Leroy Hood

Leroy Hood

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Leroy Hood

Publications by authors named "Leroy Hood"

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Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity.

Am J Physiol Endocrinol Metab 2019 Nov 19;317(5):E879-E898. Epub 2019 Jul 19.

Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts.

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http://dx.doi.org/10.1152/ajpendo.00065.2019DOI Listing
November 2019

Blood Is a Window into Health and Disease.

Clin Chem 2019 Oct 6;65(10):1204-1206. Epub 2019 Jun 6.

Institute for Systems Biology, Seattle, WA;

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http://dx.doi.org/10.1373/clinchem.2018.299065DOI Listing
October 2019

Blood metabolome predicts gut microbiome α-diversity in humans.

Nat Biotechnol 2019 10 2;37(10):1217-1228. Epub 2019 Sep 2.

Institute for Systems Biology, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41587-019-0233-9DOI Listing
October 2019

A systems approach to clinical oncology uses deep phenotyping to deliver personalized care.

Nat Rev Clin Oncol 2019 Oct 16. Epub 2019 Oct 16.

Institute for Systems Biology, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41571-019-0273-6DOI Listing
October 2019

A Blueprint for Systems Biology.

Clin Chem 2019 02 28;65(2):342-344. Epub 2018 Dec 28.

Institute for Systems Biology, Seattle, WA;

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.291
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http://dx.doi.org/10.1373/clinchem.2018.291062DOI Listing
February 2019

Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders.

Cell Syst 2019 Feb 13;8(2):122-135.e7. Epub 2019 Feb 13.

Institute for Systems Biology, Seattle, WA, USA; Institute of Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.01.002DOI Listing
February 2019

Reply to "Precision medicine in the clouds".

Nat Biotechnol 2018 08;36(8):680-682

Arivale, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nbt.4211DOI Listing
August 2018

The building blocks of successful translation of proteomics to the clinic.

Curr Opin Biotechnol 2018 06 7;51:123-129. Epub 2018 Feb 7.

Institute for Systems Biology, Seattle, WA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2017.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091638PMC
June 2018

Population-specific genetic modification of Huntington's disease in Venezuela.

PLoS Genet 2018 05 11;14(5):e1007274. Epub 2018 May 11.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965898PMC
May 2018

Taking Systems Medicine to Heart.

Circ Res 2018 04;122(9):1276-1289

From the Institute for Systems Biology, Seattle, WA (K.T., R.B., G.G., N.D.P., S.H., L.E.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926821PMC
April 2018

Human Gut Microbiota and Gastrointestinal Cancer.

Genomics Proteomics Bioinformatics 2018 02 21;16(1):33-49. Epub 2018 Feb 21.

Institute for Systems Biology, Seattle, WA 98109, USA; P4 Medicine Institute, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000254PMC
February 2018

Lessons Learned as President of the Institute for Systems Biology (2000-2018).

Authors:
Leroy E Hood

Genomics Proteomics Bioinformatics 2018 02 2;16(1):1-9. Epub 2018 Mar 2.

Providence St. Joseph Health, Seattle, WA 98057, USA; Institute for Systems Biology, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000253PMC
February 2018

Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions.

Open Biol 2017 11;7(11)

Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China

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http://dx.doi.org/10.1098/rsob.170169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717345PMC
November 2017

The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort.

PLoS One 2017 2;12(6):e0178842. Epub 2017 Jun 2.

Department of Medical Research and Development, Chang Gung Memorial Hospital-Linkou Medical Center, Taoyuan, Taiwan, Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456392PMC
September 2017

Ultrafast Comparison of Personal Genomes via Precomputed Genome Fingerprints.

Front Genet 2017 26;8:136. Epub 2017 Sep 26.

Institute for Systems Biology, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fgene.2017.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623000PMC
September 2017

The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan.

Prog Cardiovasc Dis 2017 Mar - Apr;59(5):506-521. Epub 2016 Aug 18.

College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; SARENA Clinic, Medical Center and Research Institute.

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http://dx.doi.org/10.1016/j.pcad.2016.08.002DOI Listing
June 2017

TGFβ-Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme.

Stem Cells 2016 09 4;34(9):2276-89. Epub 2016 Jul 4.

The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053103PMC
http://dx.doi.org/10.1002/stem.2411DOI Listing
September 2016

Opening a SWATH Window on Posttranslational Modifications: Automated Pursuit of Modified Peptides.

Mol Cell Proteomics 2016 Mar 24;15(3):1151-63. Epub 2015 Dec 24.

From the §Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M115.054478
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http://dx.doi.org/10.1074/mcp.M115.054478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813695PMC
March 2016

Developmental biologist Eric H. Davidson, 1937-2015.

Proc Natl Acad Sci U S A 2015 Nov 23;112(44):13423-5. Epub 2015 Oct 23.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125

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http://dx.doi.org/10.1073/pnas.1518876112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640791PMC
November 2015

Sequence-Level Analysis of the Major European Huntington Disease Haplotype.

