Michael B Yaffe

Michael B Yaffe

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Michael B Yaffe

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Substrate-based kinase activity inference identifies MK2 as driver of colitis.

Integr Biol (Camb) 2019 Oct 16. Epub 2019 Oct 16.

Cancer Research Institute and Division of Genetics, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/intbio/zyz025DOI Listing
October 2019

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Cell Syst 2019 Jul 10;9(1):74-92.e8. Epub 2019 Jul 10.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712193019
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http://dx.doi.org/10.1016/j.cels.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688637PMC
July 2019

Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.

Cancer Res 2019 May 15;79(10):2669-2683. Epub 2019 Mar 15.

Rutgers University, Biomedical and Health Sciences Center, Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, New Jersey.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-2614DOI Listing
May 2019

Atlas Drugged.

Cell 2019 May;177(4):803-805

Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Surgical Critical Care and Trauma, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.023DOI Listing
May 2019

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.

Cell Syst 2019 Feb 20;8(2):163-167.e2. Epub 2019 Feb 20.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688173PMC
February 2019

Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner.

J Trauma Acute Care Surg 2019 Jan;86(1):101-107

From the Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts (C.D.B, Y-W.K, G.S., D.L., M.B.Y.); Division of Acute Care Surgery and Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (C.D.B., M.B.Y.); Department of Surgery, University of Colorado Denver, Denver, Colorado (H.B.M., E.E.M.); Department of Radiology, University of Colorado Denver, Denver, Colorado (M.P.C.); and Department of Surgery, Denver Health Medical Center, Denver, Colorado (E.E.M.).

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http://dx.doi.org/10.1097/TA.0000000000002092DOI Listing
January 2019

Why geneticists stole cancer research even though cancer is primarily a signaling disease.

Authors:
Michael B Yaffe

Sci Signal 2019 Jan 22;12(565). Epub 2019 Jan 22.

Chief Scientific Advisor and Academic Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aaw3483DOI Listing
January 2019

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression.

Nat Commun 2019 01 24;10(1):421. Epub 2019 Jan 24.

Department of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea.

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http://dx.doi.org/10.1038/s41467-019-08287-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345998PMC
January 2019

A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils.

J Trauma Acute Care Surg 2018 11;85(5):936-943

From the Department of Surgery and Center for Vascular Biology Research (E.K.), Department of Surgery (C.J.H., L.C., N.S., L.E.O., C.H.C., K.I.), Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts; Department of Emergency Medicine (W.Y.K.), Seoul National University College of Medicine, Seoul, Republic of Korea; Massachusetts Institute of Technology (I.R., M.B.Y.), Cambridge, Massachusetts; and mAbDx, Inc (Y.C., M.M.), Eugene, Oregon.

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http://dx.doi.org/10.1097/TA.0000000000001971DOI Listing
November 2018

Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.

Bioorg Med Chem Lett 2018 10 19;28(19):3202-3205. Epub 2018 Aug 19.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287497PMC
October 2018

Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.

Cell Syst 2018 10 19;7(4):371-383.e4. Epub 2018 Sep 19.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Departments of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Divisions of Acute Care Surgery, Trauma, and Critical Care and Surgical Oncology, Harvard Medical School, Boston 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712183035
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http://dx.doi.org/10.1016/j.cels.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202253PMC
October 2018

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Proc Natl Acad Sci U S A 2018 05 16;115(18):E4236-E4244. Epub 2018 Apr 16.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142;

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http://dx.doi.org/10.1073/pnas.1722020115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939099PMC
May 2018

TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome.

J Clin Endocrinol Metab 2018 03;103(3):839-852

Thyroid Molecular Laboratory, Institute for Medical and Molecular Genetics, La Paz University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1210/jc.2017-01241DOI Listing
March 2018

Predicting the future of signaling for 2018.

Authors:
Michael B Yaffe

Sci Signal 2018 01 2;11(511). Epub 2018 Jan 2.

