Publications by authors named "Mohammed Kassab"

5 Publications

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Posthatching developmental studies on the tongue and laryngeal entrance of the common quail (Coturnix coturnix, Linnaeus, 1758) in different five age-stages.

Microsc Res Tech 2021 Feb 22. Epub 2021 Feb 22.

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Aswan University, Kafrelsheikh, Egypt.

The present study represents the first trial to characterize the ultrastructural of five ages of Coturnix coturnix. Lingual nail had membrane that differ in number among five studied ages. Filiform papillary system had four caudally directed papillae types; small (apex, rostral, and median part of body in 1 day, body in 10 and 20 days), long (apex and rostral part of body in 10 days, tip and two lateral area in 20, 30, 40-days, lateral border in 1 and 10 days, two lateral area of body in 40 days), broad (median area of body in 20, 30, 40 days). Scales on the ventral surface of apex, mound. Lingual sulci on the apex and body without reaching tip in 10, 20, 30, 40-days while, in 1 day the body had ridge caudally. Three papillae on posterior part of lateral border of body. W-shape crest had papillae on its median part while, its lateral part had two giant papillae on each side. Dorsal giant papillae terminated caudally with six processes, while ventral papillae terminated caudally with three processes. The unique root appearance, at 1 day had four papillae while in 10-day, it had one papilla however in 20, 30, 40 days, it had T-shaped ridge. Mound had one longitudinal row on each side of cleft and two transverse papillary rows at its caudal border and additional row at 40-days. Our findings exposed unique structural and functional characterizations of lingual and laryngeal entrance that reflected with feeding behavior.
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http://dx.doi.org/10.1002/jemt.23725DOI Listing
February 2021

Is This Contrast? Is This Blood? An Agreement Study on Post-thrombectomy Computed Tomography Scans.

Front Neurol 2020 22;11:593098. Epub 2020 Dec 22.

Ottawa Stroke Program, Department of Medicine (Neurology), University of Ottawa, Ottawa, ON, Canada.

Hemorrhagic transformation after acute ischemic stroke is a dreaded and severe complication of thrombolysis and thrombectomy. However, its detection on post-thrombectomy conventional non-contrast computed tomography (CT) scan can be complicated by the frequent (and sometimes concomitant) presence of contrast, resulting in changes in management. Our objective was to assess the inter- and intra-rater reliability for the detection of blood and/or contrast on day-1 post-thrombectomy CT scans. A total of 18 raters across 3 different specialties independently examined 30 post-thrombectomy CT scans selected from the Aspiration vs. STEnt-Retriever (ASTER) trial. They were asked to judge the presence of blood and contrast. Thirty days later, the same 18 raters again independently judged the 30 scans, in randomized order. Agreement was measured with Fleiss' and Cohen's statistics. Overall agreement on blood and/ or contrast presence was only fair, = 0.291 (95% CI = 0.273-0.309). There were 0 scans with consensus among the 18 readers on the presence of blood and/or contrast. However, intra-rater global agreement across all 18 physicians was relatively high, with a median kappa value of 0.675. This intra-rater consistency was seen across all specialties, regardless of level of training. Physician judgment for the presence of blood and/or contrast on day-1 post-thrombectomy non-contrast CT scan shows limited inter-observer reliability. Advanced imaging modalities may then be warranted for challenging clinical cases.
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http://dx.doi.org/10.3389/fneur.2020.593098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783397PMC
December 2020

Transition to virtual appointments for interventional neuroradiology due to the COVID-19 pandemic: a survey of satisfaction.

J Neurointerv Surg 2020 Dec 7;12(12):1153-1156. Epub 2020 Oct 7.

Ottawa Stroke Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Background: The COVID-19 pandemic has changed the way medicine is practiced, including the implementation of virtual care in many specialties. In the field of interventional neuroradiology (INR), virtual clinics are an uncommon practice with minimal literature to support its use. Our objective was to report prospective, single-centre data regarding patient and physician experience with virtual INR clinics for routine follow-up appointments.

Methods: We surveyed all patients that participated in a virtual INR clinic follow-up appointment at our hospital over a 3 month period. Information gathered included length of appointment delays (ie, wait times), length of appointment times, overall satisfaction, and perceived safety metrics. A survey was also sent out to all physicians who participated in virtual clinics with similar questions.

Results: 118/122 patients and 6/6 physicians completed the survey. Wait times before previous in-person appointments were perceived to be much longer than virtual appointments, whereas in-person appointment times were longer. 112/118 (94.9%) patients and 4/6 (67%) physicians reported general satisfaction with their virtual clinic experience. There were 8/118 patients who felt their conditions could not be safely assessed virtually, compared with 1/6 (17%) physicians. Lastly, 72.2% of patients reported that they would prefer virtual or telephone visits in the future for non-urgent follow-up, and 5/6 (83%) of physicians reported the same.

Conclusion: Virtual INR clinics are more efficient and are preferred among patients and physicians for non-urgent follow-up appointments. Our study demonstrates the feasibility of a virtual platform for INR care, which could be sustainable for future practice.
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http://dx.doi.org/10.1136/neurintsurg-2020-016805DOI Listing
December 2020

Xeno-free trans-differentiation of adipose tissue-derived mesenchymal stem cells into glial and neuronal cells.

Am J Stem Cells 2019 15;8(2):38-51. Epub 2019 Aug 15.

Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University Mansoura, Egypt.

Mesenchymal stem cells (MSCs) are undifferentiated cells that have the ability of self-renewal and trans-differentiation into other cell types. They hold out hope for finding a cure for many diseases. Nevertheless, there are still some obstacles that limit their clinical transplantation. One of these obstacles are the xenogeneic substances added in either proliferation or differentiation media with subsequent immunogenic and infectious transmission problems. In this study, we aimed to replace fetal bovine serum (FBS), the main nutrient source for MSC proliferation with xeno-free blood derivatives. We tested the effect of human activated pure platelet-rich plasma (P-PRP) and advanced platelet-rich fibrin (A-PRF) on the proliferation of human adipose derived-MSCs (AD-MSCs) at different concentrations. For the induction of MSC neural differentiation, we used human cerebrospinal fluid (CSF) at different concentrations in combination with P-PRP to effect xeno-free/species-specific neuronal/glial differentiation and we found that media with 10% CSF and 10% PRP promoted glial differentiation, while media with only 10% PRP induced a neuron-like phenotype.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737383PMC
August 2019

Minimally invasive endoscopic removal of a massive trabecular juvenile ossifying fibroma of the paranasal sinuses.

Saudi Med J 2014 Aug;35(8):872-5

Department of Otolaryngology-Head & Neck Surgery, Umm Al-Qura University, King Abdullah Medical City, Makkah, Kingdom of Saudi Arabia. E-mail.

An 11-year-old female patient presented with left-sided nasal obstruction and upward displacement of the left eye of 3 months duration. Clinical examination revealed a firm mass in the left nasal cavity. A CT scan showed a massive tumor involving the left maxillary sinus with extension into the ethmoid sinus, and encroaching on the left orbit. Histopathological examination revealed trabecular juvenile ossifying fibroma, which was removed via a transnasal endoscopic surgery by the Otorhinolaryngology, Head and Neck and the skull base team. She tolerated the lengthy procedure well, and there was no recurrence postoperatively as the tumor was resected completely. There was no external scarring and no psychological trauma discerned. 
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August 2014