Publications

Quantification of size effect on protein rotational mobility in cells byF NMR spectroscopy.
Anal Bioanal Chem 2018 Jan 28;410(3):869-874. Epub 2017 Nov 28.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China.

Backbone resonance assignment of the response regulator protein PhoBfrom Escherichia coli.
Biomol NMR Assign 2018 Jan 3. Epub 2018 Jan 3.
Key Laboratory of Magnetic Resonance in Biological Systems, National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan, 430071, China.

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.
Nat Commun 2017 Dec 13;8(1):2104. Epub 2017 Dec 13.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China.

Measurement of amide proton chemical shift anisotropy in perdeuterated proteins using CSA amplification.
J Magn Reson 2017 Nov 19;284:33-38. Epub 2017 Sep 19.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. Electronic address:

Chemical shift assignments of polyketide cyclase_like protein CGL2373 from Corynebacterium glutamicum.
Biomol NMR Assign 2017 Oct 20;11(2):289-292. Epub 2017 Aug 20.
State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China.

Ultrasensitive MicroRNA Assay via Surface Plasmon Resonance Responses of Au@Ag Nanorods Etching.
Anal Chem 2017 Oct 19;89(19):10585-10591. Epub 2017 Sep 19.
: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210023, China.

Chemical shift assignments of Mb1858 (24-155), a FHA domain-containing protein from Mycobacterium bovis.
Biomol NMR Assign 2017 Aug 30. Epub 2017 Aug 30.
State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China.

Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation.
ACS Appl Mater Interfaces 2017 Jul 5;9(28):23400-23408. Epub 2017 Jul 5.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan 430071, P. R. China.

HyperpolarizedXe Magnetic Resonance Imaging Sensor for HS.
Chemistry 2017 Jun 21;23(32):7648-7652. Epub 2017 Mar 21.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China.

Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells.
Annu Rev Anal Chem (Palo Alto Calif) 2017 Jun 9;10(1):157-182. Epub 2017 Mar 9.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China; email: ,

C-I···π Halogen Bonding Driven Supramolecular Helix of Bilateral N-Amidothioureas Bearing β-Turns.
J Am Chem Soc 2017 May 10;139(19):6605-6610. Epub 2017 Feb 10.
Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Xiamen University , Xiamen 361005, China.

Solution NMR structure of zinc finger 4 and 5 from human INSM1, an essential regulator of neuroendocrine differentiation.
Proteins 2017 May 16;85(5):957-962. Epub 2017 Feb 16.
State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China.

Solution NMR structure of RHE_CH02687 from Rhizobium etli: A novel flavonoid-binding protein.
Proteins 2017 May 16;85(5):951-956. Epub 2017 Feb 16.
State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan Center for Magnetic Resonance, CAS Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, China.

The Effects of Macromolecular Crowding on Calmodulin Structure and Function.
Chemistry 2017 May 18;23(28):6736-6740. Epub 2017 Apr 18.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, P. R. China.

Reconstructing diffusion ordered NMR spectroscopy by simultaneous inversion of Laplace transform.
J Magn Reson 2017 May 7;278:1-7. Epub 2017 Mar 7.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. Electronic address:

Mitochondria Targeted and Intracellular Biothiol Triggered HyperpolarizedXe Magnetofluorescent Biosensor.
Anal Chem 2017 Feb 9;89(4):2288-2295. Epub 2017 Feb 9.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Collaborative Innovation Center of Chemistry for Life Sciences, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan 430071, People's Republic of China.

Macromolecular and Small Molecular Crowding Have Similar Effects on α-Synuclein Structure.
Chemphyschem 2017 Jan 2;18(1):55-58. Epub 2016 Dec 2.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, P. R. China.

Confinement Alters the Structure and Function of Calmodulin.
Angew Chem Int Ed Engl 2017 Jan 9;56(2):530-534. Epub 2016 Dec 9.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Collaborative Innovation Center of Chemistry for Life Sciences, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, P.R. China.

NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway.
Sci Rep 2016 Dec 7;6:38710. Epub 2016 Dec 7.
State Key Laboratory of Bioorganic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.

Compositional differences among Chinese soy sauce types studied by (13)C NMR spectroscopy coupled with multivariate statistical analysis.
Talanta 2016 Sep 13;158:89-99. Epub 2016 May 13.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China. Electronic address:

(13)C-NMR-Based Metabolomic Profiling of Typical Asian Soy Sauces.
Molecules 2016 Sep 2;21(9). Epub 2016 Sep 2.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.

Biothiol Xenon MRI Sensor Based on Thiol-Addition Reaction.
Anal Chem 2016 Jun 10;88(11):5835-40. Epub 2016 May 10.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan, 430071, China.