Chief Scientific Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA. David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/scisignal.aar7429DOI Listing
January 2018

Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.

J Trauma Acute Care Surg 2017 12;83(6):1053-1061

From the Koch Institute for Integrative Cancer Research (C.D.B.), Massachusetts Institute of Technology, Cambridge, Massachusetts; Department of Surgery (C.D.B.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Departments of Surgery (H.B.M., A.B., E.E.M.) and Pediatrics (C.C.S.), University of Colorado Denver, Denver, Colorado; Bonfils Blood Center (C.C.S.), Denver, Colorado; Department of Surgery (E.E.M.), Denver Health Medical Center, Denver, Colorado; Koch Institute (M.B.Y.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and Division of Acute Care Surgery and Critical Care, Department of Surgery (M.B.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/TA.0000000000001685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767103PMC
December 2017

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Cancer Cell 2017 10 28;32(4):411-426.e11. Epub 2017 Sep 28.

The David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929990PMC
October 2017

Highlight: Understanding radiation sialadenitis.

Authors:
Michael B Yaffe

Sci Signal 2017 Jun 6;10(482). Epub 2017 Jun 6.

Science Signaling, AAAS, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aan8666DOI Listing
June 2017

Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents.

J Am Chem Soc 2017 03 16;139(8):3033-3044. Epub 2017 Feb 16.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/jacs.6b12108DOI Listing
March 2017

Podcast for 14 March 2017: The Cancer Moonshot.

Sci Signal 2017 Mar 14;10(470). Epub 2017 Mar 14.

Associate Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aan1418DOI Listing
March 2017

Protein Regulation in Signal Transduction.

Cold Spring Harb Perspect Biol 2016 Jun 1;8(6). Epub 2016 Jun 1.

David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a005918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888820PMC
June 2016

Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma.

Cancer Cell 2016 Apr;29(4):435-436

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108163010
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http://dx.doi.org/10.1016/j.ccell.2016.03.022DOI Listing
April 2016

Leveraging signaling research to understand and treat disease.

Sci Signal 2016 Mar 29;9(421):eg4. Epub 2016 Mar 29.

Editor, Science Signaling, AAAS, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aaf6275DOI Listing
March 2016

Computational prediction of protein-protein interactions.

Methods Mol Biol 2015 ;1278:57-75

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2425-7_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435844PMC
December 2015

Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.

Biopolymers 2015 Nov;104(6):663-73

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702.

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http://dx.doi.org/10.1002/bip.22698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865893PMC
November 2015

Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.

Clin Cancer Res 2015 Oct 1;21(19):4410-9. Epub 2015 Jun 1.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://clincancerres.aacrjournals.org/content/early/2015/08/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624301PMC
October 2015

A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.

J Biomol Screen 2015 Sep 27;20(8):985-97. Epub 2015 Apr 27.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA Broad Institute of MIT and Harvard, Cambridge, MA, USA Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.1177/1087057115583037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377593PMC
September 2015

Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome.

Shock 2015 Aug;44(2):128-36

*Department of Biology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; †Department of Surgery, ‡Division of Translational Research, §Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and ∥Department of Biological Engineering, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1097/SHK.0000000000000386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830084PMC
August 2015

Engineered bromodomains to explore the acetylproteome.

Proteomics 2015 May 5;15(9):1470-5. Epub 2015 Mar 5.

Department of Biological Engineering, MIT, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/pmic.201400401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535431PMC
May 2015

Reproducibility in science.

Authors:
Michael B Yaffe

Sci Signal 2015 Apr 7;8(371):eg5. Epub 2015 Apr 7.

Michael B. Yaffe is the Chief Scientific Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA, and Professor at David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail:

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http://dx.doi.org/10.1126/scisignal.aaa5764DOI Listing
April 2015

Criteria for biological reproducibility: what does "n" mean?

Sci Signal 2015 Apr 7;8(371):fs7. Epub 2015 Apr 7.

David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aab1125DOI Listing
April 2015

Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.

