Publications by authors named "Miguel Mano"

46Publications

Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription.

Nucleic Acids Res 2020 06;48(11):5891-5906

SAFU Laboratory, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.

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http://dx.doi.org/10.1093/nar/gkaa344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293028PMC
June 2020

Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection.

Nat Microbiol 2020 01 2;5(1):192-205. Epub 2019 Dec 2.

Host RNA Metabolism Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/s41564-019-0614-3DOI Listing
January 2020

Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction.

Microbiol Spectr 2019 05;7(3)

Host RNA Metabolism Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1128/microbiolspec.BAI-0002-2019DOI Listing
May 2019

Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.

Cell Rep 2019 05;27(9):2759-2771.e5

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy; School of Cardiovascular Medicine and Sciences, King's College London British Heart Foundation Centre, London SE5 9NU, UK; Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193061
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http://dx.doi.org/10.1016/j.celrep.2019.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547019PMC
May 2019

Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation.

Nat Commun 2019 02 25;10(1):926. Epub 2019 Feb 25.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149, Trieste, Italy.

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http://dx.doi.org/10.1038/s41467-019-08810-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389893PMC
February 2019

MicroRNAs at the Host-Bacteria Interface: Host Defense or Bacterial Offense.

Trends Microbiol 2019 03 23;27(3):206-218. Epub 2018 Nov 23.

Host RNA Metabolism Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany; RNA & Infection Group, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0966842X183023
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http://dx.doi.org/10.1016/j.tim.2018.10.011DOI Listing
March 2019

Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens.

EMBO J 2018 12 2;37(23). Epub 2018 Nov 2.

Host RNA Metabolism Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany

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http://dx.doi.org/10.15252/embj.201798529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276891PMC
December 2018

Shedding light on microRNA function via microscopy-based screening.

Methods 2019 01 5;152:55-64. Epub 2018 Oct 5.

Functional Genomics and RNA-based Therapeutics Group, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2018.09.011DOI Listing
January 2019

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.

Cell Death Differ 2018 12 19;25(12):2147-2164. Epub 2018 Apr 19.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Molecular Mechanisms of Cell Cycle Control Unit, Milan, Italy.

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http://dx.doi.org/10.1038/s41418-018-0100-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262016PMC
December 2018

High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors.

Hum Mol Genet 2017 11;26(22):4375-4387

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

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http://dx.doi.org/10.1093/hmg/ddx323DOI Listing
November 2017

Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.

Cancer Lett 2017 03 29;389:59-69. Epub 2016 Dec 29.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.12.025DOI Listing
March 2017

Human MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic Stress.

J Biol Chem 2015 Dec 14;290(49):29652-62. Epub 2015 Oct 14.

the Departamento de Química Biológica and Instituto de Química Biológica Ciencias Exactas y Naturales/Consejo de Investigaciones Científicas y Técnicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.671982
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http://dx.doi.org/10.1074/jbc.M115.671982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705963PMC
December 2015

Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction.

Proc Natl Acad Sci U S A 2015 Sep 24;112(36):11276-81. Epub 2015 Aug 24.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Hospital, 34149 Trieste, Italy

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http://dx.doi.org/10.1073/pnas.1503607112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568673PMC
September 2015

MicroRNA Screening and the Quest for Biologically Relevant Targets.

J Biomol Screen 2015 Sep 30;20(8):1003-17. Epub 2015 Mar 30.

International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy UC-BIOTECH, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal

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http://dx.doi.org/10.1177/1087057115578837DOI Listing
September 2015

MicroRNAs in glioblastoma: role in pathogenesis and opportunities for targeted therapies.

CNS Neurol Disord Drug Targets 2015 ;14(2):222-38

Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Faculty of Medicine, Pólo I, 3004-504 Coimbra, Portugal.

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http://dx.doi.org/10.2174/1871527314666150116123610DOI Listing
November 2015

Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection.

Nat Commun 2014 Aug 22;5:4718. Epub 2014 Aug 22.

Institute for Molecular Infection Biology (IMIB), University of Würzburg, Josef-Schneider-Strasse 2/D15, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1038/ncomms5718DOI Listing
August 2014

MicroRNAs in the interaction between host and bacterial pathogens.

FEBS Lett 2014 Nov 12;588(22):4140-7. Epub 2014 Aug 12.

