Marthe H R Ludtmann

Marthe H R Ludtmann

UNVERIFIED PROFILE

Are you Marthe H R Ludtmann?   Register this Author

Register author
Marthe H R Ludtmann

Marthe H R Ludtmann

Publications by authors named "Marthe H R Ludtmann"

Are you Marthe H R Ludtmann?   Register this Author

17Publications

364Reads

16Profile Views

FBS/BSA media concentration determines CCCP's ability to depolarize mitochondria and activate PINK1-PRKN mitophagy.

Authors:
Marc P M Soutar Liam Kempthorne Emily Annuario Christin Luft Selina Wray Robin Ketteler Marthe H R Ludtmann Hélène Plun-Favreau

Autophagy 2019 Nov 7;15(11):2002-2011. Epub 2019 May 7.

Neurodegenerative Disease, UCL Institute of Neurology , London , UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/15548627.2019.1603549DOI Listing
November 2019

LRRK2 deficiency induced mitochondrial Ca efflux inhibition can be rescued by Na/Ca/Li exchanger upregulation.

Authors:
Marthe H R Ludtmann Marko Kostic Amy Horne Sonia Gandhi Israel Sekler Andrey Y Abramov

Cell Death Dis 2019 Mar 19;10(4):265. Epub 2019 Mar 19.

Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41419-019-1469-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424963PMC
March 2019

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.

Authors:
Marthe H R Ludtmann Plamena R Angelova Mathew H Horrocks Minee L Choi Margarida Rodrigues Artyom Y Baev Alexey V Berezhnov Zhi Yao Daniel Little Blerida Banushi Afnan Saleh Al-Menhali Rohan T Ranasinghe Daniel R Whiten Ratsuda Yapom Karamjit Singh Dolt Michael J Devine Paul Gissen Tilo Kunath Morana Jaganjac Evgeny V Pavlov David Klenerman Andrey Y Abramov Sonia Gandhi

Nat Commun 2018 06 12;9(1):2293. Epub 2018 Jun 12.

Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-018-04422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997668PMC
June 2018

Mitochondrial calcium imbalance in Parkinson's disease.

Authors:
Marthe H R Ludtmann Andrey Y Abramov

Neurosci Lett 2018 01 26;663:86-90. Epub 2017 Aug 26.

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neulet.2017.08.044DOI Listing
January 2018

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy.

Authors:
Andreea Manole Zane Jaunmuktane Iain Hargreaves Marthe H R Ludtmann Vincenzo Salpietro Oscar D Bello Simon Pope Amelie Pandraud Alejandro Horga Renata S Scalco Abi Li Balasubramaniem Ashokkumar Charles M Lourenço Simon Heales Rita Horvath Patrick F Chinnery Camilo Toro Andrew B Singleton Thomas S Jacques Andrey Y Abramov Francesco Muntoni Michael G Hanna Mary M Reilly Tamas Revesz Dimitri M Kullmann James E C Jepson Henry Houlden

Brain 2017 11;140(11):2820-2837

Department of Molecular Neuroscience and Neurogenetics Laboratory, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/brain/awx231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808726PMC
November 2017

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.

Authors:
Marthe H R Ludtmann Charles Arber Fernando Bartolome Macarena de Vicente Elisavet Preza Eva Carro Henry Houlden Sonia Gandhi Selina Wray Andrey Y Abramov

J Biol Chem 2017 05 30;292(21):8907-8917. Epub 2017 Mar 30.

From the Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, United Kingdom,

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1074/jbc.M116.762898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448124PMC
May 2017

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

Authors:
Marthe H R Ludtmann Plamena R Angelova Natalia N Ninkina Sonia Gandhi Vladimir L Buchman Andrey Y Abramov

J Neurosci 2016 10;36(41):10510-10521

Department of Molecular Neuroscience, University College London Institute of Neurology, London WC1N 3BG, United Kingdom, and

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1523/JNEUROSCI.1659-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059426PMC
October 2016

Ca2+ is a key factor in α-synuclein-induced neurotoxicity.

Authors:
Plamena R Angelova Marthe H R Ludtmann Mathew H Horrocks Alexander Negoda Nunilo Cremades David Klenerman Christopher M Dobson Nicholas W Wood Evgeny V Pavlov Sonia Gandhi Andrey Y Abramov

J Cell Sci 2016 05 17;129(9):1792-801. Epub 2016 Mar 17.

UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1242/jcs.180737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893653PMC
May 2016

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

Authors:
Emma Deas Nunilo Cremades Plamena R Angelova Marthe H R Ludtmann Zhi Yao Serene Chen Mathew H Horrocks Blerida Banushi Daniel Little Michael J Devine Paul Gissen David Klenerman Christopher M Dobson Nicholas W Wood Sonia Gandhi Andrey Y Abramov

Antioxid Redox Signal 2016 Mar 1;24(7):376-91. Epub 2016 Feb 1.

1 Department of Molecular Neuroscience, UCL Institute of Neurology , Queen Square, London, United Kingdom .

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1089/ars.2015.6343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999647PMC
March 2016

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons.

Authors:
Marko Kostic Marthe H R Ludtmann Hilmar Bading Michal Hershfinkel Erin Steer Charleen T Chu Andrey Y Abramov Israel Sekler

Cell Rep 2015 Oct 1;13(2):376-86. Epub 2015 Oct 1.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.celrep.2015.08.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709126PMC
October 2015

A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia.

Authors:
Niccolo E Mencacci Ignacio Rubio-Agusti Anselm Zdebik Friedrich Asmus Marthe H R Ludtmann Mina Ryten Vincent Plagnol Ann-Kathrin Hauser Sara Bandres-Ciga Conceição Bettencourt Paola Forabosco Deborah Hughes Marc M P Soutar Kathryn Peall Huw R Morris Daniah Trabzuni Mehmet Tekman Horia C Stanescu Robert Kleta Miryam Carecchio Giovanna Zorzi Nardo Nardocci Barbara Garavaglia Ebba Lohmann Anne Weissbach Christine Klein John Hardy Alan M Pittman Thomas Foltynie Andrey Y Abramov Thomas Gasser Kailash P Bhatia Nicholas W Wood

Am J Hum Genet 2015 Jun 14;96(6):938-47. Epub 2015 May 14.

Department of Molecular Neuroscience, Institute of Neurology, University College London, WC1N 3BG London, UK. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00029297150014
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2015.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457957PMC
June 2015

Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function.

Authors:
Marianne T Neary Keat-Eng Ng Marthe H R Ludtmann Andrew R Hall Izabela Piotrowska Sang-Bing Ong Derek J Hausenloy Timothy J Mohun Andrey Y Abramov Ross A Breckenridge

J Mol Cell Cardiol 2014 Sep 28;74:340-52. Epub 2014 Jun 28.

MRC National Institute for Medical Research, Mill Hill, London NW7 1AA; UCL Division of Medicine, London WC1E 6JJ.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.yjmcc.2014.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121533PMC
September 2014

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.

Authors:
Marthe H R Ludtmann Grant P Otto Christina Schilde Zhi-Hui Chen Claire Y Allan Selina Brace Philip W Beesley Alan R Kimmel Paul Fisher Richard Killick Robin S B Williams

J Cell Sci 2014 Apr 24;127(Pt 7):1576-84. Epub 2014 Jan 24.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London TW20 0EX, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1242/jcs.140939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970561PMC
April 2014

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

Authors:
Marthe H R Ludtmann Plamena R Angelova Ying Zhang Andrey Y Abramov Albena T Dinkova-Kostova

Biochem J 2014 Feb;457(3):415-24

*Department of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, U.K.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1042/BJ20130863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208297PMC
February 2014

Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.

Authors:
Hilary K Siddall Derek M Yellon Sang-Bing Ong Uma A Mukherjee Niall Burke Andrew R Hall Plamena R Angelova Marthe H R Ludtmann Emma Deas Sean M Davidson Mihaela M Mocanu Derek J Hausenloy

PLoS One 2013 29;8(4):e62400. Epub 2013 Apr 29.

The Hatter Cardiovascular Institute, University College London, London, United Kingdom.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062400PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639249PMC
November 2013

Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder.

Authors:
Marthe H R Ludtmann Katrina Boeckeler Robin S B Williams

Semin Cell Dev Biol 2011 Feb 18;22(1):105-13. Epub 2010 Nov 18.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.semcdb.2010.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032892PMC
February 2011

Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, Schistosoma mansoni.

Authors:
Marthe H R Ludtmann David Rollinson Aidan M Emery Anthony J Walker

Int J Parasitol 2009 Sep 24;39(11):1223-33. Epub 2009 Apr 24.

School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ijpara.2009.04.002DOI Listing
September 2009