Mingzhou Guo

Mingzhou Guo

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Mingzhou Guo

Publications by authors named "Mingzhou Guo"

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Epigenetic heterogeneity in cancer.

Biomark Res 2019 31;7:23. Epub 2019 Oct 31.

3The Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Ave., Pittsburgh, PA 15213 USA.

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http://dx.doi.org/10.1186/s40364-019-0174-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824025PMC
October 2019

Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin.

J Cancer 2019 15;10(24):6124-6134. Epub 2019 Oct 15.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing 100853, China.

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http://dx.doi.org/10.7150/jca.32511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856579PMC
October 2019

HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer.

Sci Rep 2019 Sep 2;9(1):12628. Epub 2019 Sep 2.

MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41598-019-48992-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718431PMC
September 2019

Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells.

Mol Cell Proteomics 2019 07 16;18(7):1320-1329. Epub 2019 Apr 16.

From the ‡MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, School of Life Sciences;

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http://dx.doi.org/10.1074/mcp.RA119.001457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601205PMC
July 2019

MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.

Gastroenterology 2019 06 16;156(8):2281-2296.e6. Epub 2019 Feb 16.

State Key Laboratories for Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health and, College of Biological Sciences, China Agricultural University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.02.023DOI Listing
June 2019

Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer.

Clin Epigenetics 2018 23;10:69. Epub 2018 May 23.

1Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853 China.

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http://dx.doi.org/10.1186/s13148-018-0501-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966878PMC
May 2019

Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma.

Clin Epigenetics 2018 11 6;10(1):137. Epub 2018 Nov 6.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853, China.

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https://clinicalepigeneticsjournal.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13148-018-0570-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219251PMC
November 2018

Phase Ib/II study of safety and efficacy of low-dose decitabine-primed chemoimmunotherapy in patients with drug-resistant relapsed/refractory alimentary tract cancer.

Int J Cancer 2018 09 26;143(6):1530-1540. Epub 2018 Apr 26.

Department of Molecular Biology and Bio-therapeutic, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.31531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099263PMC
September 2018

Methylation of ZNF331 is an independent prognostic marker of colorectal cancer and promotes colorectal cancer growth.

Clin Epigenetics 2017 18;9:115. Epub 2017 Oct 18.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 China.

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http://dx.doi.org/10.1186/s13148-017-0417-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648453PMC
July 2018

Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.

Clin Epigenetics 2017 23;9:116. Epub 2017 Oct 23.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853 China.

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http://dx.doi.org/10.1186/s13148-017-0412-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654145PMC
July 2018

DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1.

J Genet Genomics 2018 04 13;45(4):205-214. Epub 2018 Apr 13.

Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing 100086, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2018.04.003DOI Listing
April 2018

Correction to: Methylation of ZNF331 is an independent prognostic marker of colorectal cancer and promotes colorectal cancer growth.

Clin Epigenetics 2018 14;10:36. Epub 2018 Mar 14.

1Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 China.

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http://dx.doi.org/10.1186/s13148-018-0467-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851308PMC
March 2018

Methylation of promotes colorectal cancer progression and may serve as a marker for poor prognosis.

Clin Epigenetics 2017 10;9:50. Epub 2017 May 10.

Department of Gastroenterology and Hepatology, Chinese People's Liberation Army General Hospital, #28 Fuxing Road, Beijing, 100853 China.

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http://dx.doi.org/10.1186/s13148-017-0348-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424295PMC
January 2018

Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma.

J Mol Med (Berl) 2017 11 26;95(11):1237-1249. Epub 2017 Aug 26.

College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, 100044, China.

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http://dx.doi.org/10.1007/s00109-017-1578-5DOI Listing
November 2017

Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development.

Oncotarget 2017 Sep 25;8(41):70035-70048. Epub 2017 Jul 25.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.18632/oncotarget.19550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642535PMC
September 2017

Synthesis and biological evaluation of novel steroidal 5α,8α-endoperoxide derivatives with aliphatic side-chain as potential anticancer agents.

