Publications by authors named "Mingyuan Zhang"

96 Publications

Bayes Consistency vs. -Consistency: The Interplay between Surrogate Loss Functions and the Scoring Function Class.

Adv Neural Inf Process Syst 2020 Dec;33:16927-16936

University of Pennsylvania, Philadelphia, PA 19104.

A fundamental question in multiclass classification concerns understanding the consistency properties of surrogate risk minimization algorithms, which minimize a (often convex) surrogate to the multiclass 0-1 loss. In particular, the framework of calibrated surrogates has played an important role in analyzing of such algorithms, i.e. in studying convergence to a Bayes optimal classifier (Zhang, 2004; Tewari and Bartlett, 2007). However, follow-up work has suggested this framework can be of limited value when studying ; in particular, concerns have been raised that even when the data comes from an underlying linear model, minimizing certain convex calibrated surrogates over linear scoring functions fails to recover the true model (Long and Servedio, 2013). In this paper, we investigate this apparent conundrum. We find that while some calibrated surrogates can indeed fail to provide -consistency when minimized over a naturallooking but naïvely chosen scoring function class , the situation can potentially be remedied by minimizing them over a more carefully chosen class of scoring functions . In particular, for the popular one-vs-all hinge and logistic surrogates, both of which are calibrated (and therefore provide Bayes consistency) under realizable models, but were previously shown to pose problems for realizable -consistency, we derive a form of scoring function class that enables Hconsistency. When is the class of linear models, the class consists of certain piecewise linear scoring functions that are characterized by the same number of parameters as in the linear case, and minimization over which can be performed using an adaptation of the min-pooling idea from neural network training. Our experiments confirm that the one-vs-all surrogates, when trained over this class of scoring functions , yield better multiclass classifiers than when trained over standard linear scoring functions.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307545PMC
December 2020

Convex Calibrated Surrogates for the Multi-Label F-Measure.

Proc Mach Learn Res 2020 Jul;119:11246-11255

Department of Computer and Information Science, University of Pennsylvania, Philadelphia, PA, USA.

The -measure is a widely used performance measure for multi-label classification, where multiple labels can be active in an instance simultaneously (e.g. in image tagging, multiple tags can be active in any image). In particular, the -measure explicitly balances recall (fraction of active labels predicted to be active) and precision (fraction of labels predicted to be active that are actually so), both of which are important in evaluating the overall performance of a multi-label classifier. As with most discrete prediction problems, however, directly optimizing the -measure is computationally hard. In this paper, we explore the question of designing convex surrogate losses that are for the -measure - specifically, that have the property that minimizing the surrogate loss yields (in the limit of sufficient data) a Bayes optimal multi-label classifier for the -measure. We show that the -measure for an -label problem, when viewed as a 2 × 2 loss matrix, has rank at most + 1, and apply a result of Ramaswamy et al. (2014) to design a family of convex calibrated surrogates for the -measure. The resulting surrogate risk minimization algorithms can be viewed as decomposing the multi-label -measure learning problem into + 1 binary class probability estimation problems. We also provide a quantitative regret transfer bound for our surrogates, which allows any regret guarantees for the binary problems to be transferred to regret guarantees for the overall -measure problem, and discuss a connection with the algorithm of Dembczynski et al. (2013). Our experiments confirm our theoretical findings.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276679PMC
July 2020

Quality of Life in Patients With Heart Failure With Recovered Ejection Fraction.

JAMA Cardiol 2021 May 5. Epub 2021 May 5.

University of Utah School of Medicine, Salt Lake City.

Importance: Heart failure with recovered ejection fraction (HFrecEF) is a recently recognized phenotype of patients with a history of reduced left ventricular ejection fraction (LVEF) that has subsequently normalized. It is unknown whether such LVEF improvement is associated with improvements in health status.

Objective: To examine changes in health-related quality of life in patients with heart failure with reduced ejection fraction (HFrEF) whose LVEF normalized, compared with those whose LVEF remains reduced and those with HF with preserved EF (HFpEF).

Design, Setting, And Participants: This prospective cohort study was conducted at a tertiary care hospital from November 2016 to December 2018. Consecutive patients seen in a heart failure clinic who completed patient-reported outcome assessments were included. Clinical data were abstracted from the electronic health record. Data analysis was completed from February to December 2020.

Main Outcomes And Measures: Changes in Kansas City Cardiomyopathy Questionnaire overall summary score, Visual Analog Scale score, and Patient-Reported Outcomes Measurement Information System domain scores on physical function, fatigue, depression, and satisfaction with social roles over 1-year follow-up.

Results: The study group included 319 patients (mean [SD] age, 60.4 [15.5] years; 120 women [37.6%]). At baseline, 212 patients (66.5%) had HFrEF and 107 (33.5%) had HFpEF. At a median follow-up of 366 (interquartile range, 310-421) days, LVEF had increased to 50% or more in 35 patients with HFrEF (16.5%). Recovery of systolic function was associated with heart failure-associated quality-of-life improvement, such that for each 10% increase in LVEF, the Kansas City Cardiomyopathy Questionnaire score improved by an mean (SD) of 4.8 (1.6) points (P = .003). Recovery of LVEF was also associated with improvement of physical function, satisfaction with social roles, and a reduction in fatigue.

Conclusions And Relevance: Among patients with HFrEF in this study, normalization of left ventricular systolic function was associated with a significant improvement in health-related quality of life.
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http://dx.doi.org/10.1001/jamacardio.2021.0939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100912PMC
May 2021

Epigenetic Landscape Analysis of the Long Non-Coding RNA and Messenger RNA in a Mouse Model of Corneal Alkali Burns.

Invest Ophthalmol Vis Sci 2021 Apr;62(4):28

Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's Republic of China.

Purpose: Corneal alkali burns (CABs) are a common clinical ocular disease, presenting a poor prognosis. Although some long noncoding RNAs (lncRNAs) reportedly play a key role in epigenetic regulation associated with CABs, studies regarding the lncRNA signature in CABs remain rare and elusive.

Methods: A CAB model was established in C57BL/6J mice and profiling of lncRNA expressions was performed by RNA-Seq. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to predicate the related pathological pathways and candidate genes. RT-qPCR was used to verify the expression pattern of lncRNAs and related mRNAs, both in vitro and in vivo. Data were statistically analyzed by GraphPad Prism version 6.0.

