Publications by authors named "Michael B Yaffe"

100Publications

COVID-19: All the wrong moves in all the wrong places.

Sci Signal 2020 09 15;13(649). Epub 2020 Sep 15.

Christopher D. Barrett, Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Divisions of Acute Care Surgery, Trauma and Surgical Critical Care and Surgical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Dr. Barrett has patents pending related to the field of fibrinolysis and COVID-19 therapy. Email:

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http://dx.doi.org/10.1126/scisignal.abe4242DOI Listing
September 2020

Plasmin TEG Rapidly Identifies Trauma Patients at Risk for Massive Transfusion, Mortality and Hyperfibrinolysis: A Diagnostic Tool to Resolve an International Debate on TXA?

J Trauma Acute Care Surg 2020 Sep 9. Epub 2020 Sep 9.

Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA and Division of Acute Care Surgery and Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA University of Colorado Denver, Department of Surgery, Denver, CO University of Colorado Denver, Department of Surgery, Denver, CO Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA Ernest E. Moore Shock and Trauma Center, Denver Health Medical Center, Denver, CO University of Colorado Denver, Department of Radiology, Denver, CO University of Colorado Denver, Department of Surgery, Denver, CO University of Colorado Denver, Department of Surgery, Denver, CO and Ernest E. Moore Shock and Trauma Center, Denver Health Medical Center, Denver, CO Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA and Division of Acute Care Surgery and Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/TA.0000000000002941DOI Listing
September 2020

Modern Management of Bleeding, Clotting, and Coagulopathy in Trauma Patients: What Is the Role of Viscoelastic Assays?

Curr Trauma Rep 2020 Mar 23;6(1):69-81. Epub 2020 Jan 23.

Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1007/s40719-020-00183-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453728PMC
March 2020

Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression.

Cell Rep 2020 Aug;32(8):108064

Center for Precision Cancer Medicine, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Divisions of Acute Care Surgery, Trauma and Surgical Critical Care, and Surgical Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108064DOI Listing
August 2020

STudy of Alteplase for Respiratory failure in SARS-Cov2/COVID-19: Study Design of the Phase IIa STARS Trial.

Res Pract Thromb Haemost 2020 May 21. Epub 2020 May 21.

Koch Institute for Integrative Cancer Research Center for Precision Cancer Medicine Departments of Biological Engineering and Biology Massachusetts Institute of Technology Cambridge MA USA.

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http://dx.doi.org/10.1002/rth2.12395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280574PMC
May 2020

BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.

Nat Commun 2020 08 14;11(1):4083. Epub 2020 Aug 14.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-020-17503-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428008PMC
August 2020

Development of Rapid Response Capabilities in a Large COVID-19 Alternate Care Site Using Failure Modes and Effect Analysis with In Situ Simulation.

Anesthesiology 2020 Aug 11. Epub 2020 Aug 11.

From the Boston Hope Field Hospital, Boston, Massachusetts (N.L., R.J.E., R.E.H., S.H.J., M.B.Y., A.L.) Department of Anesthesia, Critical Care and Pain Medicine (N.L., L.Z., S.K.R., S.B., A.L.) Department of Surgery (M.B.Y.), Beth Israel Deaconess Medical Center, Boston, Massachusetts Department of Plastic and Reconstructive Surgery (R.J.E.) Department of Physical Medicine and Rehabilitation (R.E.H.), Massachusetts General Hospital, Boston, Massachusetts Spaulding Rehabilitation Hospital, Boston, Massachusetts (R.E.H.) Department of Nursing, Atrius Health, Newton, Massachusetts (S.H.J.).

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http://dx.doi.org/10.1097/ALN.0000000000003521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434018PMC
August 2020

Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography.

Blood Coagul Fibrinolysis 2020 Jul 27. Epub 2020 Jul 27.

Departments of Biological Engineering and Biology, Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge.

