Lina M Obeid

Lina M Obeid

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Lina M Obeid

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Delivery of long chain C and C ceramide in HeLa cells using oxidized graphene nanoribbons.

J Biomed Mater Res B Appl Biomater 2020 Apr 24;108(3):1141-1156. Epub 2019 Aug 24.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York.

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http://dx.doi.org/10.1002/jbm.b.34465DOI Listing
April 2020

Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases.

J Lipid Res 2019 Nov 26;60(11):1841-1850. Epub 2019 Jun 26.

Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY

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http://dx.doi.org/10.1194/jlr.M094722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824496PMC
November 2019

A novel role for DGATs in cancer.

Adv Biol Regul 2019 05 13;72:89-101. Epub 2018 Dec 13.

Stony Brook Cancer Center and the Department of Medicine, Stony Brook University, Health Sciences Center, Stony Brook, NY, 11794, USA; The Northport VA Medical Center, Northport, NY, 11768, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488436PMC
May 2019

Advances in determining signaling mechanisms of ceramide and role in disease.

J Lipid Res 2019 May 7;60(5):913-918. Epub 2019 Mar 7.

Stony Brook Cancer Center and the Department of Medicine, Health Sciences Center, Stony Brook University, Stony Brook, NY 11794

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http://dx.doi.org/10.1194/jlr.S092874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495170PMC
May 2019

Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue.

Prostaglandins Other Lipid Mediat 2019 04 19;141:40-48. Epub 2019 Feb 19.

Health Science Center, L-4, 179, Stony Brook University Medical Center, Stony Brook, NY, 11794-8430, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467697PMC
April 2019

Oxidized graphene nanoparticles as a delivery system for the pro-apoptotic sphingolipid C ceramide.

J Biomed Mater Res A 2019 01 13;107(1):25-37. Epub 2018 Nov 13.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York.

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http://dx.doi.org/10.1002/jbm.a.36474DOI Listing
January 2019

Functions of neutral ceramidase in the Golgi apparatus.

J Lipid Res 2018 11 28;59(11):2116-2125. Epub 2018 Aug 28.

Department of Medicine, Stony Brook University, Stony Brook, NY

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http://www.jlr.org/lookup/doi/10.1194/jlr.M088187
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http://dx.doi.org/10.1194/jlr.M088187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210901PMC
November 2018

Molecular mechanisms of regulation of sphingosine kinase 1.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 11 30;1863(11):1413-1422. Epub 2018 Aug 30.

Department of Medicine, The Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11790, USA; Northport Veterans Affairs Medical Center, Northport, NY 11768, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436826PMC
November 2018

Author Correction: Sphingolipids and their metabolism in physiology and disease.

Nat Rev Mol Cell Biol 2018 Oct;19(10):673

Stony Brook Cancer Center and Department of Medicine, Stony Brook University, New York, 11794, USA.

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http://dx.doi.org/10.1038/s41580-018-0046-6DOI Listing
October 2018

AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.

Oncogene 2018 07 17;37(28):3852-3863. Epub 2018 Apr 17.

Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.

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http://dx.doi.org/10.1038/s41388-018-0236-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041258PMC
July 2018

Role of sphingolipids in senescence: implication in aging and age-related diseases.

J Clin Invest 2018 07 2;128(7):2702-2712. Epub 2018 Jul 2.

Stony Brook Cancer Center and Department of Medicine, Stony Brook University, Stony Brook, New York, USA.

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https://www.jci.org/articles/view/97949
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http://dx.doi.org/10.1172/JCI97949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025964PMC
July 2018

Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry.

J Lipid Res 2018 06 2;59(6):1046-1057. Epub 2018 Apr 2.

Departments of Medicine Stony Brook University, Stony Brook, NY

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http://dx.doi.org/10.1194/jlr.D081646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983394PMC
June 2018

Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.

Cell Death Differ 2018 05 11;25(5):841-856. Epub 2017 Dec 11.

Department of Medicine, State University of New York (SUNY), Stony Brook, NY, 11794, USA.

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http://dx.doi.org/10.1038/s41418-017-0018-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943524PMC
May 2018

Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.

FASEB J 2018 03 3;32(3):1716-1728. Epub 2018 Jan 3.

Department of Medicine, Stony Brook University School of Medicine, Stony Brook, New York, USA.

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http://www.fasebj.org/doi/10.1096/fj.201701067R
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http://dx.doi.org/10.1096/fj.201701067RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892732PMC
March 2018

Sphingolipids and their metabolism in physiology and disease.

