI Listing
March 2014

Quality control: Genome maintenance in pluripotent stem cells.

J Cell Biol 2014 Jan;204(2):153-63

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1083/jcb.201310135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897183PMC
January 2014

Global indiscriminate methylation in cell-specific gene promoters following reprogramming into human induced pluripotent stem cells.

Stem Cell Reports 2013 12;1(6):509-17. Epub 2013 Dec 12.

Stem Cell Unit, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel ; Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.stemcr.2013.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871396PMC
May 2015

Involvement of parental imprinting in the antisense regulation of onco-miR-372-373.

Nat Commun 2013 ;4:2724

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/ncomms3724DOI Listing
July 2014

Human pluripotent stem cells with distinct X inactivation status show molecular and cellular differences controlled by the X-Linked ELK-1 gene.

Cell Rep 2013 Jul 18;4(2):262-70. Epub 2013 Jul 18.

Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1016/j.celrep.2013.06.026DOI Listing
July 2013

Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells.

Nat Commun 2013 ;4:1992

Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/ncomms2992DOI Listing
December 2013

New balance in pluripotency: reprogramming with lineage specifiers.

Cell 2013 May;153(5):939-40

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1016/j.cell.2013.04.051DOI Listing
May 2013

Virtual karyotyping of pluripotent stem cells on the basis of their global gene expression profiles.

Nat Protoc 2013 May 25;8(5):989-97. Epub 2013 Apr 25.

Department of Genetics, Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nprot.2013.051DOI Listing
May 2013

Genomic stability in reprogramming.

Curr Opin Genet Dev 2012 Oct 4;22(5):444-9. Epub 2012 Oct 4.

Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1016/j.gde.2012.09.003DOI Listing
October 2012

DUXO, a novel double homeobox transcription factor, is a regulator of the gastrula organizer in human embryonic stem cells.

Stem Cell Res 2012 Nov 18;9(3):261-9. Epub 2012 Aug 18.

Stem Cell Unit, Department of Genetics, Alexander Silberman Institute of Life Sciences, Hebrew University, Jerusalem, 91904, Israel.

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http://dx.doi.org/10.1016/j.scr.2012.08.003DOI Listing
November 2012

Reprogramming of the MHC-I and its regulation by NFκB in human-induced pluripotent stem cells.

Stem Cells 2012 Dec;30(12):2700-8

Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://doi.wiley.com/10.1002/stem.1242
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http://dx.doi.org/10.1002/stem.1242DOI Listing
December 2012

The in vitro survival of human monosomies and trisomies as embryonic stem cells.

Stem Cell Res 2012 Nov 22;9(3):218-24. Epub 2012 Jul 22.

Regenerative Medicine Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.scr.2012.07.002DOI Listing
November 2012

Expanding the boundaries of embryonic stem cells.

Cell Stem Cell 2012 Jun;10(6):666-677

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2012.05.003DOI Listing
June 2012

High prevalence of evolutionarily conserved and species-specific genomic aberrations in mouse pluripotent stem cells.

Stem Cells 2012 Apr;30(4):612-22

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1002/stem.1057DOI Listing
April 2012

Stepwise differentiation of human embryonic stem cells into early endoderm derivatives and their molecular characterization.

Stem Cell Res 2012 May 21;8(3):335-45. Epub 2011 Dec 21.

Stem Cell Unit, Department of Genetics, The Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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https://linkinghub.elsevier.com/retrieve/pii/S18735061110016
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http://dx.doi.org/10.1016/j.scr.2011.12.006DOI Listing
May 2012

