Publications by authors named "Liangsu Wang"

32Publications

Identification of a metabolic, transcriptomic and molecular signature of PNPLA3-mediated acceleration of steatohepatitis.

Authors:
Bubu A Banini Divya P Kumar Sophie Cazanave Mulugeta Seneshaw Faridoddin Mirshahi Prasanna K Santhekadur Liangsu Wang Hong Ping Guan Abdul Oseini Cristina Alonso Pierre Bedossa Srinivas V Koduru Hae-Ki Min Arun J Sanyal

Hepatology 2020 Nov 1. Epub 2020 Nov 1.

Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, VA, USA.

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November 2020

Author Correction: The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.

Authors:
Sophie Cazanave Alexei Podtelezhnikov Kristian Jensen Mulugeta Seneshaw Divya P Kumar Hae-Ki Min Prasanna K Santhekadur Bubu Banini Adolfo Gabriele Mauro Abdul M Oseini Robert Vincent Keith Q Tanis Andrea L Webber Liangsu Wang Pierre Bedossa Faridoddin Mirshahi Arun J Sanyal

Sci Rep 2020 May 15;10(1):8374. Epub 2020 May 15.

Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.

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May 2020

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Authors:
Bhagirath Chaurasia Trevor S Tippetts Rafael Mayoral Monibas Jinqi Liu Ying Li Liping Wang Joseph L Wilkerson C Rufus Sweeney Renato Felipe Pereira Doris Hissako Sumida J Alan Maschek James E Cox Vincent Kaddai Graeme Iain Lancaster Monowarul Mobin Siddique Annelise Poss Mackenzie Pearson Santhosh Satapati Heather Zhou David G McLaren Stephen F Previs Ying Chen Ying Qian Aleksandr Petrov Margaret Wu Xiaolan Shen Jun Yao Christian N Nunes Andrew D Howard Liangsu Wang Mark D Erion Jared Rutter William L Holland David E Kelley Scott A Summers

Science 2019 07 4;365(6451):386-392. Epub 2019 Jul 4.

Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.

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July 2019

GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia.

Authors:
Nina Xiaoyan Li Stacey Brown Tim Kowalski Margaret Wu Liming Yang Ge Dai Aleksandr Petrov Yuyan Ding Tamara Dlugos Harold B Wood Liangsu Wang Mark Erion Robert Sherwin David E Kelley

Diabetes 2018 07 18;67(7):1401-1413. Epub 2018 Apr 18.

Discovery, Preclinical and Early Development, Merck & Co., Inc., Kenilworth, NJ

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July 2018

The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.

Authors:
Sophie Cazanave Alexei Podtelezhnikov Kristian Jensen Mulugeta Seneshaw Divya P Kumar Hae-Ki Min Prasanna K Santhekadur Bubu Banini Adolfo Gabriele Mauro Abdul M Oseini Robert Vincent Keith Q Tanis Andrea L Webber Liangsu Wang Pierre Bedossa Faridoddin Mirshahi Arun J Sanyal

Sci Rep 2017 12 8;7(1):17193. Epub 2017 Dec 8.

Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.

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December 2017

Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice.

Authors:
Vijay R More Julie Lao David G McLaren Anne-Marie Cumiskey Beth Ann Murphy Ying Chen Stephen Previs Steven Stout Rajesh Patel Santhosh Satapati Wenyu Li Edward Kowalik Daphne Szeto Andrea Nawrocki Alessandro Pocai Liangsu Wang Paul Carrington

PLoS One 2017 24;12(10):e0186586. Epub 2017 Oct 24.

Cardiometabolic Diseases Biology- Discovery, Merck & Co., Inc., Kenilworth, NJ, United States of America.

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November 2017

GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.

Authors:
Santhosh Satapati Ying Qian Margaret S Wu Aleksandr Petrov Ge Dai Sheng-Ping Wang Yonghua Zhu Xiaolan Shen Eric S Muise Ying Chen Emanuel Zycband Adam Weinglass Jerry Di Salvo John S Debenham Jason M Cox Ping Lan Vinit Shah Stephen F Previs Mark Erion David E Kelley Liangsu Wang Andrew D Howard Jin Shang

J Lipid Res 2017 08 5;58(8):1561-1578. Epub 2017 Jun 5.

