Nikhil Munshi

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Introduction by the Guest Editor: At a Crossroad to Cure: From Molecule to Management Strategies in Multiple Myeloma.

Authors:
Nikhil C Munshi

Cancer J 2019 Jan/Feb;25(1)

From the Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, and VA Boston Healthcare System, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/PPO.0000000000000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386173PMC
January 2020

Monitoring the cytogenetic architecture of minimal residual plasma cells indicates therapy-induced clonal selection in multiple myeloma.

Leukemia 2019 Oct 7. Epub 2019 Oct 7.

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 300020, Tianjin, China.

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http://dx.doi.org/10.1038/s41375-019-0590-xDOI Listing
October 2019

Monoclonal Gammopathy May Be of Unpredictable Significance.

JAMA Oncol 2019 Jul 18. Epub 2019 Jul 18.

Genomics of Myeloma Laboratory, L'Institut Universitaire du Cancer Oncopole, Toulouse, France.

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http://dx.doi.org/10.1001/jamaoncol.2019.1580DOI Listing
July 2019

Immunotherapy in Multiple Myeloma: Accelerating on the Path to the Patient.

Clin Lymphoma Myeloma Leuk 2019 Jun 20;19(6):332-344. Epub 2019 Feb 20.

Winship Cancer Institute of Emory University, Atlanta, GA. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2019.02.004DOI Listing
June 2019

The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma.

Leukemia 2019 Jun 10. Epub 2019 Jun 10.

Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-019-0498-5DOI Listing
June 2019

Rational Reprogramming of Cellular States by Combinatorial Perturbation.

Cell Rep 2019 Jun;27(12):3486-3499.e6

Laboratory of Regulatory Genomics, Cecil H. and Ida Green Center for Reproductive Biology Sciences, Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667192PMC
June 2019

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma.

N Engl J Med 2019 05;380(18):1726-1737

From the Massachusetts General Hospital Cancer Center (N.R., M.V.M.), Beth Israel Deaconess Medical Center (J.R.), and Dana-Farber Cancer Institute and Veterans Affairs Boston Healthcare System (N.M.), Boston, and Bluebird Bio, Cambridge (A.T., L.-P.L., R.A.M., K.F., M.M., F.P., M.T.Q.) - all in Massachusetts; Sarah Cannon Research Institute and Tennessee Oncology, Nashville (J.B.); Mayo Clinic, Rochester, MN (Y.L.); Hackensack University Medical Center, Hackensack (D.S.), and Celgene, Summit (J.W., G.R., Z.Y.) - both in New Jersey; Mount Sinai Medical Center, New York (S.J., D.M.); Stanford University Medical Center, Palo Alto (M.L.), and Celgene, San Francisco (T.C., K.H.) - both in California; and the Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (J.N.K.).

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http://www.nejm.org/doi/10.1056/NEJMoa1817226
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http://dx.doi.org/10.1056/NEJMoa1817226DOI Listing
May 2019

Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming.

Cell Rep 2019 May;27(8):2354-2369.e7

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657359PMC
May 2019

PAN-INTACT enables direct isolation of lineage-specific nuclei from fibrous tissues.

PLoS One 2019 2;14(4):e0214677. Epub 2019 Apr 2.

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214677PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445515PMC
April 2019

APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications.

Leukemia 2019 02 22;33(2):426-438. Epub 2018 Aug 22.

Jerome Lipper Multiple Myeloma Center, LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41375-018-0242-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367000PMC
February 2019

pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.

Dev Dyn 2019 02 10;248(2):173-188. Epub 2018 Dec 10.

Department of Internal Medicine - Cardiology, UT Southwestern Medical Center, Dallas, Texas.

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http://doi.wiley.com/10.1002/dvdy.2
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http://dx.doi.org/10.1002/dvdy.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340724PMC
February 2019

Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition.

Sci Rep 2019 Feb 14;9(1):2106. Epub 2019 Feb 14.

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41598-019-38683-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375990PMC
February 2019

Multiple myeloma clonal evolution in homogeneously treated patients.

Leukemia 2018 12 12;32(12):2636-2647. Epub 2018 Jun 12.

IUC-Oncopole, and CRCT INSERM U1037, 31100, Toulouse, France.

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http://dx.doi.org/10.1038/s41375-018-0153-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603429PMC
December 2018

Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14).

Blood 2018 12 14;132(26):2778-2780. Epub 2018 Nov 14.

Unit for Genomics in Myeloma, Institut Universitaire du Cancer-Oncopole, Toulouse, France.

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http://dx.doi.org/10.1182/blood-2018-09-876433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307986PMC
December 2018

Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma.