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

Authors:
Katherine Amps Peter W Andrews George Anyfantis Lyle Armstrong Stuart Avery Hossein Baharvand Julie Baker Duncan Baker Maria B Munoz Stephen Beil Nissim Benvenisty Dalit Ben-Yosef Juan-Carlos Biancotti Alexis Bosman Romulo Martin Brena Daniel Brison Gunilla Caisander María V Camarasa Jieming Chen Eric Chiao Young Min Choi Andre B H Choo Daniel Collins Alan Colman Jeremy M Crook George Q Daley Anne Dalton Paul A De Sousa Chris Denning Janet Downie Petr Dvorak Karen D Montgomery Anis Feki Angela Ford Victoria Fox Ana M Fraga Tzvia Frumkin Lin Ge Paul J Gokhale Tamar Golan-Lev Hamid Gourabi Michal Gropp Guangxiu Lu Ales Hampl Katie Harron Lyn Healy Wishva Herath Frida Holm Outi Hovatta Johan Hyllner Maneesha S Inamdar Astrid Kresentia Irwanto Tetsuya Ishii Marisa Jaconi Ying Jin Susan Kimber Sergey Kiselev Barbara B Knowles Oded Kopper Valeri Kukharenko Anver Kuliev Maria A Lagarkova Peter W Laird Majlinda Lako Andrew L Laslett Neta Lavon Dong Ryul Lee Jeoung Eun Lee Chunliang Li Linda S Lim Tenneille E Ludwig Yu Ma Edna Maltby Ileana Mateizel Yoav Mayshar Maria Mileikovsky Stephen L Minger Takamichi Miyazaki Shin Yong Moon Harry Moore Christine Mummery Andras Nagy Norio Nakatsuji Kavita Narwani Steve K W Oh Sun Kyung Oh Cia Olson Timo Otonkoski Fei Pan In-Hyun Park Steve Pells Martin F Pera Lygia V Pereira Ouyang Qi Grace Selva Raj Benjamin Reubinoff Alan Robins Paul Robson Janet Rossant Ghasem H Salekdeh Thomas C Schulz Karen Sermon Jameelah Sheik Mohamed Hui Shen Eric Sherrer Kuldip Sidhu Shirani Sivarajah Heli Skottman Claudia Spits Glyn N Stacey Raimund Strehl Nick Strelchenko Hirofumi Suemori Bowen Sun Riitta Suuronen Kazutoshi Takahashi Timo Tuuri Parvathy Venu Yuri Verlinsky Dorien Ward-van Oostwaard Daniel J Weisenberger Yue Wu Shinya Yamanaka Lorraine Young Qi Zhou

Nat Biotechnol 2011 Nov 27;29(12):1132-44. Epub 2011 Nov 27.

Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, UK.

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http://www.nature.com/articles/nbt.2051
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http://dx.doi.org/10.1038/nbt.2051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454460PMC
November 2011

Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells.

Cell Stem Cell 2011 Aug;9(2):97-102

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 91904, Israel.

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http://dx.doi.org/10.1016/j.stem.2011.06.013DOI Listing
August 2011

Aneuploid human embryonic stem cells: origins and potential for modeling chromosomal disorders.

Regen Med 2011 Jul;6(4):493-503

Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.2217/rme.11.27DOI Listing
July 2011

Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells.

Cell Stem Cell 2011 Jul;9(1):17-23

Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Israel.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091100293
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http://dx.doi.org/10.1016/j.stem.2011.06.007DOI Listing
July 2011

Assessing the safety of stem cell therapeutics.

Cell Stem Cell 2011 Jun;8(6):618-28

MRC Centre for Drug Safety Science, Division of Molecular & Clinical Pharmacology, The Institute of Translational Medicine, The University of Liverpool, Liverpool L69 3GE, UK.

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http://dx.doi.org/10.1016/j.stem.2011.05.012DOI Listing
June 2011

Global analysis of parental imprinting in human parthenogenetic induced pluripotent stem cells.

Nat Struct Mol Biol 2011 Jun 15;18(6):735-41. Epub 2011 May 15.

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nsmb.2050DOI Listing
June 2011

The tumorigenicity of human embryonic and induced pluripotent stem cells.

Nat Rev Cancer 2011 Apr 10;11(4):268-77. Epub 2011 Mar 10.

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://www.nature.com/articles/nrc3034
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April 2011

Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells.

Stem Cells 2011 Apr;29(4):600-8

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://doi.wiley.com/10.1002/stem.621
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http://dx.doi.org/10.1002/stem.621DOI Listing
April 2011

Publishing SNP genotypes of human embryonic stem cell lines: policy statement of the International Stem Cell Forum Ethics Working Party.