Results: In all, 4436 aberrantly expressed lncRNAs were identified in CAB mice when compared with control mice. In the top 13 aberrantly expressed lncRNAs, Bc037156 and 4930511E03Rik were confirmed as the most significantly altered lncRNAs. Pathway analysis revealed that mitogen-activated protein kinase (MAPK) signaling pathway was most enriched. Following 4930511E03Rik siRNA treated, Srgn, IL-1β and Cxcr2 were significant upregulated in corneal epithelial cells, corneal keratocytes, and bone marrow dendritic cells, with NaOH treatment. Moreover, after Bc037156 siRNA treated, expression levels of IL-1β and Srgn were significantly downregulated in the three cell lines.

Conclusions: Our study suggests that Bc037156 and 4930511E03Rik may be involved in inflammation, immune response, and neovascularization by regulating Srgn, IL-1β, and Cxcr2 expression after CAB. These candidate lncRNAs and mRNAs may be the potential targets for the treatment strategy of the alkali injured cornea.
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http://dx.doi.org/10.1167/iovs.62.4.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083103PMC
April 2021

Liver sinusoidal endothelial cells are implicated in multiple fibrotic mechanisms.

Mol Biol Rep 2021 Mar 17;48(3):2803-2815. Epub 2021 Mar 17.

Department of Hepatology, The First Hospital of Jilin University, NO. 71, Xinmin Street, Changchun, 130021, Jilin, China.

Chronic liver diseases are attributed to liver injury. Development of fibrosis from chronic liver diseases is a dynamic process that involves multiple molecular and cellular processes. As the first to be impacted by injury, liver sinusoidal endothelial cells (LSECs) are involved in the pathogenesis of liver diseases caused by a variety of etiologies. Moreover, capillarization of LSECs has been recognized as an important event in the development of chronic liver diseases and fibrosis. Studies have reported that various cytokines (such as vascular endothelial growth factor, transforming growth factor-β), and pathways (such as hedgehog, and Notch), as well as epigenetic and metabolic factors are involved in the development of LSEC-mediated liver fibrosis. This review describes the complexity and plasticity of LSECs in fibrotic liver diseases from several perspectives, including the cross-talk between LSECs and other intra-hepatic cells. Moreover, it summarizes the mechanisms of several kinds of LSECs-targeting anti-fibrosis chemicals, and provides a theoretical basis for future studies.
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http://dx.doi.org/10.1007/s11033-021-06269-1DOI Listing
March 2021

Trelagliptin Mitigates Macrophage Infiltration by Preventing the Breakdown of the Blood-Brain Barrier in the Brain of Middle Cerebral Artery Occlusion Mice.

Chem Res Toxicol 2021 Apr 17;34(4):1016-1023. Epub 2021 Mar 17.

Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, China.

Stroke is a significant cardiovascular disease that influences the health of human beings all over the world, especially the elderly population. It is reported that the blood-brain barrier (BBB) can be easily destroyed by stroke, which is one of the main factors responsible for macrophage infiltration and central nervous inflammation. Here, we report the protective effects of Trelagliptin against BBB injury and macrophage infiltration. Our results indicate that the infraction volume, the neurological score, and macrophage infiltration staining with CD68 were increased in middle cerebral artery occlusion (MCAO) mice but significantly reversed by treatment with Trelagliptin. Additionally, Trelagliptin reduced the permeability of the BBB by increasing the expression of the tight junction zonula occludens protein-1 (ZO-1) in the cerebral cortex. In an hypoxia model of endothelial cells, the increased migration of macrophages, enlarged permeability of endothelial monolayer, downregulation of ZO-1, and elevated expression level of CXCL1 by hypoxic conditions were all reversed by treatment with Trelagliptin in a dose-dependent manner. Our results demonstrate that Trelagliptin might mitigate macrophage infiltration by preventing the breakdown of the blood-brain barrier in the brains of MCAO mice.
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http://dx.doi.org/10.1021/acs.chemrestox.0c00323DOI Listing
April 2021

Highly dispersed and stabilized CoO/C anchored on porous biochar for bisphenol A degradation by sulfate radical advanced oxidation process.

Sci Total Environ 2021 Jul 20;777:145794. Epub 2021 Feb 20.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China.

Cobalt oxide and porous carbon materials are desirable catalysts for peroxymonosulfate (PMS) advanced oxidation reaction in the degradation of organic pollutants. Herein, carbon-coated CoO (CoO/C) mounted biochar (BC) composites (CoO/C-BC) with a three-dimensional spongy-like network were constructed by driving a dual-precursors of zeolitic imidazolate framework (ZIF-67) and Eichhornia crassipes. Considering the unique structures and compositions, the CoO/C-BC composites enhanced the dispersion of CoO/C nanoparticles, minimized the Co leaching, mediated the size of CoO/C nanoparticles, and enhanced the overall catalytic activity. CoO/C-BC effectively activated PMS for bisphenol A (BPA) degradation along with satisfactory reusability in advanced oxidation reaction. Electron paramagnetic resonance and radical quenching tests revealed that the generation and effect of sulfate and hydroxyl radicals in reaction process. This work not only provided a promising catalyst for the degradation of organic pollutants but also expanded BPA degradation pathway and PMS activation mechanism.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145794DOI Listing
July 2021

Neutrophil-to-Lymphocyte Ratio and Albumin: New Serum Biomarkers to Predict the Prognosis of Male Alcoholic Cirrhosis Patients.

Biomed Res Int 2020 21;2020:7268459. Epub 2020 Dec 21.

Department of Hepatology, First Hospital of Jilin University, Xinmin Street, No. 71, Changchun, Jilin Province 130021, China.

Background And Aims: Alcohol-associated liver disease is exhibiting an increasing disease burden. In terms of pathogenesis, inflammation is closely related to alcohol-induced liver injury. The neutrophil-to-lymphocyte ratio (NLR) is a novel inflammatory biomarker. Here, we aim to evaluate the role of the NLR and other biomarkers in predicting short-term mortality in alcoholic cirrhotic patients.

Methods: This was a retrospective study that included 459 male alcoholic cirrhosis patients. Among them, 345 patients completed follow-up. Based on their 30-day mortality information, patients were separated into surviving and nonsurviving groups. Demographic, clinical, and biochemical features were collected for further analysis. Logistic regression was used to identify factors associated with short-term mortality, and receiver operating characteristic (ROC) curve analysis was used to establish the predictive value of these factors.