Cell Rep 2018 12;25(13):3693-3705.e6

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; VA Boston Healthcare System, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407615PMC
December 2018

Tolerance, Kinetics, and Depth of Response for Subcutaneous Versus Intravenous Administration of Bortezomib Combination in Chinese Patients With Newly Diagnosed Multiple Myeloma.

Clin Lymphoma Myeloma Leuk 2018 06 15;18(6):422-430. Epub 2018 Mar 15.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academic Medical Science and Peking Union Medical College, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970050PMC
June 2018

Functional cargo delivery into mouse and human fibroblasts using a versatile microfluidic device.

Biomed Microdevices 2018 06 25;20(3):52. Epub 2018 Jun 25.

Department of Internal Medicine-Cardiology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/s10544-018-0292-6DOI Listing
June 2018

Widespread intronic polyadenylation diversifies immune cell transcriptomes.

Nat Commun 2018 04 30;9(1):1716. Epub 2018 Apr 30.

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/s41467-018-04112-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928244PMC
April 2018

Diagnosis of Castleman Disease.

Hematol Oncol Clin North Am 2018 02;32(1):53-64

Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, M230 Boston, MA 02215, USA; VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898588173014
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http://dx.doi.org/10.1016/j.hoc.2017.09.005DOI Listing
February 2018

Castleman Disease.

Hematol Oncol Clin North Am 2018 02;32(1):xiii-xiv

Dana Farber Cancer Institute, VA Boston Healthcare System, Harvard Medical School, 450 Brookline Avenue, M230, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2017.10.001DOI Listing
February 2018

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.

Sci Rep 2018 01 19;8(1):1258. Epub 2018 Jan 19.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1038/s41598-018-19539-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775342PMC
January 2018

Determining therapeutic susceptibility in multiple myeloma by single-cell mass accumulation.

Nat Commun 2017 11 20;8(1):1613. Epub 2017 Nov 20.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main St., Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-017-01593-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694762PMC
November 2017

Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma.

Clin Cancer Res 2017 Sep 25;23(17):5225-5237. Epub 2017 Apr 25.

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581671PMC
September 2017

Prospective Evaluation of Magnetic Resonance Imaging and [F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study.

J Clin Oncol 2017 Sep 7;35(25):2911-2918. Epub 2017 Jul 7.

Philippe Moreau, Florence Caillon, Caroline Bodet-Milin, Aurelie Gaultier, Jean-Michel Nguyen, Benoit Dupas, Eric Frampas, and Françoise Kraeber-Bodere, University Hospital, Nantes; Michel Attal, University Hospital, Toulouse; Denis Caillot, University Hospital, Dijon; Margaret Macro, University Hospital, Caen; Lionel Karlin, University Hospital, Lyon; Laurent Garderet, University Hospital Saint-Antoine, Paris; Thierry Facon, University Hospital, Lille; Lotfi Benboubker, University Hospital, Tours; Martine Escoffre-Barbe, University Hospital, Rennes; Anne-Marie Stoppa, Institut Paoli-Calmettes, Marseille; Kamel Laribi, University Hospital, Le Mans; Cyrille Hulin and Gerald Marit, University Hospital, Bordeaux; Aurore Perrot, University Hospital, Nancy; Jean-Richard Eveillard, University Hospital, Brest; Brigitte Pegourie, University Hospital, Grenoble; Veronique Dorvaux, University Hospital, Metz; Carine Chaleteix, University Hospital, Clermont-Ferrand; and Herve Avet-Loiseau, University Hospital, Toulouse, France; and Kenneth Anderson, Paul Richardson, and Nikhil C. Munshi, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2017.72.2975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578392PMC
September 2017

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma.

Clin Cancer Res 2017 Aug 1;23(15):4290-4300. Epub 2017 Mar 1.

LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540790PMC
August 2017

Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells.

Clin Cancer Res 2017 Aug 7;23(15):4280-4289. Epub 2017 Mar 7.

LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540781PMC
August 2017

Phenotypically silent Cre recombination within the postnatal ventricular conduction system.

PLoS One 2017 30;12(3):e0174517. Epub 2017 Mar 30.

Department of Internal Medicine (Cardiology Division), UT Southwestern Medical Center, Dallas, TX, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174517PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373586PMC
August 2017

Myeloma Minimal Residual Disease and Surrogacy-Reply.

JAMA Oncol 2017 08;3(8):1136-1137

Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, England.

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http://dx.doi.org/10.1001/jamaoncol.2017.0404DOI Listing
August 2017

Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma.

