Nicholas C Turner

Nicholas C Turner

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Nicholas C Turner

Publications by authors named "Nicholas C Turner"

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Molecular Residual Disease and Adjuvant Trial Design in Solid Tumors.

Clin Cancer Res 2019 May 14. Epub 2019 May 14.

Breast Cancer Now Research Centre, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0152DOI Listing
May 2019

Assessing HER2 Amplification in Plasma cfDNA.

Methods Mol Biol 2018 ;1768:161-172

Breast Cancer Now Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1007/978-1-4939-7778-9_10DOI Listing
February 2019

Palbociclib and Fulvestrant in Breast Cancer. Reply.

N Engl J Med 2019 Feb;380(8):797

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1056/NEJMc1816595DOI Listing
February 2019

Molecular Testing in Breast Cancer.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:e1-e7. Epub 2019 May 17.

3 Institute of Cancer Research, NHS Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1200/EDBK_237715DOI Listing
January 2019

Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer.

N Engl J Med 2018 Nov 20;379(20):1926-1936. Epub 2018 Oct 20.

From the Institute of Cancer Research and Royal Marsden Hospital, London (N.C.T.); David Geffen School of Medicine at University of California, Los Angeles, Santa Monica (D.J.S.), and Pfizer Oncology, San Diego (X.H.) - both in California; National Cancer Center, Goyang-si, Gyeonggi-do (J.R.), and Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul (S.-A.I.) - both in South Korea; Dnipropetrovsk Medical Academy, City Multiple-Discipline Clinical Hospital 4, Dnipropetrovsk, Ukraine (I.B.); National Hospital Organization Osaka National Hospital, Osaka (N.M.), and Aichi Cancer Center Hospital, Nagoya (H.I.) - both in Japan; Istituto Europeo di Oncologia (M. Colleoni) and Pfizer Oncology (C.G.) - both in Milan; Abramson Cancer Center, University of Pennsylvania, Philadelphia (A.D.), and Pfizer Oncology, Collegeville (C.H.B.) - both in Pennsylvania; Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia (S. Loi); Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada (S.V.); Brustzentrum der Universität München, Munich (N.H.), and the German Breast Group, Neu-Isenburg (S. Loibl) - both in Germany; Institut Gustave Roussy, Villejuif, France (F.A.); Pfizer Oncology, Cambridge, MA (K.P.T.); and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Feinberg School of Medicine, Chicago (M. Cristofanilli).

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http://www.nejm.org/doi/10.1056/NEJMoa1810527
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http://dx.doi.org/10.1056/NEJMoa1810527DOI Listing
November 2018

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review.

Arch Pathol Lab Med 2018 10 5;142(10):1242-1253. Epub 2018 Mar 5.

Jason D. Merker and Maximilian Diehn, Stanford University School of Medicine; Stanford, CA; Geoffrey R. Oxnard, Dana Farber Cancer Institute and Harvard Medical School; Neal Lindeman, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Carolyn Compton, Arizona State University, Tempe, AZ; Patricia Hurley, Richard L. Schilsky, Thomas K. Oliver, and Suanna S. Bruinooge, American Society of Clinical Oncology, Alexandria, VA; Alexander J. Lazar and Apostolia M. Tsimberidou, The University of Texas MD Anderson Cancer Center, Houston, TX; hristina M. Lockwood, University of Washington, Seattle, WA; Alex J. Rai, Columbia University Medical Center, New York, NY; Patricia Vasalos and Brooke L. Billman, College of American Pathologists, Northfield, IL; Daniel F. Hayes, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; and Nicholas C. Turner, Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-090
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http://dx.doi.org/10.5858/arpa.2018-0901-SADOI Listing
October 2018

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review.

J Clin Oncol 2018 06 5;36(16):1631-1641. Epub 2018 Mar 5.

Jason D. Merker and Maximilian Diehn, Stanford University School of Medicine; Stanford, CA; Geoffrey R. Oxnard, Dana Farber Cancer Institute and Harvard Medical School; Neal Lindeman, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Carolyn Compton, Arizona State University, Tempe, AZ; Patricia Hurley, Richard L. Schilsky, Thomas K. Oliver, and Suanna S. Bruinooge, American Society of Clinical Oncology, Alexandria, VA; Alexander J. Lazar and Apostolia M. Tsimberidou, The University of Texas MD Anderson Cancer Center, Houston, TX; Christina M. Lockwood, University of Washington, Seattle, WA; Alex J. Rai, Columbia University Medical Center, New York, NY; Patricia Vasalos and Brooke L. Billman, College of American Pathologists, Northfield, IL; Daniel F. Hayes, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; and Nicholas C. Turner, Royal Marsden Hospital and Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.76.8671DOI Listing
June 2018

Signatures of DNA-Repair Deficiencies in Breast Cancer.

