Mohammad A Zafar, MBBS - Aortic Institute at Yale-New Haven Hospital - Research Director

Mohammad A Zafar

MBBS

Aortic Institute at Yale-New Haven Hospital

Research Director

New Haven, CT | United States

Main Specialties: Cardiothoracic Radiology, Cardiovascular Disease, Surgery, Thoracic Surgery, Vascular Surgery

ORCID logohttps://orcid.org/0000-0003-1666-199X


Top Author

Mohammad A Zafar, MBBS - Aortic Institute at Yale-New Haven Hospital - Research Director

Mohammad A Zafar

MBBS

Introduction

Mohammad Abdullah Zafar currently works at the Cardiothoracic Surgery Program at the Yale University School of Medicine, as the Associate Research Director of the Aortic Institute at Yale-New Haven Hospital. Mohammad does research in Cardiology, Cardiothoracic Surgery and Surgery. Their current project is 'Natural History of Thoracic Aortic Aneurysm'.

Primary Affiliation: Aortic Institute at Yale-New Haven Hospital - New Haven, CT , United States

Specialties:

Research Interests:


View Mohammad A Zafar’s Resume / CV

Education

Mar 2013
University of Health Sciences
MBBS

Experience

Mar 2014
Postdoctoral Fellow

Aortic Institute at Yale-New Haven

Publications

43Publications

1929Reads

22Profile Views

Subacute/chronic type A aortic dissection: a retrospective cohort study.

Eur J Cardiothorac Surg 2020 Feb;57(2):388-396

Department of Cardiovascular Surgery, Fuwai Hospital, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1093/ejcts/ezz209DOI Listing
February 2020
20 Reads
3.304 Impact Factor

Nonsyndromic Thoracic Aortic Aneurysms and Dissections-Is Screening Possible?

Semin Thorac Cardiovasc Surg 2019 Winter;31(4):628-634. Epub 2019 Jun 15.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1053/j.semtcvs.2019.05.035DOI Listing
January 2020
19 Reads

Chronologic and Climatic Factors of Acute Aortic Dissection: Study of 1642 Patients in 2 Continents.

Ann Thorac Surg 2019 Dec 28. Epub 2019 Dec 28.

Department of Cardiovascular Surgery, Beijing Anzhen Hospital of Capital Medical University, and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; and Aortic Institute at Yale-New Haven Hospital, Yale School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2019.11.013DOI Listing
December 2019
3.849 Impact Factor

Routine anterior spinal artery visualization prior to descending and thoracoabdominal aneurysm repair: High detection success.

J Card Surg 2019 Dec 9;34(12):1563-1568. Epub 2019 Nov 9.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1111/jocs.14310DOI Listing
December 2019
5 Reads
0.888 Impact Factor

Natural history of descending thoracic and thoracoabdominal aortic aneurysms

J Thorac Cardiovasc Surg 2019. Epub 2019.

The Journal of Thoracic and Cardiovascular Surgery

Objectives: Elucidating critical aortic diameters at which natural complications occur (rupture, dissection, death) is paramount to guide timely surgical intervention. Natural history knowledge for descending thoracic or thoracoabdominal aortic aneurysms (DTTAA) is sparse. Our small early studies recommended repairing DTTAAs before a critical diameter of 7.0cm. Here we focus exclusively on a large number of DTTAAs followed over time, enabling more detailed analysis with greater granularity across aortic sizes.

Methods: Aortic diameters and long-term complications of 907 patients with DTTAA were reviewed. Growth rates (instrumental variables approach), yearly complication rates, 5-year event-free survival (Kaplan-Meier), and risk of complications as a function of aortic-height index (AHI) (aortic diameter [cm]/height [m]) (Competing-risks regression) were calculated. 

Results: Estimated mean growth rate of DTTAAs was 0.19 cm/year, increasing with increasing aortic size. Median size at acute type B dissection was 4.1cm. 80% of dissections occurred below 5cm, whereas 93% of ruptures occurred above 5cm. DTTAA diameter ≥ 6cm was associated with a 19% yearly rate of rupture, dissection, or death. 5-year complication free survival progressively decreased with increasing AHI. Hazard of complications showed 6-fold increase at AHI  4.2 compared to AHI 3.0-3.5 (P < .05). Probability of fatal complications (aortic rupture or death) increased sharply at 2 hinge points: 6.0 and 6.5 cm.

Conclusion: Acute type B dissections occur frequently at small aortic sizes; thus, prophylactic size-based surgery may not afford a means for dissection protection. However, fatal complications increase dramatically at 6.0 cm, suggesting that preemptive intervention before that criterion can save lives. 

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December 2019

Impact Factor 5.261

13 Reads

Natural history and management of Kommerell's diverticulum in a single tertiary referral center.

J Vasc Surg 2019 Nov 7. Epub 2019 Nov 7.