N Engl J Med 2017 04;376(14):1311-1320

From the Institut Universitaire du Cancer de Toulouse-Oncopole (M.A., M.R., C.P., S.R., H.A.-L.) and Service d'Epidémiologie, Centre Hospitalier et Universitaire de Toulouse (V.L.-C.), Toulouse, Hôpital Haut-Lévêque, Bordeaux Pessac (C.H.), Centre Hospitalier et Universitaire la Miletrie, Poitiers (X.L.), Centre Hospitalier Le Bocage, Dijon (D.C.), Centre Hospitalier et Universitaire de Rennes, Rennes (M.E.), Hôpital St.-Louis (B.A., J.P.F.), Centre Hospitalier Universitaire, Hôpital St.-Antoine (L.G.), Institut Curie (C.M.), and Haute Autorité de Santé (J.-L.H.), Paris, Institut d'Hématologie de Basse Normandie, Centre Hospitalier et Universitaire de Caen, Caen (M.M.), Centre Hospitalier et Universitaire Henri Mondor, Creteil (K.B.), Hôpital Claude Huriez, Lille (T.F.), and Hôtel Dieu, Nantes (P.M.) - all in France; Institut Jules Bordet, Brussels (N. Meuleman); and Dana-Farber Cancer Institute, Boston (M.E.M., A.A.Z., E.A.W., N. Munshi, K.C.A., P.G.R.).

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http://dx.doi.org/10.1056/NEJMoa1611750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201242PMC
April 2017

Resident Macrophages: Near and Dear to Your Heart.

Authors:
Nikhil V Munshi

Cell 2017 04;169(3):376-377

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA; McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.04.002DOI Listing
April 2017

The Promise of Cardiac Regeneration by In Situ Lineage Conversion.

Circulation 2017 03;135(10):914-916

From Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN (Y.-J.N.); Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (N.V.M.); McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX (N.V.M.); Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX (N.V.M.); and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX (N.V.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410767PMC
March 2017

Genomics of Multiple Myeloma.

J Clin Oncol 2017 Mar 13;35(9):963-967. Epub 2017 Feb 13.

Sebastien Robiou du Pont, Charlotte Fontan, Michel Attal, Jill Corre, and Hervé Avet-Loiseau, L'Institut Universitaire du Cancer Oncopole, Toulouse; Alice Cleynen, Centre National de la Recherche Scientifique, and Montpellier University, Montpellier, France; and Nikhil Munshi, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2016.70.6705DOI Listing
March 2017

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts.

J Vis Exp 2017 03 22(121). Epub 2017 Mar 22.

Department of Internal Medicine- Cardiology, UT Southwestern Medical Center;

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http://dx.doi.org/10.3791/55456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409299PMC
March 2017

Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells.

J Gastroenterol Hepatol Res 2017 21;6(1):2286-2295. Epub 2017 Feb 21.

Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute, Boston, MA, the United States. VA Health Care System, West Roxbury, MA, the United States.

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http://dx.doi.org/10.17554/j.issn.2224-3992.2017.06.687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796564PMC
February 2017

Next-Generation Sequencing Informing Therapeutic Decisions and Personalized Approaches.

Am Soc Clin Oncol Educ Book 2016 ;35:e442-8

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; VA Boston Healthcare System, Boston, MA.

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http://dx.doi.org/10.1200/EDBK_159017DOI Listing
January 2017

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.

Authors:
Kristin A Rand Chi Song Eric Dean Daniel J Serie Karen Curtin Xin Sheng Donglei Hu Carol Ann Huff Leon Bernal-Mizrachi Michael H Tomasson Sikander Ailawadhi Seema Singhal Karen Pawlish Edward S Peters Cathryn H Bock Alex Stram David J Van Den Berg Christopher K Edlund David V Conti Todd Zimmerman Amie E Hwang Scott Huntsman John Graff Ajay Nooka Yinfei Kong Silvana L Pregja Sonja I Berndt William J Blot John Carpten Graham Casey Lisa Chu W Ryan Diver Victoria L Stevens Michael R Lieber Phyllis J Goodman Anselm J M Hennis Ann W Hsing Jayesh Mehta Rick A Kittles Suzanne Kolb Eric A Klein Cristina Leske Adam B Murphy Barbara Nemesure Christine Neslund-Dudas Sara S Strom Ravi Vij Benjamin A Rybicki Janet L Stanford Lisa B Signorello John S Witte Christine B Ambrosone Parveen Bhatti Esther M John Leslie Bernstein Wei Zheng Andrew F Olshan Jennifer J Hu Regina G Ziegler Sarah J Nyante Elisa V Bandera Brenda M Birmann Sue A Ingles Michael F Press Djordje Atanackovic Martha J Glenn Lisa A Cannon-Albright Brandt Jones Guido Tricot Thomas G Martin Shaji K Kumar Jeffrey L Wolf Sandra L Deming Halverson Nathaniel Rothman Angela R Brooks-Wilson S Vincent Rajkumar Laurence N Kolonel Stephen J Chanock Susan L Slager Richard K Severson Nalini Janakiraman Howard R Terebelo Elizabeth E Brown Anneclaire J De Roos Ann F Mohrbacher Graham A Colditz Graham G Giles John J Spinelli Brian C Chiu Nikhil C Munshi Kenneth C Anderson Joan Levy Jeffrey A Zonder Robert Z Orlowski Sagar Lonial Nicola J Camp Celine M Vachon Elad Ziv Daniel O Stram Dennis J Hazelett Christopher A Haiman Wendy Cozen