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http://dx.doi.org/10.1097/MBC.0000000000000938DOI Listing
July 2020

Redox priming promotes Aurora A activation during mitosis.

Sci Signal 2020 Jul 21;13(641). Epub 2020 Jul 21.

MIT Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, and Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scisignal.abb6707DOI Listing
July 2020

Fibrinolytic therapy for refractory COVID-19 acute respiratory distress syndrome: Scientific rationale and review.

Res Pract Thromb Haemost 2020 May 12;4(4):524-531. Epub 2020 Jun 12.

Center for Precision Cancer Medicine Departments of Biological Engineering and Biology Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA USA.

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http://dx.doi.org/10.1002/rth2.12357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267116PMC
May 2020

Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series.

J Trauma Acute Care Surg 2020 09;89(3):453-457

From the Division of Acute Care Surgery (C.D.B., R.J., M.B.Y.), Trauma and Surgical Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; Departments of Biological Engineering and Biology (C.D.B., M.B.Y.), Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge; Department of Anesthesia (A.O.-G., A.M.I., M.L.K., D.S.T., S.S.), Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Division of Trauma and Surgical Critical Care (E.C., S.H.R., M.U.), Department of Surgery, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York; Division of Pulmonary and Critical Care (A.H.M.), Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts; Department of Surgery (M.J.M.), Scripps Mercy Hospital, San Diego, California; Department of Emergency Medicine (A.M.I.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Surgery (H.B.M., E.E.M.), University of Colorado Denver, Aurora; Department of Surgery (E.E.M.), Ernest E Moore Shock Trauma Center at Denver Health, Denver, Colorado; Division of Pulmonary, Critical Care and Sleep Medicine (E.N.B.-K.), Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/TA.0000000000002786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484332PMC
September 2020

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.

J Thromb Haemost 2020 Aug 25;18(8):1900-1910. Epub 2020 Jun 25.

Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA.

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http://dx.doi.org/10.1111/jth.14875DOI Listing
August 2020

Influence of tranexamic acid on the complement system in trauma.

ANZ J Surg 2020 04;90(4):418-420

Koch Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1111/ans.15538DOI Listing
April 2020

Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis.

World J Emerg Surg 2020 04 20;15(1):29. Epub 2020 Apr 20.

Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1186/s13017-020-00305-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169373PMC
April 2020

ISTH interim guidance on recognition and management of coagulopathy in COVID-19: A comment.

J Thromb Haemost 2020 08 14;18(8):2060-2063. Epub 2020 Jun 14.

Department of Surgery, University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1111/jth.14860DOI Listing
August 2020

Is there a role for tissue plasminogen activator as a novel treatment for refractory COVID-19 associated acute respiratory distress syndrome?

J Trauma Acute Care Surg 2020 06;88(6):713-714

From the Department of Surgery (H.B.M., E.E.M., R.C.M.), University of Colorado Denver, Denver, Colorado; Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Departments of Biological Engineering and Biology (C.D.B., M.B.Y.), Massachusetts Institute of Technology, Cambridge; Division of Acute Care Surgery, Trauma and Surgical Critical Care, Department of Surgery (C.D.B., M.B.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Surgery (E.E.M.), Ernest E Moore Shock Trauma Center at Denver Health; Department of Medicine (P.K.M.), University of Colorado Denver, Denver, Colorado; Department of Anesthesia, Critical Care and Pain Medicine (D.S.T.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and Department of Surgery (F.A.M.), University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1097/TA.0000000000002694DOI Listing
June 2020

Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series.

J Thromb Haemost 2020 07 11;18(7):1752-1755. Epub 2020 May 11.

Center for Precision Cancer Medicine, Departments of Biological Engineering and Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1111/jth.14828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262152PMC
July 2020

Influence of Tranexamic Acid on Inflammatory Signaling in Trauma.

