Milton Packer

Milton Packer

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Milton Packer

Milton Packer

Publications by authors named "Milton Packer"

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Interplay of adenosine monophosphate-activated protein kinase/sirtuin-1 activation and sodium influx inhibition mediates the renal benefits of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes: A novel conceptual framework.

Authors:
Milton Packer

Diabetes Obes Metab 2020 May 20;22(5):734-742. Epub 2020 Feb 20.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1111/dom.13961DOI Listing
May 2020

Characterization, Pathogenesis, and Clinical Implications of Inflammation-Related Atrial Myopathy as an Important Cause of Atrial Fibrillation.

Authors:
Milton Packer

J Am Heart Assoc 2020 Apr 3;9(7):e015343. Epub 2020 Apr 3.

Baylor Heart and Vascular Institute Baylor University Medical Center Dallas TX.

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http://dx.doi.org/10.1161/JAHA.119.015343DOI Listing
April 2020

Critical Examination of Mechanisms Underlying the Reduction in Heart Failure Events With SGLT2 Inhibitors: Identification of a Molecular Link Between Their Actions to Stimulate Erythrocytosis and to Alleviate Cellular Stress.

Authors:
Milton Packer

Cardiovasc Res 2020 Apr 3. Epub 2020 Apr 3.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX and Imperial College, London, UK.

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http://dx.doi.org/10.1093/cvr/cvaa064DOI Listing
April 2020

Epicardial Adipose Tissue Inflammation Can Cause the Distinctive Pattern of Cardiovascular Disorders Seen in Psoriasis.

Authors:
Milton Packer

Am J Med 2020 Mar 11;133(3):267-272. Epub 2019 Sep 11.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Tex; Imperial College, London. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.08.027DOI Listing
March 2020

SGLT2 Inhibitors Produce Cardiorenal Benefits by Promoting Adaptive Cellular Reprogramming to Induce a State of Fasting Mimicry: A Paradigm Shift in Understanding Their Mechanism of Action.

Authors:
Milton Packer

Diabetes Care 2020 Mar;43(3):508-511

Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX

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http://dx.doi.org/10.2337/dci19-0074DOI Listing
March 2020

Mitigation of the Adverse Consequences of Nutrient Excess on the Kidney: A Unified Hypothesis to Explain the Renoprotective Effects of Sodium-Glucose Cotransporter 2 Inhibitors.

Authors:
Milton Packer

Am J Nephrol 2020 Mar 3:1-5. Epub 2020 Mar 3.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas, USA,

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http://dx.doi.org/10.1159/000506534DOI Listing
March 2020

How Should Physicians Assess Myocardial Contraction?: Redefining Heart Failure With a Preserved Ejection Fraction.

JACC Cardiovasc Imaging 2020 Mar;13(3):873-878

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Imperial College, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2019.12.021DOI Listing
March 2020

Role of Deranged Energy Deprivation Signaling in the Pathogenesis of Cardiac and Renal Disease in States of Perceived Nutrient Overabundance.

Authors:
Milton Packer

Circulation 2020 Mar 13. Epub 2020 Mar 13.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX and Imperial College, London, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.045561DOI Listing
March 2020

A putative placebo analysis of the effects of sacubitril/valsartan in heart failure across the full range of ejection fraction.

Eur Heart J 2020 Mar 28. Epub 2020 Mar 28.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/eurheartj/ehaa184DOI Listing
March 2020

Early Effects of Starting Doses of Enalapril in Patients with Chronic Heart Failure in the SOLVD Treatment Trial.

Am J Med 2020 Feb 8;133(2):e25-e31. Epub 2019 Aug 8.

Veterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; George Washington University, Washington, DC. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.06.053DOI Listing
February 2020

Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction in Patients With Nonalcoholic Fatty Liver Disease.

Authors:
Milton Packer

Am J Med 2020 Feb 14;133(2):170-177. Epub 2019 Oct 14.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Tex; Imperial College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.09.002DOI Listing
February 2020

Do most patients with obesity or type 2 diabetes, and atrial fibrillation, also have undiagnosed heart failure? A critical conceptual framework for understanding mechanisms and improving diagnosis and treatment.

