Louis H Philipson

Louis H Philipson

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Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry.

Acta Diabetol 2018 Dec 11. Epub 2018 Dec 11.

Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, University of Chicago, 5841 South Maryland Ave., MC 1027, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1007/s00592-018-1267-zDOI Listing
December 2018

Precision medicine in KCNJ11 permanent neonatal diabetes.

Lancet Diabetes Endocrinol 2018 Aug 4;6(8):594-595. Epub 2018 Jun 4.

Departments of Medicine and Pediatrics, University of Chicago, Chicago, IL, USA; Kovler Diabetes Center, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(18)30138-4DOI Listing
August 2018

Monogenic Diabetes in Children and Adolescents: Recognition and Treatment Options.

Curr Diab Rep 2018 Jun 22;18(8):58. Epub 2018 Jun 22.

Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, 5841 S. Maryland Ave., MC 1027, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1007/s11892-018-1024-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312113PMC
June 2018

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Cell Rep 2018 Mar;22(10):2667-2676

Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.032DOI Listing
March 2018

Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.

Diabetes 2018 01 16;67(1):71-77. Epub 2017 Oct 16.

Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada

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http://dx.doi.org/10.2337/db17-0982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741145PMC
January 2018

Early Intensive Insulin Use May Preserve -Cell Function in Neonatal Diabetes Due to Mutations in the Proinsulin Gene.

J Endocr Soc 2018 Jan 24;2(1):1-8. Epub 2017 Nov 24.

Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, Illinois, 60637.

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http://dx.doi.org/10.1210/js.2017-00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738118PMC
January 2018

Diabetes Presentation in Infancy: High Risk of Diabetic Ketoacidosis.

Diabetes Care 2017 10 4;40(10):e147-e148. Epub 2017 Aug 4.

Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Chicago, Chicago, IL

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http://dx.doi.org/10.2337/dc17-1145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606305PMC
October 2017

Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis.

PLoS One 2016 3;11(5):e0152869. Epub 2016 May 3.

Departments of Medicine and Pediatrics, the Kovler Diabetes Center, The University of Chicago, Chicago, IL, 60637, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152869PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854486PMC
April 2017

GCK-MODY in the US National Monogenic Diabetes Registry: frequently misdiagnosed and unnecessarily treated.

Acta Diabetol 2016 Oct 22;53(5):703-8. Epub 2016 Apr 22.

Departments of Pediatrics and Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1007/s00592-016-0859-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016218PMC
October 2016

Growth Hormone-Releasing Hormone in Diabetes.

Front Endocrinol (Lausanne) 2016 10;7:129. Epub 2016 Oct 10.

Department of Medicine, Kovler Diabetes Center, The University of Chicago, Chicago, IL, USA; Department of Pediatrics, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.3389/fendo.2016.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056186PMC
October 2016

The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.

Diabetes 2016 09 12;65(9):2711-23. Epub 2016 Apr 12.

Kovler Diabetes Center, Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL

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http://dx.doi.org/10.2337/db15-0629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001176PMC
September 2016

A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling.

Endocrinology 2016 05 10;157(5):1852-65. Epub 2016 Feb 10.

Anatomy and Cell Biology (Y.Y., X.S., W.X., B.L., N.H., S.R.T., J.F.E.), Departments of Pathology (K.G.-C.) and Pediatrics (A.U., K.L.O., A.W.N.), Fraternal Order of Eagles Diabetes Research Center (A.W.N., J.F.E.), and Department of Biostatistics (K.W.), College of Public Health, University of Iowa, Iowa City, Iowa 52242; and Department of Medicine (L.H.P., M.H.), University of Chicago, Chicago, Illinois 60637.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2015-1935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870869PMC
May 2016

An online monogenic diabetes discussion group: supporting families and fueling new research.

Transl Res 2015 Nov 28;166(5):425-31. Epub 2015 Jun 28.

Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes, & Metabolism, The University of Chicago, Chicago, Ill; Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes, & Metabolism, The University of Chicago, Chicago, Ill. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744474PMC
November 2015

PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids.

Mol Metab 2015 Nov 14;4(11):811-22. Epub 2015 Aug 14.

Laboratory of Molecular Mechanisms of Diabetes, Institut de Recherches Cliniques de Montreal (IRCM), 110 Ave des Pins Ouest, Montreal, Quebec, H2W 1R7, Canada ; Department of Anatomy and Cell Biology, McGill University, 845 Rue Sherbrooke Ouest, Montreal, Quebec, H3A 0G4, Canada ; Montreal Diabetes Research Center, CRCHUM, Department of Medicine, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montreal, Quebec, H3T 1J4, Canada.

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http://dx.doi.org/10.1016/j.molmet.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632114PMC
November 2015

Metastatic Insulinoma Following Resection of Nonsecreting Pancreatic Islet Cell Tumor: A Case Report and Review of the Literature.

J Investig Med High Impact Case Rep 2013 Jan-Mar;1(1):2324709612473274. Epub 2013 Jan 1.

University of Chicago Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1177/2324709612473274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528785PMC
October 2015

Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism.

J Med Genet 2015 Sep 22;52(9):612-6. Epub 2015 Jun 22.

Departments of Medicine and Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes, & Metabolism, The University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1136/jmedgenet-2015-103220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744477PMC
September 2015

Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes.

Diabetologia 2015 Jul 17;58(7):1430-5. Epub 2015 Apr 17.

Departments of Pediatrics and Medicine, Section of Adult and Pediatric Endocrinology, Diabetes, & Metabolism, University of Chicago, 5841 S. Maryland Ave., MC 1027, Chicago, IL, 60637, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00125-015-35
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http://link.springer.com/10.1007/s00125-015-3593-9
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http://dx.doi.org/10.1007/s00125-015-3593-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641523PMC
July 2015

Insulin dosing in pediatric diabetic ketoacidosis: where to start?

JAMA 2015 Jun;313(22):2274-5

Departments of Medicine and Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2015.135DOI Listing
June 2015

Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A.

Mol Metab 2015 Apr 3;4(4):265-76. Epub 2015 Feb 3.

Kovler Diabetes Center, The University of Chicago, USA ; Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, USA ; Committee on Molecular Metabolism and Nutrition, The University of Chicago, USA.

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http://dx.doi.org/10.1016/j.molmet.2015.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354925PMC
April 2015

Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.

Endocrinology 2015 Feb 26;156(2):444-52. Epub 2014 Nov 26.

Graduate School of Medical Science and Engineering (K.K., C.-M.O., S.P., J.N., H.K.), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea; Department of Biochemistry (M.O.-I., S.N.), Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan; Department of Biochemistry (S.P.), Catholic Kwandong University College of Medicine, Gangneung, Gangwondo 210-701, Republic of Korea; Department of Biochemistry (J.N.), Yonsei University Wonju College of Medicine, Wonju, Gangwondo 220-701, Republic of Korea; Department of Genetics and Development (V.K.Y., G.K.), Columbia University Medical Center, New York, New York 10032; Department of Medicine (N.A.T., L.H.P.), The University of Chicago, Chicago, Illinois 60637; Departments of Medicine and Cell and Developmental Biology (M.W.R.), State University of New York Upstate Medical University, Syracuse, New York 13210; and Diabetes Center (M.S.G.), Hormone Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California 94143.

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http://dx.doi.org/10.1210/en.2014-1687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298319PMC
February 2015

A review of the mental health issues of diabetes conference.

Diabetes Care 2015 Feb;38(2):333-8

Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, TX

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http://dx.doi.org/10.2337/dc14-1383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302262PMC
February 2015

Update on diabetes classification.

Med Clin North Am 2015 Jan 22;99(1):1-16. Epub 2014 Nov 22.

Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA; Department of Pediatrics, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.mcna.2014.08.015DOI Listing
January 2015

Donald F. Steiner MD, 1930-2014: discoverer of proinsulin.

Proc Natl Acad Sci U S A 2015 Jan 5;112(4):940-1. Epub 2015 Jan 5.

Dean and Executive Vice President, Division of Biological Sciences, The Prtizker School of Medicine, University of Chicago, Chicago, IL 60637.

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http://dx.doi.org/10.1073/pnas.1423774112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313841PMC
January 2015

Sulfonylurea treatment before genetic testing in neonatal diabetes: pros and cons.

J Clin Endocrinol Metab 2014 Dec;99(12):E2709-14

Departments of Medicine and Pediatrics (D.C., C.D.B., J.L.H., J.T.D., R.N.N., L.H.P., S.A.W.G., Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, Illinois 60637; Department of Pediatric Endocrinology (D.I.S.), Albany Medical Center Hospital, Albany, New York 12208; Department of Endocrinology and Diabetes (D.L.F.), Louisiana State University Health Sciences Center and Children's Hospital, New Orleans, Louisiana 70112; Academic Endocrinology and Edward Hospital (C.A.Z.), Naperville, Illinois 60540; Department of Pediatrics (A.O.D.), Division of Pediatric Endocrinology, MetroHealth Medical Center, Cleveland, Ohio 44109; and Nunnelee Pediatric Specialty Clinic (K.K.), Betty H. Cameron Women's and Children's Hospital, New Hanover Regional Medical Center, Wilmington, North Carolina 28401.

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http://dx.doi.org/10.1210/jc.2014-2494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255121PMC
December 2014

Routine depression screening for patients with diabetes--reply.

JAMA 2014 Dec;312(22):2413

Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1001/jama.2014.14778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145797PMC
December 2014

Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets.

PLoS One 2014 3;9(3):e90519. Epub 2014 Mar 3.

Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090519PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940889PMC
November 2014

The mental health comorbidities of diabetes.

JAMA 2014 Aug;312(7):691-2

Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1001/jama.2014.8040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439400PMC
August 2014

The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.

Cell Metab 2014 Jun 15;19(6):1050-7. Epub 2014 May 15.

Division of Endocrinology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA; Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45237, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109713PMC
June 2014

Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.

Cell Metab 2014 Jan 12;19(1):109-21. Epub 2013 Dec 12.

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.11.007DOI Listing
January 2014

Distribution of directional change as a signature of complex dynamics.

Proc Natl Acad Sci U S A 2013 Dec 18;110(49):19689-94. Epub 2013 Nov 18.

James Franck Institute, Department of Chemistry, Institute for Biophysical Dynamics, Department of Medicine, and Department of Physics, University of Chicago, Chicago, IL 60637.

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http://dx.doi.org/10.1073/pnas.1319473110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856831PMC
December 2013

A computational systems analysis of factors regulating α cell glucagon secretion.

Islets 2012 Jul-Aug;4(4):262-83. Epub 2012 Jul 1.

The Kovler Diabetes Center, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.4161/isl.22193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496652PMC
June 2013

β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.

Diabetes 2013 May 24;62(5):1527-36. Epub 2013 Jan 24.

Kovler Diabetes Center, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.2337/db12-1013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636652PMC
May 2013

Intracellular transport of insulin granules is a subordinated random walk.

Proc Natl Acad Sci U S A 2013 Mar 11;110(13):4911-6. Epub 2013 Mar 11.

James Franck Institute, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.1221962110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612641PMC
March 2013

Transgenic zebrafish model of the C43G human insulin gene mutation.

J Diabetes Investig 2013 Mar 5;4(2):157-67. Epub 2012 Nov 5.

Committee on Molecular Metabolism and Nutrition Chicago IL USA ; Department of Medicine University of Chicago Chicago, Illinois, USA IL USA.

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http://dx.doi.org/10.1111/jdi.12015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019270PMC
March 2013

SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion.

