Publications by authors named "Nassih H"

9 Publications

  • Page 1 of 1

Atypical Presentation of Celiac Disease: Recurrent Acute Small Bowel Obstruction.

Clin Med Insights Case Rep 2021 13;14:1179547620986152. Epub 2021 Jan 13.

Pediatric B Department, Mother-Child Pole, Mohammed VI University Hospital, Marrakesh, Morocco.

Context: Intussusception is the most common cause of small bowel obstruction in children under 4 years of age. Intussusception is not a widely recognized complication of celiac disease.

Case Report: We present a clinical case of a 23-month-old boy with a 1-month history of watery diarrhea complicated by 2 episodes of intestinal obstruction, both had required surgery. He presented with acute and severe abdominal distention with bilious vomiting, and an appearance of intussusception on abdominal ultrasound. Upon further investigation, the diarrhea was found to be malabsorptive. The diagnosis of celiac disease was confirmed by the presence of specific serum autoantibodies (IgA Tissue transglutaminase and endomysium Antibodies >200 UI/ml with normal serum IgA level). He started a gluten-free diet and his symptoms were almost completely resolved.

Conclusion: Recurrent intussusception may be associated with celiac disease, so celiac serology is recommended in children with recurrent intussusceptions. However, intestinal tuberculosis and lymphoma associated with enteropathy should be considered in the differential diagnosis. Intussusception in celiac disease is usually transient and should be managed expectantly rather than early surgical reduction.
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http://dx.doi.org/10.1177/1179547620986152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809297PMC
January 2021

Severe Acral Necrosis Complicating Thrombotic Microangiopathy in Two Toddlers.

Case Rep Pediatr 2020 15;2020:8869883. Epub 2020 Dec 15.

Pediatric Intensive Care Unit, Department of Pediatrics, Child and Mother Hospital, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, Marrakesh, Morocco.

Acral ischemia/necrosis is one of the rarest but most dreadful complications of thrombotic microangiopathy in pediatric patients. It is more reported with thrombotic thrombocytopenic purpura than with hemolytic and uremic syndrome. Even with anticoagulant therapy, it is often irreversible, leading to amputation.
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http://dx.doi.org/10.1155/2020/8869883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787831PMC
December 2020

A New Presentation: Aphallia, Vesicoureteral Reflux, Rectovesical Fistula, and Adrenal Insufficiency.

Case Rep Pediatr 2020 23;2020:8826520. Epub 2020 Nov 23.

Pediatric B Department-Mother-Child Pole, Mohammed VI University Hospital, Marrakesh, Morocco.

Aphallia or penile agenesis is a rare congenital malformation with an estimated incidence rate of 1 in 10 to 30 million births. More than half of aphallia cases have associated anomalies including caudal axis, cardiovascular, genitourinary, and gastrointestinal anomalies. The penile agenesis associated with adrenal insufficiency has never been reported in an infant. We report a rare case of a newborn that was diagnosed as a case of aphallia with vesicorectal fistula and vesicoureteral reflux, complicated by adrenal insufficiency with salt-wasting crisis.
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http://dx.doi.org/10.1155/2020/8826520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704127PMC
November 2020

Third Cranial Nerve Palsy Presenting with Unilateral Diplopia and Strabismus in a 24-Year-Old Woman with COVID-19.

Am J Case Rep 2020 Oct 15;21:e925897. Epub 2020 Oct 15.

Ophthalmology Department, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, Marrakesh, Morocco.

BACKGROUND Coronavirus disease (COVID 19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is the causative agent of a serious disease that is of great global public health concern. Palsy of the third cranial nerve is very rare in patients with confirmed 2019 novel coronavirus disease (COVID-19). We describe the case of a patient with an incomplete palsy of the left third cranial nerve sparing the pupils in the context of SARS-CoV-2 virus infection. CASE REPORT We report the case of a 24-year-old woman with confirmed COVID-19, which presented with acute onset of diplopia and strabismus of the left eye that occurred 3 days after the start of general symptoms. The patient had no significant medical history. Based on detailed ophthalmic and neurological examination, acute painless incomplete palsy of the third cranial nerve was suspected. Oculo-cerebral magnetic resonance angiography was unremarkable. Blood tests revealed mild normocytic regenerative anemia. According to the Moroccan recommendations, chloroquine and azithromycin were started. After what, a quick improvement of exotropia and diplopia was observed, and complete recovery was obtained by the sixth day of treatment. No adverse effects of the treatment were noted. CONCLUSIONS Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause neurological complications such as cranial nerve palsy. The pathological mechanism remains unclear. Full recovery of the ocular motricity is possible, and prognosis depends on the severity of the respiratory illness.
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http://dx.doi.org/10.12659/AJCR.925897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571280PMC
October 2020

Laboratory abnormalities in children with novel Coronavirus Disease 2019.