Authors:
Milton Packer

Eur J Heart Fail 2020 Feb 17;22(2):214-227. Epub 2019 Dec 17.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1646DOI Listing
February 2020

Impaired systemic venous capacitance: the neglected mechanism in patients with heart failure and a preserved ejection fraction?

Eur J Heart Fail 2020 Feb 16;22(2):173-176. Epub 2020 Jan 16.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1702DOI Listing
February 2020

Concerns about the use of metformin as a first-line agent to slow the progression of chronic kidney disease in diabetes.

Authors:
Milton Packer

Diabetes Res Clin Pract 2020 02 16;160:108024. Epub 2020 Jan 16.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA; Imperial College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2020.108024DOI Listing
February 2020

Potential Role of Atrial Myopathy in the Pathogenesis of Stroke in Rheumatoid Arthritis and Psoriasis: A Conceptual Framework and Implications for Prophylaxis.

Authors:
Milton Packer

J Am Heart Assoc 2020 Feb 24;9(3):e014764. Epub 2020 Jan 24.

Baylor Heart and Vascular Institute Baylor University Medical Center Dallas TX.

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http://dx.doi.org/10.1161/JAHA.119.014764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033881PMC
February 2020

Autophagy stimulation and intracellular sodium reduction as mediators of the cardioprotective effect of sodium-glucose cotransporter 2 inhibitors.

Authors:
Milton Packer

Eur J Heart Fail 2020 Feb 10. Epub 2020 Feb 10.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1732DOI Listing
February 2020

Does Metformin Interfere With the Cardiovascular Benefits of SGLT2 Inhibitors? Questions About Its Role as the Cornerstone of Diabetes Treatment.

Authors:
Milton Packer

Am J Med 2020 Feb 12. Epub 2020 Feb 12.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Tex; Imperial College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.01.016DOI Listing
February 2020

Comparison of BNP and NT-proBNP in Patients With Heart Failure and Reduced Ejection Fraction.

Circ Heart Fail 2020 Feb 17;13(2):e006541. Epub 2020 Feb 17.

BHF Cardiovascular Research Centre, University of Glasgow, United Kingdom (R.R., P.S.J., S.L.K., P.W., J.J.V.M.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.006541DOI Listing
February 2020

New Evidence Supporting a Novel Conceptual Framework for Distinguishing Proportionate and Disproportionate Functional Mitral Regurgitation.

JAMA Cardiol 2020 Feb 19. Epub 2020 Feb 19.

Baylor Scott & White Heart and Vascular Hospital, Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1001/jamacardio.2019.5971DOI Listing
February 2020

Disproportionate functional mitral regurgitation: a new therapeutic target in patients with heart failure and a reduced ejection fraction.

Authors:
Milton Packer

Eur J Heart Fail 2020 Jan 24;22(1):23-25. Epub 2019 Apr 24.

Baylor Scott and White Heart and Vascular Hospital, Baylor University Medical Center, Dallas, TX, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ejhf.1469
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http://dx.doi.org/10.1002/ejhf.1469DOI Listing
January 2020

Is Long-Standing Atrial Fibrillation a Biomarker of or Contributor to the Symptoms or Progression of Chronic Heart Failure?

Authors:
Milton Packer

Am J Med 2020 Jan 17;133(1):17-18. Epub 2019 Jun 17.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Imperial College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.05.026DOI Listing
January 2020

A Compelling Case for Less Aggressive Arrhythmia Management in Patients With Chronic Heart Failure and Long-Standing Atrial Fibrillation.

Authors:
Milton Packer

J Card Fail 2020 Jan 26;26(1):85-92. Epub 2019 Aug 26.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Imperial College, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2019.08.011DOI Listing
January 2020

HFpEF Is the Substrate for Stroke in Obesity and Diabetes Independent of Atrial Fibrillation.

Authors:
Milton Packer

JACC Heart Fail 2020 Jan 6;8(1):35-42. Epub 2019 Nov 6.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; and Imperial College, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2019.09.002DOI Listing
January 2020

Prior Heart Failure Hospitalization, Clinical Outcomes, and Response to Sacubitril/Valsartan Compared With Valsartan in HFpEF.

J Am Coll Cardiol 2020 Jan 11;75(3):245-254. Epub 2019 Nov 11.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.11.003DOI Listing
January 2020

Do amiodarone and dronedarone prevent thrombo-embolic stroke by treating the atrial myopathy of patients with atrial fibrillation? A provocative hypothesis.