Cancer Cell 2015 Apr;27(4):489-501

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398916PMC
April 2015

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Mol Cell 2015 Jan 4;57(1):95-107. Epub 2014 Dec 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289430PMC
January 2015

Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs.

Biochemistry 2014 Sep 3;53(36):5771-8. Epub 2014 Sep 3.

Departments of Chemistry and Biology, and ‡Departments of Biology and Biological Engineering, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/bi500862cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165445PMC
September 2014

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Cell 2014 Aug;158(5):1094-1109

Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140098
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http://dx.doi.org/10.1016/j.cell.2014.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250222PMC
August 2014

A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways.

Sci Signal 2014 May 13;7(325):ra44. Epub 2014 May 13.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA. Institute for Soldier Nanotechnologies, MIT, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scisignal.2005261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138219PMC
May 2014

Death of a Titan.

Sci Signal 2013 Dec 17;6(306):eg6. Epub 2013 Dec 17.

1Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2004914
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http://dx.doi.org/10.1126/scisignal.2004914DOI Listing
December 2013

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Cell Rep 2013 Nov 14;5(4):868-77. Epub 2013 Nov 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962842PMC
November 2013

Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.

Chem Biol 2013 Oct 10;20(10):1255-64. Epub 2013 Oct 10.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859306PMC
October 2013

Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy.

Prog Mol Biol Transl Sci 2012 ;110:289-314

Department of Biology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-387665-2.00011-0DOI Listing
September 2013

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.

Nat Rev Mol Cell Biol 2013 Sep;14(9):563-80

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/nrm3640DOI Listing
September 2013

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.

Bioorg Med Chem 2013 May 27;21(9):2623-34. Epub 2013 Feb 27.

Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk 363-883, Cheongwon, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2013.02.020DOI Listing
May 2013

Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Science 2013 May 11;340(6134):871-5. Epub 2013 Apr 11.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1235822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884217PMC
May 2013

The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment.

Authors:
Michael B Yaffe

Sci Signal 2013 Apr 2;6(269):pe13. Epub 2013 Apr 2.

Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2003684
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http://dx.doi.org/10.1126/scisignal.2003684DOI Listing
April 2013

2012: Signaling breakthroughs of the year.

Sci Signal 2013 Jan 1;6(256):eg1. Epub 2013 Jan 1.

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http://dx.doi.org/10.1126/scisignal.2003881DOI Listing
January 2013

Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions.

Mol Biosyst 2012 Oct;8(10):2771-82

The David H. Koch Institute for Integrative Cancer Research, Washington University in St. Louis, St. Louis, MO 63130, USA.

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http://xlink.rsc.org/?DOI=c2mb25200g
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http://dx.doi.org/10.1039/c2mb25200gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501258PMC
October 2012

O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.

Integr Biol (Camb) 2012 Oct;4(10):1237-55

Biological Engineering Department, Biology Department, Center for Environmental Health Sciences, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://xlink.rsc.org/?DOI=c2ib20091k
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http://dx.doi.org/10.1039/c2ib20091kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574819PMC
October 2012

Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks.

Philos Trans R Soc Lond B Biol Sci 2012 Sep;367(1602):2574-83

The David H. Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1098/rstb.2012.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415838PMC
September 2012

Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.

Chembiochem 2012 Jun 8;13(9):1291-6. Epub 2012 May 8.

Chemical Biology Laboratory, Frederick National Lab, NCI, NIH, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1002/cbic.201200206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536914PMC
June 2012

Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.

ACS Chem Biol 2012 May 14;7(5):805-10. Epub 2012 Feb 14.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1021/cb200469aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355227PMC
May 2012

Computational approaches for analyzing information flow in biological networks.

Sci Signal 2012 Apr 17;5(220):re1. Epub 2012 Apr 17.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1126/scisignal.2002961DOI Listing
April 2012

Fixin' to divide.

Mol Cell 2012 Feb;45(3):273-5

David H. Koch Institute for Integrative Cancer Research, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501254PMC
February 2012

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.