Am J Physiol Endocrinol Metab 2012 Mar 10;302(6):E714-23. Epub 2012 Jan 10.

Univ. of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/ajpendo.00486.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311292PMC
March 2012

Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment.

Curr Diab Rep 2011 Dec;11(6):519-32

Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/s11892-011-0234-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226065PMC
December 2011

Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis.

Prog Biophys Mol Biol 2011 Nov 8;107(2):293-303. Epub 2011 Sep 8.

Department of Medicine and Pediatrics, The Kovler Diabetes Center, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.pbiomolbio.2011.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439405PMC
November 2011

Who should have genetic testing for maturity-onset diabetes of the young?

Clin Endocrinol (Oxf) 2011 Oct;75(4):422-6

Department of Medicine, The Kovler Diabetes Center, The University of Chicago, Chicago, IL 606037, USA.

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http://dx.doi.org/10.1111/j.1365-2265.2011.04049.xDOI Listing
October 2011

Creation of the Web-based University of Chicago Monogenic Diabetes Registry: using technology to facilitate longitudinal study of rare subtypes of diabetes.

J Diabetes Sci Technol 2011 Jul 1;5(4):879-86. Epub 2011 Jul 1.

Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, Illinois 60637, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192593PMC
http://dx.doi.org/10.1177/193229681100500409DOI Listing
July 2011

Genetics and pathophysiology of neonatal diabetes mellitus.

J Diabetes Investig 2011 Jun;2(3):158-69

Departments of Pediatrics ; Medicine, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/j.2040-1124.2011.00106.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014912PMC
June 2011

The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes.

Diabetes Care 2011 Mar 27;34(3):622-7. Epub 2011 Jan 27.

Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.2337/dc10-1616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041194PMC
March 2011

Glucose-induced ERM protein activation and translocation regulates insulin secretion.

Am J Physiol Endocrinol Metab 2010 Nov 24;299(5):E772-85. Epub 2010 Aug 24.

Dept. of Medicine, The Univ. of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/ajpendo.00199.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980361PMC
November 2010

Response to Jentsch et al.

Cell Metab 2010 Oct 5;12(4):310. Epub 2010 Oct 5.

Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2010.09.005DOI Listing
October 2010

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.

Rev Endocr Metab Disord 2010 Sep;11(3):205-15

Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark.

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http://dx.doi.org/10.1007/s11154-010-9151-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974937PMC
September 2010

Neonatal diabetes mellitus: a model for personalized medicine.

Trends Endocrinol Metab 2010 Aug 29;21(8):464-72. Epub 2010 Apr 29.

Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, University of Chicago Pritzker School of Medicine, 5841 S Maryland Ave, MC 1027, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.tem.2010.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914172PMC
August 2010

Intraperitoneal injection into adult zebrafish.

J Vis Exp 2010 Aug 30(42). Epub 2010 Aug 30.

Department of Organismal Biology and Anatomy, The University of Chicago, USA.

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http://dx.doi.org/10.3791/2126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278329PMC
August 2010

Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis.

Zebrafish 2010 Jun;7(2):205-13

Committee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1089/zeb.2009.0640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882991PMC
June 2010

Glucose sensing in the pancreatic beta cell: a computational systems analysis.

Theor Biol Med Model 2010 May 24;7:15. Epub 2010 May 24.

Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

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http://tbiomed.biomedcentral.com/articles/10.1186/1742-4682-
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http://dx.doi.org/10.1186/1742-4682-7-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896931PMC
May 2010

Update in neonatal diabetes.

Curr Opin Endocrinol Diabetes Obes 2010 Feb;17(1):13-9

Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1097/MED.0b013e328334f158DOI Listing
February 2010

The granular chloride channel ClC-3 is permissive for insulin secretion.

Cell Metab 2009 Oct;10(4):316-23

Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.cmet.2009.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778193PMC
October 2009

Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.

Mol Cell Biol 2009 Jun 16;29(11):3151-62. Epub 2009 Mar 16.