Results: The prognostic scores were significantly higher in the nonsurviving group than in the surviving group: NLR: 5.5 vs. 3.2 ( < 0.001), model for end-stage liver disease (MELD): 15.4 vs. 7.9 ( < 0.001), Maddrey's discriminant function (MDF): 39.8 vs. 12.7 ( < 0.001), and the integrated MELD (i-MELD): 37.9 vs. 28.4 ( < 0.001). Logistic regression demonstrated that albumin (ALB), NLR, and i-MELD values were significantly correlated with patient death in 30 days. On ROC analysis, the diagnostic accuracy for 30-day mortality of the NLR (area under the ROC curve (AUROC) of 0.72, < 0.001) was similar to that of the MELD or i-MELD (AUROCs of 0.71 and 0.74, respectively, < 0.001). The new biomarker, NLA, calculated as 100 × NLR/ALB, had the best prognostic value. The cutoff values of the NLR and NLA for predicting 30-day mortality were 4.2 and 19.6, respectively.

Conclusions: The NLR and its related biomarker NLA are simple and robust predictors of 30-day mortality in alcoholic cirrhosis patients.
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http://dx.doi.org/10.1155/2020/7268459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769654PMC
December 2020

Association analysis between the interaction of RAS family genes mutations and papillary thyroid carcinoma in the Han Chinese population.

Int J Med Sci 2021 1;18(2):441-447. Epub 2021 Jan 1.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.

Papillary thyroid carcinoma (PTC) is the major subtype of thyroid cancer, accounting for 75%-85% of all thyroid malignancies. This study aimed to identify the association between the interactions of single nucleotide polymorphisms (SNPs) in RAS family genes and PTC in the Han Chinese population, to provide clues to the pathogenesis and potential therapeutic targets for PTC. Hap Map and NCBI-db SNP databases were used to retrieve SNPs. Haploview 4.2 software was used to filter SNPs based on specific parameters, six SNPs of RAS gene (KRAS-rs12427141, KRAS-rs712, KRAS-rs7315339, HRAS-rs12628, NRAS-rs14804 and NRAS-rs2273267) were genotyped by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) in 673 PTC patients and 657 healthy controls, the interactive effect was evaluated by crossover analysis, logistic regression and GMDR software. We found that genetic mutation in rs712 have significant associations with PTC risk after Bonferroni correction (<0.001). The interaction between KRAS-rs12427141 and HRAS-rs12628 increased the risk of PTC (U=-2.119, <0.05), the interaction between KRAS-rs2273267 and HRAS-rs7315339 reduced the risk of PTC (U=2.195, <0.05). GMDR analysis showed that the two-factor model (KRAS-rs712, NRAS-rs2273267) was the best (=0.0107). Summarily, there are PTC-related interactions between RAS family genes polymorphisms in the Han Chinese population.
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http://dx.doi.org/10.7150/ijms.50026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757130PMC
January 2021

Application of laser cleaning in postwelding treatment of aluminum alloy.

Appl Opt 2020 Dec;59(34):10967-10972

This paper presents a new method of postweld treatment. The 5154 aluminum alloy was cleaned by Nd:YAG laser after welding. The surface morphology, energy spectrum, friction and wear properties, hardness, and residual stress of the welded joint at different cleaning speeds were studied. The results show that an Nd:YAG laser can effectively remove the welding slag and eliminate the pores in the weld under a certain cleaning speed. When the cleaning speed is in the range of 5.2-20.7 mm/s, laser cleaning can improve the heat-affected zone's tribological characteristics. Laser cleaning can eliminate the residual stress of the welded joint and improve the welding joint's strength, which provides a reference for laser cleaning instead of traditional heat treatment.
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http://dx.doi.org/10.1364/AO.406171DOI Listing
December 2020

Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older.

Sci Total Environ 2021 Mar 19;758:143638. Epub 2020 Nov 19.

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:

High environmental arsenic exposure can increase chronic oxidative stress in experimental studies and in occupational epidemiology studies. Many regulatory agencies have put forth arsenic exposure limits, it is still unclear that whether low environmental arsenic exposure was associated with adverse health outcome in general population. This study aimed to explore the association of low blood arsenic with malondialdehyde in community-dwelling older adults. We used a cross-sectional study of 2384 older adult individuals aged ≥65 years (mean age: 85 years) from the Healthy Aging and Biomarkers Cohort Study in 2017. The median blood arsenic level was 1.41 μg/L. High oxidative stress was categorized according to the 95th percentile of MDA levels (7.47 nmol/mL). Restricted cubic spline models showed that blood arsenic levels were positively associated with malondialdehyde levels (P < 0.01); and the risk of high oxidative stress was no longer significantly increased when blood arsenic level up to 8.74 μg/L. After adjusting for potential confounders, the odds ratios of high oxidative stress for the second, third, and fourth quartiles of blood arsenic were 2.35 (1.11-4.96), 3.87 (1.90-7.91), and 4.18 (2.00-8.72) (P < 0.01), compared with the first quartile. We concluded that even low arsenic exposure was associated with higher risk of oxidative stress, in a nonlinear dose-response.
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http://dx.doi.org/10.1016/j.scitotenv.2020.143638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897719PMC
March 2021

Cohort profile: China National Human Biomonitoring (CNHBM)-A nationally representative, prospective cohort in Chinese population.

Environ Int 2021 01 23;146:106252. Epub 2020 Nov 23.

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.

Objective: Globally, developed countries such as the United States, Canada, Germany, Korea, have carried out long-term and systematic biomonitoring programs for environmental chemicals in their populations. The China National Human Biomonitoring (CNHBM) was to document the extent of human exposure to a wide array of environmental chemicals, to understand exposure profiles, magnitude and ongoing trends in exposure in the general Chinese population, and to establish a national biorepository.

Methods: CNHBM adopted three-stage sampling method to obtain a nationally representative sample of the population. A total of 21,888 participants who were permanent residents in 31 provinces were designed to interviewed in this national biomonitoring (152 monitoring sites × 3 survey units × 2 sexes × 6 age groups × 4 persons = 21,888 persons) in 2017-2018. Unlike the US National Health and Nutrition Examination Survey, the CNHBM will follow the same participants in subsequent cycles allowing for dynamic, longitudinal data sets for epidemiologic follow-up. Each survey cycle of CNHBM will last 2 years and each subsequent cycle will occur 3 years after the prior cycle's completion.

