Massimo Tabaton

Massimo Tabaton

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Massimo Tabaton

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Preface.

J Alzheimers Dis 2018 ;64(s1):S1

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http://dx.doi.org/10.3233/JAD-179945DOI Listing
June 2019

The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease.

J Alzheimers Dis 2018 ;62(3):1241-1245

Department of Internal Medicine and Medical Specialties (DIMI), Unit of Geriatric Medicine, University of Genova, Genova, Italy.

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http://dx.doi.org/10.3233/JAD-170581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870015PMC
May 2019

Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation.

J Alzheimers Dis 2019 ;70(1):11-15

Ospedale Policlinico San Martino, I.R.C.C.S. Per l'Oncologia, Genoa, Italy.

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http://dx.doi.org/10.3233/JAD-190363DOI Listing
January 2019

Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice.

J Alzheimers Dis 2017 ;59(2):743-751

Department of Internal Medicine and Medical Specialties (DIMI), Unit of Geriatric Medicine, University of Genova, Genova, Italy.

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http://dx.doi.org/10.3233/JAD-170298DOI Listing
April 2018

Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.

Aging Cell 2016 10 12;15(5):914-23. Epub 2016 Jul 12.

Unit of Geriatric Medicine, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 6, 16132, Genova, Italy.

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http://dx.doi.org/10.1111/acel.12500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013016PMC
October 2016

Amnestic mild cognitive impairment and conversion to Alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters.

J Alzheimers Dis 2015 ;45(1):89-95

Department of Internal Medicine and Medical Specialties (DiMI), Section of Geriatrics. University of Genova, Genova, Italy IRCCS AOU San Martino-IST, Genova, Italy.

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http://dx.doi.org/10.3233/JAD-142511DOI Listing
February 2016

Relationship between balance and cognitive performance in older people.

J Alzheimers Dis 2015 ;45(3):705-7

School of Medicine, DIMI, University of Genova, Genova, Italy.

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http://dx.doi.org/10.3233/JAD-142883DOI Listing
January 2016

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis.

Autophagy 2014 Oct 12;10(10):1827-43. Epub 2014 Aug 12.

Department of Neuroscience; University of Torino; Torino, Italy; Neuroscience Institute of Cavalieri Ottolenghi Foundation (NICO); University of Torino; Torino, Italy.

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http://dx.doi.org/10.4161/auto.30001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198366PMC
October 2014

Monomeric Aβ1-42 and RAGE: key players in neuronal differentiation.

Neurobiol Aging 2014 Jun 10;35(6):1301-8. Epub 2014 Jan 10.

Department of Experimental Medicine, University of Genoa, Genoa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.002DOI Listing
June 2014

Survival rate in patients affected by dementia followed by memory clinics (UVA) in Italy.

J Alzheimers Dis 2013 ;36(2):303-9

Section of Geriatrics, Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Genova, Italy.

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http://dx.doi.org/10.3233/JAD-130002DOI Listing
January 2014

Amyloid-β production: major link between oxidative stress and BACE1.

Neurotox Res 2012 Oct 15;22(3):208-19. Epub 2011 Oct 15.

General Pathology Section, Department of Experimental Medicine and Oncology, University of Torino, Corso Raffaello 30, 10125 Turin, Italy.

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http://dx.doi.org/10.1007/s12640-011-9283-6DOI Listing
October 2012

β-amyloid 1-42 induces physiological transcriptional regulation of BACE1.

J Neurochem 2012 Sep 11;122(5):1023-31. Epub 2012 Jul 11.

Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07834.xDOI Listing
September 2012

Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway.

J Alzheimers Dis 2011 ;27(4):871-83

Department of Experimental Medicine and Oncology, General Pathology Section, University of Torino, Torino, Italy.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-2011-110884DOI Listing
April 2012

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation.

Neurobiol Aging 2012 Jan 17;33(1):196.e13-27. Epub 2010 Jul 17.