N Engl J Med 2017 12;377(25):2490-2492

From the Breast Cancer Now Research Centre, Institute of Cancer Research, and the Breast Unit, Royal Marsden Hospital, London.

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http://dx.doi.org/10.1056/NEJMcibr1710161DOI Listing
December 2017

Modeling Therapy Resistance in -Mutant Cancers.

Mol Cancer Ther 2017 09 15;16(9):2022-2034. Epub 2017 Jun 15.

The CRUK Gene Function Laboratory and The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-17-0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157714PMC
September 2017

Targeting PIK3CA-mutant advanced breast cancer in the clinical setting.

Lancet Oncol 2017 07 30;18(7):842-843. Epub 2017 May 30.

Breast Unit, The Royal Marsden Hospital, London, SW3 6JJ, UK; The Breast Cancer Now Research Centre, Institute of Cancer Research, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30430-8DOI Listing
July 2017

Advances in the treatment of advanced oestrogen-receptor-positive breast cancer.

Lancet 2017 Jun 7;389(10087):2403-2414. Epub 2016 Dec 7.

INSERM U981, Gustave Roussy Cancer Center, Université Paris Sud, Villejuif, France.

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http://dx.doi.org/10.1016/S0140-6736(16)32419-9DOI Listing
June 2017

Advances and challenges in targeting FGFR signalling in cancer.

Nat Rev Cancer 2017 05 17;17(5):318-332. Epub 2017 Mar 17.

Breast Cancer Now Research Centre, Institute of Cancer Research, London SW3 6JB, UK.

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http://dx.doi.org/10.1038/nrc.2017.8DOI Listing
May 2017

Gatekeeper Mutations and Intratumoral Heterogeneity in -Translocated Cholangiocarcinoma.

Cancer Discov 2017 03;7(3):248-249

Molecular Oncology, Breast Cancer Now Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0057DOI Listing
March 2017

Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.

J Clin Oncol 2016 09 6;34(25):2961-8. Epub 2016 Jun 6.

Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.67.3061DOI Listing
September 2016

Treating cancer with selective CDK4/6 inhibitors.

Nat Rev Clin Oncol 2016 07 31;13(7):417-30. Epub 2016 Mar 31.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1038/nrclinonc.2016.26DOI Listing
July 2016

CDK4/6 Inhibitors: Promising Opportunities beyond Breast Cancer.

Cancer Discov 2016 07;6(7):697-9

The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0563DOI Listing
July 2016

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer.

Sci Transl Med 2015 Aug;7(302):302ra133

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK. Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

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http://dx.doi.org/10.1126/scitranslmed.aab0021DOI Listing
August 2015

Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer.

N Engl J Med 2015 Jul 1;373(3):209-19. Epub 2015 Jun 1.

From Royal Marsden Hospital, London (N.C.T.); National Cancer Center, Goyang-si, South Korea (J.R.); Institut Gustave Roussy, Villejuif, France (F.A.); Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia (S. Loi); Sunnybrook Odette Cancer Centre, Toronto (S.V.); Aichi Cancer Center Hospital, Nagoya, Japan (H.I.); Brustzentrum der Universität München, Munich (N.H.), and German Breast Group Forschungs, Neu-Isenburg (S. Loibl) - both in Germany; Pfizer, New York (C.H.B., M.K.), La Jolla, CA (K.Z., S.R.), and Milan (C.G.); and Thomas Jefferson University, Philadelphia (M.C.).

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http://dx.doi.org/10.1056/NEJMoa1505270DOI Listing
July 2015

Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.

Mol Cancer Ther 2015 Apr 11;14(4):865-76. Epub 2015 Feb 11.

CRUK Gene Function Laboratory, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom. Breast Unit, Royal Marsden Hospital, London, United Kingdom.

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http://mct.aacrjournals.org/content/14/4/865.full.pdf
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http://mct.aacrjournals.org/content/molcanther/early/2015/02
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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
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http://dx.doi.org/10.1158/1535-7163.MCT-14-0845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485454PMC
April 2015

The history and future of targeting cyclin-dependent kinases in cancer therapy.

Nat Rev Drug Discov 2015 Feb;14(2):130-46

Simmons Cancer Center and Department of Pathology, University of Texas Southwestern, Dallas, USA.

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http://dx.doi.org/10.1038/nrd4504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480421PMC
February 2015

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours.

Nat Commun 2015 Jan 22;6:5973. Epub 2015 Jan 22.