Steroids 2017 08 9;124:46-53. Epub 2017 Jun 9.

Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China; Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2017.05.013DOI Listing
August 2017

Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents.

Bioorg Med Chem Lett 2017 08 21;27(16):3856-3861. Epub 2017 Jun 21.

Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China; Beijing Key Laboratory of Environmental and Viral Oncology, Beijing University of Technology, Beijing 100124, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.06.048DOI Listing
August 2017

Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016.

Epigenomics 2017 07 22;9(7):937-941. Epub 2017 May 22.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.2217/epi-2017-0030DOI Listing
July 2017

Methylation of TMEM176A is an independent prognostic marker and is involved in human colorectal cancer development.

Epigenetics 2017 07 5;12(7):575-583. Epub 2017 Jul 5.

a Department of Gastroenterology & Hepatology , Chinese PLA General Hospital , Beijing , China.

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http://dx.doi.org/10.1080/15592294.2017.1341027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687330PMC
July 2017

Methylation of SLFN11 is a marker of poor prognosis and cisplatin resistance in colorectal cancer.

Epigenomics 2017 06 13;9(6):849-862. Epub 2017 Apr 13.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing 100853, China.

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http://dx.doi.org/10.2217/epi-2017-0019DOI Listing
June 2017

Methylation of DACT2 promotes breast cancer development by activating Wnt signaling.

Sci Rep 2017 06 12;7(1):3325. Epub 2017 Jun 12.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, 100853, China.

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http://dx.doi.org/10.1038/s41598-017-03647-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468316PMC
June 2017

The safety, efficacy, and treatment outcomes of a combination of low-dose decitabine treatment in patients with recurrent ovarian cancer.

Oncoimmunology 2017 17;6(9):e1323619. Epub 2017 May 17.

Department of Molecular Biology and Bio-therapeutic, Institute of Basic Medicine, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.1080/2162402X.2017.1323619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599090PMC
May 2017

Synthesis of 5α,8α-Ergosterol Peroxide 3-Carbamate Derivatives and a Fluorescent Mitochondria-Targeting Conjugate for Enhanced Anticancer Activities.

ChemMedChem 2017 03 9;12(6):466-474. Epub 2017 Mar 9.

College of Life Science and Bioengineering, Beijing University of Technology, Beijing, 100124, China.

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http://dx.doi.org/10.1002/cmdc.201700021DOI Listing
March 2017

Epigenetic regulation of voltage-gated potassium ion channel molecule Kv1.3 in mechanisms of colorectal cancer.

Discov Med 2017 03;23(126):155-162

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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March 2017

ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.

Genes Cancer 2017 Mar;8(3-4):528-535

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.18632/genesandcancer.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489650PMC
March 2017

Recurrently deregulated lncRNAs in hepatocellular carcinoma.

Nat Commun 2017 02 13;8:14421. Epub 2017 Feb 13.

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Center for Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1038/ncomms14421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316832PMC
February 2017

Genetic and Methylation-Induced Loss of miR-181a2/181b2 within chr9q33.3 Facilitates Tumor Growth of Cervical Cancer through the PIK3R3/Akt/FoxO Signaling Pathway.

Clin Cancer Res 2017 Jan 8;23(2):575-586. Epub 2016 Aug 8.

Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0303DOI Listing
January 2017

The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma.

Clin Epigenetics 2016 22;8:43. Epub 2016 Apr 22.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853 China.

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http://dx.doi.org/10.1186/s13148-016-0210-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840959PMC
December 2016

Design, synthesis, and biological activity of 4-(imidazo[1,2-b]pyridazin-3-yl)-1H-pyrazol-1-yl-phenylbenzamide derivatives as BCR-ABL kinase inhibitors.

Bioorg Med Chem Lett 2016 12 18;26(23):5830-5835. Epub 2016 Oct 18.

Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.1016/j.bmcl.2016.10.007DOI Listing
December 2016

Silencing NKD2 by Promoter Region Hypermethylation Promotes Esophageal Cancer Progression by Activating Wnt Signaling.

J Thorac Oncol 2016 11 30;11(11):1912-1926. Epub 2016 Jun 30.

Department of Gastroenterology and Hepatology, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.06.015DOI Listing
November 2016

Portraying breast cancers with long noncoding RNAs.

Sci Adv 2016 09 2;2(9):e1600220. Epub 2016 Sep 2.

Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.

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http://dx.doi.org/10.1126/sciadv.1600220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010371PMC
September 2016

C(OH): a potential histone deacetylase inhibitor with anti-angiogenic activity.

Nanoscale 2016 Sep;8(36):16332-16339

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China.

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http://dx.doi.org/10.1039/c6nr04875gDOI Listing
September 2016

The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer.

Oncotarget 2016 Jun;7(24):37331-37346

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.18632/oncotarget.7949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095080PMC
June 2016

Epigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-κB Activation.

Antioxid Redox Signal 2016 05 30;24(15):839-54. Epub 2016 Mar 30.

1 Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital/Institute , Beijing, P.R. China .

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http://dx.doi.org/10.1089/ars.2014.6128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876530PMC
May 2016

Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling.

Oncotarget 2016 Apr;7(14):17957-69

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.18632/oncotarget.7647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951263PMC
April 2016

Expression profiling and functional prediction of long noncoding RNAs in nasopharyngeal nonkeratinizing carcinoma.

Discov Med 2016 04;21(116):239-50

Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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April 2016

Systematic study of novel lncRNAs in different gastrointestinal cancer cells.

Discov Med 2016 03;21(115):159-71

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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March 2016

Silencing GPX3 Expression Promotes Tumor Metastasis in Human Thyroid Cancer.

Curr Protein Pept Sci 2015 ;16(4):316-21

Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, #1 Jianshe Road, Zhengzhou 450052, China.

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http://dx.doi.org/10.2174/138920371604150429154840DOI Listing
January 2016

Methylation of ZNF331 Promotes Cell Invasion and Migration in Human Esophageal Cancer.

Curr Protein Pept Sci 2015 ;16(4):322-8

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.2174/138920371604150429155255DOI Listing
January 2016

Epigenome-based personalized medicine in human cancer.

Epigenomics 2016 Jan 7;8(1):119-33. Epub 2015 Sep 7.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing 100853, China.

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http://dx.doi.org/10.2217/epi.15.84DOI Listing
January 2016

Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling.

PLoS One 2014 6;9(11):e112336. Epub 2014 Nov 6.

The Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing 100853, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112336PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223043PMC
December 2015

Hypermethylation of ZNF545 is associated with poor prognosis in patients with early-stage hepatocellular carcinoma after thermal ablation.

Gut 2015 Nov 19;64(11):1836-7. Epub 2015 Aug 19.

Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.1136/gutjnl-2015-310258DOI Listing
November 2015

Methylation of RASSF10 promotes cell proliferation and serves as a docetaxel resistant marker in human breast cancer.

Discov Med 2015 Nov;20(111):261-71

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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November 2015

Epigenetic changes and functional study of HOXA11 in human gastric cancer.

Epigenomics 2015 15;7(2):201-13. Epub 2015 Jan 15.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.2217/epi.14.92DOI Listing
September 2015

Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth.

Oncotarget 2015 Sep;6(26):22126-38

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing 100853, China.

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http://dx.doi.org/10.18632/oncotarget.4244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673151PMC
September 2015

Epigenetics of colorectal cancer.

Methods Mol Biol 2015 ;1238:405-24

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853, China.

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http://dx.doi.org/10.1007/978-1-4939-1804-1_22DOI Listing
July 2015

Epigenetics of gastric cancer.