Results: In 2017-2018, the CNHBM created a large cohort of Chinese citizens that included districts/counties questionnaire, community questionnaire collecting information on villages/communities, individual questionnaire, household questionnaire, comprehensive medical examination, and collection of blood and urine samples for measurement of clinical and exposure biomarkers. A total of 21,746 participants were finally included in CNHBM, accounting for 99.4% of the designed sample size; and 152 PSUs questionnaires, 454 community questionnaires, 21,619 family questionnaires, 21,712 cases of medical examinations, 21,700 individual questionnaires, 21,701 blood samples and 21,704 urine samples were collected, respectively. Planned analyses of blood and urine samples were to measure both inorganic and organic chemicals, including 13 heavy metals and metalloids, 18 poly- and per-fluorinated alkyl substances, 12 phthalate metabolites, 9 polycyclic aromatic hydrocarbons metabolites, 4 environmental alkylated phenols, and 2 benzene metabolites.

Conclusions: CNHBM established the first nationally representative, prospective cohort in the Chinese population to understand the baseline and trend of internal exposure of environmental chemicals in general population, and to understand environmental toxicity.
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http://dx.doi.org/10.1016/j.envint.2020.106252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828642PMC
January 2021

Fasudil attenuates glial cell-mediated neuroinflammation via ERK1/2 and AKT signaling pathways after optic nerve crush.

Mol Biol Rep 2020 Nov 8;47(11):8963-8973. Epub 2020 Nov 8.

Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.

To investigate the functional role of fasudil in optic nerve crush (ONC), and further explore its possible molecular mechanism. After ONC injury, the rats were injected intraperitoneally either with fasudil or normal saline once a day until euthanized. RGCs survival was assessed by retrograde labeling with FluoroGold. Retinal glial cells activation and population changes (GFAP, iba-1) were measured by immunofluorescence. The expressions of cleaved caspase 3 and 9, p-ERK1/2 and p-AKT were detected by western blot. The levels of the pro-inflammatory cytokines were determined using real-time polymerase chain reaction. Fasudil treatment inhibited RGCs apoptosis and reduced RGCs loss demonstrated by the decreased apoptosis-associated proteins expression and the increased fluorogold labeling of RGCs after ONC, respectively. In addition, the ONC + fasudil group compared had a significantly lower expression of GFAP and iba1 compared with the ONC group. The levels of pro-inflammatory cytokines were significantly reduced in the ONC + fasudil group than in the ONC group. Furthermore, the phosphorylation levels of ERK1/2 and AKT (p-ERK1/2 and p-AKT) were obviously elevated by the fasudil treatment. Our study demonstrated that fasudil attenuated glial cell-mediated neuroinflammation by up-regulating the ERK1/2 and AKT signaling pathways in rats ONC models. We conclude that fasudil may be a novel treatment for traumatic optic neuropathy.
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http://dx.doi.org/10.1007/s11033-020-05953-yDOI Listing
November 2020

Patient-reported outcomes and subsequent management in atrial fibrillation clinical practice: Results from the Utah mEVAL AF program.

J Cardiovasc Electrophysiol 2020 12 11;31(12):3187-3195. Epub 2020 Nov 11.

Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.

Background: Atrial fibrillation (AF) significantly reduces health-related quality of life (HRQoL), previously measured in clinical trials using patient-reported outcomes (PROs). We examined AF PROs in clinical practice and their association with subsequent clinical management.

Methods: The Utah My Evaluation (mEVAL) program collects the Toronto AF Symptom Severity Scale (AFSS) in AF outpatients at the University of Utah. Baseline factors associated with worse AF symptom score (range 0-35, higher is worse) were identified in univariate and multivariable analyses. Secondary outcomes included AF burden and AF healthcare utilization. We also compared subsequent clinical management at 6 months between patients with better versus worse AF HRQoL.

Results: Overall, 1338 patients completed the AFSS symptom score, which varied by sex (mean 7.26 for males vs. 10.27 for females; p < .001), age (<65, 9.73; 65-74, 7.66; ≥75, 7.58; p < .001), heart failure (9.39 with HF vs. 7.67 without; p < .001), and prior ablation (7.28 with prior ablation vs. 8.84; p < .001). In multivariable analysis, younger age (mean difference 2.92 for <65 vs. ≥75; p < .001), female sex (mean difference 2.57; p < .001), pulmonary disease (mean difference 1.88; p < .001), and depression (mean difference 2.46; p < .001) were associated with higher scores. At 6-months, worse baseline symptom score was associated with the use of rhythm control (37.1% vs. 24.5%; p < .001). Similar cofactors and results were associated with increased AF burden and health care utilization scores.

Conclusions: AF PROs in clinical practice identify highly-symptomatic patients, corroborating findings in more controlled, clinical trials. Increased AFSS score correlates with more aggressive clinical management, supporting the utility of disease-specific PROs guiding clinical practice.
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http://dx.doi.org/10.1111/jce.14795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749047PMC
December 2020

Clinical characteristics of familial schizophrenia.

Asia Pac Psychiatry 2021 Jun 14;13(2):e12422. Epub 2020 Oct 14.

Department of Psychiatry, Xijing Hospital, Xi'an, China.

Introduction: A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated.

Methods: This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia.

Results: Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P = .004), tobacco dependence (OR = 1.48, P = .006), alcohol dependence (OR = 1.74, P = .013), and physical illness (OR = 1.89, P = .001) were independently and significantly associated with a family history of mental disease.

Conclusion: Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.
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http://dx.doi.org/10.1111/appy.12422DOI Listing
June 2021

Association Between Selenium Level in Blood and Glycolipid Metabolism in Residents of Enshi Prefecture, China.

Biol Trace Elem Res 2021 Jul 6;199(7):2456-2466. Epub 2020 Oct 6.

China National Center for Food Safety Risk Assessment, Beijing, 100021, China.

The present study aimed to detect selenium (Se) levels in the blood of Enshi Prefecture residents in China and investigate the relationship between blood Se levels and glucose or lipid metabolism disorder. A cross-sectional study was conducted, and 1876 subjects were selected through cluster random sampling from Enshi Prefecture using a questionnaire survey, physical examinations, and biochemical blood tests. The mean blood Se level in the overall population was 0.128 ± 0.178 μg/mL. Se exhibits a "U"-shaped curve on the serum fasting plasma glucose (FPG) of the total samples, that is, when the blood Se is more than 0.131 μg/mL or less than 0.062 μg/mL, the FPG increases significantly. A significant negative correlation was demonstrated between the FPG levels of the 4-17-year-old age group and different blood Se levels (P < 0.001). No significant correlation was demonstrated between the serum triglyceride (TG) and blood Se levels. However, a positive correlation was demonstrated between blood Se and serum total cholesterol (TC) levels and the incidence of high cholesterol in the total population (P < 0.001). The odds ratio and related 95% confidence interval for the incidence of high cholesterol between the highest (≥ 0.133 μg/mL) and lowest blood Se (< 0.064 μg/mL) levels was 2.64 and 1.48-4.79, respectively. The results of this study are very important for the safety scope and risk-benefit assessment of Se in the human; however, further investigation with a larger sample size is required.
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http://dx.doi.org/10.1007/s12011-020-02372-9DOI Listing
July 2021

The Association between Dietary Patterns and Depressive Symptoms in Chinese Adults.

