Publications by authors named "Nikhil Munshi"

100Publications

Risk factors in MM: is it time for a revision?

Blood 2020 Sep 5. Epub 2020 Sep 5.

Centre de Recherches en Cancérologie de Toulouse, France.

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http://dx.doi.org/10.1182/blood.2019004309DOI Listing
September 2020

Preclinical evaluation of CD8+ anti-BCMA mRNA CAR T cells for treatment of multiple myeloma.

Leukemia 2020 Jul 6. Epub 2020 Jul 6.

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-020-0951-5DOI Listing
July 2020

Author Correction: Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.

Sci Rep 2020 Feb 28;10(1):4069. Epub 2020 Feb 28.

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41598-020-60915-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046679PMC
February 2020

A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma.

Leukemia 2020 08 14;34(8):2150-2162. Epub 2020 Feb 14.

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-020-0745-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392808PMC
August 2020

Development of the Cardiac Conduction System.

Cold Spring Harb Perspect Biol 2020 Jan 27. Epub 2020 Jan 27.

Department of Internal Medicine, Division of Cardiology, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1101/cshperspect.a037408DOI Listing
January 2020

Moving From Cancer Burden to Cancer Genomics for Smoldering Myeloma: A Review.

JAMA Oncol 2020 Mar;6(3):425-432

Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1001/jamaoncol.2019.4659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430066PMC
March 2020

Monitoring the cytogenetic architecture of minimal residual plasma cells indicates therapy-induced clonal selection in multiple myeloma.

Leukemia 2020 02 7;34(2):578-588. Epub 2019 Oct 7.

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 300020, Tianjin, China.

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http://dx.doi.org/10.1038/s41375-019-0590-xDOI Listing
February 2020

Monoclonal Gammopathy May Be of Unpredictable Significance.

JAMA Oncol 2019 Jul 18. Epub 2019 Jul 18.

Genomics of Myeloma Laboratory, L'Institut Universitaire du Cancer Oncopole, Toulouse, France.

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http://dx.doi.org/10.1001/jamaoncol.2019.1580DOI Listing
July 2019

Rational Reprogramming of Cellular States by Combinatorial Perturbation.

Cell Rep 2019 06;27(12):3486-3499.e6

Laboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667192PMC
June 2019

The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma.

Leukemia 2020 01 10;34(1):167-179. Epub 2019 Jun 10.

Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-019-0498-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901818PMC
January 2020

Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming.

Cell Rep 2019 05;27(8):2354-2369.e7

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657359PMC
May 2019

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma.

N Engl J Med 2019 05;380(18):1726-1737

From the Massachusetts General Hospital Cancer Center (N.R., M.V.M.), Beth Israel Deaconess Medical Center (J.R.), and Dana-Farber Cancer Institute and Veterans Affairs Boston Healthcare System (N.M.), Boston, and Bluebird Bio, Cambridge (A.T., L.-P.L., R.A.M., K.F., M.M., F.P., M.T.Q.) - all in Massachusetts; Sarah Cannon Research Institute and Tennessee Oncology, Nashville (J.B.); Mayo Clinic, Rochester, MN (Y.L.); Hackensack University Medical Center, Hackensack (D.S.), and Celgene, Summit (J.W., G.R., Z.Y.) - both in New Jersey; Mount Sinai Medical Center, New York (S.J., D.M.); Stanford University Medical Center, Palo Alto (M.L.), and Celgene, San Francisco (T.C., K.H.) - both in California; and the Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (J.N.K.).

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http://www.nejm.org/doi/10.1056/NEJMoa1817226
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http://dx.doi.org/10.1056/NEJMoa1817226DOI Listing
May 2019

Immunotherapy in Multiple Myeloma: Accelerating on the Path to the Patient.

Clin Lymphoma Myeloma Leuk 2019 06 20;19(6):332-344. Epub 2019 Feb 20.

Winship Cancer Institute of Emory University, Atlanta, GA. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2019.02.004DOI Listing
June 2019

PAN-INTACT enables direct isolation of lineage-specific nuclei from fibrous tissues.

PLoS One 2019 2;14(4):e0214677. Epub 2019 Apr 2.

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214677PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445515PMC
December 2019

Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.

Sci Rep 2019 02 14;9(1):2106. Epub 2019 Feb 14.

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41598-019-38683-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375990PMC
February 2019

Introduction by the Guest Editor: At a Crossroad to Cure: From Molecule to Management Strategies in Multiple Myeloma.

Authors:
Nikhil C Munshi

Cancer J 2019 Jan/Feb;25(1)

From the Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, and VA Boston Healthcare System, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PPO.0000000000000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386173PMC
March 2020

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma.