Semin Thromb Hemost 2020 Mar 11;46(2):183-188. Epub 2020 Mar 11.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1055/s-0040-1702169DOI Listing
March 2020

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Cell Syst 2019 07 10;9(1):74-92.e8. Epub 2019 Jul 10.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712193019
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http://dx.doi.org/10.1016/j.cels.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688637PMC
July 2019

Atlas Drugged.

Cell 2019 05;177(4):803-805

Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Surgical Critical Care and Trauma, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.023DOI Listing
May 2019

Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.

Cancer Res 2019 05 15;79(10):2669-2683. Epub 2019 Mar 15.

Rutgers University, Biomedical and Health Sciences Center, Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, New Jersey.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-2614DOI Listing
May 2019

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest.

Cell Syst 2019 02 20;8(2):163-167.e2. Epub 2019 Feb 20.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688173PMC
February 2019

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression.

Nat Commun 2019 01 24;10(1):421. Epub 2019 Jan 24.

Department of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul, 02841, South Korea.

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http://dx.doi.org/10.1038/s41467-019-08287-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345998PMC
January 2019

Why geneticists stole cancer research even though cancer is primarily a signaling disease.

Authors:
Michael B Yaffe

Sci Signal 2019 01 22;12(565). Epub 2019 Jan 22.

Chief Scientific Advisor and Academic Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aaw3483DOI Listing
January 2019

Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner.

J Trauma Acute Care Surg 2019 01;86(1):101-107

From the Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts (C.D.B, Y-W.K, G.S., D.L., M.B.Y.); Division of Acute Care Surgery and Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (C.D.B., M.B.Y.); Department of Surgery, University of Colorado Denver, Denver, Colorado (H.B.M., E.E.M.); Department of Radiology, University of Colorado Denver, Denver, Colorado (M.P.C.); and Department of Surgery, Denver Health Medical Center, Denver, Colorado (E.E.M.).

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http://dx.doi.org/10.1097/TA.0000000000002092DOI Listing
January 2019

Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.

Cell Syst 2018 10 19;7(4):371-383.e4. Epub 2018 Sep 19.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Departments of Biology and Bioengineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Divisions of Acute Care Surgery, Trauma, and Critical Care and Surgical Oncology, Harvard Medical School, Boston 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712183035
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http://dx.doi.org/10.1016/j.cels.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202253PMC
October 2018

Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.

Bioorg Med Chem Lett 2018 10 19;28(19):3202-3205. Epub 2018 Aug 19.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287497PMC
October 2018

A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils.

J Trauma Acute Care Surg 2018 11;85(5):936-943

From the Department of Surgery and Center for Vascular Biology Research (E.K.), Department of Surgery (C.J.H., L.C., N.S., L.E.O., C.H.C., K.I.), Department of Surgery, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts; Department of Emergency Medicine (W.Y.K.), Seoul National University College of Medicine, Seoul, Republic of Korea; Massachusetts Institute of Technology (I.R., M.B.Y.), Cambridge, Massachusetts; and mAbDx, Inc (Y.C., M.M.), Eugene, Oregon.

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http://dx.doi.org/10.1097/TA.0000000000001971DOI Listing
November 2018

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Proc Natl Acad Sci U S A 2018 05 16;115(18):E4236-E4244. Epub 2018 Apr 16.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142;

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http://dx.doi.org/10.1073/pnas.1722020115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939099PMC
May 2018

Predicting the future of signaling for 2018.

Authors:
Michael B Yaffe

Sci Signal 2018 01 2;11(511). Epub 2018 Jan 2.

Chief Scientific Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA. David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Email:

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http://dx.doi.org/10.1126/scisignal.aar7429DOI Listing
January 2018

TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome.

J Clin Endocrinol Metab 2018 03;103(3):839-852

Thyroid Molecular Laboratory, Institute for Medical and Molecular Genetics, La Paz University Hospital, Madrid, Spain.