Biomed Res Int 2020 29;2020:8380151. Epub 2020 Aug 29.

Cancer System Biology Center, China-Japan Union Hospital, Jilin University, Changchun 130033, China.

Background: Previous studies of the relationship between diet and depression have focused on single nutrients or food. Recent research suggested that dietary patterns may offer more information than an individual nutrient in assessing disease risk. We designed this study to assess the association between dietary patterns and depressive symptoms in the adult population of China.

Methods: We identified 372 Chinese residents for this research. Factor analysis was used to extract dietary patterns from 30 predefined food groups. Dietary intake was assessed using an effective self-administered food frequency questionnaire, and depressive symptoms were assessed using the 9-item Patient Health Questionnaire (PHQ-9) score. Subjects were considered to have depressive symptoms when they had a PHQ-9 score of >4.

Results: We identified four eating patterns: "vegetables-fruits," "traditional Chinese," "pastry-fruits," and "animal food" dietary patterns. After adjusting for potential confounders, participants in the highest tertile animal food pattern (considered to be an unhealthy pattern) were more prone to depressive symptoms compared with participants in the lowest tertile (OR = 2.08, 95% CI: 1.02-4.24).

Conclusions: The animal food pattern was associated with an increased risk of depressive symptoms.
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http://dx.doi.org/10.1155/2020/8380151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475746PMC
May 2021

High hepatitis C virus cure rates with approved interferon-free direct-acting antivirals among diverse mainland Chinese patients including genotypes 3a and 3b.

J Gastroenterol Hepatol 2021 Mar 5;36(3):767-774. Epub 2020 Aug 5.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.

Background And Aim: Globally, China has the highest chronic hepatitis C (CHC) burden, but its real-world direct-acting antiviral (DAA) data are limited. Our aim is to investigate the real-world outcome of China Food and Drug Administration-approved DAA therapies across mainland China including those with genotype (GT) 3.

Methods: The REAL-C is a multinational real-world interferon-free DAA-treated CHC registry of several mainland China and other Asian centers. We evaluated the sustained virological response rate 12 weeks after end of treatment (SVR12), adverse events, and treatment effect on liver function and fibrosis (fibrosis-4 index).

Results: We analyzed 859 DAA-treated CHC patients (6/1/2017-5/30/2019) from 12 mainland China centers (three municipalities and nine provinces): median age 52, 49.9% male, 33.1% cirrhosis, 95% treatment naïve, and 2.5% HBsAg . The most common GT was GT1b (523, 62.2%), followed by GT2a (156, 18.5%), GT3b (74, 8.8%), GT3a (41, 4.9%), and GT6 (37, 4.4%). SVR12 rates were 98.0% overall (95% confidence interval 96.9-98.8%), 98.1% for GT1b, 96.8% GT2a, 100% GT3a, 97.3% GT3b, and 100% GT6. Baseline cirrhosis and male sex but not prior treatment history, renal dysfunction, age, and GTs were associated with SVR12. For both cirrhotic and non-cirrhotic patients, there were significant improvement in liver function tests, alpha fetoprotein, and fibrosis-4 index with SVR12. Serious adverse events were rare (1.1%) with only nine patients discontinuing therapy prematurely and anemia being the most common adverse event (13.1%, mostly with ribavirin).

Conclusions: In real-world Chinese patients with diverse GTs, Chinese Food and Drug Administration-approved interferon-free DAAs were well tolerated, provided high cure rates (98.0% overall) including GT3a/3b, and led to improvement of liver function.
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http://dx.doi.org/10.1111/jgh.15192DOI Listing
March 2021

Enhancement of catalytic toluene combustion over Pt-CoO catalyst through in-situ metal-organic template conversion.

Chemosphere 2021 Jan 21;262:127738. Epub 2020 Jul 21.

School of Environment and Energy, South China University of Technology, 510006 Guangzhou, China; National Engineering Laboratory for VOCs Pollution Control Technology and Equipment (SCUT), 510006 Guangzhou, China; Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control (SCUT), 510006 Guangzhou, China; Guangdong Provincial Engineering and Technology Research Centre for Environmental Risk Prevention and Emergency Disposal (SCUT), 510006 Guangzhou, China. Electronic address:

A Pt-CoO catalyst named Pt-Co(OH)-O was prepared by metal-organic templates (MOTs) conversion and used for catalytic oxidation of toluene. Through the conversion, the morphology of catalysts transformed from rhombic dodecahedron to nanosheet and the coated Pt nanoparticles (NPs) were more exposed. The Binding energy shift in XPS test indicates that the strong metal-support strong interaction (SMSI) has enhanced, and the physicochemical changes caused by it are characterized by other techniques. At the same time, Pt-Co(OH)-O showed the best catalytic performance (T = 157 °C, T = 167 °C, E = 40.85 kJ mol, TOF = 2.68 × 10 s) and good stability. In addition, the in situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) studies have shown that because SMSI weakened the Co-O bond, the introduction of Pt NPs can make the migration of oxygen in the catalyst easier. The change of binding energy change and the content of various species in the quasi in situ XPS experiment further confirmed that the Pt-Co(OH)-O catalyst has stronger SMSI, resulting in its stronger electron transfer ability and oxygen migration ability, which is conducive to catalytic reactions. This work provides new ideas for the development of supported catalysts and provides a theoretical reference for the relevant verification of SMSI.
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http://dx.doi.org/10.1016/j.chemosphere.2020.127738DOI Listing
January 2021

[Circular RNA homeodomain-interacting protein kinase 3 (circHIPK3) promotes growth and metastasis of glioma cells by sponging miR-124-3p].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 Jul;36(7):609-615

Department of Neurosurgery, First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China.

