Moshe Oren

Moshe Oren

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Moshe Oren

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p53: not just a tumor suppressor.

Authors:
Moshe Oren

J Mol Cell Biol 2019 Jul;11(7):539-543

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1093/jmcb/mjz070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736137PMC
July 2019

New insights into YAP/TAZ nucleo-cytoplasmic shuttling: new cancer therapeutic opportunities?

Mol Oncol 2019 Jun 17;13(6):1335-1341. Epub 2019 May 17.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1002/1878-0261.12498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547617PMC
June 2019

Correction: Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.

Oncotarget 2019 05 7;10(34):3203-3206. Epub 2019 May 7.

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.18632/oncotarget.26921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516712PMC
May 2019

Functional characterization of the p53 "mutome".

Mol Cell Oncol 2018 25;5(6):e1511207. Epub 2018 Sep 25.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1080/23723556.2018.1511207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276857PMC
September 2018

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.

Mol Cell 2018 07;71(1):178-190.e8

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.06.012DOI Listing
July 2018

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

Blood 2018 06 13;131(25):2789-2802. Epub 2018 Apr 13.

Molecular Therapy in Haematology and Oncology, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2017-09-806679DOI Listing
June 2018

PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma.

Oncogene 2018 04 30;37(17):2213-2224. Epub 2018 Jan 30.

Clinical Research Institute at Rambam, Division of Oncology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1038/s41388-017-0040-zDOI Listing
April 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

p53 shades of Hippo.

Cell Death Differ 2018 01 6;25(1):81-92. Epub 2017 Oct 6.

Department of Molecular Cell Biology, The Weizmann Institute, Rehovot, Israel.

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http://dx.doi.org/10.1038/cdd.2017.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729527PMC
January 2018

Tumor Suppression by p53: Bring in the Hippo!

Cancer Cell 2017 10;32(4):397-399

Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.09.010DOI Listing
October 2017

The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry.

Hepatology 2016 11 25;64(5):1623-1636. Epub 2016 Jul 25.

The Goldyne Savad Institute of Gene and Cell Therapy, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem, Israel.

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http://dx.doi.org/10.1002/hep.28679DOI Listing
November 2016

The Paradox of p53: What, How, and Why?

Cold Spring Harb Perspect Med 2016 Oct 3;6(10). Epub 2016 Oct 3.

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1101/cshperspect.a026328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046691PMC
October 2016

The Hippo pathway, p53 and cholesterol.

Cell Cycle 2016 Sep 15;15(17):2248-55. Epub 2016 Jul 15.

a Department of Molecular Cell Biology , The Weizmann Institute of Science , Rehovot , Israel.

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http://dx.doi.org/10.1080/15384101.2016.1207840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004696PMC
September 2016

p53 mutations promote proteasomal activity.

Nat Cell Biol 2016 Jul;18(8):833-5

Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel.

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http://www.nature.com/articles/ncb3392
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http://dx.doi.org/10.1038/ncb3392DOI Listing
July 2016

The relationship between the nucleolus and cancer: Current evidence and emerging paradigms.

Semin Cancer Biol 2016 06 23;37-38:36-50. Epub 2015 Dec 23.

Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2015.12.004DOI Listing
June 2016

Targeting mutant p53 for cancer therapy.

Aging (Albany NY) 2016 06;8(6):1159-60

Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931821PMC
http://dx.doi.org/10.18632/aging.100992DOI Listing
June 2016

Down-regulation of LATS kinases alters p53 to promote cell migration.

Genes Dev 2015 Nov;29(22):2325-30

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel;

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http://dx.doi.org/10.1101/gad.268185.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691886PMC
November 2015

Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq.

Nat Protoc 2015 Apr 26;10(4):605-18. Epub 2015 Mar 26.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1038/nprot.2015.035DOI Listing
April 2015

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.

Genome Res 2014 Oct 21;24(10):1572-83. Epub 2014 Jul 21.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel;

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http://dx.doi.org/10.1101/gr.176487.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199367PMC
October 2014

Writing and reading H2B monoubiquitylation.

Biochim Biophys Acta 2014 Aug 8;1839(8):694-701. Epub 2014 Jan 8.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.01.002DOI Listing
August 2014

p53 and ribosome biogenesis stress: the essentials.

FEBS Lett 2014 Aug 18;588(16):2571-9. Epub 2014 Apr 18.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Electronic address:

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http://doi.wiley.com/10.1016/j.febslet.2014.04.014
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http://dx.doi.org/10.1016/j.febslet.2014.04.014DOI Listing
August 2014

Caught in the cross fire: p53 in inflammation.

Carcinogenesis 2014 Aug 18;35(8):1680-90. Epub 2014 Jun 18.

