Publications by authors named "Li-Fan Lu"

52Publications

miR-155 promotes T reg cell development by safeguarding medullary thymic epithelial cell maturation.

J Exp Med 2021 Feb;218(2)

Division of Biological Sciences, University of California, San Diego, La Jolla, CA.

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http://dx.doi.org/10.1084/jem.20192423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608066PMC
February 2021

Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation.

Biosens Bioelectron 2020 Oct 17;165:112389. Epub 2020 Jun 17.

Department of Mechanical Engineering, Johns Hopkins University, MD, 21218, USA; Center for Cell Dynamics, Johns Hopkins University, MD, 21218, USA; Institute for NanoBioTechnology, Johns Hopkins University, MD, 21218, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2020.112389DOI Listing
October 2020

MicroRNAs and Their Targetomes in Tumor-Immune Communication.

Cancers (Basel) 2020 Jul 24;12(8). Epub 2020 Jul 24.

Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.3390/cancers12082025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465095PMC
July 2020

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.

Immunity 2019 12 19;51(6):1059-1073.e9. Epub 2019 Nov 19.

Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935268PMC
December 2019

miRNA-Microbiota Interaction in Gut Homeostasis and Colorectal Cancer.

Trends Cancer 2019 11 14;5(11):666-669. Epub 2019 Oct 14.

Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.08.003DOI Listing
November 2019

Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival.

J Immunother Cancer 2019 07 31;7(1):201. Epub 2019 Jul 31.

Department of Medicine and Sciences of Aging, G. d'Annunzio University of Chieti-Pescara, Via L. Polacchi 11, 66100, Chieti, Italy.

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http://dx.doi.org/10.1186/s40425-019-0668-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670138PMC
July 2019

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.

Cell Rep 2019 06;27(12):3629-3645.e6

Pediatric Diabetes Research Center, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701704PMC
June 2019

[Protective effect of simvastatin on kidney of rats with diabetes mellitus and the possible mechanism].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2018 Apr;34(4):313-317

Department of Physiology, College of Preclinical Medicine, Shanxi Medical University, First Hospital of Shanxi Medical University, Taiyuan 030001, China.

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http://dx.doi.org/10.12047/j.cjap.5636.2018.072DOI Listing
April 2018

[Simvastatin prevented myocardium of diabetes rats from apoptosis through inhibition of oxidative stress].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2018 May;34(5):422-426 469

Department of Physiology, Shanxi Medical University, Taiyuan 030001.

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http://dx.doi.org/10.12047/j.cjap.5653.2018.096DOI Listing
May 2018

An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity in Mice.

Hepatology 2019 06 13;69(6):2518-2532. Epub 2019 Mar 13.

Department of Pathology, Division of Biological Sciences and Moores Cancer Center, University of California at San Diego, La Jolla, CA.

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http://dx.doi.org/10.1002/hep.30528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541536PMC
June 2019

Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.

Nat Commun 2018 08 16;9(1):3338. Epub 2018 Aug 16.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

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http://www.nature.com/articles/s41467-018-05720-5
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http://dx.doi.org/10.1038/s41467-018-05720-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095848PMC
August 2018

[SR 59230A on the expression of MicroRNAs in myocardium of heart failure rats].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2017 May;33(5):456-460

Department of Physiology, Cell Physiology Key laboratory of Shanxi Province, Shanxi Medical University, Taiyuan, Shanxi 030001, China.

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http://dx.doi.org/10.12047/j.cjap.5561.2017.109DOI Listing
May 2017

Conditional Gene-Targeting in Mice: Problems and Solutions.

Immunity 2018 05;48(5):835-836

Division of Biological Sciences, Center for Microbiome Innovation and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.immuni.2018.05.002DOI Listing
May 2018

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.

Nat Commun 2017 10 11;8(1):851. Epub 2017 Oct 11.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

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http://dx.doi.org/10.1038/s41467-017-00972-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636846PMC
October 2017

miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS.

Nat Cell Biol 2017 Oct 18;19(10):1286-1296. Epub 2017 Sep 18.

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ncb3615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658024PMC
October 2017

MicroRNA in Immune Regulation.

Curr Top Microbiol Immunol 2017;410:249-267

Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/82_2017_65DOI Listing
June 2019

A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses.

J Immunol 2017 05 12;198(10):3919-3926. Epub 2017 Apr 12.

Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093;

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http://dx.doi.org/10.4049/jimmunol.1601404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437976PMC
May 2017

[Silencing of PKG1 expression enhances the efficacy of vemurafenib against melanoma cell].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2017 Apr;33(4):289-293

Department of Physiology, Cell Physiology Key Laboratory of Shanxi Province, Shanxi Medical University, Taiyuan 030001, China.

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http://dx.doi.org/10.12047/j.cjap.5559.2017.071DOI Listing
April 2017

A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.

J Exp Med 2016 08 1;213(9):1901-19. Epub 2016 Aug 1.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361005, China Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1084/jem.20160204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995083PMC
August 2016

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.