Objective To investigate the effect of circular RNA homeodomain-interacting protein kinase 3 (circHIPK3) on the proliferation and metastasis of glioma cells via sponging miR-124-3p. Methods T98G cells were transfected with circHIPK3 short hairpin RNA (sh-circHIPK3), pcDNA3.1-circHIPK3, miR-124-3p mimics or pcDNA3.1-WEE1 using Lipofectamine 3000 reagent following the manufacturer's instructions. Real-time quantitative PCR was performed to evaluate the expression of circHIPK3 and miR-124-3p in glioma tissues and cell lines. CCK-8 assay was employed to assess the proliferation of T98G cells. Transwell assay was applied to validate the invasion of T98G cells. The targeting relationship among miR-124-3p, circHIPK3 and serine/threonine kinase WEE1 were verified by dual-luciferase reporter gene assay. The expression of WEE1 and epithelial mesenchymal transition (EMT)-related factors (E-cadherin, N-cadherin and vimentin) were measured by Western blot analysis. In addition, after the competitive binding of circHIPK3 and WEE1 to miR-124-3p, the proliferation of T98G cells was detected by CCK-8 assay; the invasion of T98G cells was evaluated by Transwell assay. Results The circHIPK3 was upregulated in glioma tissues and cell lines. Knockdown of circHIPK3 repressed the proliferation, invasion and EMT of T98G cells. Dual-luciferase reporter gene assay confirmed that miR-124-3p was the target gene of circHIPK3, while WEE1 was the target gene of miR-124-3p. The miR-124-3p was over-expressed simultaneously with circHIPK3 or WEE1. Co-transfected sh-circHIPK3 and pcDNA3.1-WEE1 restored the inhibitory effect of miR-124-3p overexpression on the proliferation, invasion and EMT of T98G cells. Conclusion The circRNA-HIPK3 and WEE1 can promote the proliferation, invasion and EMT of glioma cells by sponging miR-124-3p.
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July 2020

Contribution of Penicillin Allergy Labels to Second-Line Broad-Spectrum Antibiotic Prescribing for Pediatric Respiratory Tract Infections.

Infect Dis Ther 2020 Sep 13;9(3):677-681. Epub 2020 Jul 13.

Boise VA Medical Center, Boise, ID, USA.

Introduction: Antibiotic allergies are overdiagnosed. This may lead to unnecessary use of second-line broader-spectrum agents in place of narrower-spectrum guideline-recommended first-line therapies especially for uncomplicated respiratory tract infections. The extent to which this occurs for children with respiratory tract infections is unknown.

Methods: We included outpatient encounters for patients < 18 years with acute respiratory tract infections (sinusitis, bronchitis, bronchiolitis, upper respiratory tract infection, pharyngitis, otitis media). Patients were classified as penicillin allergic based on the presence of an allergy label in the electronic medical record. First-line guideline-recommended antibiotics included penicillin, amoxicillin or amoxicillin-clavulanate; all others were considered second line. The percentage of patients treated with first-line versus second-line antibiotics was compared between those with and without penicillin allergy. Additionally, we calculated the contribution of penicillin allergy to overall use of second-line antibiotics.

Results: Among 17,578 eligible encounters for respiratory tract infections, 1332 (8%) included patients with a penicillin allergy label. Overall, second-line antibiotics were prescribed in 15% of encounters. Second-line antibiotics were prescribed in 91% of encounters for penicillin-allergic patients, compared with 8% of encounters for non-allergic patients (P < 0.001). Patients with penicillin allergy labels accounted for 47% of all second-line antibiotic prescriptions.

Conclusion: In a large population of pediatric outpatient encounters for acute respiratory tract infections, patients labeled with a penicillin allergy accounted for nearly half of second-line antibiotics, which are often broader spectrum. Efforts to de-label children with penicillin allergies have the potential to reduce broader-spectrum antibiotic use.
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http://dx.doi.org/10.1007/s40121-020-00320-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452971PMC
September 2020

Surgical resection of primary tumor is associated with prolonged survival in low-grade pancreatic neuroendocrine tumors.

Clin Res Hepatol Gastroenterol 2021 Jan 5;45(1):101432. Epub 2020 May 5.

Cancer System Biology Center, China-Japan Union Hospital, Jilin University, China; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China. Electronic address:

Introduction: The incidence of pancreatic neuroendocrine tumors (PNETs) is increasing over the past few decades. Surgery for low-grade and small PNETs of less than 2cm and N0M0 is still debated. The purpose of this study is to examine the association between surgical resection and survival in patients with low-grade nonfunctioning PNETs.

Materials And Methods: Patients diagnosed with PNETs between 2004 and 2015 were extracted from SEER. Kaplan-Meier methods and Cox proportional hazard models were used to estimate independent predictors in PNETs patients.

Results: A total of 2637 patients (2147 underwent surgical resection and 490 did not undergo surgery) with histologically confirmed low-grade PNETs in this cohort study. Overall survival (OS) and cancer-specific survival (CSS) of patients with surgery was better than those without surgery (log rank test P<0.001, P<0.001). Multivariate Cox regression analysis showed that surgical status was an independent prognostic factor associated with OS (HR 3.257, 95%CI: 2.635, 4.026) and CSS (HR 3.546, 95%CI: 2.798, 4.493). Subgroup analysis suggested the patients receiving surgery apparently had better OS and CSS regardless of tumor size (all log rank test P<0.001, all log rank test P<0.001) and SEER stage (all log rank test P<0.001, all log rank test P<0.001), compared to patients without removal of the primary tumor.

Conclusions: Surgical resection of primary tumor may have a significant benefit on survival for patients with low-grade nonfunctioning PNETs. To determine the optimal management, grade, stage and tumor size should be considered comprehensively.
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http://dx.doi.org/10.1016/j.clinre.2020.04.003DOI Listing
January 2021

Association of High-Mobility Group Box-1 with Inflammationrelated Cytokines in the Aqueous Humor with Acute Primary Angle-Closure Eyes.

Curr Mol Med 2021 ;21(3):237-245

Laboratory Animal Center, Guangxi Medical University, Nanning 530021, China.

Aim: The aim of this study was to measure the levels of High-mobility group box-1 (HMGB1) and inflammation-related cytokines in the aqueous humor of patients with acute primary angle-closure glaucoma (APAG) and age-related cataract eyes (ARC).

Methods: Aqueous humor samples were obtained from 59 eyes of 59 Chinese subjects (APAG, 32 eyes; and ARC, 27eyes). The multiplex bead immunoassay technique was used to measure the levels of HMGB1 and IL-8, IL-6, G-CSF, MCP-3, VEGF, sVEGFR- 1, sVEFGR-2, TNF-α, PDGF, and IL-10 in aqueous. The data of Patients' demographics and preoperative intraocular pressure (IOP) were also collected for detailed analysis.