Cardiometabolic Disease, Merck & Co., Inc., Kenilworth, NJ 07033

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August 2017

ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption.

Authors:
Enrico Bertaggia Kristian K Jensen Jose Castro-Perez Yimeng Xu Gilbert Di Paolo Robin B Chan Liangsu Wang Rebecca A Haeusler

Am J Physiol Endocrinol Metab 2017 08 4;313(2):E121-E133. Epub 2017 Apr 4.

Department of Pathology and Cell Biology, Columbia University, New York, New York;

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August 2017

Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.

Authors:
Jin Shang Stephen F Previs Stacey Conarello Keefe Chng Yonghua Zhu Sandra C Souza Michael Staup Ying Chen Dan Xie Emanuel Zycband Karni Schlessinger Victoria Plamadeala Johnson Gladys Arreaza Franklin Liu Diane Levitan Liangsu Wang Margaret van Heek Mark Erion Yixin Wang David E Kelley

Am J Physiol Endocrinol Metab 2017 04 31;312(4):E235-E243. Epub 2017 Jan 31.

Merck & Company, Incorporated, Kenilworth, New Jersey; and.

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April 2017

Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.

Authors:
Sheo B Singh Ling Kang Andrea R Nawrocki Dan Zhou Margaret Wu Stephen Previs Corey Miller Haiying Liu Catherine D G Hines Maria Madeira Jin Cao Kithsiri Herath Larry D Spears Clay F Semenkovich Liangsu Wang David E Kelley Cai Li Hong-Ping Guan

PLoS One 2017;12(1):e0170721. Epub 2017 Jan 19.

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January 2017

The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.

Authors:
Sheo B Singh Ling Kang Andrea R Nawrocki Dan Zhou Margaret Wu Stephen Previs Corey Miller Haiying Liu Catherine D G Hines Maria Madeira Jin Cao Kithsiri Herath Larry D Spears Clay F Semenkovich Liangsu Wang David E Kelley Cai Li Hong-Ping Guan

PLoS One 2016 3;11(10):e0164133. Epub 2016 Oct 3.

Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America.

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June 2017

Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice.

Authors:
Jin Shang Jose M Castro-Perez Xiaolan Shen Yonghua Zhu Haiying Liu Ying Qian Stephen Previs Andrew D Howard Mark Erion David E Kelley Liangsu Wang

Obesity (Silver Spring) 2016 09 26;24(9):1938-45. Epub 2016 Jul 26.

Cardiometabolic Disease, Merck Research Laboratories, Kenilworth, New Jersey, USA.

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September 2016

Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity.

Authors:
Rebecca A Haeusler Stefania Camastra Monica Nannipieri Brenno Astiarraga Jose Castro-Perez Dan Xie Liangsu Wang Manu Chakravarthy Ele Ferrannini

J Clin Endocrinol Metab 2016 05 18;101(5):1935-44. Epub 2015 Dec 18.

Department of Pathology and Cell Biology (R.A.H.), Columbia University, New York, New York 10032; Department of Clinical and Experimental Medicine (S.C., M.N., B.A., E.F.), University of Pisa School of Medicine, 56100 Pisa, Italy; Merck Research Laboratories (J.C.-P., D.X., L.W., M.C.), Cardiometabolic Disease, Kenilworth, New Jersey 07033; and CNR Institute of Clinical Physiology (E.F.), 56100 Pisa, Italy.

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May 2016

Glucagon receptor antagonism induces increased cholesterol absorption.

Authors:
Hong-Ping Guan Xiaodong Yang Ku Lu Sheng-Ping Wang Jose M Castro-Perez Stephen Previs Michael Wright Vinit Shah Kithsiri Herath Dan Xie Daphne Szeto Gail Forrest Jing Chen Xiao Oksana Palyha Li-Ping Sun Paula J Andryuk Samuel S Engel Yusheng Xiong Songnian Lin David E Kelley Mark D Erion Harry R Davis Liangsu Wang

J Lipid Res 2015 Nov 15;56(11):2183-95. Epub 2015 Sep 15.

Departments of Cardiometabolic Disease, Merck Research Laboratories, Kenilworth, NJ 07033.