Department of Experimental Medicine and Oncology, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.05.026DOI Listing
January 2012

Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors.

Front Aging Neurosci 2010 9;2. Epub 2010 Feb 9.

Department of Experimental Medicine and Oncology, University of Turin Turin, Italy.

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http://dx.doi.org/10.3389/neuro.24.003.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874401PMC
July 2011

Oxidative stress in Alzheimer disease: a possibility for prevention.

Neuropharmacology 2010 Sep-Oct;59(4-5):290-4. Epub 2010 Apr 13.

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2010.04.005DOI Listing
June 2011

Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease.

J Neurosci Methods 2010 Jul 16;190(2):244-7. Epub 2010 May 16.

Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2010.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906114PMC
July 2010

Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease.

Am J Pathol 2010 Feb 17;176(2):540-1. Epub 2009 Dec 17.

Department of Neuroscience, University of Genova, Genova, Italy.

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http://dx.doi.org/10.2353/ajpath.2010.090856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808061PMC
February 2010

Signaling effect of amyloid-beta(42) on the processing of AbetaPP.

Exp Neurol 2010 Jan 9;221(1):18-25. Epub 2009 Sep 9.

Departments of Neuroscience, Ophthalmology, and Genetics, University of Genova, Genova, Italy.

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http://dx.doi.org/10.1016/j.expneurol.2009.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812589PMC
January 2010

Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study.

Exp Gerontol 2010 Jan 9;45(1):47-52. Epub 2009 Oct 9.

Department of Neurology, University Hospitals-Case Medical Center and University Memory and Cognition Center, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.exger.2009.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815174PMC
January 2010

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells.

Neurosci Lett 2010 Jan 13;468(3):267-71. Epub 2009 Nov 13.

Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.neulet.2009.11.010DOI Listing
January 2010

Coffee "breaks" Alzheimer's disease.

Authors:
Massimo Tabaton

J Alzheimers Dis 2009 ;17(3):699-700; discussion 701-2

Department of Internal Medicine, University of Genova, Genova, Italy.

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http://dx.doi.org/10.3233/JAD-2009-1089DOI Listing
December 2009

JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1.

Neurobiol Aging 2009 Oct 6;30(10):1563-73. Epub 2008 Feb 6.

Department of Experimental Medicine and Oncology, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.12.015DOI Listing
October 2009

N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42.

Biopolymers 2009 Oct;91(10):861-73

Institute for Macromolecular Studies, National Research Council, 16149 Genoa, Italy.

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http://dx.doi.org/10.1002/bip.21271DOI Listing
October 2009

Mutant presenilin 1 increases the expression and activity of BACE1.

J Biol Chem 2009 Apr 5;284(14):9027-38. Epub 2009 Feb 5.

Department of Neuroscience, Ophthalmology, and Genetics and Internal Medicine and Medical Specialties, University of Genova, Genova, Italy.

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http://dx.doi.org/10.1074/jbc.M805685200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666551PMC
April 2009

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role.

Mol Neurodegener 2008 Sep 2;3:12. Epub 2008 Sep 2.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1186/1750-1326-3-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538519PMC
September 2008

Increased autophagic degradation of mitochondria in Alzheimer disease.

Autophagy 2007 Nov-Dec;3(6):614-5. Epub 2007 Aug 14.

Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.4161/auto.4872DOI Listing
January 2008

The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease.

Neurobiol Aging 2007 Jul;28(7):1009-14

Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Via De Toni 5, 16132 Genova, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.05.004DOI Listing
July 2007

Soluble amyloid-beta in the brain: the scarlet pimpernel.

J Alzheimers Dis 2006 ;9(3 Suppl):127-32

University of Genova, Institute of Neurology, Via De Toni 5, 16132 Genova, Italy.

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http://dx.doi.org/10.3233/jad-2006-9s315DOI Listing
October 2006

The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression.