Results: The APAG group showed significantly elevated concentrations of HMGB1, IL- 8, IL-6, G-CSF, VEGF, sVEGFR-1, and TNF-α than those in the ARC group. Aqueous HMGB1 level correlated significantly with IOP, IL-8, IL-6, G-CSF and sVEGFR-1 levels but not with age, TNF-α, or VEGF levels.

Conclusion: The aqueous level of HMGB1 is elevated in APAG and associated with aqueous level of inflammation-related cytokines, suggesting an association between elevated levels of HMGB1, APAC and certain inflammatory modulators which, of course, should lead to further investigations in order to demonstrate the cause and effect.
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http://dx.doi.org/10.2174/1566524020666200413113107DOI Listing
January 2021

Association of the CACNA2D2 gene with schizophrenia in Chinese Han population.

PeerJ 2020 5;8:e8521. Epub 2020 Feb 5.

Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, Jilin, China.

Background: Schizophrenia (SCZ) is a severely complex psychiatric disorder in which ~80% can be explained by genetic factors. Single nucleotide polymorphisms (SNPs) in calcium channel genes are potential genetic risk factors for a spectrum of psychiatric disorders including SCZ. This study evaluated the association between SNPs in the voltage-gated calcium channel auxiliary subunit alpha2delta 2 gene () and SCZ in the Han Chinese population of Northeast China.

Methods: A total of 761 SCZ patients and 775 healthy controls were involved in this case-control study. Three SNPs (rs3806706, rs45536634 and rs12496815) of were genotyped by the MALDI-TOF-MS technology. Genotype distribution and allele frequency differences between cases and controls were tested by Chi-square (χ ) in males and females respectively using SPSS 24.0 software. Linkage disequilibrium and haplotype analyses were conducted using Haploview4.2. The false discovery rate correction was utilized to control for Type I error by R3.2.3.

Results: There was a significant difference in allele frequencies (χ = 9.545, = 0.006) and genotype distributions (χ = 9.275, = 0.006) of rs45536634 between female SCZ patients and female healthy controls after adjusting for multiple comparisons. Minor allele A (OR = 1.871, 95% CI [1.251-2.798]) and genotype GA + AA (OR = 1.931, 95% CI [1.259-2.963]) were associated with an increased risk of SCZ. Subjects with haplotype AG consisting of rs45536634 and rs12496815 alleles had a higher risk of SCZ (OR = 1.91, 95% CI [1.26-2.90]) compared those with other haplotypes.

Conclusions: This study provides evidence that polymorphisms may influence the susceptibility to SCZ in Han Chinese women.
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http://dx.doi.org/10.7717/peerj.8521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007731PMC
February 2020

The expression and role of PIDD in retina after optic nerve crush.

J Mol Histol 2020 Feb 17;51(1):89-97. Epub 2020 Feb 17.

Laboratory Animal Center, Guangxi Medical University, Nanning, 530021, China.

To examine the expression of P53-induced protein with a death domain (PIDD) at retina in animal model of optic nerve crush (ONC) and to investigate the role of PIDD in retinal glial activation and NF-κB activation induced by optic nerve damage, ONC animal model was established in Sprague-Dawley rats. PIDD has three isoforms (Isof); Western blot was performed to examine the expression of PIDD (Isof-1, Isof-2, and Isof-3, respectively) in retina at different time points after ONC. Retinal glial activation is closely associated with retinal neuronal death and is monitored by the expression of GFAP+ glial cells and IBA1+ microglia, then activated microglia leads to inflammatory cytokine production. NF-kB activation in glial cells also can promote neuronal death. In our study, the role of PIDD in retinal glial activation and NF-kB activation was investigated with PIDD inhibition selectively. PIDD expression (Isof-1 and Isof-3) was dramatically increased, and peaked at 3 days after ONC, while Isof-2 did not show any difference. In the ONC animal model, the number of GFAP+ glial cells and IBA1+ microglia in retinal layers was increased significantly, inflammatory cytokine production was upregulated, and NF-κB in glial cell was also activated. Moreover, those responses induced by optic nerve damage were attenuated with PIDD inhibition, which indicated that PIDD could regulate retinal glial activation, neuro-inflammation, and NF-κB activation. These results provided the direct demonstration that the PIDD (Isof-1and Isof-3) was overexpressed in retina after ONC, and PIDD may be involved in retinal neurodegenerative diseases by regulating retinal glial activation and NF-κB activation.
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http://dx.doi.org/10.1007/s10735-020-09860-1DOI Listing
February 2020

Macroscopic Hexagonal CoO Tubes Derived from Controllable Two-Dimensional Metal-Organic Layer Single Crystals: Formation Mechanism and Catalytic Activity.

Inorg Chem 2020 Mar 12;59(5):3062-3071. Epub 2020 Feb 12.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, China.

Macroscopic CoO hexagonal tubes were successfully synthesized using hollow two-dimensional (2D) MOL (metal-organic layer) single crystals as sacrificial templates. The hollow 2D MOL single crystals were prepared under hydrothermal conditions with acetonitrile (MeCN) as an interference agent. The formation of hollow-structured 2D MOL single crystals was tracked by time-dependent experiments, and two simultaneous paths-namely, the crystal-to-crystal transformation in solution and the dissolution + migration (toward the external surface) of inner crystallites-were identified as playing a key role in the formation of the unique hollow structure. The calculated change in Gibbs free energy (Δ = -1.18 eV) indicated that the crystal-to-crystal transformation was spontaneous at 393 K. Further addition of MeCN as an interference agent eventually leads to the formation of macroscopic hexagonal tubes. Among all of the as-synthesized CoO, Co-MeCN-O with a hexagonal tube morphology exhibited the best catalytic performance in toluene oxidation, it achieved a toluene conversion of 90% () at ∼227 °C (a space velocity of 60 000 mL g h) and the activity energy () is 69.5 kJ mol. A series of characterizations were performed to investigate the structure-activity correlation. It was found that there are more structure defects, more adsorbed surface oxygen species, more surface Co species, and higher reducibility at low temperatures on the Co-MeCN-O than on other CoO samples; these factors are responsible for its excellent catalytic performance. The in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) characterization showed that, when there is no oxygen in the atmosphere, the lattice oxygen may be involved in the activation of toluene, and the gas-phase oxygen replenished by the oxygen vacancies was essential for the total oxidation of toluene on the surface of the Co-MeCN-O catalysts, it also proves the importance of oxygen vacancies. Moreover, for the Co-MeCN-O catalysts, no obvious decrease in catalytic performance was observed after 120 h at 220 °C and it is still stable after cycling tests, which indicates that it exhibits excellent stability for toluene oxidation. This study sheds lights on the controllable synthesis of macroporous-microporous materials in single-crystalline form without an external template, and, thus, it may serve as a reference for future design and synthesis of hollow porous materials with outstanding catalytic performance.
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http://dx.doi.org/10.1021/acs.inorgchem.9b03396DOI Listing
March 2020

Evaluation of a new point-of-care oral anti-HCV test for screening of hepatitis C virus infection.

