Navdeep S Chandel

Navdeep S Chandel

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Navdeep S Chandel

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Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function.

Cell Rep 2019 Jul;28(1):159-171.e4

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679941PMC
July 2019

Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate.

Dev Cell 2019 Jun 16;49(5):748-763.e7. Epub 2019 May 16.

Departments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.04.029DOI Listing
June 2019

Glucose Metabolism Linked to Antiviral Responses.

Cell 2019 Jun;178(1):10-11

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Biochemistry & Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.057DOI Listing
June 2019

There Is No Smoke without Mitochondria.

Am J Respir Cell Mol Biol 2019 May;60(5):489-491

1 Department of Medicine Northwestern University Chicago, Illinois.

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http://dx.doi.org/10.1165/rcmb.2018-0348EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503615PMC
May 2019

Immunometabolism of pro-repair cells.

J Clin Invest 2019 05 13;129(7):2597-2607. Epub 2019 May 13.

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https://www.jci.org/articles/view/124613
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http://dx.doi.org/10.1172/JCI124613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597201PMC
May 2019

Serine Metabolism Supports Macrophage IL-1β Production.

Cell Metab 2019 Apr 14;29(4):1003-1011.e4. Epub 2019 Feb 14.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447453PMC
April 2019

NAD-biosynthetic pathways regulate innate immunity.

Nat Immunol 2019 04;20(4):380-382

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41590-019-0353-xDOI Listing
April 2019

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.

Cell Rep 2019 Apr;27(1):226-237.e4

Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 North St. Clair Street, Suite 2210, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461402PMC
April 2019

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair.

Cell Metab 2019 Feb 27;29(2):443-456.e5. Epub 2018 Dec 27.

Department of Pathology, Feinberg School of Medicine, Chicago, IL, USA; Feinberg Cardiovascular & Renal Research Institute, Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471613PMC
February 2019

Probing mitochondrial metabolism in vivo.

Proc Natl Acad Sci U S A 2019 01 18;116(1):20-22. Epub 2018 Dec 18.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611

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http://dx.doi.org/10.1073/pnas.1819614116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320514PMC
January 2019

IDH3α regulates one-carbon metabolism in glioblastoma.

Sci Adv 2019 Jan 2;5(1):eaat0456. Epub 2019 Jan 2.

Ken and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/sciadv.aat0456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314828PMC
January 2019

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis.

Nat Metab 2019 Jan 7;1(1):158-171. Epub 2019 Jan 7.

Departments of Medicine and Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.

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http://dx.doi.org/10.1038/s42255-018-0011-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521885PMC
January 2019

Hexokinase 2 is dispensable for T cell-dependent immunity.

Cancer Metab 2018 17;6:10. Epub 2018 Aug 17.

1Department of Medicine, Northwestern University Feinberg School of Medicine, McGaw Pavilion, Rm. M-334, 240 East Huron Street, Chicago, IL 60611 USA.

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https://cancerandmetabolism.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40170-018-0184-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098591PMC
August 2018

ROS Promotes Cancer Cell Survival through Calcium Signaling.

Cancer Cell 2018 06;33(6):949-951

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.05.010DOI Listing
June 2018

Regulation of redox balance in cancer and T cells.

J Biol Chem 2018 05 27;293(20):7499-7507. Epub 2017 Dec 27.

From the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611

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http://www.jbc.org/lookup/doi/10.1074/jbc.TM117.000257
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http://dx.doi.org/10.1074/jbc.TM117.000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961053PMC
May 2018

To Claim Growth Turf, mTOR Says SOD Off.

Mol Cell 2018 05;70(3):383-384

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.04.015DOI Listing
May 2018

Acetyl-CoA-directed gene transcription in cancer cells.

Genes Dev 2018 04;32(7-8):463-465

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1101/gad.315168.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959230PMC
April 2018

E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells.

Circ Res 2018 03 22;122(5):701-711. Epub 2018 Jan 22.