Stem Cell Rev Rep 2011 Sep;7(3):482-4

International Stem Cell Forum Ethics Working Party. Centre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics McGill University, 740 Dr. Penfield Avenue, Rm 5214, Montreal, QC, H3A 1A4, Canada.

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http://dx.doi.org/10.1007/s12015-010-9226-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137773PMC
September 2011

Meta-analysis of the heterogeneity of X chromosome inactivation in human pluripotent stem cells.

Stem Cell Res 2011 Mar 13;6(2):187-93. Epub 2010 Dec 13.

Stem Cell Unit, Department of Genetics, Institute of Life Sciences, The Hebrew University, Edmund J. Safra Campus, Givat Ram, Jerusalem, 91904, Israel.

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http://dx.doi.org/10.1016/j.scr.2010.12.001DOI Listing
March 2011

Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.

Cell Stem Cell 2010 Oct;7(4):521-31

Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1016/j.stem.2010.07.017DOI Listing
October 2010

Human embryonic stem cells as models for aneuploid chromosomal syndromes.

Stem Cells 2010 Sep;28(9):1530-40

The International Stem Cell Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/stem.483DOI Listing
September 2010

Teratogen screening using transcriptome profiling of differentiating human embryonic stem cells.

J Cell Mol Med 2011 Jun 17;15(6):1393-401. Epub 2010 Jun 17.

Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://doi.wiley.com/10.1111/j.1582-4934.2010.01105.x
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http://dx.doi.org/10.1111/j.1582-4934.2010.01105.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373338PMC
June 2011

Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.

Cell Stem Cell 2010 May;6(5):407-11

Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S19345909100016
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http://dx.doi.org/10.1016/j.stem.2010.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354574PMC
May 2010

Human embryonic stem cells from aneuploid blastocysts identified by pre-implantation genetic screening.

In Vitro Cell Dev Biol Anim 2010 Apr 12;46(3-4):309-16. Epub 2010 Mar 12.

The International Stem Cell Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://link.springer.com/10.1007/s11626-010-9303-5
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http://dx.doi.org/10.1007/s11626-010-9303-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855810PMC
April 2010

Human ES cell lines--introduction.

In Vitro Cell Dev Biol Anim 2010 Apr 7;46(3-4):167-8. Epub 2010 Mar 7.

Centre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1007/s11626-010-9306-2DOI Listing
April 2010

Characterization of gastrulation-stage progenitor cells and their inhibitory crosstalk in human embryoid bodies.

Stem Cells 2010 Jan;28(1):75-83

Stem Cell Unit, Department of Genetics, The Institute of Life Sciences, The Hebrew University, Edmund J. Safra Campus, Givat Ram, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1002/stem.260DOI Listing
January 2010

The tumorigenicity of diploid and aneuploid human pluripotent stem cells.

Cell Cycle 2009 Dec 14;8(23):3822-30. Epub 2009 Dec 14.

Stem Cell Unit, Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://www.tandfonline.com/doi/abs/10.4161/cc.8.23.10067
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http://dx.doi.org/10.4161/cc.8.23.10067DOI Listing
December 2009

Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells.

Stem Cells 2009 Nov;27(11):2686-90

Stem Cell Unit, Department of Genetics, The Hebrew University, Edmund Safra Campus - Givat Ram, Jerusalem 91904, Israel.

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https://www.researchgate.net/profile/Marjorie_Pick/publicati
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http://doi.wiley.com/10.1002/stem.205
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http://dx.doi.org/10.1002/stem.205DOI Listing
November 2009

Developmental programming of CpG island methylation profiles in the human genome.

Nat Struct Mol Biol 2009 May 19;16(5):564-71. Epub 2009 Apr 19.

Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://www.nature.com/articles/nsmb.1594
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May 2009

The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells.

Nat Biotechnol 2009 Mar 1;27(3):281-7. Epub 2009 Mar 1.

Stem Cell Unit, Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/nbt.1527DOI Listing
March 2009