Virol J 2020 01 31;17(1):14. Epub 2020 Jan 31.

Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China.

Background: Hepatitis C virus (HCV) infection is a public health issue for which an effective universal screening method is urgently needed. An oral anti-HCV test could provide a noninvasive and rapid screening strategy for HCV infection. This study evaluated the performance of a new point-of-care oral assay developed by Well for the detection of HCV antibody.

Methods: Individuals from three centers with and without HCV infection were enrolled. All participants were tested for oral HCV antibody using the Well assay and for serum HCV antibody using established tests (ARCHITECT i2000 anti-HCV assay and InTec serum anti-HCV assay). For participants who obtained positive results, HCV RNA was tested for verification. Some patients underwent the OraQuick HCV test at the same time, and some self-tested with the Well assay during the same period.

Results: A total of 1179 participants, including 486 patients with chronic HCV infection, 108 patients with other liver diseases, and 585 individuals who underwent physical examination, were enrolled. The Well anti-HCV test had a sensitivity of 91.88% (95% confidence interval [CI]: 88.97-94.09%) and a specificity of 98.00% (96.58-98.86%) for oral HCV antibody detection. The consistency between the Well and InTec assays was 97.02% (1138/1179). The consistency between the Well and OraQuick assays was 98.50% (197/200). Furthermore, the results of self-testing were highly consistent with those of researcher-administered tests (Kappa = 0.979). In addition, the HCV RNA results also showed that HCV RNA could only be detected on 1 of the 39 false-negative samples, and for 172 positive HCV RNA results, 171 could be detected by the Well oral anti-HCV assay.

Conclusions: The Well oral anti-HCV test offers high sensitivity and specificity and performed comparably to both the OraQuick assay and InTec assay for HCV diagnosis. Thus, the Well test represents a new tool for universal HCV screening to identify infected patients, particularly in regions with limited medical resources.
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http://dx.doi.org/10.1186/s12985-020-1293-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995050PMC
January 2020

Characterization of Adult IgA Vasculitis Patients at a Same-Day Dermatology Clinic: A Retrospective Chart Review.

J Cutan Med Surg 2020 Jan/Feb;24(1):86-87

7060 Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1177/1203475419882637DOI Listing
November 2020

Toluene oxidation over Co-rich spinel CoO: Evaluation of chemical and by-product species identified by in situ DRIFTS combined with PTR-TOF-MS.

J Hazard Mater 2020 03 23;386:121957. Epub 2019 Dec 23.

School of Environment and Energy, South China University of Technology, Guangzhou, 510006, PR China; National Engineering Laboratory for VOCs Pollution Control Technology and Equipment, Guangzhou Higher Education Mega Centre, Guangzhou, 510006, PR China; Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control (SCUT), Guangzhou Higher Education Mega Centre, Guangzhou, 510006, PR China. Electronic address:

Series of Co-rich spinel CoO catalysts were synthesized and evaluated by toluene catalytic oxidation. An outstanding activity was achieved over CoO-N utilizing Co(NO)·6HO as precursor (T = 211 °C, T = 217 °C at conditions: 1000 ppm(v), WHSV = 60 000 mL g h). Results of comparative characterizations demonstrated that such excellent performance was mainly attributed to large surface area, high reducibility at low temperature, high abundance of Co ions and structure defects, as well as highly active surface oxygen. The results of in situ DRIFTS revealed that in the air or N atmosphere, the by-products were almost the same. The reaction pathway of toluene oxidation can be described as follow: transformation of toluene from benzyl alcohol, benzaldehyde, benzoate, benzene, phenol, benzoquinone, maleic acid and to final products, which were fully confirmed by PTR-TOF-MS. Besides, ring opened by-products, such as acetone, acetic acid, acetaldehyde, etc. were also detected. In this work, the combination of in situ DRIFTS and PTR-TOF-MS provided a promising approach for further understanding of the mechanism of VOCs elimination.
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http://dx.doi.org/10.1016/j.jhazmat.2019.121957DOI Listing
March 2020

Catalytic Performance of Toluene Combustion over Pt Nanoparticles Supported on Pore-Modified Macro-Meso-Microporous Zeolite Foam.

Nanomaterials (Basel) 2019 Dec 20;10(1). Epub 2019 Dec 20.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, China.

Herein, to investigate the pore effect on toluene catalytic oxidation activity, novel supports for Pt nanoparticles-ZSM-5 foam (ZF) fabricated using polyurethane foam (PUF) templates and pore-modified ZSM-5 foam (ZF-D) treated by acid etching, comparing with conventional ZSM-5 and pore-modified ZSM-5 (ZSM-5-D), were successfully synthesized. Pt nanoparticles were loaded on series ZSM-5 supports by the impregnation method. The Pt loaded on ZF-D (Pt/ZF-D) showed the highest activity of toluene catalytic combustion (i.e., T = 158 °C), with extraordinary stability and an anti-coking ability. Based on various catalysts characterizations, the unique macropores of ZF facilitated the process of acid etching as compared to conventional ZSM-5. The mesopores volume of ZF-D significantly increased due to acid etching, which enlarged toluene adsorption capacity and led to a better Pt distribution since some Pt nanoparticles were immobilized into some mesopores. Specifically, the microporous distribution was centered in the range of 0.7-0.8 nm close to the molecular diameter of toluene (ca. 0.67 nm), which was key to the increasing toluene diffusion rate due to pore levitation effect of catalysts and accessibility of metal. Furthermore, the reducibility of Pt nanoparticles was improved on Pt/ZF-D, which enhanced the activity of toluene catalytic oxidation.
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http://dx.doi.org/10.3390/nano10010030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023492PMC
December 2019
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