Authors:
Milton Packer

Europace 2020 Jan 3. Epub 2020 Jan 3.

Baylor Heart and Vascular Institute, Baylor University Medical Center, 621 N. Hall Street, Dallas, TX 75226, USA.

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http://dx.doi.org/10.1093/europace/euz347DOI Listing
January 2020

Drugs That Ameliorate Epicardial Adipose Tissue Inflammation May Have Discordant Effects in Heart Failure With a Preserved Ejection Fraction as Compared With a Reduced Ejection Fraction.

Authors:
Milton Packer

J Card Fail 2019 Dec 18;25(12):986-1003. Epub 2019 Sep 18.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Imperial College, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cardfail.2019.09.002DOI Listing
December 2019

Heightened risk of intensive rate control in patients with atrial fibrillation who are obese or have type 2 diabetes: A critical review and re-evaluation.

Authors:
Milton Packer

J Cardiovasc Electrophysiol 2019 Dec 29;30(12):3020-3024. Epub 2019 Oct 29.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1111/jce.14236DOI Listing
December 2019

Why Are Physicians So Confused about Acute Heart Failure?. Reply.

Authors:
Milton Packer

N Engl J Med 2019 12;381(24):2375-2376

Baylor University Medical Center, Dallas, TX

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http://dx.doi.org/10.1056/NEJMc1913976DOI Listing
December 2019

Is Any Patient with Chronic Heart Failure Receiving the Right Dose of the Right Beta-Blocker in Primary Care?

Authors:
Milton Packer

Am J Med 2019 11 12;132(11):e761-e762. Epub 2019 Apr 12.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.03.026DOI Listing
November 2019

Digoxin Use and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction.

Am J Med 2019 11 29;132(11):1311-1319. Epub 2019 May 29.

Veterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; George Washington University, Washington, DC. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.05.012DOI Listing
November 2019

Methodological and Clinical Heterogeneity and Extraction Errors in Meta-Analyses of Catheter Ablation for Atrial Fibrillation in Heart Failure.

Authors:
Milton Packer

J Am Heart Assoc 2019 Nov 18;8(21):e013779. Epub 2019 Oct 18.

Baylor Heart and Vascular Institute Baylor University Medical Center Dallas TX.

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http://dx.doi.org/10.1161/JAHA.119.013779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898828PMC
November 2019

Are healthcare systems now ready to adopt sacubitril/valsartan as the preferred approach to inhibiting the renin-angiotensin system in chronic heart failure? The culmination of a 20-year journey.

Authors:
Milton Packer

Eur Heart J 2019 Oct;40(40):3353-3355

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz281DOI Listing
October 2019

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.

N Engl J Med 2019 10 1;381(17):1609-1620. Epub 2019 Sep 1.

From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charité Universitätsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montréal, Université de Montréal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Université de Lorraine, Centre Hospitalier Régional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontifícia Universidade Católica de Campinas, São Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.).

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http://dx.doi.org/10.1056/NEJMoa1908655DOI Listing
October 2019

Neurohormonal Antagonists Are Preferred to an Implantable Cardioverter-Defibrillator in Preventing Sudden Death in Heart Failure.

Authors:
Milton Packer

JACC Heart Fail 2019 Oct 11;7(10):902-906. Epub 2019 Sep 11.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas; Imperial College, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2019.05.013DOI Listing
October 2019

Lessons learned from the DAPA-HF trial concerning the mechanisms of benefit of SGLT2 inhibitors on heart failure events in the context of other large-scale trials nearing completion.

Authors:
Milton Packer

Cardiovasc Diabetol 2019 10 4;18(1):129. Epub 2019 Oct 4.

Baylor Heart and Vascular Institute, Baylor University Medical Center, 621N. Hall Street, Dallas, TX, 75226, USA.

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http://dx.doi.org/10.1186/s12933-019-0938-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778368PMC
October 2019

The Parable of Schrödinger's Cat and the Illusion of Statistical Significance in Clinical Trials.

Authors:
Milton Packer

Circulation 2019 Sep 3;140(10):799-800. Epub 2019 Sep 3.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX. Imperial College, London, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.041245DOI Listing
September 2019

Redefining Heart Failure With a Reduced Ejection Fraction.

