Publications by authors named "Lilia M Iakoucheva"

43Publications

Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.

Cell Rep 2019 09;28(13):3320-3328.e4

Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988705PMC
September 2019

Getting to the Cores of Autism.

Cell 2019 09;178(6):1287-1298

University of California San Diego, Department of Psychiatry, La Jolla, CA 92093, USA; University of California San Diego, School of Medicine, Department of Cellular & Molecular Medicine, La Jolla, CA 92093, USA; University of California San Diego, Beyster Center for Psychiatric Genomics, La Jolla, CA 92093. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039308PMC
September 2019

Pathogenicity and functional impact of non-frameshifting insertion/deletion variation in the human genome.

PLoS Comput Biol 2019 06 14;15(6):e1007112. Epub 2019 Jun 14.

School of Informatics, Computing, and Engineering, Indiana University, Bloomington, Indiana, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1007112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594643PMC
June 2019

Comprehensive Analyses of Tissue-Specific Networks with Implications to Psychiatric Diseases.

Methods Mol Biol 2017 ;1613:371-402

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/978-1-4939-7027-8_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699888PMC
May 2018

Frequency and Complexity of De Novo Structural Mutation in Autism.

Am J Hum Genet 2016 Apr 24;98(4):667-79. Epub 2016 Mar 24.

Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833290PMC
April 2016

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

Cell 2016 Feb;164(4):805-17

Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science (CEGS), Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882190PMC
February 2016

A proteome-scale map of the human interactome network.

Cell 2014 Nov;159(5):1212-1226

Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://llama.mshri.on.ca/publications/Rolland_Cell_2014.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741401422
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http://dx.doi.org/10.1016/j.cell.2014.10.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266588PMC
November 2014

Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.

Chem Rev 2014 Jul 15;114(13):6844-79. Epub 2014 May 15.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute and ∥Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida , Tampa, Florida 33612, United States.

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http://pubs.acs.org/doi/10.1021/cr400713r
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http://dx.doi.org/10.1021/cr400713rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100540PMC
July 2014

Predicted disorder-to-order transition mutations in IκBα disrupt function.

Phys Chem Chem Phys 2014 Apr 6;16(14):6480-5. Epub 2014 Mar 6.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0378, USA.

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http://dx.doi.org/10.1039/c3cp54427cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040282PMC
April 2014

Disease mutations in disordered regions--exception to the rule?

Mol Biosyst 2012 Jan 14;8(1):27-32. Epub 2011 Nov 14.

Department of Computer Science, Columbia University, New York, NY 10027, USA.

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http://dx.doi.org/10.1039/c1mb05251aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307532PMC
January 2012

Graphlet kernels for prediction of functional residues in protein structures.

J Comput Biol 2010 Jan;17(1):55-72

Department of Computer Science and Engineering, University of California, Riverside, California, USA.

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http://dx.doi.org/10.1089/cmb.2009.0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921594PMC
January 2010

Loss of post-translational modification sites in disease.

Pac Symp Biocomput 2010 :337-47

School of Informatics and Computing, Indiana University, Bloomington, IN 47408, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813771PMC
http://dx.doi.org/10.1142/9789814295291_0036DOI Listing
November 2013

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases.

BMC Genomics 2009 Jul 7;10 Suppl 1:S7. Epub 2009 Jul 7.

Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1186/1471-2164-10-S1-S7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709268PMC
July 2009

Prediction of intrinsic disorder and its use in functional proteomics.

Methods Mol Biol 2007 ;408:69-92

School of Medicine, Indiana University, Indianapolis, USA.

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http://dx.doi.org/10.1007/978-1-59745-547-3_5DOI Listing
April 2008

RNA association or phosphorylation of the RS domain prevents aggregation of RS domain-containing proteins.

Biochim Biophys Acta 2008 Feb 1;1780(2):214-25. Epub 2007 Nov 1.

Laboratory of Biochemistry, Department of Chemistry, The Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

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http://dx.doi.org/10.1016/j.bbagen.2007.10.014DOI Listing
February 2008

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.

J Proteome Res 2007 May 29;6(5):1882-98. Epub 2007 Mar 29.

Center for Information Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA.

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http://dx.doi.org/10.1021/pr060392uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543138PMC
May 2007

Intrinsic disorder and functional proteomics.

Biophys J 2007 Mar 8;92(5):1439-56. Epub 2006 Dec 8.

School of Informatics, Indiana University, Bloomington, Indiana, USA.

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http://dx.doi.org/10.1529/biophysj.106.094045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796814PMC
March 2007

Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments.

Bioinformatics 2006 Jun 21;22(12):1536-7. Epub 2006 Apr 21.

Computer Science and Engineering Department, University of California Riverside, CA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btl151DOI Listing
June 2006

Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins.

Nucleic Acids Res 2006 10;34(1):305-12. Epub 2006 Jan 10.

The Rockefeller University, Laboratory of Statistical Genetics, 1230 York Avenue, New York, NY 10021, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkj424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326245PMC
January 2006

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

FEBS J 2005 Oct;272(20):5129-48

Department of Biochemistry and Molecular Biology, and Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://doi.wiley.com/10.1111/j.1742-4658.2005.04948.x
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http://dx.doi.org/10.1111/j.1742-4658.2005.04948.xDOI Listing
October 2005

Combining prediction, computation and experiment for the characterization of protein disorder.

Curr Opin Struct Biol 2004 Oct;14(5):570-6

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0959440X040013
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http://dx.doi.org/10.1016/j.sbi.2004.08.003DOI Listing
October 2004

DisProt: a database of protein disorder.

Bioinformatics 2005 Jan 13;21(1):137-40. Epub 2004 Aug 13.

Center for Information Science and Technology, Temple University Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1093/bioinformatics/bth476DOI Listing
January 2005

The importance of intrinsic disorder for protein phosphorylation.

Nucleic Acids Res 2004 11;32(3):1037-49. Epub 2004 Feb 11.

School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkh253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC373391PMC
May 2004

Order, disorder, and flexibility: prediction from protein sequence.

Structure 2003 Nov;11(11):1316-7

The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.str.2003.10.009DOI Listing
November 2003

Intrinsic disorder in cell-signaling and cancer-associated proteins.

J Mol Biol 2002 Oct;323(3):573-84

Department of Biochemistry and Biophysics, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4660, USA.

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http://dx.doi.org/10.1016/s0022-2836(02)00969-5DOI Listing
October 2002

Intrinsic disorder and protein function.

Biochemistry 2002 May;41(21):6573-82

School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA.

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http://dx.doi.org/10.1021/bi012159+DOI Listing
May 2002

Equilibrium and stop-flow kinetic studies of fluorescently labeled DNA substrates with DNA repair proteins XPA and replication protein A.

Biochemistry 2002 Jan;41(1):131-43

Pacific Northwest National Laboratory (PNNL), Molecular Biosciences Department, P.O. Box 999, Richland, Washington 99352, USA.

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http://dx.doi.org/10.1021/bi011041qDOI Listing
January 2002