University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1128/MCB.01792-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681997PMC
June 2009

Cold climate genes and the prevalence of type 2 diabetes mellitus.

Med Hypotheses 2006 23;67(5):1034-41. Epub 2006 Jun 23.

Department of Medicine, University of Chicago, MC-1027, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.mehy.2006.04.057DOI Listing
May 2009

A nanoporous, transparent microcontainer for encapsulated islet therapy.

J Diabetes Sci Technol 2009 Mar;3(2):297-303

The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739746PMC
http://dx.doi.org/10.1177/193229680900300210DOI Listing
March 2009

The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing.

Diabetes 2009 Feb;58(2):304-6

Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, Illinois, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db08-16
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628601PMC
February 2009

Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells.

Cell Calcium 2008 Dec 2;44(6):533-44. Epub 2008 May 2.

Department of Medicine, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.ceca.2008.03.007DOI Listing
December 2008

The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution.

Proc Natl Acad Sci U S A 2008 Nov 30;105(44):16843-8. Epub 2008 Oct 30.

Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.0807916105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579341PMC
November 2008

When BAD is good for beta cells.

Cell Metab 2008 Apr;7(4):280-1

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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April 2008

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Am J Physiol Endocrinol Metab 2008 Feb 25;294(2):E217-29. Epub 2007 Sep 25.

Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1152/ajpendo.00474.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268609PMC
February 2008

Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach.

Am J Physiol Cell Physiol 2007 Dec 10;293(6):C1924-33. Epub 2007 Oct 10.

Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.

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December 2007

Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.

Am J Physiol Endocrinol Metab 2007 Jun 30;292(6):E1543-54. Epub 2007 Jan 30.

Department of Medicine, The University of Chicago, Chicago, USA.

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http://dx.doi.org/10.1152/ajpendo.00620.2006DOI Listing
June 2007

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.

Diabetes 2006 Dec;55(12):3256-63

Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.

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December 2006

Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.

Am J Physiol Endocrinol Metab 2006 Sep 18;291(3):E587-95. Epub 2006 Apr 18.

Department of Medicine, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/ajpendo.00612.2005DOI Listing
September 2006

Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy.

Methods Mol Biol 2006 ;319:37-66

Department of Medicine, University of Chicago, IL, USA.

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August 2006

Functional MR microimaging of pancreatic beta-cell activation.

Cell Transplant 2006 ;15(2):195-203

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.

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June 2006

Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis.

Curr Diabetes Rev 2006 May;2(2):241-59

Department of Medicine, University of Chicago, MC-1027, 5841 S. Maryland Ave., Chicago, IL 60637, USA.

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May 2006

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

Science 2006 Mar;311(5768):1774-5

Section of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/science.1123510DOI Listing
March 2006

Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches.

Ann N Y Acad Sci 2005 Dec;1066:136-51

Department of Medicine, MC-1027, The University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.

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http://dx.doi.org/10.1196/annals.1363.019DOI Listing
December 2005

Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions.

Am J Physiol Endocrinol Metab 2005 Nov 28;289(5):E839-48. Epub 2005 Jun 28.

Dept. of Medicine, The Univ. of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/ajpendo.00595.2004DOI Listing
November 2005

Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.

Diabetes 2005 Nov;54(11):3073-81

Department of Medicine, MC 1027, University of Chicago, Chicago, IL 60637, USA.

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November 2005

Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling.

Am J Physiol Endocrinol Metab 2005 Oct 12;289(4):E578-85. Epub 2005 Jul 12.

Dept. of Medicine, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1152/ajpendo.00054.2005DOI Listing
October 2005

FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets.

Am J Physiol Cell Physiol 2005 Jul 9;289(1):C224-9. Epub 2005 Mar 9.

Department of Medicine, MC1027, Division of Biological Sciences, Pritzker School of Medicine, University of Chicago, 5841 S. Maryland Ave., Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1152/ajpcell.00004.2005DOI Listing
July 2005