Cell Rep 2018 12;25(13):3693-3705.e6

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; VA Boston Healthcare System, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407615PMC
December 2018

pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.

Dev Dyn 2019 02 10;248(2):173-188. Epub 2018 Dec 10.

Department of Internal Medicine - Cardiology, UT Southwestern Medical Center, Dallas, Texas.

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http://doi.wiley.com/10.1002/dvdy.2
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http://dx.doi.org/10.1002/dvdy.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340724PMC
February 2019

Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14).

Blood 2018 12 14;132(26):2778-2780. Epub 2018 Nov 14.

Unit for Genomics in Myeloma, Institut Universitaire du Cancer-Oncopole, Toulouse, France.

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http://dx.doi.org/10.1182/blood-2018-09-876433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307986PMC
December 2018

APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications.

Leukemia 2019 02 22;33(2):426-438. Epub 2018 Aug 22.

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-018-0242-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367000PMC
February 2019

Functional cargo delivery into mouse and human fibroblasts using a versatile microfluidic device.

Biomed Microdevices 2018 06 25;20(3):52. Epub 2018 Jun 25.

Department of Internal Medicine-Cardiology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/s10544-018-0292-6DOI Listing
June 2018

Multiple myeloma clonal evolution in homogeneously treated patients.

Leukemia 2018 12 12;32(12):2636-2647. Epub 2018 Jun 12.

IUC-Oncopole, and CRCT INSERM U1037, 31100, Toulouse, France.

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http://dx.doi.org/10.1038/s41375-018-0153-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603429PMC
December 2018

Widespread intronic polyadenylation diversifies immune cell transcriptomes.

Nat Commun 2018 04 30;9(1):1716. Epub 2018 Apr 30.

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/s41467-018-04112-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928244PMC
April 2018

Tolerance, Kinetics, and Depth of Response for Subcutaneous Versus Intravenous Administration of Bortezomib Combination in Chinese Patients With Newly Diagnosed Multiple Myeloma.

Clin Lymphoma Myeloma Leuk 2018 06 15;18(6):422-430. Epub 2018 Mar 15.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academic Medical Science and Peking Union Medical College, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970050PMC
June 2018

Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells.

J Gastroenterol Hepatol Res 2017 21;6(1):2286-2295. Epub 2017 Feb 21.

Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, Boston, MA, the United States. VA Health Care System, West Roxbury, MA, the United States.

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http://dx.doi.org/10.17554/j.issn.2224-3992.2017.06.687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796564PMC
February 2017

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.

Sci Rep 2018 01 19;8(1):1258. Epub 2018 Jan 19.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1038/s41598-018-19539-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775342PMC
January 2018

Castleman Disease.

Hematol Oncol Clin North Am 2018 02;32(1):xiii-xiv

Dana Farber Cancer Institute, VA Boston Healthcare System, Harvard Medical School, 450 Brookline Avenue, M230, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2017.10.001DOI Listing
February 2018

Diagnosis of Castleman Disease.

Hematol Oncol Clin North Am 2018 02;32(1):53-64

Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, M230 Boston, MA 02215, USA; VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898588173014
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http://dx.doi.org/10.1016/j.hoc.2017.09.005DOI Listing
February 2018

Determining therapeutic susceptibility in multiple myeloma by single-cell mass accumulation.

Nat Commun 2017 11 20;8(1):1613. Epub 2017 Nov 20.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St., Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-017-01593-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694762PMC
November 2017

Prospective Evaluation of Magnetic Resonance Imaging and [F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study.

J Clin Oncol 2017 Sep 7;35(25):2911-2918. Epub 2017 Jul 7.

Philippe Moreau, Florence Caillon, Caroline Bodet-Milin, Aurelie Gaultier, Jean-Michel Nguyen, Benoit Dupas, Eric Frampas, and Françoise Kraeber-Bodere, University Hospital, Nantes; Michel Attal, University Hospital, Toulouse; Denis Caillot, University Hospital, Dijon; Margaret Macro, University Hospital, Caen; Lionel Karlin, University Hospital, Lyon; Laurent Garderet, University Hospital Saint-Antoine, Paris; Thierry Facon, University Hospital, Lille; Lotfi Benboubker, University Hospital, Tours; Martine Escoffre-Barbe, University Hospital, Rennes; Anne-Marie Stoppa, Institut Paoli-Calmettes, Marseille; Kamel Laribi, University Hospital, Le Mans; Cyrille Hulin and Gerald Marit, University Hospital, Bordeaux; Aurore Perrot, University Hospital, Nancy; Jean-Richard Eveillard, University Hospital, Brest; Brigitte Pegourie, University Hospital, Grenoble; Veronique Dorvaux, University Hospital, Metz; Carine Chaleteix, University Hospital, Clermont-Ferrand; and Herve Avet-Loiseau, University Hospital, Toulouse, France; and Kenneth Anderson, Paul Richardson, and Nikhil C. Munshi, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2017.72.2975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578392PMC
September 2017

Myeloma Minimal Residual Disease and Surrogacy-Reply.