1] Division of Genetics and Epidemiology, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK [2] William Harvey Research Institute, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/ncomms6973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338546PMC
January 2015

Determination of HER2 amplification status on tumour DNA by digital PCR.

PLoS One 2013 26;8(12):e83409. Epub 2013 Dec 26.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom ; Breast Unit, Royal Marsden Hospital, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873285PMC
September 2014

An update on the medical management of breast cancer.

BMJ 2014 Jun 9;348:g3608. Epub 2014 Jun 9.

Royal Free Hospital, London NW3 2QG, UK

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http://dx.doi.org/10.1136/bmj.g3608DOI Listing
June 2014

Tackling the diversity of triple-negative breast cancer.

Clin Cancer Res 2013 Dec;19(23):6380-8

Authors' Affiliations: The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research; Breast Unit, Royal Marsden Hospital, London, United Kingdom; Department of Pathology; and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0915DOI Listing
December 2013

Targeting receptor tyrosine kinases in HER2-negative breast cancer.

Curr Opin Oncol 2013 Nov;25(6):594-601

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http://dx.doi.org/10.1097/CCO.0000000000000021DOI Listing
November 2013

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.

Cancer Discov 2013 Sep 6;3(9):1058-71. Epub 2013 Jun 6.

1The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research; 2Breast Unit, Royal Marsden Hospital, London; 3Institute of Cancer Therapeutics, University of Bradford, Bradford; and 4Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770512PMC
September 2013

Tumour selective targeting of cell cycle kinases for cancer treatment.

Curr Opin Pharmacol 2013 Aug 15;13(4):529-35. Epub 2013 Apr 15.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.coph.2013.03.012DOI Listing
August 2013

Noninvasive detection of HER2 amplification with plasma DNA digital PCR.

Clin Cancer Res 2013 Jun 1;19(12):3276-84. Epub 2013 May 1.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485473PMC
June 2013

Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.

Cancer Discov 2012 Jun 23;2(6):524-39. Epub 2012 Apr 23.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research; Breast Unit, UK.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0320DOI Listing
June 2012

Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer.

Breast Cancer Res 2012 Jun 19;14(3):208. Epub 2012 Jun 19.

Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

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http://dx.doi.org/10.1186/bcr3139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446326PMC
June 2012

Genetic heterogeneity and cancer drug resistance.

Lancet Oncol 2012 Apr 30;13(4):e178-85. Epub 2012 Mar 30.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1016/S1470-2045(11)70335-7DOI Listing
April 2012

Biomarkers of PARP inhibitor sensitivity.

Breast Cancer Res Treat 2011 May 8;127(1):283-6. Epub 2011 Feb 8.

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

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http://dx.doi.org/10.1007/s10549-011-1375-8DOI Listing
May 2011

A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.

Clin Cancer Res 2010 Dec 27;16(24):6159-68. Epub 2010 Aug 27.

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Academic Department of Biochemistry, and Breast Unit, Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432445PMC
December 2010

A therapeutic target for smoking-associated lung cancer.

Sci Transl Med 2010 Dec;2(62):62ps56

Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

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http://dx.doi.org/10.1126/scitranslmed.3001942DOI Listing
December 2010

A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.

DNA Repair (Amst) 2008 Dec 15;7(12):2010-9. Epub 2008 Oct 15.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.dnarep.2008.08.014DOI Listing
December 2008

Management of breast cancer--part I.

BMJ 2008 Jul 4;337:a421. Epub 2008 Jul 4.

Department of Medical Oncology, Royal Free Hospital NHS Foundation Trust, London NW3 2QG.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453305PMC
http://dx.doi.org/10.1136/bmj.a421DOI Listing
July 2008

Management of breast cancer--Part II.

BMJ 2008 Jul 11;337:a540. Epub 2008 Jul 11.

Department of Medical Oncology, Royal Free Hospital NHS Foundation Trust, London NW3 2QG.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483889PMC
http://dx.doi.org/10.1136/bmj.a540DOI Listing
July 2008

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.

EMBO J 2008 May 3;27(9):1368-77. Epub 2008 Apr 3.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/emboj.2008.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374839PMC
May 2008

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.

Cancer Cell 2008 Feb;13(2):91-104

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.ccr.2008.01.001DOI Listing
February 2008

FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis.

Breast Cancer Res 2007 ;9(2):R23

Department of Histopathology, School of Molecular Medical Sciences, Queen's Medical Centre, Nottingham University Hospitals Trust and University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/bcr1665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868920PMC
June 2007

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.

Cancer Res 2006 Aug;66(16):8109-15

Cancer Research UK Gene Function and Regulation Group and The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0140DOI Listing
August 2006