Optimization protocol for the extraction of antioxidant components from Origanum vulgare leaves using response surface methodology.
Saudi J Biol Sci 2016 May 21;23(3):389-96. Epub 2015 Apr 21.
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China; University of Chinese Academy of Sciences, 10049 Beijing, PR China.

MRI-guided liposomes for targeted tandem chemotherapy and therapeutic response prediction.
Acta Biomater 2016 Apr 9;35:260-8. Epub 2016 Feb 9.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. Electronic address:

A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized (129)Xe Molecular Clamp Probe.
Chemistry 2016 Mar 2;22(12):3967-70. Epub 2016 Feb 2.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, P.R. China.

Impact of the α-Synuclein Initial Ensemble Structure on Fibrillation Pathways and Kinetics.
J Phys Chem B 2016 Mar 18;120(12):3140-7. Epub 2016 Mar 18.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center of Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan 430071, P.R. China.

MRI-visible liposome nanovehicles for potential tumor-targeted delivery of multimodal therapies.
Nanoscale 2015 Aug;7(30):12843-50
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.

Labeling strategy and signal broadening mechanism of Protein NMR spectroscopy in Xenopus laevis oocytes.
Chemistry 2015 Jun 12;21(24):8686-90. Epub 2015 May 12.
Key Laboratory of Magnetic Resonance in Biological Systems State, Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance Department, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071 (P.R. China).

Direct observation of Ca(2+) -induced calmodulin conformational transitions in intact Xenopus laevis oocytes by (19) F NMR spectroscopy.
Angew Chem Int Ed Engl 2015 Apr 5;54(18):5328-30. Epub 2015 Mar 5.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China).

Beryllium fluoride exchange rate accelerated by Mg²⁺ as discovered by ¹⁹F NMR.
J Phys Chem A 2015 Jan 22;119(1):24-8. Epub 2014 Dec 22.
Key Laboratory of Magnetic Resonance in Biological Systems, National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan 430071, China.

Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions.
Talanta 2014 May 31;122:101-5. Epub 2014 Jan 31.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, PR China. Electronic address:

Strategies for protein NMR in Escherichia coli.
Biochemistry 2014 Apr 20;53(12):1971-81. Epub 2014 Mar 20.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan 430071, P. R. China.

Ca(2+) modulating α-synuclein membrane transient interactions revealed by solution NMR spectroscopy.
Biochim Biophys Acta 2014 Mar 4;1838(3):853-8. Epub 2013 Dec 4.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China. Electronic address:

pH-Triggered Au-fluorescent mesoporous silica nanoparticles for 19F MR/fluorescent multimodal cancer cellular imaging.
Chem Commun (Camb) 2014 Jan 30;50(3):283-5. Epub 2013 Oct 30.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.

(19) F NMR spectroscopy as a probe of cytoplasmic viscosity and weak protein interactions in living cells.
Chemistry 2013 Sep 6;19(38):12705-10. Epub 2013 Aug 6.
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071 (P.R. China), Fax: (+86) 27-87199291; Graduate University of Chinese Academy of Sciences, Beijing, 100029 (P.R. China).

NMR spectroscopic approach reveals metabolic diversity of human blood plasma associated with protein-drug interaction.
Anal Chem 2013 Sep 30;85(18):8601-8. Epub 2013 Aug 30.
Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan, 430071, P. R. China.

Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway.
J Biol Chem 2012 Dec 26;287(52):43899-908. Epub 2012 Oct 26.
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy.
Exp Neurol 2008 Aug 22;212(2):377-85. Epub 2008 Apr 22.
Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.

Dynamic NMR study and theoretical calculations on the conformational exchange of valsartan and related compounds.
Magn Reson Chem 2007 Nov;45(11):929-36
Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, People's Republic of China.

Implementation of real-time two-dimensional nuclear magnetic resonance spectroscopy for on-flow high-performance liquid chromatography.
J Chromatogr A 2007 Jun 19;1154(1-2):464-8. Epub 2007 Apr 19.
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.

Multiple quantum correlated spectroscopy revamped by asymmetric z-gradient echo detection signal intensity as a function of the read pulse flip angle as verified by heteronuclear 1H/31P experiments.
J Chem Phys 2007 Feb;126(5):054502
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, China and Graduate School of the Chinese Academy of Sciences, Beijing 100049, China.

Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution 1H NMR spectroscopy.
Neurochem Int 2007 Jan 30;50(2):386-94. Epub 2006 Oct 30.
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China.

NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation.
PLoS One 2015 20;10(10):e0139948. Epub 2015 Oct 20.
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, P. R. China.

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