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November 2015

Gene expression in WAT from healthy humans and monkeys correlates with FGF21-induced browning of WAT in mice.

Authors:
Karni Schlessinger Wenyu Li Yejun Tan Franklin Liu Sandra C Souza Effie Tozzo Kevin Liu John R Thompson Liangsu Wang Eric S Muise

Obesity (Silver Spring) 2015 Sep;23(9):1818-29

Department of Genetics and Pharmacogenomics, Early Development and Discovery Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA.

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September 2015

Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion.

Authors:
Ele Ferrannini Stefania Camastra Brenno Astiarraga Monica Nannipieri Jose Castro-Perez Dan Xie Liangsu Wang Manu Chakravarthy Rebecca A Haeusler

Diabetes 2015 Oct 26;64(10):3377-85. Epub 2015 May 26.

Department of Pathology and Cell Biology, Columbia University, New York, NY

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October 2015

Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.

Authors:
Harry R Chobanian Barbara Pio Yan Guo Hong Shen Mark A Huffman Maria Madeira Gino Salituro Jenna L Terebetski James Ormes Nina Jochnowitz Lizbeth Hoos Yuchen Zhou Dale Lewis Brian Hawes Lyndon Mitnaul Kim O'Neill Kenneth Ellsworth Liangsu Wang Tesfaye Biftu Joseph L Duffy

ACS Med Chem Lett 2015 May 13;6(5):553-7. Epub 2015 Mar 13.

Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Thrombosis, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.

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May 2015

Potentiation of insulin-mediated glucose lowering without elevated hypoglycemia risk by a small molecule insulin receptor modulator.

Authors:
Margaret Wu Ge Dai Jun Yao Scott Hoyt Liangsu Wang James Mu

PLoS One 2015 23;10(3):e0122012. Epub 2015 Mar 23.

Early Development and Discovery Sciences, Merck Research Laboratories, Merck Sharp & Dohme Corp., Whitehouse Station, NJ 08889, United States of America.

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February 2016

Racing to define pharmaceutical R&D external innovation models.

Authors:
Liangsu Wang Andrew Plump Michael Ringel

Drug Discov Today 2015 Mar 30;20(3):361-70. Epub 2014 Oct 30.

The Boston Consulting Group, Exchange Place, Boston, MA 02109, USA.

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March 2015

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.

Authors:
Roshni R Singaraja Ian Tietjen G Kees Hovingh Patrick L Franchini Chris Radomski Kenny Wong Margaret vanHeek Ioannis M Stylianou Linus Lin Liangsu Wang Lyndon Mitnaul Brian Hubbard Michael Winther Maryanne Mattice Annick Legendre Robin Sherrington John J Kastelein Karen Akinsanya Andrew Plump Michael R Hayden

J Lipid Res 2014 Aug 2;55(8):1693-701. Epub 2014 Jun 2.

A*STAR Institute and Yong Loo Lin School of Medicine, National University of Singapore, Singapore Centre for Molecular Medicine and Therapeutics, and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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August 2014

Differential profiles of thrombin inhibitors (heparin, hirudin, bivalirudin, and dabigatran) in the thrombin generation assay and thromboelastography in vitro.

Authors:
Yiming Xu Weizhen Wu Liangsu Wang Madhu Chintala Andrew S Plump Martin L Ogletree Zhu Chen

Blood Coagul Fibrinolysis 2013 Apr;24(3):332-8

Thrombosis, Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA.

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April 2013

Identification of genes affecting apolipoprotein B secretion following siRNA-mediated gene knockdown in primary human hepatocytes.

Authors:
Xun Shen Wei Wang Liangsu Wang Caroline Houde Weizhen Wu Matt Tudor John R Thompson Christine McCrary Sisk Brian Hubbard Jing Li

Atherosclerosis 2012 May 16;222(1):154-7. Epub 2012 Feb 16.

Cardiovascular Disease, Merck Sharp & Dohme Corp., Whitehouse Station, NJ 08889, USA.

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May 2012

Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification.

Authors:
Kristian K Jensen Stephen F Previs Lei Zhu Kithsiri Herath Sheng-Ping Wang Gowri Bhat Guanghui Hu Paul L Miller David G McLaren Myung K Shin Thomas F Vogt Liangsu Wang Kenny K Wong Thomas P Roddy Douglas G Johns Brian K Hubbard

Am J Physiol Endocrinol Metab 2012 Jan 1;302(2):E209-17. Epub 2011 Nov 1.