Methods Mol Biol 2015 ;1238:783-99

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853, China,

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http://dx.doi.org/10.1007/978-1-4939-1804-1_41DOI Listing
July 2015

Gd-Metallofullerenol Nanomaterial Suppresses Pancreatic Cancer Metastasis by Inhibiting the Interaction of Histone Deacetylase 1 and Metastasis-Associated Protein 1.

ACS Nano 2015 Jul 22;9(7):6826-36. Epub 2015 Jun 22.

‡CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology and Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China.

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http://dx.doi.org/10.1021/nn506782fDOI Listing
July 2015

Methylation-induced loss of miR-484 in microsatellite-unstable colorectal cancer promotes both viability and IL-8 production via CD137L.

J Pathol 2015 Jun 21;236(2):165-74. Epub 2015 Apr 21.

Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, PR China.

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http://dx.doi.org/10.1002/path.4525DOI Listing
June 2015

Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells.

Biochemistry 2015 May 28;54(18):2895-902. Epub 2015 Apr 28.

†CAS Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun, Chaoyang District, Beijing 100101, China.

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http://dx.doi.org/10.1021/acs.biochem.5b00259DOI Listing
May 2015

Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU.

Oncotarget 2015 May;6(13):11547-60

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484475PMC
http://dx.doi.org/10.18632/oncotarget.3413DOI Listing
May 2015

Epigenetic silencing BCL6B induced colorectal cancer proliferation and metastasis by inhibiting P53 signaling.

Am J Cancer Res 2015 15;5(2):651-62. Epub 2015 Jan 15.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital #28 Fuxing Road, Beijing 100853, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396025PMC
May 2015

Predictive value of CHFR and MLH1 methylation in human gastric cancer.

Gastric Cancer 2015 Apr 21;18(2):280-7. Epub 2014 Apr 21.

Department of Pathology, Chinese PLA General Hospital, Haitangwan Town, Sanya, 572000, Hainan, China.

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http://dx.doi.org/10.1007/s10120-014-0370-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894312PMC
April 2015

DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling.

Oncotarget 2015 Apr;6(11):8621-34

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

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http://www.oncotarget.com/fulltext/3281
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496171PMC
http://dx.doi.org/10.18632/oncotarget.3281DOI Listing
April 2015

DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling.

Oncotarget 2015 Mar;6(8):5877-88

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467408PMC
http://dx.doi.org/10.18632/oncotarget.3463DOI Listing
March 2015

CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer.

Discov Med 2015 Mar;19(104):151-8

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, 100853, China.

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March 2015

miR-127 regulates cell proliferation and senescence by targeting BCL6.

PLoS One 2013 25;8(11):e80266. Epub 2013 Nov 25.

Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China ; Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840165PMC
January 2015

Methylation of CHFR sensitizes esophageal squamous cell cancer to docetaxel and paclitaxel.

Genes Cancer 2015 Jan;6(1-2):38-48

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362483PMC
http://dx.doi.org/10.18632/genesandcancer.46DOI Listing
January 2015

Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-β signalling.

J Cell Mol Med 2014 Dec 9;18(12):2499-511. Epub 2014 Jun 9.

Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.1111/jcmm.12325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302654PMC
December 2014

The miRNA network: micro-regulator of cell signaling in cancer.

Expert Rev Anticancer Ther 2014 Dec 28;14(12):1515-27. Epub 2014 Aug 28.

Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, 100853, China.

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http://dx.doi.org/10.1586/14737140.2014.953935DOI Listing
December 2014

DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.

Am J Cancer Res 2014 19;4(6):710-24. Epub 2014 Nov 19.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital #28 Fuxing Road, Beijing 100853, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266706PMC
December 2014

DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells.

J Hematol Oncol 2014 Oct 17;7:73. Epub 2014 Oct 17.

Department of Oncology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430030, China.

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http://dx.doi.org/10.1186/s13045-014-0073-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203876PMC
October 2014

Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis.