JAMA 2019 Sep 13. Epub 2019 Sep 13.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1001/jama.2019.15600DOI Listing
September 2019

Disease-treatment interactions in the management of patients with obesity and diabetes who have atrial fibrillation: the potential mediating influence of epicardial adipose tissue.

Authors:
Milton Packer

Cardiovasc Diabetol 2019 09 24;18(1):121. Epub 2019 Sep 24.

Baylor Heart and Vascular Institute, Baylor University Medical Center, 621 N. Hall Street, Dallas, TX, 75226, USA.

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http://dx.doi.org/10.1186/s12933-019-0927-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760044PMC
September 2019

Contrasting Effects of Pharmacological, Procedural, and Surgical Interventions on Proportionate and Disproportionate Functional Mitral Regurgitation in Chronic Heart Failure.

Circulation 2019 Aug 1;140(9):779-789. Epub 2019 May 1.

Division of Cardiology, Department of Internal Medicine and the Baylor Scott and White Heart and Vascular Hospital, Baylor University Medical Center, Dallas, TX (M.P., P.A.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039612DOI Listing
August 2019

Critical role of the epicardium in mediating cardiac inflammation and fibrosis in patients with type 2 diabetes.

Authors:
Milton Packer

Diabetes Obes Metab 2019 08 17;21(8):1765-1768. Epub 2019 Jun 17.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1111/dom.13792DOI Listing
August 2019

Risks of Intensive Treatment of Long-Standing Atrial Fibrillation in Patients With Chronic Heart Failure With a Reduced or Preserved Ejection Fraction.

Authors:
Milton Packer

Circ Cardiovasc Qual Outcomes 2019 Aug 25;12(8):e005747. Epub 2019 Jul 25.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX. Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005747DOI Listing
August 2019

Digoxin Discontinuation and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction.

J Am Coll Cardiol 2019 Aug;74(5):617-627

Veterans Affairs Medical Center, Washington, DC; Georgetown University, Washington, DC; George Washington University, Washington, DC. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.05.064DOI Listing
August 2019

Reconceptualization of the Molecular Mechanism by Which Sodium-Glucose Cotransporter 2 Inhibitors Reduce the Risk of Heart Failure Events.

Authors:
Milton Packer

Circulation 2019 Aug 5;140(6):443-445. Epub 2019 Aug 5.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX. Imperial College, London, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040909DOI Listing
August 2019

What causes sudden death in patients with chronic heart failure and a reduced ejection fraction?

Authors:
Milton Packer

Eur Heart J 2019 Aug 7. Epub 2019 Aug 7.

Baylor Heart and Vascular Institute, Baylor University Medical Center, 621 N. Hall Street, Dallas, TX, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz553DOI Listing
August 2019

Why Are Physicians So Confused about Acute Heart Failure?

Authors:
Milton Packer

N Engl J Med 2019 08;381(8):776-777

From the Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas; and Imperial College London, London.

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http://dx.doi.org/10.1056/NEJMe1904713DOI Listing
August 2019

Major reduction in the risk of sudden cardiac death in patients with chronic heart failure with the use of drug and device combinations that favourably affect left ventricular structure.

Authors:
Milton Packer

Eur J Heart Fail 2019 Jul 29;21(7):823-826. Epub 2019 May 29.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1501DOI Listing
July 2019

Nonarrhythmic Sudden Cardiac Death in Chronic Heart Failure-A Preventable Event?

Authors:
Milton Packer

JAMA Cardiol 2019 Jul 17. Epub 2019 Jul 17.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1001/jamacardio.2019.2228DOI Listing
July 2019

Outcomes and Effect of Treatment According to Etiology in HFrEF: An Analysis of PARADIGM-HF.

JACC Heart Fail 2019 Jun 8;7(6):457-465. Epub 2019 May 8.

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2019.02.015DOI Listing
June 2019

Neurohormonal and Transcatheter Repair Strategies for Proportionate and Disproportionate Functional Mitral Regurgitation in Heart Failure.

JACC Heart Fail 2019 Jun 8;7(6):518-521. Epub 2019 May 8.