JAMA Oncol 2017 08;3(8):1136-1137

Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, England.

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http://dx.doi.org/10.1001/jamaoncol.2017.0404DOI Listing
August 2017

Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma.

Clin Cancer Res 2017 Sep 25;23(17):5225-5237. Epub 2017 Apr 25.

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581671PMC
September 2017

Resident Macrophages: Near and Dear to Your Heart.

Authors:
Nikhil V Munshi

Cell 2017 04;169(3):376-377

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.04.002DOI Listing
April 2017

Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma.

N Engl J Med 2017 04;376(14):1311-1320

From the Institut Universitaire du Cancer de Toulouse-Oncopole (M.A., M.R., C.P., S.R., H.A.-L.) and Service d'Epidémiologie, Centre Hospitalier et Universitaire de Toulouse (V.L.-C.), Toulouse, Hôpital Haut-Lévêque, Bordeaux Pessac (C.H.), Centre Hospitalier et Universitaire la Miletrie, Poitiers (X.L.), Centre Hospitalier Le Bocage, Dijon (D.C.), Centre Hospitalier et Universitaire de Rennes, Rennes (M.E.), Hôpital St.-Louis (B.A., J.P.F.), Centre Hospitalier Universitaire, Hôpital St.-Antoine (L.G.), Institut Curie (C.M.), and Haute Autorité de Santé (J.-L.H.), Paris, Institut d'Hématologie de Basse Normandie, Centre Hospitalier et Universitaire de Caen, Caen (M.M.), Centre Hospitalier et Universitaire Henri Mondor, Creteil (K.B.), Hôpital Claude Huriez, Lille (T.F.), and Hôtel Dieu, Nantes (P.M.) - all in France; Institut Jules Bordet, Brussels (N. Meuleman); and Dana-Farber Cancer Institute, Boston (M.E.M., A.A.Z., E.A.W., N. Munshi, K.C.A., P.G.R.).

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http://dx.doi.org/10.1056/NEJMoa1611750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201242PMC
April 2017

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts.

J Vis Exp 2017 03 22(121). Epub 2017 Mar 22.

Department of Internal Medicine- Cardiology, UT Southwestern Medical Center;

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http://dx.doi.org/10.3791/55456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409299PMC
March 2017

Phenotypically silent Cre recombination within the postnatal ventricular conduction system.

PLoS One 2017 30;12(3):e0174517. Epub 2017 Mar 30.

Department of Internal Medicine (Cardiology Division), UT Southwestern Medical Center, Dallas, TX, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174517PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373586PMC
August 2017

Genomics of Multiple Myeloma.

J Clin Oncol 2017 Mar 13;35(9):963-967. Epub 2017 Feb 13.

Sebastien Robiou du Pont, Charlotte Fontan, Michel Attal, Jill Corre, and Hervé Avet-Loiseau, L'Institut Universitaire du Cancer Oncopole, Toulouse; Alice Cleynen, Centre National de la Recherche Scientifique, and Montpellier University, Montpellier, France; and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2016.70.6705DOI Listing
March 2017

Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.

Clin Cancer Res 2017 Aug 7;23(15):4280-4289. Epub 2017 Mar 7.

LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540781PMC
August 2017

The Promise of Cardiac Regeneration by In Situ Lineage Conversion.

Circulation 2017 03;135(10):914-916

From Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN (Y.-J.N.); Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (N.V.M.); McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX (N.V.M.); Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX (N.V.M.); and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX (N.V.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410767PMC
March 2017

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma.

Clin Cancer Res 2017 Aug 1;23(15):4290-4300. Epub 2017 Mar 1.

LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540790PMC
August 2017

Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis.

Oncoimmunology 2017 7;6(1):e1261776. Epub 2016 Dec 7.

Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA; Surgery Services, VA Boston Healthcare System, West Roxbury, MA, USA.

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http://dx.doi.org/10.1080/2162402X.2016.1261776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283644PMC
December 2016

Gene Expression Profiles in Myeloma: Ready for the Real World?

Clin Cancer Res 2016 Nov;22(22):5434-5442

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546147PMC
November 2016