Molecular Cell Biology, Weizmann Institute for Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1093/carcin/bgu134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123652PMC
August 2014

microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network.

J Mol Cell Biol 2014 Jun;6(3):192-7

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel

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http://dx.doi.org/10.1093/jmcb/mju020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092252PMC
June 2014

Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis.

J Cell Sci 2013 Oct 25;126(Pt 19):4358-68. Epub 2013 Jul 25.

Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1242/jcs.125815DOI Listing
October 2013

A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.

Cancer Cell 2013 Aug 25;24(2):242-56. Epub 2013 Jul 25.

The Lautenberg Center for Immunology, Institute of Medical Research, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.ccr.2013.06.005DOI Listing
August 2013

The majority of endogenous microRNA targets within Alu elements avoid the microRNA machinery.

Bioinformatics 2013 Apr 29;29(7):894-902. Epub 2013 Jan 29.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1093/bioinformatics/btt044DOI Listing
April 2013

Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4.

Cancer Res 2013 Mar 9;73(5):1460-9. Epub 2013 Jan 9.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Auerbachstrasse 112, Stuttgart, Germany.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-2876DOI Listing
March 2013

Noise-mean relationship in mutated promoters.

Genome Res 2012 Dec 20;22(12):2409-17. Epub 2012 Jul 20.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1101/gr.139378.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514670PMC
December 2012

Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin.

Cancer Res 2012 Nov 7;72(22):5824-32. Epub 2012 Sep 7.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1201DOI Listing
November 2012

N-methylation of isopeptide bond as a strategy to resist deubiquitinases.

Angew Chem Int Ed Engl 2012 Nov 12;51(46):11535-9. Epub 2012 Oct 12.

Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

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http://doi.wiley.com/10.1002/anie.201205771
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http://dx.doi.org/10.1002/anie.201205771DOI Listing
November 2012

Nucleosome organization affects the sensitivity of gene expression to promoter mutations.

Mol Cell 2012 May 29;46(3):362-8. Epub 2012 Mar 29.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1016/j.molcel.2012.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356688PMC
May 2012

Get your fingers out of p53's way!

EMBO Rep 2012 Apr 2;13(4):282-3. Epub 2012 Apr 2.

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1038/embor.2012.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321163PMC
April 2012

Consistency test of the cell cycle: roles for p53 and EGR1.

Cancer Res 2012 Mar 7;72(5):1051-4. Epub 2012 Feb 7.

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-11-3382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294127PMC
March 2012

RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.

FEBS Lett 2011 Sep 4;585(18):2795-802. Epub 2011 Aug 4.

The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1016/j.febslet.2011.07.034DOI Listing
September 2011

DePICTing p53 activation: a new nucleolar link to cancer.

Cancer Cell 2011 Sep;20(3):283-4

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1016/j.ccr.2011.08.017DOI Listing
September 2011

An Aurora A-Lats-Aurora B axis ensures proper chromosome segregation.

Cell Cycle 2011 Sep 15;10(18):3055. Epub 2011 Sep 15.

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http://dx.doi.org/10.4161/cc.10.18.17046DOI Listing
September 2011

p53: guardian of ploidy.

Mol Oncol 2011 Aug 30;5(4):315-23. Epub 2011 Jul 30.

Department of Molecular Cell Biology, The Weizmann Institute of Science, PO Box 26, Rechovot 76100, Israel.

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http://doi.wiley.com/10.1016/j.molonc.2011.07.007
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http://dx.doi.org/10.1016/j.molonc.2011.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164924PMC
August 2011

Detection and characterization of ubiquitylated H2B in mammalian cells.

Methods 2011 Jul 23;54(3):326-30. Epub 2011 Mar 23.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1016/j.ymeth.2011.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118924PMC
July 2011

ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

OMICS 2011 May 19;15(5):305-12. Epub 2011 Feb 19.

Translational Oncogenomics Unit, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1089/omi.2010.0084DOI Listing
May 2011

RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.

Mol Cell 2011 May;42(4):477-88

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1016/j.molcel.2011.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099049PMC
May 2011

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.

Genes Cancer 2011 Apr;2(4):466-74

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1177/1947601911408889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135636PMC
April 2011

New plays in the p53 theater.

Curr Opin Genet Dev 2011 Feb 4;21(1):86-92. Epub 2010 Nov 4.

Department of Molecular Cell Biology, The Weizmann Institute of Science, PO Box 26, Rechovot 76100, Israel.

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http://dx.doi.org/10.1016/j.gde.2010.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059112PMC
February 2011

A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage.

J Cell Sci 2011 Jan 30;124(Pt 1):57-67. Epub 2010 Nov 30.

Department of Molecular Genetics, Research Institute for MicroFbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City, Osaka 565-0871, Japan.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.072918
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http://dx.doi.org/10.1242/jcs.072918DOI Listing
January 2011

p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.