Am J Hum Genet 2015 Sep 27;97(3):435-44. Epub 2015 Aug 27.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564985PMC
September 2015

Microarray based screening of peptide nano probes for HER2 positive tumor.

Anal Chem 2015 Aug 6;87(16):8367-72. Epub 2015 Aug 6.

§Institute for Systems Biology, 401 Terry Avenue North, Seattle, Washington 98109, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b01588DOI Listing
August 2015

Whole-genome sequencing of the world's oldest people.

PLoS One 2014 12;9(11):e112430. Epub 2014 Nov 12.

Depts. of Developmental Biology and Genetics, Stanford University, Stanford, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112430PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229186PMC
July 2015

P4 medicine needs P4 education.

Curr Pharm Des 2014 ;20(38):6071-2

Director, Area of Systems Medicine, IRCCS San Raffaele Pisana, Rome, Italy.

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http://dx.doi.org/10.2174/1381612820666140314145445DOI Listing
June 2015

Integrating big data and actionable health coaching to optimize wellness.

BMC Med 2015 Jan 9;13. Epub 2015 Jan 9.

Institute for Systems Biology, 401 Terry Avenue North, Seattle 98109, WA, USA.

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http://dx.doi.org/10.1186/s12916-014-0238-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288554PMC
January 2015

Endogenous molecular-cellular hierarchical modeling of prostate carcinogenesis uncovers robust structure.

Prog Biophys Mol Biol 2015 Jan 3;117(1):30-42. Epub 2015 Feb 3.

Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2015.01.004DOI Listing
January 2015

Rapid screening of peptide probes through in situ single-bead sequencing microarray.

Anal Chem 2014 Dec 14;86(23):11854-9. Epub 2014 Nov 14.

CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, China.

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http://dx.doi.org/10.1021/ac503454zDOI Listing
December 2014

Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury.

Biomarkers 2014 Nov 21;19(7):578-84. Epub 2014 Aug 21.

National Center for Nanoscience and Technology , Beijing , P.R. China .

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http://dx.doi.org/10.3109/1354750X.2014.951880DOI Listing
November 2014

Systems approach to neurodegenerative disease biomarker discovery.

Annu Rev Pharmacol Toxicol 2014 23;54:457-81. Epub 2013 Oct 23.

Institute for Systems Biology, Seattle, Washington 98109; email: , , , , , ,

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http://dx.doi.org/10.1146/annurev-pharmtox-011613-135928DOI Listing
September 2014

Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity.

Theranostics 2014 14;4(2):215-28. Epub 2014 Jan 14.

2. Institute for Systems Biology, 401 Terry Avenue N, Seattle, Washington 98109, USA.

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http://www.thno.org/v04p0215.htm
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http://dx.doi.org/10.7150/thno.7868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900804PMC
September 2014

Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging.

Anal Chem 2014 Sep 11;86(17):8857-64. Epub 2014 Aug 11.

National Center for Nanoscience and Technology , No. 11, Beiyitiao Zhongguancun, Beijing 100190, P. R. China.

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http://pubs.acs.org/doi/10.1021/ac5023056
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http://dx.doi.org/10.1021/ac5023056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151789PMC
September 2014

The Human Genome Project: big science transforms biology and medicine.

Genome Med 2013 13;5(9):79. Epub 2013 Sep 13.

Institute for Systems Biology, 401 Terry Ave N., Seattle, WA 98109, USA.

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http://dx.doi.org/10.1186/gm483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066586PMC
August 2014

Optimal scaling of digital transcriptomes.

PLoS One 2013 6;8(11):e77885. Epub 2013 Nov 6.

Institute for Systems Biology, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077885PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819321PMC
August 2014

Realistic artificial DNA sequences as negative controls for computational genomics.

Nucleic Acids Res 2014 Jul 6;42(12):e99. Epub 2014 May 6.

Institute for Systems Biology, 401 Terry Ave. N, Seattle, WA 98109, USA

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http://dx.doi.org/10.1093/nar/gku356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081056PMC
July 2014

Protein-centric N-glycoproteomics analysis of membrane and plasma membrane proteins.

J Proteome Res 2014 Jun 1;13(6):2705-14. Epub 2014 May 1.

Department of Chemistry, Simon Fraser University , 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.

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http://dx.doi.org/10.1021/pr500187gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053080PMC
June 2014

Participatory medicine: a driving force for revolutionizing healthcare.

Genome Med 2013 23;5(12):110. Epub 2013 Dec 23.

European Institute for Systems Biology & Medicine, CNRS-ENS-UCBL, Université de Lyon, 50, Avenue Tony Garnier, 69007, Lyon, France.

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http://dx.doi.org/10.1186/gm514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978637PMC
May 2014

An epigenetic biomarker panel for glioblastoma multiforme personalized medicine through DNA methylation analysis of human embryonic stem cell-like signature.