From the Department of Biomedical Engineering, Molecular Cardiology Program, School of Medicine and School of Engineering, University of Alabama at Birmingham (S.X., L.Y., E.Z., C.B., G.Q.); Feinberg Cardiovascular Research Institute (S.X., J.Z., T.S., D.W.L., G.Q.) and Department of Medicine - Pulmonary and Critical Care Medicine (N.S.C.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (S.X., J.T.); Department of Cardiology (L.Y., M.C., K.H.) and Department of Cardiovascular Surgery (J.S., N.D.), Union Hospital of Huazhong University of Science and Technology Tongji Medical College, Wuhan, China; Institute for Medical Biology and Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities, Wuhan, China (Q.L.); Department of Surgery, Roger Williams Medical Center, Boston University Medical School, Boston University, Providence, RI (T.C.Z.); Department of Basic Science, School of Medicine, Loma Linda University, CA (H.Q.); and Roudebush VA Medical Center and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis (R.A.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021021PMC
March 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Mitochondria-ER Pas de Deux Controls Memory T Cell Function.

Immunity 2018 03;48(3):479-481

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183007
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http://dx.doi.org/10.1016/j.immuni.2018.03.002DOI Listing
March 2018

Mitochondria: back to the future.

Nat Rev Mol Cell Biol 2018 02 20;19(2):76. Epub 2017 Dec 20.

Feinberg School of Medicine,Deparment of Medicine,Northwestern University, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1038/nrm.2017.133DOI Listing
February 2018

A CRISPR screen identifies a pathway required for paraquat-induced cell death.

Nat Chem Biol 2017 Dec 23;13(12):1274-1279. Epub 2017 Oct 23.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nchembio.2499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698099PMC
December 2017

Reactive oxygen species as signaling molecules in the development of lung fibrosis.

Transl Res 2017 12 10;190:61-68. Epub 2017 Oct 10.

Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2017.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730357PMC
December 2017

Waste Not, Want Not: Lactate Oxidation Fuels the TCA Cycle.

Cell Metab 2017 12;26(6):803-804

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.11.005DOI Listing
December 2017

Mitochondrial control of immunity: beyond ATP.

Nat Rev Immunol 2017 Oct 3;17(10):608-620. Epub 2017 Jul 3.

Department of Medicine, Northwestern University Feinberg School of Medicine, 240 East Huron Avenue, M-334, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/nri.2017.66DOI Listing
October 2017

Mitochondrial redox signaling enables repair of injured skeletal muscle cells.

Sci Signal 2017 Sep 5;10(495). Epub 2017 Sep 5.

Children's National Health System, Center for Genetic Medicine Research, 111 Michigan Avenue Northwest, Washington, DC 20010-2970, USA.

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http://dx.doi.org/10.1126/scisignal.aaj1978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949579PMC
September 2017

Metabolism and Skeletal Muscle Homeostasis in Lung Disease.

Am J Respir Cell Mol Biol 2017 07;57(1):28-34

Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1165/rcmb.2016-0355TRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516279PMC
July 2017

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.

Nat Cell Biol 2017 Jun 15;19(6):626-638. Epub 2017 May 15.

Children's Medical Center Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/ncb3527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771482PMC
June 2017

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.

Cell Rep 2017 05;19(9):1858-1873

Ken and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, International Institute for Nanotechnology, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564207PMC
May 2017

Mitochondrial ROS regulation of proliferating cells.

Free Radic Biol Med 2016 11 3;100:86-93. Epub 2016 May 3.

Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.198DOI Listing
November 2016

Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy.

Proc Natl Acad Sci U S A 2016 10 4;113(42):E6372-E6381. Epub 2016 Oct 4.

Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208

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http://dx.doi.org/10.1073/pnas.1608198113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081614PMC
October 2016

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

Nat Cell Biol 2016 08 18;18(8):823-32. Epub 2016 Jul 18.

Department of Medicine, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, California 94143-0667, USA.

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http://dx.doi.org/10.1038/ncb3385DOI Listing
August 2016

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics.

Cell Rep 2016 06 9;15(12):2705-18. Epub 2016 Jun 9.

Breast Cancer Clinical Research Unit, CNIO-Spanish National Cancer Research Center, Melchor Fernández Almagro, 3, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.052DOI Listing
June 2016

Fundamentals of cancer metabolism.

Sci Adv 2016 05 27;2(5):e1600200. Epub 2016 May 27.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/sciadv.1600200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928883PMC
May 2016

The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia.

Cell Rep 2016 Apr 7;15(3):451-459. Epub 2016 Apr 7.

Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838509PMC
April 2016

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

Cell Metab 2016 Apr;23(4):569-70

Goodman and Segal Cancer Centers, McGill University, 3755 Cote-Sainte-Catherine Road, Montreal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.03.010DOI Listing
April 2016

HSC Fate Is Tethered to Mitochondria.

Cell Stem Cell 2016 Mar;18(3):303-4

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)00069-2
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http://linkinghub.elsevier.com/retrieve/pii/S193459091600069
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http://dx.doi.org/10.1016/j.stem.2016.02.007DOI Listing
March 2016

CANCER. Revisiting vitamin C and cancer.

Science 2015 Dec;350(6266):1317-8

Department of Medicine and Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/science.aad8671DOI Listing
December 2015

Evolution of Mitochondria as Signaling Organelles.

Cell Metab 2015 Aug 11;22(2):204-6. Epub 2015 Jun 11.

Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131150022
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http://dx.doi.org/10.1016/j.cmet.2015.05.013DOI Listing
August 2015

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation.

Nat Immunol 2015 May 23;16(5):458-66. Epub 2015 Mar 23.

Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/ni.3130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451949PMC
May 2015

ROS-dependent signal transduction.

Curr Opin Cell Biol 2015 Apr 8;33:8-13. Epub 2014 Oct 8.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2014.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380867PMC
April 2015

Mitochondria in the regulation of innate and adaptive immunity.

Immunity 2015 Mar;42(3):406-17

Department of Medicine, Feinberg School of Medicine Northwestern University, Chicago, IL 60615, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365295PMC
March 2015

Mitochondrial reactive oxygen species and cancer.

Cancer Metab 2014 28;2:17. Epub 2014 Nov 28.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 USA.

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http://dx.doi.org/10.1186/2049-3002-2-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323058PMC
February 2015

Targeting metabolism for lupus therapy.

Sci Transl Med 2015 Feb;7(274):274fs5

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa6731DOI Listing
February 2015

Mitochondrial metabolism in TCA cycle mutant cancer cells.

Cell Cycle 2014 13;13(3):347-8. Epub 2013 Dec 13.

Department of Medicine; Northwestern University Feinberg School of Medicine; Chicago, IL USA.

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http://dx.doi.org/10.4161/cc.27513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956527PMC
January 2015

Targeting mitochondria metabolism for cancer therapy.

Nat Chem Biol 2015 Jan;11(1):9-15

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nchembio.1712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340667PMC
January 2015

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.

J Virol Methods 2014 Dec 17;209:116-20. Epub 2014 Sep 17.

Division of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2014.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315182PMC
December 2014

Mitochondrial one-carbon metabolism maintains redox balance during hypoxia.

Cancer Discov 2014 Dec;4(12):1371-3

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258875PMC
December 2014

Targeting antioxidants for cancer therapy.

Biochem Pharmacol 2014 Nov 28;92(1):90-101. Epub 2014 Jul 28.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.bcp.2014.07.017DOI Listing
November 2014

TOR signaling couples oxygen sensing to lifespan in C. elegans.

Cell Rep 2014 Oct 2;9(1):9-15. Epub 2014 Oct 2.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194168PMC
October 2014

The promise and perils of antioxidants for cancer patients.

N Engl J Med 2014 Jul;371(2):177-8

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http://dx.doi.org/10.1056/NEJMcibr1405701DOI Listing
July 2014

Futility sustains memory T cells.

Immunity 2014 Jul;41(1):1-3

Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130331PMC
July 2014

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

Cell Rep 2014 Jun 22;7(5):1679-1690. Epub 2014 May 22.

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8502, USA; McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8502, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140033
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http://dx.doi.org/10.1016/j.celrep.2014.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057960PMC
June 2014

Mitochondria and cancer.

Cancer Metab 2014 10;2. Epub 2014 Jun 10.

Feinberg School of Medicine, Northwestern University, Chicago, USA.

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http://dx.doi.org/10.1186/2049-3002-2-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050413PMC
June 2014

ROS function in redox signaling and oxidative stress.

Curr Biol 2014 May;24(10):R453-62

Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055301PMC
May 2014

Mitochondria as signaling organelles.

BMC Biol 2014 May 27;12:34. Epub 2014 May 27.

Section of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1186/1741-7007-12-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035690PMC
May 2014

Reply: antioxidants in the intensive care unit.