Cancer Epidemiol Biomarkers Prev 2016 12 1;25(12):1609-1618. Epub 2016 Sep 1.

Keck School of Medicine of USC and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524541PMC
December 2016

Review of siltuximab in the treatment of multicentric Castleman's disease.

Ther Adv Hematol 2016 Dec 23;7(6):360-366. Epub 2016 Jun 23.

Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1177/2040620716653745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089324PMC
December 2016

Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis.

Oncoimmunology 2017 7;6(1):e1261776. Epub 2016 Dec 7.

Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA; Surgery Services, VA Boston Healthcare System, West Roxbury, MA, USA.

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http://dx.doi.org/10.1080/2162402X.2016.1261776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283644PMC
December 2016

Gene Expression Profiles in Myeloma: Ready for the Real World?

Clin Cancer Res 2016 Nov;22(22):5434-5442

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546147PMC
November 2016

Deep Response in Multiple Myeloma: A Critical Review.

Biomed Res Int 2015 10;2015:832049. Epub 2015 Dec 10.

Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of hematology, Hospital 12 de Octubre, Unidad CRIS, CNIO, University of Madrid, Spain.

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http://dx.doi.org/10.1155/2015/832049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689894PMC
October 2016

Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication.

Blood 2016 09 14;128(12):1590-603. Epub 2016 Jul 14.

LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2016-03-707547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034739PMC
September 2016

DNA repair of myeloma plasma cells correlates with clinical outcome: the effect of the nonhomologous end-joining inhibitor SCR7.

Blood 2016 09 21;128(9):1214-25. Epub 2016 Jul 21.

Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens, Greece.

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http://dx.doi.org/10.1182/blood-2016-01-691618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524533PMC
September 2016

CRISPR (Clustered Regularly Interspaced Palindromic Repeat)/Cas9 System: A Revolutionary Disease-Modifying Technology.

Authors:
Nikhil V Munshi

Circulation 2016 Sep;134(11):777-9

From Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center; McDermott Center for Human Growth and Development, UT Southwestern Medical Center; Department of Molecular Biology, UT Southwestern Medical Center; and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center; Dallas, TX.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025032PMC
September 2016

Stromal CCR6 drives tumor growth in a murine transplantable colon cancer through recruitment of tumor-promoting macrophages.

Oncoimmunology 2016 Aug 24;5(8):e1189052. Epub 2016 May 24.

Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA; Surgery Service, VA Boston Healthcare System, West Roxbury, MA, USA.

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http://dx.doi.org/10.1080/2162402X.2016.1189052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007974PMC
August 2016

A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy.

Blood 2016 07 18;128(2):249-52. Epub 2016 May 18.

Medical Oncology, and LeBow Institute for Myeloma Therapeutics and Jerome Lipper Center for Multiple Myeloma Research, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA; VA Boston Healthcare System, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-03-704460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946203PMC
July 2016

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.

Blood 2016 06 28;127(25):3225-36. Epub 2016 Apr 28.

The Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA;

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http://dx.doi.org/10.1182/blood-2016-01-691162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920023PMC
June 2016

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma.

Mol Cancer Ther 2016 06 18;15(6):1364-75. Epub 2016 May 18.

Department of Experimental and Clinical Medicine, Magna Graecia University and Translational Medical Oncology Unit, Salvatore Venuta University Campus, Catanzaro, Italy. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0985DOI Listing
June 2016

Corrigendum to "Genomic heterogeneity in multiple myeloma" [Curr. Opin. Genet. Dev. 30 (2015) 56-65].

Curr Opin Genet Dev 2016 04 4;37:158. Epub 2016 Mar 4.

Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States; VA Boston Healthcare System, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2016.02.003DOI Listing
April 2016

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model.

Cancer Res 2016 Jan 7;76(2):463-71. Epub 2016 Jan 7.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1926DOI Listing
January 2016