J Cell Mol Med 2014 Aug 28;18(8):1655-66. Epub 2014 Jun 28.

Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Science Center, Beijing, China; Peking University Center for Human Disease Genomics, Peking University, Beijing, China.

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http://dx.doi.org/10.1111/jcmm.12352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190911PMC
August 2014

[Promoter region methylation of DNA damage repair genes in human gastric cancer].

Zhonghua Yi Xue Za Zhi 2014 Jul;94(28):2193-6

Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China.

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July 2014

MicroRNA-155 is involved in the pathogenesis of ulcerative colitis by targeting FOXO3a.

Inflamm Bowel Dis 2014 Apr;20(4):652-9

*Department of Gastroenterology and Hepatology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China; and †Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.1097/MIB.0000000000000009DOI Listing
April 2014

Epigenetic silencing of RASSF10 promotes tumor growth in esophageal squamous cell carcinoma.

Discov Med 2014 Apr;17(94):169-78

Institute of Digestive Disease and the Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450014, China.

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April 2014

Epigenetic changes associated with neoplasms of the exocrine and endocrine pancreas.

Discov Med 2014 Feb;17(92):67-73

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061564PMC
February 2014

Spatially gradated segregation and recovery of circulating tumor cells from peripheral blood of cancer patients.

Biomicrofluidics 2013 6;7(3):34109. Epub 2013 Jun 6.

Department of Materials Science and Engineering, Peking University, Beijing 100871, China.

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http://dx.doi.org/10.1063/1.4808456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689820PMC
January 2014

Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative response in human hepatocellular carcinoma.

Hepatology 2013 Dec 21;58(6):2012-22. Epub 2013 Oct 21.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, P.R. China.

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http://dx.doi.org/10.1002/hep.26587DOI Listing
December 2013

Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer.

Epigenetics 2013 Dec 22;8(12):1373-83. Epub 2013 Oct 22.

Department of Gastroenterology and Hepatology; Chinese PLA General Hospital; Beijing, PR China.

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http://www.tandfonline.com/doi/abs/10.4161/epi.26781
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http://dx.doi.org/10.4161/epi.26781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933496PMC
December 2013

Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion.

Discov Med 2013 Oct;16(88):137-47

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China and College of Medicine, NanKai University, Tianjin 300071, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061567PMC
October 2013

Real-time contrast-enhanced ultrasound in diagnosis of solid renal lesions.

Discov Med 2013 Aug;16(86):15-25

Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing 100853, China.

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August 2013

Glycoproteomic analysis of tissues from patients with colon cancer using lectin microarrays and nanoLC-MS/MS.

Mol Biosyst 2013 Jul 9;9(7):1877-87. Epub 2013 Apr 9.

State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, PR China.

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http://dx.doi.org/10.1039/c3mb00013cDOI Listing
July 2013

Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.

J Pathol 2013 Jun;230(2):194-204

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.1002/path.4073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061565PMC
June 2013

A facile and specific assay for quantifying microRNA by an optimized RT-qPCR approach.

PLoS One 2012 5;7(10):e46890. Epub 2012 Oct 5.

Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046890PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465266PMC
April 2013

Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.

Epigenetics 2013 Apr 28;8(4):373-82. Epub 2013 Feb 28.

Department of Gastroenterology & Hepatology; Chinese PLA General Hospital; Beijing, P.R. China.

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http://dx.doi.org/10.4161/epi.24113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674046PMC
April 2013

Methylation-mediated repression of microRNA 129-2 enhances oncogenic SOX4 expression in HCC.

Liver Int 2013 Mar;33(3):476-86

Department of Microbiology & Infectious Disease Center, School of Basic Medical Science, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1111/liv.12097DOI Listing
March 2013

Epigenetic changes in colorectal cancer.

Chin J Cancer 2013 Jan 4;32(1):21-30. Epub 2011 Nov 4.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, People's Republic of China.