Nat Rev Mol Cell Biol 2018 03 22;19(3):175-191. Epub 2017 Nov 22.

Stony Brook Cancer Center and Department of Medicine, Stony Brook University, New York 11794, USA.

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http://dx.doi.org/10.1038/nrm.2017.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902181PMC
March 2018

An intrinsic lipid-binding interface controls sphingosine kinase 1 function.

J Lipid Res 2018 03 11;59(3):462-474. Epub 2018 Jan 11.

Department of Medicine and Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11790

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http://dx.doi.org/10.1194/jlr.M081307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832922PMC
March 2018

Murine Model for Colitis-Associated Cancer of the Colon.

Methods Mol Biol 2016 ;1438:245-54

Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.

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http://dx.doi.org/10.1007/978-1-4939-3661-8_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657253PMC
December 2017

Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells.

Stem Cell Reports 2017 11 19;9(5):1488-1500. Epub 2017 Oct 19.

Department of Medicine, Stony Brook University, Stony Brook, NY, USA; Department of Medicine and Stony Brook Cancer Center, Stony Brook University, HSC T15-023, Stony Brook, NY 11794, USA; Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY, USA; Department of Dermatology, Stony Brook University, Stony Brook, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829345PMC
November 2017

Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Prostaglandins Other Lipid Mediat 2017 05 2;130:47-56. Epub 2017 Apr 2.

Department of Medicine and the, Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA; Northport Veterans Affairs Medical Center, Northport, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509055PMC
May 2017

Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets.

Cell Metab 2017 03;25(3):686-697

Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA; Northport Veterans Affairs Medical Center, Northport, NY 11768, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472424PMC
March 2017

Sphingolipids in mitochondria.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Jan 30;1862(1):56-68. Epub 2016 Sep 30.

Stony Brook Cancer Center and the Department of Medicine, Stony Brook University, Health Sciences Center, Stony Brook, NY 11794, USA; The Northport VA Medical Center, Northport, NY 11768, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13881981163026
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http://dx.doi.org/10.1016/j.bbalip.2016.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125891PMC
January 2017

Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis.

Adv Biol Regul 2017 Jan 14;63:140-155. Epub 2016 Nov 14.

Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Northport Veterans Affairs Medical Center, Northport, NY 11768, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292058PMC
January 2017

Sphingosine-1-phosphate metabolism: A structural perspective.

Crit Rev Biochem Mol Biol 2015 29;50(4):298-313. Epub 2015 Apr 29.

b Department of Medicine , Stony Brook University , Stony Brook , NY , USA .

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http://www.tandfonline.com/doi/full/10.3109/10409238.2015.10
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http://dx.doi.org/10.3109/10409238.2015.1039115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476942PMC
June 2016

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease.

PLoS One 2015 27;10(8):e0136633. Epub 2015 Aug 27.

Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America; Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136633PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552301PMC
May 2016

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.

Oncotarget 2016 Apr;7(14):18440-57

Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.18632/oncotarget.7825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951300PMC
April 2016

Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.

Biochem J 2016 Mar 8;473(6):743-55. Epub 2016 Jan 8.

Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY 40202, U.S.A. James Graham Brown Cancer Center, University of Louisville, KY 40202, U.S.A.

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http://dx.doi.org/10.1042/BJ20150586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513154PMC
March 2016

Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.

FASEB J 2015 Nov 24;29(11):4654-69. Epub 2015 Jul 24.

*Department of Medicine and the Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA; and Northport Veterans Affairs Medical Center, North Port, New York, USA

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http://dx.doi.org/10.1096/fj.15-274340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608912PMC
November 2015

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.

J Biol Chem 2015 Oct 28;290(42):25356-73. Epub 2015 Aug 28.

From the Stony Brook Cancer Center, the Department of Medicine, and the Northport Veterans Affairs Medical Center, Northport, New York 11768

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http://dx.doi.org/10.1074/jbc.M115.658658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646185PMC
October 2015

Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.

PLoS One 2014 2;9(12):e113998. Epub 2014 Dec 2.

Northport Veterans Affairs Medical Center, Northport, New York, United States of America; Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America; Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113998PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252067PMC
August 2015

Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.

Structure 2015 Aug 16;23(8):1482-1491. Epub 2015 Jul 16.

Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Department of Medicine, Stony Brook Cancer Center, Stony Brook, NY 11794, USA. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(15)00238-5.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261500238
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http://dx.doi.org/10.1016/j.str.2015.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830088PMC
August 2015

A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.