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http://dx.doi.org/10.1210/jc.2017-01241DOI Listing
March 2018

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Cancer Cell 2017 10 28;32(4):411-426.e11. Epub 2017 Sep 28.

The David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929990PMC
October 2017

Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin.

J Trauma Acute Care Surg 2017 12;83(6):1053-1061

From the Koch Institute for Integrative Cancer Research (C.D.B.), Massachusetts Institute of Technology, Cambridge, Massachusetts; Department of Surgery (C.D.B.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Departments of Surgery (H.B.M., A.B., E.E.M.) and Pediatrics (C.C.S.), University of Colorado Denver, Denver, Colorado; Bonfils Blood Center (C.C.S.), Denver, Colorado; Department of Surgery (E.E.M.), Denver Health Medical Center, Denver, Colorado; Koch Institute (M.B.Y.), Massachusetts Institute of Technology, Cambridge, Massachusetts; and Division of Acute Care Surgery and Critical Care, Department of Surgery (M.B.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/TA.0000000000001685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767103PMC
December 2017

Highlight: Understanding radiation sialadenitis.

Authors:
Michael B Yaffe

Sci Signal 2017 Jun 6;10(482). Epub 2017 Jun 6.

Science Signaling, AAAS, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aan8666DOI Listing
June 2017

Podcast for 14 March 2017: The Cancer Moonshot.

Sci Signal 2017 Mar 14;10(470). Epub 2017 Mar 14.

Associate Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aan1418DOI Listing
March 2017

Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents.

J Am Chem Soc 2017 03 16;139(8):3033-3044. Epub 2017 Feb 16.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/jacs.6b12108DOI Listing
March 2017

Protein Regulation in Signal Transduction.

Cold Spring Harb Perspect Biol 2016 Jun 1;8(6). Epub 2016 Jun 1.

David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a005918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888820PMC
June 2016

Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma.

Cancer Cell 2016 Apr;29(4):435-436

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Departments of Biological Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108163010
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http://dx.doi.org/10.1016/j.ccell.2016.03.022DOI Listing
April 2016

Leveraging signaling research to understand and treat disease.

Sci Signal 2016 Mar 29;9(421):eg4. Epub 2016 Mar 29.

Editor, Science Signaling, AAAS, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aaf6275DOI Listing
March 2016

Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.

Biopolymers 2015 Nov;104(6):663-73

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702.

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http://dx.doi.org/10.1002/bip.22698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865893PMC
November 2015

Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.

Clin Cancer Res 2015 Oct 1;21(19):4410-9. Epub 2015 Jun 1.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://clincancerres.aacrjournals.org/content/early/2015/08/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624301PMC
October 2015

Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome.

Shock 2015 Aug;44(2):128-36

*Department of Biology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; †Department of Surgery, ‡Division of Translational Research, §Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and ∥Department of Biological Engineering, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1097/SHK.0000000000000386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830084PMC
August 2015

A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.

J Biomol Screen 2015 Sep 27;20(8):985-97. Epub 2015 Apr 27.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA Broad Institute of MIT and Harvard, Cambridge, MA, USA Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.1177/1087057115583037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377593PMC
September 2015

Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.

Cancer Cell 2015 Apr;27(4):489-501

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398916PMC
April 2015

Computational prediction of protein-protein interactions.

Methods Mol Biol 2015 ;1278:57-75

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2425-7_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435844PMC
December 2015

Criteria for biological reproducibility: what does "n" mean?

Sci Signal 2015 Apr 7;8(371):fs7. Epub 2015 Apr 7.

David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

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April 2015

Reproducibility in science.

Authors:
Michael B Yaffe

Sci Signal 2015 Apr 7;8(371):eg5. Epub 2015 Apr 7.

Michael B. Yaffe is the Chief Scientific Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA, and Professor at David H. Koch Institute for Integrative Cancer Research, The Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail:

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April 2015

Engineered bromodomains to explore the acetylproteome.

Proteomics 2015 May 5;15(9):1470-5. Epub 2015 Mar 5.