Division of Cardiology, Department of Internal Medicine and the Baylor Scott and White Heart and Vascular Hospital, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jchf.2019.03.016DOI Listing
June 2019

Effect of catheter ablation on pre-existing abnormalities of left atrial systolic, diastolic, and neurohormonal functions in patients with chronic heart failure and atrial fibrillation.

Authors:
Milton Packer

Eur Heart J 2019 Jun;40(23):1873-1879

Baylor Heart and Vascular Institute, Baylor University Medical Center, 621 N. Hall Street, Dallas, TX, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568203PMC
June 2019

Compelling First-Line Drug and Device Therapies for the Prevention of Sudden Death in Patients With Chronic Heart Failure and a Reduced Ejection Fraction Who Are Candidates for an Implantable Cardioverter-Defibrillator.

Authors:
Milton Packer

Circ Arrhythm Electrophysiol 2019 06 4;12(6):e007430. Epub 2019 Jun 4.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX. Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCEP.119.007430DOI Listing
June 2019

Income Inequality and Outcomes in Heart Failure: A Global Between-Country Analysis.

JACC Heart Fail 2019 04 6;7(4):336-346. Epub 2019 Feb 6.

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2018.11.005DOI Listing
April 2019

Electrophysiological interventions in the treatment of chronic heart failure: a comparison of the strength of evidence supporting cardiac resynchronization for electrical conduction delay and catheter ablation for atrial fibrillation.

Authors:
Milton Packer

Eur J Heart Fail 2019 Apr 6;21(4):398-401. Epub 2019 Mar 6.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1447DOI Listing
April 2019

What Have We Learned From Randomized Controlled Trials of Catheter Ablation for Atrial Fibrillation in Patients With Chronic Heart Failure?

Authors:
Milton Packer

Circ Arrhythm Electrophysiol 2019 04;12(4):e007222

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX. Imperial College, London, United Kingdom.

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https://www.ahajournals.org/doi/10.1161/CIRCEP.119.007222
Publisher Site
http://dx.doi.org/10.1161/CIRCEP.119.007222DOI Listing
April 2019

Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.

JACC Cardiovasc Imaging 2019 02 12;12(2):353-362. Epub 2018 Dec 12.

Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X183101
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http://dx.doi.org/10.1016/j.jcmg.2018.11.006DOI Listing
February 2019

The conundrum of patients with obesity, exercise intolerance, elevated ventricular filling pressures and a measured ejection fraction in the normal range.

Authors:
Milton Packer

Eur J Heart Fail 2019 02 18;21(2):156-162. Epub 2018 Dec 18.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1377DOI Listing
February 2019

When Cardiovascular Trials Collide.

Authors:
Milton Packer

Eur Heart J 2019 Feb;40(6):501-504

Baylor University Medical Center, Dallas, TX, USA, Imperial College, London, UK, Tel: +1 214 820 7500.

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http://dx.doi.org/10.1093/eurheartj/ehy908DOI Listing
February 2019

Future large-scale clinical trials in cardiovascular medicine: challenges and uncertainties.

Eur J Heart Fail 2018 12;20(12):1645-1648

University of Michigan School of Medicine, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1002/ejhf.1360DOI Listing
December 2018

The epicardial adipose inflammatory triad: coronary atherosclerosis, atrial fibrillation, and heart failure with a preserved ejection fraction.

Authors:
Milton Packer

Eur J Heart Fail 2018 11 17;20(11):1567-1569. Epub 2018 Sep 17.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1294DOI Listing
November 2018

The Reply.

Authors:
Milton Packer

Am J Med 2018 10;131(10):e427

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Tex.

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https://linkinghub.elsevier.com/retrieve/pii/S00029343183048
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http://dx.doi.org/10.1016/j.amjmed.2018.05.009DOI Listing
October 2018

Risk of heart failure in diabetic patients receiving sulfonylureas: reply.

Authors:
Milton Packer

Eur J Heart Fail 2018 09 11;20(9):1372. Epub 2018 Jun 11.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1002/ejhf.1232DOI Listing
September 2018

Obesity-Associated Heart Failure as a Theoretical Target for Treatment With Mineralocorticoid Receptor Antagonists.

Authors:
Milton Packer

JAMA Cardiol 2018 09;3(9):883-887

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1001/jamacardio.2018.2090DOI Listing
September 2018

Building Castles in the Sky: Catheter Ablation in Patients With Atrial Fibrillation and Chronic Heart Failure.