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http://www.cjcsysu.cn/abstract.asp?fr=doi&idno=17937
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http://dx.doi.org/10.5732/cjc.011.10245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845587PMC
January 2013

Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer.

J Mol Diagn 2012 Nov 21;14(6):577-85. Epub 2012 Aug 21.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.1016/j.jmoldx.2012.06.004DOI Listing
November 2012

Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.

EMBO J 2012 Nov 26;31(23):4415-27. Epub 2012 Oct 26.

State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/emboj.2012.292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512391PMC
November 2012

CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer.

Cancer Biol Ther 2012 Oct 23;13(12):1152-7. Epub 2012 Aug 23.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.4161/cbt.21344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469472PMC
October 2012

SOX17 methylation inhibits its antagonism of Wnt signaling pathway in lung cancer.

Discov Med 2012 Jul;14(74):33-40

Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing 100853, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061568PMC
July 2012

AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer.

Tumour Biol 2012 Apr 19;33(2):307-14. Epub 2011 Nov 19.

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, #28 Fuxing Road, Beijing, 100853, China.

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http://dx.doi.org/10.1007/s13277-011-0266-2DOI Listing
April 2012

Methylation of TFPI-2 is an early event of esophageal carcinogenesis.

Epigenomics 2012 Apr;4(2):135-46

Department of Gastroenterology & Hepatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing 100853, China.

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http://dx.doi.org/10.2217/epi.12.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742137PMC
April 2012

Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus.

Cancer Prev Res (Phila) 2012 Jan 1;5(1):41-50. Epub 2011 Dec 1.

Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, 410 West 12 Avenue, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081263PMC
http://dx.doi.org/10.1158/1940-6207.CAPR-11-0469DOI Listing
January 2012

5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of transferrin receptor 1 (TfR1) and ferrochelatase (Fech) genes.

J Biol Chem 2011 Oct 7;286(43):37196-206. Epub 2011 Sep 7.

Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Zhongguancun Beiyitiao, Beijing 100190, China.

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http://dx.doi.org/10.1074/jbc.M111.258129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199467PMC
October 2011

Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts.

Mol Cell Biochem 2011 Jun 17;352(1-2):271-9. Epub 2011 Mar 17.

Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.

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http://dx.doi.org/10.1007/s11010-011-0763-zDOI Listing
June 2011

SOX17 antagonizes WNT/β-catenin signaling pathway in hepatocellular carcinoma.

Epigenetics 2010 Nov-Dec;5(8):743-9. Epub 2010 Nov 22.

Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, Beijing, China.

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http://dx.doi.org/10.4161/epi.5.8.13104DOI Listing
March 2011

Effects of simulated weightlessness on tight junction protein occludin and Zonula Occluden-1 expression levels in the intestinal mucosa of rats.

J Huazhong Univ Sci Technolog Med Sci 2011 Feb 19;31(1):26-32. Epub 2011 Feb 19.

Department of Gastroenterology and Research Center of Aeropathy, General Hospital of Air Force, PLA, Beijing, 100036, China.

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http://link.springer.com/10.1007/s11596-011-0145-5
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http://dx.doi.org/10.1007/s11596-011-0145-5DOI Listing
February 2011

CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.

J Immunol 2010 Dec 8;185(12):7654-62. Epub 2010 Nov 8.

Key Laboratory of Infection and Immunity, Institute of Biophysics, Graduate University, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.4049/jimmunol.1000927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601909PMC
December 2010

DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus.

Am J Gastroenterol 2009 Sep 7;104(9):2153-60. Epub 2009 Jul 7.

Department of Medicine (Gastroenterology), Johns Hopkins University, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/ajg.2009.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090447PMC
September 2009

Promoter methylation of HIN-1 in the progression to esophageal squamous cancer.

Epigenetics 2008 Nov 8;3(6):336-41. Epub 2008 Nov 8.

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

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http://dx.doi.org/10.4161/epi.3.6.7158DOI Listing
November 2008