Clin Med Insights Pediatr 2020 11;14:1179556520955177. Epub 2020 Sep 11.

Department of Paediatrics, University hospital of Mohammed VI, Marrakesh, Morocco.

The novel Coronavirus disease 2019 continues to be a worldwide pandemic. Yet, little is still known about the biological features of this emergent infection in children. In this prospective study, we collected 68 children infected with SARS-COV-2 from March 2020 to May 2020, in Marrakesh, Morocco. No severe cases were observed in this cohort, and 66% of the patients were asymptomatic. The main laboratory abnormalities were hematological, as we found Leucopoenia in 4.4% of the cases, hyperleukocytosis in 1.6%. Neutropenia was found in 5 patients (7%) and only 2 cases (3%) had Lymphopenia. The inflammation and coagulation biomarkers were normal in the majority of the cases, as for liver and kidney function. Lactate dehydrogenase (LDH) serum levels were elevated in 8 cases (11.67%). The COVID-19 in children seems to have mild course and better outcome than in adults, which impacts the laboratory findings in this category. More studies must be conducted to learn more about the laboratory abnormalities in pediatric COVID-19.
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http://dx.doi.org/10.1177/1179556520955177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488170PMC
September 2020

Scabies complicated by necrotizing lymphocytic vasculitis in an infant.

Pan Afr Med J 2020 9;36:166. Epub 2020 Jul 9.

Pediatric Ward, Department of Pediatrics, Marrakesh Medical and Pharmacy Faculty, Child and Mother Hospital, Mohammed VI University Hospital Center, Caddy Ayad University, Marrakesh, Morocco.

Scabies is very common among children. It is often a harmless infectious disease, responding well to antiparasitic medication. Nevertheless, severe forms can occur in immunocompromised populations like newborns and infants. We report a unique case of scabies in a three-months-old infant, complicated by generalized cutaneous lymphocytic vasculitis and unilateral acral necroses.
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http://dx.doi.org/10.11604/pamj.2020.36.166.24431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467883PMC
January 2021

Epidemiology and Clinical Features of Coronavirus Disease 2019 in Moroccan Children.

Indian Pediatr 2020 Sep 12;57(9):808-810. Epub 2020 Jul 12.

Department of Pediatrics, Child and Mother Hospital, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, Marrakesh, Morocco.

Objective: This study aims to analyze the epidemiological and clinical features of coronavirus disease 19 (COVID-19) in a Moroccan pediatric population.

Methods: A retrospective study of a cohort of 74 children with RT-PCR confirmed COVID-19. We collected information on clinical and laboratory features of all children (age <18 years) admitted between 2 March, 2020 and 1 April, 2020.

Results: The mean (SD) age of the 74 children (40 girls) was 7 (1.5) years. The mean (SD) time from illness onset to diagnosis was 2 (1) days. 54 children were asymptomatic, while eight had fever, and five cases had cough. Recovery was after a mean (SD) of 12 (1) days.

Conclusion: COVID-19 was mostly mild in the pediatric population in Morocco.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498552PMC
September 2020

Absence of Evidence of Transmission of Coronavirus Disease 2019 from a Young Child to Mother Despite Prolonged Contact.

Indian J Pediatr 2020 09 13;87(9):754. Epub 2020 Jun 13.

Department of Pediatrics, Child and Mother Hospital, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, Marrakesh, Morocco.

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http://dx.doi.org/10.1007/s12098-020-03382-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292798PMC
September 2020

Hepatitis A Virus Infection Associated with Cryoglobulinemic Vasculitis.

Indian Pediatr 2020 01;57(1):71-72

Department of Pediatrics, Child and Mother Hospital, Mohammed VI University Hospital Center, Marrakesh Medical and Pharmacy Faculty, Caddy Ayad University, City of Marrakesh, Morocco.

Atypical symptoms, especially immune complex disorders, are uncommonly reported with hepatitis A virus (HAV) infection. We report an 8-year-old child who contracted HAV infection complicated by cryoglobulinemic vasculitis, and responded well to oral steroids. HAV infection may be considered in the etiology of cryoglobulinemia in children.
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January 2020