Circulation 2018 08;138(8):751-753

Lankenau Heart Institute, Wynnewood, PA (P.R.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034583DOI Listing
August 2018

Questioning the obvious: does dyspnoea really matter in heart failure?

Authors:
Milton Packer

Eur Heart J 2018 08;39(30):2822-2824

Baylor Heart and Vascular Institute, Baylor University, Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1093/eurheartj/ehy354DOI Listing
August 2018

The CABANA Trial: an honourable view.

Authors:
Milton Packer

Eur Heart J 2018 Aug;39(30):2770

Distinguished Scholar in Cardiovascular Science, Baylor University Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1093/eurheartj/ehy381DOI Listing
August 2018

Potential mechanisms underlying differences in the effect of incretin-based antidiabetic drugs on the risk of major atherosclerotic ischemic events.

Authors:
Milton Packer

J Diabetes Complications 2018 06 24;32(6):616-617. Epub 2018 Mar 24.

Baylor Heart and Vascular Institute, Baylor University, Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2018.03.006DOI Listing
June 2018

Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure.

JACC Heart Fail 2018 06 11;6(6):489-498. Epub 2018 Apr 11.

British Heart Foundation (BHF) Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2018.02.004DOI Listing
June 2018

Potentiation of Insulin Signaling Contributes to Heart Failure in Type 2 Diabetes: A Hypothesis Supported by Both Mechanistic Studies and Clinical Trials.

Authors:
Milton Packer

JACC Basic Transl Sci 2018 Jun 25;3(3):415-419. Epub 2018 Jun 25.

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1016/j.jacbts.2018.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058949PMC
June 2018

Response by Packer to Letter Regarding Article, "Activation and Inhibition of Sodium-Hydrogen Exchange Is a Mechanism That Links the Pathophysiology and Treatment of Diabetes Mellitus With That of Heart Failure".

Authors:
Milton Packer

Circulation 2018 05;137(18):1981-1982

Baylor Heart and Vascular Institute, Baylor University Medical Center, Cardiology, Dallas, TX.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033088DOI Listing
May 2018

The Alchemist's Nightmare: Might Mesenchymal Stem Cells That Are Recruited to Repair the Injured Heart Be Transformed Into Fibroblasts Rather Than Cardiomyocytes?

Authors:
Milton Packer

Circulation 2018 05;137(19):2068-2073

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032190DOI Listing
May 2018

Epicardial Adipose Tissue May Mediate Deleterious Effects of Obesity and Inflammation on the Myocardium.

Authors:
Milton Packer

J Am Coll Cardiol 2018 05;71(20):2360-2372

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183437
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http://dx.doi.org/10.1016/j.jacc.2018.03.509DOI Listing
May 2018

Does a Target Dose or a Target Heart Rate Matter to Outcomes When Prescribing β-Blockers to Patients With Chronic Heart Failure?

Authors:
Milton Packer

Circ Cardiovasc Qual Outcomes 2018 04;11(4):e004605

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004605DOI Listing
April 2018

Leptin-Aldosterone-Neprilysin Axis: Identification of Its Distinctive Role in the Pathogenesis of the Three Phenotypes of Heart Failure in People With Obesity.

Authors:
Milton Packer

Circulation 2018 04;137(15):1614-1631

Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032474DOI Listing
April 2018

Incidence, Predictors, and Outcomes Associated With Hypotensive Episodes Among Heart Failure Patients Receiving Sacubitril/Valsartan or Enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure).

Circ Heart Fail 2018 04;11(4):e004745

Minneapolis VA Health Care System and University of Minnesota (O.V.). University of Colorado, Aurora (S.M.P.). Brigham and Women's Hospital, Harvard University, Boston, MA (B.C., A.S.D., S.D.S.). Novartis Pharmaceuticals Corporation, East Hanover, NJ (J.K., M.L., V.S.). University of Glasgow, United Kingdom (J.J.V.M.). Baylor University Medical Center, Dallas, TX (M.P.). Université de Montréal, Canada (J.R.). Medical University of South Carolina, Charleston (M.R.Z.). University of Gothenburg, Sweden (K.S.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004745DOI Listing
April 2018