Aortic Institute at Yale-New Haven Hospital, Yale School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2019.08.260DOI Listing
November 2019
3.021 Impact Factor

Predicting in-hospital rupture of type A aortic dissection using Random Forest.

J Thorac Dis 2019 Nov;11(11):4634-4646

Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

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http://dx.doi.org/10.21037/jtd.2019.10.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940214PMC
November 2019

Reply: Keen questions appreciated.

J Thorac Cardiovasc Surg 2019 Oct 21. Epub 2019 Oct 21.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jtcvs.2019.06.127DOI Listing
October 2019
5 Reads
4.168 Impact Factor

Ascending Aortic Length and Risk of Aortic Adverse Events: The Neglected Dimension.

J Am Coll Cardiol 2019 Oct 13;74(15):1883-1894. Epub 2019 Sep 13.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.07.078DOI Listing
October 2019
353 Reads
16.503 Impact Factor

Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass.

Cardiology 2018 23;140(4):213-221. Epub 2018 Aug 23.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1159/000490924DOI Listing
October 2019
34 Reads
2.044 Impact Factor

Commentary: Toward truth in advertising.

J Thorac Cardiovasc Surg 2019 Oct 8;158(4):1055-1057. Epub 2019 Aug 8.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jtcvs.2019.07.053DOI Listing
October 2019
4.168 Impact Factor

Diabetes Mellitus: Is It Protective against Aneurysm? A Narrative Review.

Cardiology 2018 19;141(2):107-122. Epub 2018 Nov 19.

Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut, USA,

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https://www.karger.com/Article/FullText/490373
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http://dx.doi.org/10.1159/000490373DOI Listing
September 2019
47 Reads
2.044 Impact Factor

Complex two-stage open surgical repair of an aortoesophageal fistula after thoracic endovascular aortic repair.

J Vasc Surg Cases Innov Tech 2019 Sep 25;5(3):261-263. Epub 2019 Jun 25.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jvscit.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601018PMC
September 2019

Predictability of acute aortic dissection: A dream in evolution.

J Thorac Cardiovasc Surg 2019 Jun 28;157(6):e324-e326. Epub 2019 Feb 28.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jtcvs.2019.01.097DOI Listing
June 2019
3 Reads
4.168 Impact Factor

Commentary: Should we routinely prescribe β-blockers after surgical repair of type A dissection?

J Thorac Cardiovasc Surg 2019 Jun 15. Epub 2019 Jun 15.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jtcvs.2019.06.006DOI Listing
June 2019
1 Read
4.168 Impact Factor

Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2019 Update and Clinical Implications.

Aorta (Stamford) 2019 Jun 16;7(4):99-107. Epub 2019 Dec 16.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1055/s-0039-3400233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914358PMC
June 2019

Bicuspid aortic disease: "Marfan light"?

J Thorac Cardiovasc Surg 2019 May 28;157(5):e240-e242. Epub 2019 Jan 28.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jtcvs.2018.12.048DOI Listing
May 2019
23 Reads
4.168 Impact Factor

Decision-making algorithm for ascending aortic aneurysm: Effectiveness in clinical application?

J Thorac Cardiovasc Surg 2019 May 14;157(5):1733-1745. Epub 2018 Nov 14.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2018.09.124DOI Listing
May 2019
28 Reads
4.168 Impact Factor

Commentary: Surprisingly good results from a complex, lengthy aortic arch technique.

J Thorac Cardiovasc Surg 2019 Apr 15;157(4):1379-1380. Epub 2018 Nov 15.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn.

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http://dx.doi.org/10.1016/j.jtcvs.2018.10.143DOI Listing
April 2019
5 Reads
4.168 Impact Factor

Fluoroquinolones and Aortic Diseases: Is There a Connection.

Aorta (Stamford) 2019 Apr 17;7(2):35-41. Epub 2019 Sep 17.

Department of Surgery, Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1055/s-0039-1693468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748841PMC
April 2019
2 Reads

Symptoms Matter: A Symptomatic but Radiographically Elusive Ascending Aortic Dissection.

Int J Angiol 2019 Mar 29;28(1):31-33. Epub 2018 Nov 29.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1055/s-0038-1675849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417893PMC
March 2019
8 Reads

Descending threshold for ascending aortic aneurysmectomy: Is it time for a "left-shift" in guidelines?

J Thorac Cardiovasc Surg 2019 01 23;157(1):37-42. Epub 2018 Oct 23.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2018.07.114DOI Listing
January 2019
6 Reads
4.168 Impact Factor

Thoracic aortic aneurysm: unlocking the "silent killer" secrets.

Gen Thorac Cardiovasc Surg 2019 Jan 4;67(1):1-11. Epub 2017 Dec 4.

Aortic Institute at Yale-New Haven, Yale University School of Medicine, 789 Howard Avenue, Clinic Building CB317, P.O. Box 208039, New Haven, CT, USA.

