Publications

Effects of nintedanib on the microvascular architecture in a lung fibrosis model.
Angiogenesis 2017 Aug 10;20(3):359-372. Epub 2017 Mar 10.
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Johann-Joachim-Becher-Weg 13, 55128, Mainz, Germany.

Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis.
Ann Rheum Dis 2017 Aug 16. Epub 2017 Aug 16.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Nintedanib reduces radiation-induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator.
Radiother Oncol 2017 Jul 31. Epub 2017 Jul 31.
Department of Radiation Oncology (Maastro), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands. Electronic address:

Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats.
Am J Physiol Heart Circ Physiol 2016 Sep 24;311(3):H604-12. Epub 2016 Jun 24.
Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands;

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis.
Ann Rheum Dis 2016 May 9;75(5):883-90. Epub 2015 Apr 9.
Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis.
J Pharmacol Exp Ther 2014 May 20;349(2):209-20. Epub 2014 Feb 20.
Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany (L.W., A.H.); UMR7355, INEM, CNRS and University of Orleans, Orleans, France (I.M., V.Q., B.R.); and IIDMM, University of Cape Town, Cape Town, Republic of South Africa (B.R.).

OF