Cancer Res 2010 Dec 15;70(23):9650-8. Epub 2010 Oct 15.

Department of Biological Regulation, The Weizmann Institute, Rehovot, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999653PMC
December 2010

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.

Genes Dev 2010 Nov;24(21):2420-9

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1101/gad.1954410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964752PMC
November 2010

p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy.

Genome Res 2010 Oct 17;20(10):1361-8. Epub 2010 Aug 17.

Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel.

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http://dx.doi.org/10.1101/gr.103945.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945185PMC
October 2010

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation.

Proc Natl Acad Sci U S A 2010 Oct 11;107(43):18511-6. Epub 2010 Oct 11.

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1073/pnas.1006124107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972967PMC
October 2010

Repression of transposable-elements - a microRNA anti-cancer defense mechanism?

Trends Genet 2010 Jun 22;26(6):253-9. Epub 2010 Apr 22.

Molecular Genetics Department, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1016/j.tig.2010.03.006DOI Listing
June 2010

Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma.

Biochem Biophys Res Commun 2010 Apr 15;394(3):817-23. Epub 2010 Mar 15.

Department of Internal Medicine I and Clinical Chemistry, University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2010.03.082DOI Listing
April 2010

NFκB and p53: A life and death affair.

Cell Cycle 2010 Mar 15;9(6):1027. Epub 2010 Mar 15.

Weizmann Institute of Science, Rehovot, Israel.

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March 2010

Involvement of stromal p53 in tumor-stroma interactions.

Semin Cell Dev Biol 2010 Feb 13;21(1):47-54. Epub 2009 Nov 13.

Division of Medical Oncology, The Ottawa Hospital Cancer Center, General Campus, Ottawa, Ontario, K1H 8L6 Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S10849521090023
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http://dx.doi.org/10.1016/j.semcdb.2009.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823948PMC
February 2010

Mutant p53 gain-of-function in cancer.

Cold Spring Harb Perspect Biol 2010 Feb;2(2):a001107

Department of Molecular Cell Biology, The Weizmann Institute, Rehovot 76100, Israel.

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http://dx.doi.org/10.1101/cshperspect.a001107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828285PMC
February 2010

Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity.

Cancer Res 2009 Dec;69(24):9337-45

Dr Margarete-Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0548DOI Listing
December 2009

Discovery of novel proteasome inhibitors using a high-content cell-based screening system.

PLoS One 2009 Dec 30;4(12):e8503. Epub 2009 Dec 30.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797363PMC
December 2009

The first 30 years of p53: growing ever more complex.

Nat Rev Cancer 2009 10;9(10):749-58

Arnold J. Levine is at the Institute for Advanced Study, School of Natural Sciences, Einstein Drive, Princeton, New Jersey 08540, USA.

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http://www.nature.com/articles/nrc2723
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http://dx.doi.org/10.1038/nrc2723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771725PMC
October 2009

Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family.

Biochem Biophys Res Commun 2009 Sep 16;387(2):399-404. Epub 2009 Jul 16.

Department of Internal Medicine I and Clinical Chemistry, University Hospital, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2009.07.063DOI Listing
September 2009

Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate.

Aging (Albany NY) 2009 Sep 8;1(9):762-70. Epub 2009 Sep 8.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815735PMC
http://dx.doi.org/10.18632/aging.100085DOI Listing
September 2009

CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.

EMBO Rep 2009 Aug 3;10(8):894-900. Epub 2009 Jul 3.

Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1038/embor.2009.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726677PMC
August 2009

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.

Mol Cell 2008 Oct;32(2):180-9

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1016/j.molcel.2008.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587494PMC
October 2008

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy.

Cell Cycle 2008 Jun 16;7(12):1870-9. Epub 2008 Jun 16.

Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.4161/cc.7.12.6161DOI Listing
June 2008

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells.

Nat Cell Biol 2008 Apr 16;10(4):483-8. Epub 2008 Mar 16.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1038/ncb1712DOI Listing
April 2008

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.

Proc Natl Acad Sci U S A 2008 Mar 21;105(12):4838-43. Epub 2008 Mar 21.

Department of Molecular Oncology, Institute of Gerontology, Nippon Medical School, Kawasaki, Kanagawa 211-8533, Japan.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0712216105
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http://dx.doi.org/10.1073/pnas.0712216105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290789PMC
March 2008

Tiny actors, great roles: microRNAs in p53's service.

Cell Cycle 2007 Nov 19;6(21):2656-61. Epub 2007 Aug 19.

Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.4161/cc.6.21.4915DOI Listing
November 2007

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

Cancer Cell 2007 Oct;12(4):342-54

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.08.033DOI Listing
October 2007