Department of Atherosclerosis, Merck Research Labs., Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, NJ 07065, USA.

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January 2012

Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters.

Authors:
Zhu Chen Sheng-ping Wang Mihajlo L Krsmanovic Jose Castro-Perez Karen Gagen Vivienne Mendoza Ray Rosa Vinit Shah Timothy He Steve J Stout Neil S Geoghagen Sang H Lee David G McLaren Liangsu Wang Thomas P Roddy Andrew S Plump Brian K Hubbard Christopher J Sinz Douglas G Johns

Metabolism 2012 Apr 14;61(4):470-81. Epub 2011 Oct 14.

Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA.

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April 2012

Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.

Authors:
H Howard Xu John D Trawick Robert J Haselbeck R Allyn Forsyth Robert T Yamamoto Rich Archer Joe Patterson Molly Allen Jamie M Froelich Ian Taylor Danny Nakaji Randy Maile G C Kedar Marshall Pilcher Vickie Brown-Driver Melissa McCarthy Amy Files David Robbins Paula King Susan Sillaots Cheryl Malone Carlos S Zamudio Terry Roemer Liangsu Wang Philip J Youngman Daniel Wall

Antimicrob Agents Chemother 2010 Sep 14;54(9):3659-70. Epub 2010 Jun 14.

Elitra Pharmaceuticals, San Diego, California 92121, USA.

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September 2010

A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds.

Authors:
Robert G K Donald Stephen Skwish R Allyn Forsyth Jennifer W Anderson Tanya Zhong Colleen Burns Suzy Lee Xin Meng Lynn LoCastro Lisa Wang Jarantow Jesus Martin Sang Ho Lee Ian Taylor David Robbins Cheryl Malone Liangsu Wang Carlos S Zamudio Philip J Youngman John W Phillips

Chem Biol 2009 Aug;16(8):826-36

Merck Research Laboratories, Merck & Co., Rahway, NJ 07065, USA.

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August 2009

Development of an integrated semi-automated system for in vitro pharmacodynamic modelling.

Authors:
Liangsu Wang Michael K Wismer Fred Racine Donald Conway Robert A Giacobbe Olga Berejnaia Gary S Kath

J Antimicrob Chemother 2008 Nov 21;62(5):1070-7. Epub 2008 Jul 21.

Department of Infectious Disease Research, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA.

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November 2008

Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus.

Authors:
Allyn Forsyth Liangsu Wang

Methods Mol Biol 2008 ;416:307-21

GHC Technologies, Inc., La Jolla, CA, USA.

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June 2008

Control and prevention of MRSA infections.

Authors:
Liangsu Wang John F Barrett

Methods Mol Biol 2007 ;391:209-25

Infectious Disease Research, Merck & Co Inc, Rahway, NJ, USA.

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January 2008

Pharmacoeconomics of treatment with the newer anti-Gram-positive agents.

Authors:
Liangsu Wang John F Barrett

Expert Opin Pharmacother 2006 May;7(7):885-97

Department of Infectious Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA.

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May 2006

Genome-wide operon prediction in Staphylococcus aureus.

Authors:
Liangsu Wang John D Trawick Robert Yamamoto Carlos Zamudio

Nucleic Acids Res 2004 13;32(12):3689-702. Epub 2004 Jul 13.

Elitra Pharmaceuticals Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.

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July 2004

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus.

Authors:
R Allyn Forsyth Robert J Haselbeck Kari L Ohlsen Robert T Yamamoto Howard Xu John D Trawick Daniel Wall Liangsu Wang Vickie Brown-Driver Jamie M Froelich Kedar G C Paula King Melissa McCarthy Cheryl Malone Brian Misiner David Robbins Zehui Tan Zhan-yang Zhu Zy Grant Carr Deborah A Mosca Carlos Zamudio J Gordon Foulkes Judith W Zyskind

Mol Microbiol 2002 Mar;43(6):1387-400

Elitra Pharmaceuticals, San Diego, CA 92121, USA.

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March 2002