FASEB J 2015 Jul 24;29(7):2803-13. Epub 2015 Mar 24.

*Stony Brook Cancer Center and the Department of Medicine, Stony Brook University, Health Sciences Center, Stony Brook, New York, USA; Department of Biochemistry, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt; and Northport Veterans Affairs Medical Center, Northport, New York, USA

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http://www.fasebj.org/content/early/2015/03/24/fj.15-270413.
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http://www.fasebj.org/cgi/doi/10.1096/fj.15-270413
Publisher Site
http://dx.doi.org/10.1096/fj.15-270413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478804PMC
July 2015

Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization.

Biochim Biophys Acta 2015 Apr 4;1850(4):628-39. Epub 2014 Dec 4.

Stony Brook Cancer Center and the Department of Medicine, Stony Brook University, Health Sciences Center, Stony Brook, NY 11794, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2014.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435939PMC
April 2015

Evolving concepts in cancer therapy through targeting sphingolipid metabolism.

Biochim Biophys Acta 2014 Aug 30;1841(8):1174-88. Epub 2013 Dec 30.

Department of Medicine and the Stony Brook Cancer Center, Health Science Center, Stony Brook University, 100 Nicolls Road, L4, 178, 11794 Stony Brook, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2013.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221100PMC
August 2014

Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.

Biochim Biophys Acta 2014 May 12;1841(5):727-37. Epub 2013 Jul 12.

The Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; The Northport VA Medical Center, Northport, NY 11768, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2013.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888837PMC
May 2014

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.

FASEB J 2014 Jan 11;28(1):495-505. Epub 2013 Oct 11.

2Stony Brook Cancer Center and Department of Medicine, Stony Brook University, 100 Nicolls Rd., Stony Brook, NY 11794, USA.

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http://dx.doi.org/10.1096/fj.13-230557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868841PMC
January 2014

Sphingosine-1-phosphate receptor 2.

FEBS J 2013 Dec 19;280(24):6354-66. Epub 2013 Aug 19.

Department of Medicine, Stony Brook University, NY, USA.

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http://dx.doi.org/10.1111/febs.12446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349199PMC
December 2013

Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.

Rheumatol Int 2013 Oct 3;33(10):2677-81. Epub 2012 Aug 3.

Departments of Microbiology and Immunology, 173 Ashley Avenue MSC 504 Room 203, Charleston, SC, 29425, USA.

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http://link.springer.com/10.1007/s00296-012-2493-2
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http://dx.doi.org/10.1007/s00296-012-2493-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784643PMC
October 2013

Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.

PLoS One 2013 3;8(1):e53521. Epub 2013 Jan 3.

Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053521PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536755PMC
August 2013

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.

FASEB J 2013 Aug 29;27(8):3155-66. Epub 2013 Apr 29.

Department of Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, South Carolina, USA.

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http://dx.doi.org/10.1096/fj.13-228460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714586PMC
August 2013

Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity.

J Biol Chem 2013 Aug 13;288(31):22193-206. Epub 2013 Jun 13.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M113.477786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829312PMC
August 2013

Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway.

Handb Exp Pharmacol 2013 (216):275-303

The Department of Molecular and Cellular Biology and Pathobiology, The Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1007/978-3-7091-1511-4_14DOI Listing
July 2013

Sphingosine kinase 1 in cancer.

Adv Cancer Res 2013 ;117:201-35

Molecular and Cellular Biology and Pathobiology Program, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1016/B978-0-12-394274-6.00007-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491387PMC
June 2013

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins.

Biochem J 2013 Feb;449(3):661-72

Departments of Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1042/BJ20120213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623934PMC
February 2013

Effect of sphingosine kinase 1 inhibition on blood pressure.

FASEB J 2013 Feb 29;27(2):656-64. Epub 2012 Oct 29.

University of Hawaii Cancer Center, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1096/fj.12-219014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545530PMC
February 2013

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors.

Biochim Biophys Acta 2013 Jan 16;1831(1):157-66. Epub 2012 Jul 16.

The Department of Molecular and Cellular Biology, The Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.bbalip.2012.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661866PMC
January 2013

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.

Prostaglandins Other Lipid Mediat 2012 Dec 31;99(3-4):124-30. Epub 2012 Aug 31.

Ralph H Johnson VA Medical Center, Medical University of South Carolina, Charleston, SC 29401, United States.

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http://dx.doi.org/10.1016/j.prostaglandins.2012.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661865PMC
December 2012

Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner.

J Biol Chem 2012 Sep 24;287(38):31794-803. Epub 2012 Jul 24.

Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA.

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http://dx.doi.org/10.1074/jbc.M112.385765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442513PMC
September 2012

Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.

Crit Rev Biochem Mol Biol 2011 Aug;46(4):342-51

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425-7790, USA.

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http://dx.doi.org/10.3109/10409238.2011.597737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144498PMC
August 2011

Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.

J Lipid Res 2012 May 29;53(5):918-28. Epub 2012 Feb 29.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1194/jlr.M019075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329391PMC
May 2012

Ceramide synthases at the centre of sphingolipid metabolism and biology.

Biochem J 2012 Feb;441(3):789-802

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://biochemj.org/lookup/doi/10.1042/BJ20111626
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http://dx.doi.org/10.1042/BJ20111626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689921PMC
February 2012

Impact of sphingosine kinase on inflammatory pathways in fibroblast-like synoviocytes.

Inflamm Allergy Drug Targets 2011 Dec;10(6):464-71

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, 29425, USA.

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http://dx.doi.org/10.2174/187152811798104863DOI Listing
December 2011

Dihydroceramide-based response to hypoxia.

J Biol Chem 2011 Nov 13;286(44):38069-78. Epub 2011 Sep 13.

Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M111.297994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207482PMC
November 2011

p53 and regulation of bioactive sphingolipids.

Adv Enzyme Regul 2011 28;51(1):219-28. Epub 2010 Oct 28.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425-7790, USA.

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http://dx.doi.org/10.1016/j.advenzreg.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078951PMC
August 2011

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.

FASEB J 2011 Aug 6;25(8):2782-91. Epub 2011 May 6.

Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd., St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1096/fj.10-178095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136338PMC
August 2011

Many ceramides.

J Biol Chem 2011 Aug 21;286(32):27855-62. Epub 2011 Jun 21.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SouthCarolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.R111.254359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151029PMC
August 2011

Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.

Crit Rev Biochem Mol Biol 2011 Aug;46(4):342-51

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425-7790, USA.

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http://dx.doi.org/10.3109/10409238.2011.597737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144498PMC
August 2011

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

J Biol Chem 2011 Jul 4;286(28):24754-64. Epub 2011 May 4.

Division of Hematology/Oncology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M111.250779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137051PMC
July 2011

Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia.

Neurosci Lett 2011 Jul 13;499(1):4-8. Epub 2011 May 13.

Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/j.neulet.2011.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119782PMC
July 2011

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.

J Biol Chem 2011 May 9;286(18):15929-42. Epub 2011 Mar 9.

Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M111.230870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091202PMC
May 2011

Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.

J Biol Chem 2011 Apr 18;286(15):13292-303. Epub 2011 Feb 18.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M110.163378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075676PMC
April 2011

A role of sphingosine kinase 1 in head and neck carcinogenesis.

Cancer Prev Res (Phila) 2011 Mar 5;4(3):454-62. Epub 2011 Jan 5.

Department of Hematology/Oncology, Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342666PMC
March 2011

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

J Lipid Res 2011 Feb 16;52(2):278-88. Epub 2010 Nov 16.

Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P R China.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M012161
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http://dx.doi.org/10.1194/jlr.M012161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023548PMC
February 2011

Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis.

J Biol Chem 2011 Feb 10;286(6):4644-58. Epub 2010 Dec 10.

Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA.

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http://dx.doi.org/10.1074/jbc.M110.164392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039377PMC
February 2011

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.

J Lipid Res 2011 Jan 11;52(1):68-77. Epub 2010 Oct 11.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1194/jlr.M009142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999923PMC
January 2011

An overview of sphingolipid metabolism: from synthesis to breakdown.

Adv Exp Med Biol 2010 ;688:1-23

Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069696PMC
http://dx.doi.org/10.1007/978-1-4419-6741-1_1DOI Listing
November 2010

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.

J Biol Chem 2010 Oct 2;285(42):32476-85. Epub 2010 Aug 2.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M110.141028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952249PMC
October 2010

Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.

J Biol Chem 2010 Sep 13;285(38):29078-90. Epub 2010 Jul 13.

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1074/jbc.M110.105296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937939PMC
September 2010

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.

FASEB J 2010 Aug 24;24(8):2727-38. Epub 2010 Mar 24.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, 29425, USA.

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http://dx.doi.org/10.1096/fj.09-150540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909287PMC
August 2010

Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.

J Immunol 2010 Aug 19;185(4):2570-9. Epub 2010 Jul 19.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.4049/jimmunol.1000644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942019PMC
August 2010