Free Radic Biol Med 2006 Jul 14;41(2):202-12. Epub 2006 Feb 14.

General Pathology Section, Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, 10125 Turin, Italy.

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http://dx.doi.org/10.1016/j.freeradbiomed.2006.01.021DOI Listing
July 2006

Plasma levels of insulin and amyloid beta 42 are correlated in patients with amnestic Mild Cognitive Impairment.

J Alzheimers Dis 2005 Dec;8(3):243-5

Gerontology and Geriatrics, Department of Internal Medicine University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy.

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http://dx.doi.org/10.3233/jad-2005-8303DOI Listing
December 2005

Neprylisin decreases uniformly in Alzheimer's disease and in normal aging.

FEBS Lett 2005 Nov 5;579(27):6027-30. Epub 2005 Oct 5.

Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy.

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http://dx.doi.org/10.1016/j.febslet.2005.09.054DOI Listing
November 2005

Role of water-soluble amyloid-beta in the pathogenesis of Alzheimer's disease.

Int J Exp Pathol 2005 Jun;86(3):139-45

Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy.

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http://dx.doi.org/10.1111/j.0959-9673.2005.00428.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517412PMC
June 2005

Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

J Neurochem 2005 Feb;92(3):628-36

Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Corso Raffaello 30, 10125 Turin, Italy.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02895.xDOI Listing
February 2005

Protein levels of glycogen synthase 3 kinase are normal in progressive supranuclear palsy.

Neurosci Lett 2004 Aug;366(1):67-70

Department of Neurosciences, Ophthalmology and Genetic, University of Genova, Via De Toni, 5, 16132 Genova, Italy.

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http://dx.doi.org/10.1016/j.neulet.2004.05.014DOI Listing
August 2004

Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.

J Neurochem 2004 Jun;89(5):1224-32

Department of Pharmacology, University of Bologna, via Irnerio 48, 40126 Bologna, Italy.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02413.xDOI Listing
June 2004

Neuroprotective properties of Bcl-w in Alzheimer disease.

J Neurochem 2004 Jun;89(5):1233-40

Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02416.xDOI Listing
June 2004

Microarray analysis in Alzheimer's disease and normal aging.

IUBMB Life 2004 Jun;56(6):349-54

Department of Experimental Medicine, University of Genoa, via L.B. Alberti 2, 16132 Genoa, Italy.

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http://dx.doi.org/10.1080/15216540412331286002DOI Listing
June 2004

Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob disease.

Ann Neurol 2004 Feb;55(2):294-6

Department of Neurosciences, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.1002/ana.20038DOI Listing
February 2004

Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.

J Alzheimers Dis 2004 Feb;6(1):45-51

Department of Neurological Sciences, Psychiatry and Genetics, University of Genova, Italy.

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http://dx.doi.org/10.3233/jad-2004-6106DOI Listing
February 2004

Oxidative damage in the olfactory system in Alzheimer's disease.

Acta Neuropathol 2003 Dec 29;106(6):552-6. Epub 2003 Aug 29.

Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1007/s00401-003-0761-7DOI Listing
December 2003

Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways.

Antioxid Redox Signal 2003 Oct;5(5):571-6

Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1089/152308603770310220DOI Listing
October 2003

Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.

Free Radic Biol Med 2003 Jul;35(1):45-58

Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Corso Raffaello 30, 10125 Turin, Italy.

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http://dx.doi.org/10.1016/s0891-5849(03)00244-2DOI Listing
July 2003

Oxidative stress increases expression and activity of BACE in NT2 neurons.

Neurobiol Dis 2002 Aug;10(3):279-88

Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1006/nbdi.2002.0515DOI Listing
August 2002

Mechanisms of phenotypic heterogeneity in prion, Alzheimer and other conformational diseases.

J Alzheimers Dis 2001 Feb;3(1):87-95

Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.3233/jad-2001-3113DOI Listing
February 2001