Mol Syst Biol 2012 Jan 31;8:568. Epub 2012 Jan 31.

Department of Biology, David H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/msb.2012.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296916PMC
January 2012

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.

Cell Cycle 2011 Dec 15;10(24):4330-40. Epub 2011 Dec 15.

Translational Oncogenomics Unit, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.4161/cc.10.24.18682DOI Listing
December 2011

14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.

Semin Cell Dev Biol 2011 Sep 14;22(7):688-95. Epub 2011 Sep 14.

Department of Biology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.semcdb.2011.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507455PMC
September 2011

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.

Nat Chem Biol 2011 Jul 17;7(9):595-601. Epub 2011 Jul 17.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, USA.

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http://dx.doi.org/10.1038/nchembio.614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158281PMC
July 2011

MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets.

PLoS Comput Biol 2011 Jul 21;7(7):e1002119. Epub 2011 Jul 21.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.plos.org/10.1371/journal.pcbi.1002119
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140961PMC
July 2011

Focus issue: conquering the data mountain.

Sci Signal 2011 Feb 15;4(160):eg2. Epub 2011 Feb 15.

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http://dx.doi.org/10.1126/scisignal.2001871DOI Listing
February 2011

Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

Cell Cycle 2011 Jan 1;10(1):23-7. Epub 2011 Jan 1.

University Hospital Cologne, Center for Internal Medicine, Division of Hematology and Oncology, Cologne, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048069PMC
http://dx.doi.org/10.4161/cc.10.1.14351DOI Listing
January 2011

Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.

Structure 2010 Dec;18(12):1587-95

Division of Molecular Structure, MRC National Institute for Medical Research, The Ridgeway, London NW71AA, UK.

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http://dx.doi.org/10.1016/j.str.2010.09.014DOI Listing
December 2010

PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies.

Mol Cell Proteomics 2010 Nov 14;9(11):2558-70. Epub 2010 Jul 14.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1074/mcp.M110.001206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984232PMC
November 2010

TAZ as a novel enhancer of MyoD-mediated myogenic differentiation.

FASEB J 2010 Sep 13;24(9):3310-20. Epub 2010 May 13.

College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Woman's University, Science Bldg C206, 11-1 Daehyun-Dong, Sudaemun-Ku, Seoul 120-750, Korea.

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http://dx.doi.org/10.1096/fj.09-151324DOI Listing
September 2010

Looking ahead to the past.

Authors:
Michael B Yaffe

Sci Signal 2010 Sep 7;3(138):eg7. Epub 2010 Sep 7.

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http://dx.doi.org/10.1126/scisignal.3138eg7DOI Listing
September 2010

A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1.

J Mol Signal 2010 Jul 1;5. Epub 2010 Jul 1.

Karmanos Cancer Institute, Wayne State University and John D, Dingell VA Medical Center, Room B4325, 4646 John R, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1186/1750-2187-5-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904743PMC
July 2010

Cell cycle re-entry mechanisms after DNA damage checkpoints: giving it some gas to shut off the breaks!

Cell Cycle 2010 Jun 1;9(11):2097-101. Epub 2010 Jun 1.

Department of Medical Oncology, University Medical Centre Groningen, Groningen, The Netherlands.

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June 2010

Microfluidic preparative free-flow isoelectric focusing: system optimization for protein complex separation.

Anal Chem 2010 Feb;82(4):1253-60

Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1021/ac902157eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826279PMC
February 2010

Living by the numbers.

Authors:
Michael B Yaffe

Sci Signal 2009 Dec 1;2(99):eg15. Epub 2009 Dec 1.

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http://dx.doi.org/10.1126/scisignal.299eg15DOI Listing
December 2009

Exploiting synthetic lethal interactions for targeted cancer therapy.

Cell Cycle 2009 Oct;8(19):3112-9

The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.4161/cc.8.19.9626DOI Listing
October 2009