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http://dx.doi.org/10.1007/s11748-017-0874-xDOI Listing
January 2019
36 Reads

Open Replacement of the Thoracoabdominal Aorta: Short- and Long-term Outcomes at a Single Institution.

Int J Angiol 2018 Jun 23;27(2):114-120. Epub 2018 May 23.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1055/s-0038-1649517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995682PMC
June 2018
7 Reads

Intraoperative descending aortic dissection during aortic root replacement: successful management.

J Thorac Dis 2018 May;10(5):3065-3069

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.21037/jtd.2018.05.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006070PMC
May 2018
5 Reads

A systematic review on management of nutcracker syndrome.

J Vasc Surg Venous Lymphat Disord 2018 03 29;6(2):271-278. Epub 2017 Dec 29.

Section of Vascular and Endovascular Surgery, Yale University School of Medicine, New Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jvsv.2017.11.005DOI Listing
March 2018
18 Reads

Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications.

Aorta (Stamford) 2018 Feb 27;6(1):13-20. Epub 2018 Jul 27.

Department of Surgery, Section of Cardiac Surgery, Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1055/s-0038-1639612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136681PMC
February 2018
8 Reads

Precipitous Resolution of Type-A Intramural Hematoma with Medical Management in a Patient with Metastatic Stage 4 Renal Cell Carcinoma.

Int J Angiol 2017 Dec 24;26(4):267-270. Epub 2017 Aug 24.

Aortic Institute at Yale New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1055/s-0037-1604333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685788PMC
December 2017
34 Reads

Medical management of aortic disease in Marfan syndrome.

Ann Cardiothorac Surg 2017 Nov;6(6):654-661

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.21037/acs.2017.11.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721117PMC
November 2017
38 Reads

Natural history of aortic root aneurysms in Marfan syndrome.

Ann Cardiothorac Surg 2017 Nov;6(6):625-632

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.21037/acs.2017.11.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721101PMC
November 2017
17 Reads

The Effect of Blood Transfusion on Outcomes in Aortic Surgery.

Int J Angiol 2017 Sep 27;26(3):135-142. Epub 2017 Jul 27.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1055/s-0037-1604417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552894PMC
September 2017
55 Reads

Positive family history of aortic dissection dramatically increases dissection risk in family members.

Int J Cardiol 2017 Aug 25;240:132-137. Epub 2017 Apr 25.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.04.080DOI Listing
August 2017
55 Reads
4.036 Impact Factor

Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery?

J Thorac Dis 2017 Aug;9(8):2491-2497

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.21037/jtd.2017.06.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594166PMC
August 2017
62 Reads

Elective surgery for ascending aortic aneurysm in the elderly: should there be an age cut-off?

Eur J Cardiothorac Surg 2017 May;51(5):965-970

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1093/ejcts/ezw437DOI Listing
May 2017
24 Reads
3.304 Impact Factor

Iatrogenic Aortic Dissection: Review of the Literature.

Aorta (Stamford) 2016 Dec 1;4(6):240-243. Epub 2016 Dec 1.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.12945/j.aorta.2016.16.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425263PMC
December 2016
35 Reads

Early Spontaneous Resolution of an Iatrogenic Acute Type A Aortic Dissection.

Aorta (Stamford) 2016 Dec 1;4(6):235-239. Epub 2016 Dec 1.

Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.12945/j.aorta.2016.16.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425262PMC
December 2016
38 Reads

Advanced Glycation End Products and its Soluble Receptors in the Pathogenesis of Thoracic Aortic Aneurysm.

Aorta (Stamford) 2016 Feb 1;4(1):1-10. Epub 2016 Feb 1.

Aortic Institute at Yale-New Haven, Yale University School of Medicine, Connecticut, USA.

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http://dx.doi.org/10.12945/j.aorta.2015.15.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068493PMC
February 2016
41 Reads

Are thromboembolic and bleeding complications a drawback for composite aortic root replacement?

Ann Thorac Surg 2012 Sep 23;94(3):737-43. Epub 2012 May 23.

Section of Cardiac Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2012.04.007DOI Listing
September 2012
338 Reads
3.849 Impact Factor

Top co-authors

John A Elefteriades
John A Elefteriades

Yale University School of Medicine

39
Bulat A Ziganshin
Bulat A Ziganshin

Yale University School of Medicine

36
Adam J Brownstein
Adam J Brownstein

Yale School of Medicine

14
Camilo A Velasquez
Camilo A Velasquez

Aortic Institute at Yale-New Haven Hospital

11
Young Erben
Young Erben

Mayo Clinic

10
John A Rizzo
John A Rizzo

Colorado School of Public Health

9
Maryam Tanweer
Maryam Tanweer

Aortic Institute at Yale-New Haven Hospital

6
Yupeng Li
Yupeng Li

The University of Texas MD Anderson Cancer Center

6