Department of Biological Engineering, MIT, Cambridge, MA, USA; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/pmic.201400401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535431PMC
May 2015

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Mol Cell 2015 Jan 4;57(1):95-107. Epub 2014 Dec 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289430PMC
January 2015

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Cell 2014 Aug;158(5):1094-1109

Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA; Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250222PMC
August 2014

Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs.

Biochemistry 2014 Sep 3;53(36):5771-8. Epub 2014 Sep 3.

Departments of Chemistry and Biology, and ‡Departments of Biology and Biological Engineering, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165445PMC
September 2014

A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways.

Sci Signal 2014 May 13;7(325):ra44. Epub 2014 May 13.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA. Institute for Soldier Nanotechnologies, MIT, Cambridge, MA 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138219PMC
May 2014

Death of a Titan.

Sci Signal 2013 Dec 17;6(306):eg6. Epub 2013 Dec 17.

1Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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December 2013

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Cell Rep 2013 Nov 14;5(4):868-77. Epub 2013 Nov 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962842PMC
November 2013

Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.

Chem Biol 2013 Oct 10;20(10):1255-64. Epub 2013 Oct 10.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859306PMC
October 2013

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.

Nat Rev Mol Cell Biol 2013 Sep;14(9):563-80

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/nrm3640DOI Listing
September 2013

Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Science 2013 May 11;340(6134):871-5. Epub 2013 Apr 11.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1235822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884217PMC
May 2013

The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment.

Authors:
Michael B Yaffe

Sci Signal 2013 Apr 2;6(269):pe13. Epub 2013 Apr 2.

Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

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April 2013

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.

Bioorg Med Chem 2013 May 27;21(9):2623-34. Epub 2013 Feb 27.

Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chung-Buk 363-883, Cheongwon, Republic of Korea.

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May 2013

2012: Signaling breakthroughs of the year.

Sci Signal 2013 Jan 1;6(256):eg1. Epub 2013 Jan 1.

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January 2013

O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.

Integr Biol (Camb) 2012 Oct;4(10):1237-55

Biological Engineering Department, Biology Department, Center for Environmental Health Sciences, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574819PMC
October 2012

Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks.

Philos Trans R Soc Lond B Biol Sci 2012 Sep;367(1602):2574-83

The David H. Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1098/rstb.2012.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415838PMC
September 2012

Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions.

Mol Biosyst 2012 Oct;8(10):2771-82

The David H. Koch Institute for Integrative Cancer Research, Washington University in St. Louis, St. Louis, MO 63130, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501258PMC
October 2012

Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy.

Prog Mol Biol Transl Sci 2012 ;110:289-314

Department of Biology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-387665-2.00011-0DOI Listing
September 2013

Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.

Chembiochem 2012 Jun 8;13(9):1291-6. Epub 2012 May 8.

Chemical Biology Laboratory, Frederick National Lab, NCI, NIH, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1002/cbic.201200206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536914PMC
June 2012

Computational approaches for analyzing information flow in biological networks.

Sci Signal 2012 Apr 17;5(220):re1. Epub 2012 Apr 17.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1126/scisignal.2002961DOI Listing
April 2012

Fixin' to divide.

Mol Cell 2012 Feb;45(3):273-5

David H. Koch Institute for Integrative Cancer Research, Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501254PMC
February 2012

Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.

Mol Syst Biol 2012 Jan 31;8:568. Epub 2012 Jan 31.

Department of Biology, David H Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/msb.2012.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296916PMC
January 2012

Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification.

ACS Chem Biol 2012 May 14;7(5):805-10. Epub 2012 Feb 14.

Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1021/cb200469aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355227PMC
May 2012

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.

Cell Cycle 2011 Dec 15;10(24):4330-40. Epub 2011 Dec 15.

Translational Oncogenomics Unit, Regina Elena Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.4161/cc.10.24.18682DOI Listing
December 2011