Am J Respir Crit Care Med 2014 Apr;189(8):1008

1 Northwestern University Chicago, Illinois.

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http://dx.doi.org/10.1164/rccm.201402-0232LEDOI Listing
April 2014

Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response.

Am J Respir Cell Mol Biol 2013 Dec;49(6):892-901

1 Department of Medicine, Division of Pulmonary & Critical Care Medicine, Jesse Brown Veterans Affairs Medical Center and Northwestern University Feinberg School of Medicine, Chicago, Illinois; and.

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http://dx.doi.org/10.1165/rcmb.2013-0053OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931115PMC
December 2013

Rethinking antioxidants in the intensive care unit.

Am J Respir Crit Care Med 2013 Dec;188(11):1283-5

1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1164/rccm.201307-1380CPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919077PMC
December 2013

Hydrophilic interaction liquid chromatography coupled with MS/MS to detect and quantify dicarboxyethyl glutathione, a metabolic biomarker of the fumarate hydratase deficient cancer cell.

J Sep Sci 2013 Oct 10;36(20):3303-9. Epub 2013 Sep 10.

Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX.

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http://dx.doi.org/10.1002/jssc.201300602DOI Listing
October 2013

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

Mol Cell 2013 Jul 6;51(2):236-48. Epub 2013 Jun 6.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775267PMC
July 2013

The good and the bad of antibiotics.

Sci Transl Med 2013 Jul;5(192):192fs25

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://collinslab.mit.edu/files/stm_focus.pdf
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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30065
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http://dx.doi.org/10.1126/scitranslmed.3006567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997060PMC
July 2013

ROS links glucose metabolism to breast cancer stem cell and EMT phenotype.

Cancer Cell 2013 Mar;23(3):265-7

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.02.021DOI Listing
March 2013

ROS.

Curr Biol 2013 Feb;23(3):R100-2

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.cub.2012.12.011DOI Listing
February 2013

Metabolic changes in cancer cells upon suppression of MYC.

Cancer Metab 2013 Feb 4;1(1). Epub 2013 Feb 4.

Department of Medicine, Feinberg School of Medicine, Northwestern University, 60611, Chicago, IL, USA.

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http://dx.doi.org/10.1186/2049-3002-1-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178210PMC
February 2013

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling.

J Biol Chem 2013 Jan 30;288(2):770-7. Epub 2012 Nov 30.

Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M112.431973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543026PMC
January 2013

Mitochondrial metabolism as a regulator of keratinocyte differentiation.

Cell Logist 2013 Jan 24;3(1):e25456. Epub 2013 Jun 24.

Department of Medicine, Division of Pulmonary and Critical Care Medicine and Department of Cell and Molecular Biology; Northwestern University Medical School; Chicago, IL USA.

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http://www.tandfonline.com/doi/abs/10.4161/cl.25456
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http://dx.doi.org/10.4161/cl.25456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891634PMC
January 2013

Physiological roles of mitochondrial reactive oxygen species.

Mol Cell 2012 Oct;48(2):158-67

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484374PMC
October 2012

Mitochondria and telomeres: the promiscuous roles of TIN2.

Mol Cell 2012 Sep;47(6):823-4

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.09.006DOI Listing
September 2012

MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism.

FASEB J 2012 Aug 24;26(8):3140-7. Epub 2012 Apr 24.

Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1096/fj.11-198515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405266PMC
August 2012

microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation.

Proc Natl Acad Sci U S A 2012 Aug 13;109(35):14030-4. Epub 2012 Aug 13.

Department of Dermatology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.1111292109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435188PMC
August 2012

Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor.

PLoS One 2012 17;7(1):e30448. Epub 2012 Jan 17.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030448PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260305PMC
June 2012

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.

Nature 2012 May 9;485(7400):661-5. Epub 2012 May 9.

Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

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http://dx.doi.org/10.1038/nature11066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607316PMC
May 2012

Targeting glucose metabolism for cancer therapy.

J Exp Med 2012 Feb;209(2):211-5

Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1084/jem.20120162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280882PMC
February 2012

The role of nuclear lamin B1 in cell proliferation and senescence.

Genes Dev 2011 Dec 8;25(24):2579-93. Epub 2011 Dec 8.

Department of Cell and Molecular Biology, Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://genesdev.cshlp.org/content/25/24/2579.full.pdf
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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.179515.111
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http://dx.doi.org/10.1101/gad.179515.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248680PMC
December 2011