Institute for Molecular Infection Biology (IMIB), University of Würzburg, 97080 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.08.002DOI Listing
November 2014

Metabolic control of YAP and TAZ by the mevalonate pathway.

Nat Cell Biol 2014 Apr 23;16(4):357-66. Epub 2014 Mar 23.

1] Laboratorio Nazionale CIB (LNCIB), Area Science Park, 34149 Trieste, Italy [2] Dipartimento di Scienze della Vita, Università degli Studi di Trieste, 34127 Trieste, Italy.

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http://dx.doi.org/10.1038/ncb2936DOI Listing
April 2014

Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity.

J Mol Cell Biol 2014 Apr 11;6(2):116-27. Epub 2014 Mar 11.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

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http://dx.doi.org/10.1093/jmcb/mju010DOI Listing
April 2014

Effect of class IV laser therapy on chemotherapy-induced oral mucositis: a clinical and experimental study.

Am J Pathol 2013 Dec 3;183(6):1747-1757. Epub 2013 Oct 3.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440130061
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http://dx.doi.org/10.1016/j.ajpath.2013.09.003DOI Listing
December 2013

Functional screening identifies miRNAs inducing cardiac regeneration.

Nature 2012 Dec 5;492(7429):376-81. Epub 2012 Dec 5.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy.

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http://dx.doi.org/10.1038/nature11739DOI Listing
December 2012

Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins.

Mol Ther 2012 Nov 31;20(11):2087-97. Epub 2012 Jul 31.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

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http://dx.doi.org/10.1038/mt.2012.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493462PMC
November 2012

Cell-Penetrating Peptides-Mechanisms of Cellular Uptake and Generation of Delivery Systems.

Pharmaceuticals (Basel) 2010 Mar 30;3(4):961-993. Epub 2010 Mar 30.

Center for Neuroscience and Cell Biology of Coimbra, Department of Zoology, University of Coimbra, Portugal.

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http://www.mdpi.com/1424-8247/3/4/961
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http://dx.doi.org/10.3390/ph3040961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034016PMC
March 2010

S4(13)-PV cell-penetrating peptide forms nanoparticle-like structures to gain entry into cells.

Bioconjug Chem 2010 Apr;21(4):774-83

Department of Developmental Biology, Institute of Molecular and Cell Biology, University of Tartu, EE51010 Tartu, Estonia.

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http://dx.doi.org/10.1021/bc900577eDOI Listing
April 2010

Nanoparticles from lipid-based liquid crystals: emulsifier influence on morphology and cytotoxicity.

J Phys Chem B 2010 Mar;114(10):3518-25

Department of Chemical Science, Cagliari University, CNBS and CSGI, ss 554, bivio Sestu, 09042 Monserrato (CA), Italy.

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http://dx.doi.org/10.1021/jp9098655DOI Listing
March 2010

Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.

J Cell Sci 2008 Feb;121(Pt 3):349-57

Molecular Biology Laboratory, Scuola Normale Superiore, AREA della Ricerca del CNR, Via Moruzzi 1, Pisa, Italy.

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http://dx.doi.org/10.1242/jcs.003632DOI Listing
February 2008

Cellular uptake of S413-PV peptide occurs upon conformational changes induced by peptide-membrane interactions.

Biochim Biophys Acta 2006 Mar 10;1758(3):336-46. Epub 2006 Feb 10.

Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.bbamem.2006.01.014DOI Listing
March 2006

Cationic liposomes for gene delivery.

Expert Opin Drug Deliv 2005 Mar;2(2):237-54

University of Coimbra, Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, Portugal.

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http://dx.doi.org/10.1517/17425247.2.2.237DOI Listing
March 2005

On the mechanisms of the internalization of S4(13)-PV cell-penetrating peptide.

Biochem J 2005 Sep;390(Pt 2):603-12

Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-517 Coimbra, Portugal.

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http://dx.doi.org/10.1042/BJ20050577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1198940PMC
September 2005

Biophysical characterization of cationic liposome-DNA complexes and their interaction with cells.

Methods Enzymol 2003 ;373:298-312

Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, 3000 Coimbra, Portugal.

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http://dx.doi.org/10.1016/s0076-6879(03)73019-5DOI Listing
February 2004