OMICS 2014 May 6;18(5):310-23. Epub 2014 Mar 6.

1 Department of Computer Science and Information Engineering, National Cheng Kung University , Tainan City, Taiwan .

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http://dx.doi.org/10.1089/omi.2013.0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012637PMC
May 2014

Multi-study integration of brain cancer transcriptomes reveals organ-level molecular signatures.

PLoS Comput Biol 2013 25;9(7):e1003148. Epub 2013 Jul 25.

Institute for Systems Biology, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723500PMC
February 2014

Demystifying disease, democratizing health care.

Sci Transl Med 2014 Feb;6(225):225ed5

Leroy Hood is President of the Institute for Systems Biology, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008665DOI Listing
February 2014

Relationship estimation from whole-genome sequence data.

PLoS Genet 2014 Jan 30;10(1):e1004144. Epub 2014 Jan 30.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907355PMC
January 2014

An automated Teflon microfluidic peptide synthesizer.

Lab Chip 2013 Sep 8;13(17):3347-50. Epub 2013 Jul 8.

National Center for Nanoscience and Technology, No.11 ZhongGuanCun BeiYiTiao, 100190 Beijing, PR China.

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http://dx.doi.org/10.1039/c3lc50632kDOI Listing
September 2013

Every life has equal value.

Cell 2013 Sep;154(6):1178-9

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.08.046DOI Listing
September 2013

Interview with Leroy Hood.

Authors:
Leroy Hood

Bioanalysis 2013 Jun;5(12):1475-8

Institute for Systems Biology, Seattle, WA 98105, USA.

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http://dx.doi.org/10.4155/bio.13.119DOI Listing
June 2013

A systems approach to rheumatoid arthritis.

PLoS One 2012 11;7(12):e51508. Epub 2012 Dec 11.

School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051508PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519858PMC
May 2013

A Review of Computational Tools in microRNA Discovery.

Front Genet 2013 15;4:81. Epub 2013 May 15.

Institute for Systems Biology Seattle, WA, USA ; Pós-Graduaçao em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília Brasília, Brazil ; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília Brasília, Brazil.

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http://dx.doi.org/10.3389/fgene.2013.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654206PMC
May 2013

Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients.

PLoS One 2012 17;7(8):e41335. Epub 2012 Aug 17.

Systems Biology Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041335PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422347PMC
April 2013

Systems biology and p4 medicine: past, present, and future.

Authors:
Leroy Hood

Rambam Maimonides Med J 2013 Apr 30;4(2):e0012. Epub 2013 Apr 30.

President, Institute for Systems Biology, Seattle, WA, USA.

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http://dx.doi.org/10.5041/RMMJ.10112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678833PMC
April 2013

Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain.

Proc Natl Acad Sci U S A 2013 Feb 5;110(8):3095-100. Epub 2013 Feb 5.

Institute for Genomic Biology and Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.1222897110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581870PMC
February 2013

P4 medicine: how systems medicine will transform the healthcare sector and society.

Per Med 2013 ;10(6):565-576

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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http://dx.doi.org/10.2217/pme.13.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204402PMC
January 2013

A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory.

N Biotechnol 2012 Sep 18;29(6):613-24. Epub 2012 Mar 18.

Institute for Systems Biology, 401N. Terry Ave, Seattle, WA 98121, USA.

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http://dx.doi.org/10.1016/j.nbt.2012.03.004DOI Listing
September 2012

Revolutionizing medicine in the 21st century through systems approaches.

Biotechnol J 2012 Aug 20;7(8):992-1001. Epub 2012 Jul 20.

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA.

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http://doi.wiley.com/10.1002/biot.201100306
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http://dx.doi.org/10.1002/biot.201100306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962497PMC
August 2012

Editorial: Systems biology and personalized medicine - the future is now.

Biotechnol J 2012 Aug;7(8):938-9

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http://dx.doi.org/10.1002/biot.201200242DOI Listing
August 2012

Systems approaches to biology and disease enable translational systems medicine.

Genomics Proteomics Bioinformatics 2012 Aug 23;10(4):181-5. Epub 2012 Aug 23.

Institute for Systems Biology, Seattle, WA 98109-5234, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S167202291200052
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http://dx.doi.org/10.1016/j.gpb.2012.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844613PMC
August 2012

Tackling the microbiome.

Authors:
Leroy Hood

Science 2012 Jun 6;336(6086):1209. Epub 2012 Jun 6.

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http://dx.doi.org/10.1126/science.1225475DOI Listing
June 2012

RNASEQR--a streamlined and accurate RNA-seq sequence analysis program.

Nucleic Acids Res 2012 Mar 22;40(6):e42. Epub 2011 Dec 22.

Institute for Systems Biology, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1093/nar/gkr1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315322PMC
March 2012

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):419-24. Epub 2011 Dec 27.

Nanosystems Biology Cancer Center, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1110865109
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http://dx.doi.org/10.1073/pnas.1110865109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258586PMC
January 2012