Nat Immunol 2016 07 23;17(7):834-43. Epub 2016 May 23.

Department of Biological Sciences, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ni.3461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915968PMC
July 2016

miR-23∼27∼24 clusters control effector T cell differentiation and function.

J Exp Med 2016 Feb 1;213(2):235-49. Epub 2016 Feb 1.

Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1084/jem.20150990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749926PMC
February 2016

IFNγ signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells.

PLoS Pathog 2015 Feb 6;11(2):e1004635. Epub 2015 Feb 6.

Division of Biological Sciences, University of California, San Diego, La Jolla, California, United States of America; Moores Cancer Center, University of California, San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450074PMC
February 2015

Progress and challenge of microRNA research in immunity.

Front Genet 2014 12;5:178. Epub 2014 Jun 12.

Division of Biological Sciences, University of California, San Diego La Jolla, CA, USA ; Moores Cancer Center, University of California, San Diego La Jolla, CA, USA.

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http://dx.doi.org/10.3389/fgene.2014.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053854PMC
June 2014

Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon.

Nat Commun 2014 ;5:3344

1] Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, Taiwan [2] NTU Center for Genomic Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan [3] Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.

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http://dx.doi.org/10.1038/ncomms4344DOI Listing
November 2015

Regulatory T cells: mechanisms of differentiation and function.

Annu Rev Immunol 2012 6;30:531-64. Epub 2012 Jan 6.

Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.immunol.25.
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http://dx.doi.org/10.1146/annurev.immunol.25.022106.141623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066374PMC
July 2012

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.

J Exp Med 2011 Mar 7;208(3):577-92. Epub 2011 Mar 7.

Department of Microbiology and Immunology, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03766, USA.

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http://dx.doi.org/10.1084/jem.20100619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058578PMC
March 2011

Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses.

Cell 2010 Sep;142(6):914-29

Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2010.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049116PMC
September 2010

MicroRNA in the adaptive immune system, in sickness and in health.

J Clin Immunol 2010 May 27;30(3):339-46. Epub 2010 Feb 27.

VIB and University of Leuven, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1007/s10875-010-9378-5DOI Listing
May 2010

MicroRNA in the immune system, microRNA as an immune system.

Immunology 2009 Jul;127(3):291-8

Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://doi.wiley.com/10.1111/j.1365-2567.2009.03092.x
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http://dx.doi.org/10.1111/j.1365-2567.2009.03092.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712098PMC
July 2009

Molecular orchestration of differentiation and function of regulatory T cells.

Genes Dev 2009 Jun;23(11):1270-82

Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.1791009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763538PMC
June 2009

Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells.

J Immunol 2008 Oct;181(7):4752-60

Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572718PMC
http://dx.doi.org/10.4049/jimmunol.181.7.4752DOI Listing
October 2008

Dicer-dependent microRNA pathway safeguards regulatory T cell function.

J Exp Med 2008 Sep 25;205(9):1993-2004. Epub 2008 Aug 25.

Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20081062
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http://dx.doi.org/10.1084/jem.20081062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526195PMC
September 2008

G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells.

Mol Cell Biol 2007 Dec 24;27(23):8065-72. Epub 2007 Sep 24.

Department of Immunology, University of Washington, Seattle, WA 98195-7650, USA.

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http://dx.doi.org/10.1128/MCB.01075-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169173PMC
December 2007

The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation.

Blood 2007 Jul 14;110(1):193-200. Epub 2007 Mar 14.

Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-07-03
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http://dx.doi.org/10.1182/blood-2006-07-038414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896113PMC
July 2007

Mast cells are essential intermediaries in regulatory T-cell tolerance.

Nature 2006 Aug 20;442(7106):997-1002. Epub 2006 Aug 20.

Department of Microbiology & Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA.

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http://dx.doi.org/10.1038/nature05010DOI Listing
August 2006

NF kappa B-inducing kinase deficiency results in the development of a subset of regulatory T cells, which shows a hyperproliferative activity upon glucocorticoid-induced TNF receptor family-related gene stimulation.

J Immunol 2005 Aug;175(3):1651-7

Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA.

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http://dx.doi.org/10.4049/jimmunol.175.3.1651DOI Listing
August 2005

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.

J Immunol 2005 Feb;174(4):1783-6

Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA.

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http://dx.doi.org/10.4049/jimmunol.174.4.1783DOI Listing
February 2005

Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8+ T cells.

Cancer Gene Ther 2004 Feb;11(2):135-47

Cancer Research Cooperative Laboratory at National Taiwan University Hospital, Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan.

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http://dx.doi.org/10.1038/sj.cgt.7700663DOI Listing
February 2004

CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding site.

J Biol Chem 2003 Nov 5;278(46):45414-8. Epub 2003 Sep 5.

Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.

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http://dx.doi.org/10.1074/jbc.M309601200DOI Listing
November 2003