Publications by authors named "Leroy Hood"

100Publications

Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types.

Cell Rep 2020 Aug;32(7):108029

Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462736PMC
August 2020

Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.

Mol Psychiatry 2020 Jul 10. Epub 2020 Jul 10.

Weill Institute for Neurosciences and Department of Psychiatry, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41380-020-0837-yDOI Listing
July 2020

A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD.

Mol Psychiatry 2020 May 7. Epub 2020 May 7.

Weill Institute for Neurosciences and Department of Psychiatry, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41380-020-0755-zDOI Listing
May 2020

Deep phenotyping during pregnancy for predictive and preventive medicine.

Sci Transl Med 2020 01;12(527)

Magee-Womens Research Institute and Departments of OBGYN and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1126/scitranslmed.aay1059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268934PMC
January 2020

A systems approach to clinical oncology uses deep phenotyping to deliver personalized care.

Nat Rev Clin Oncol 2020 03 16;17(3):183-194. Epub 2019 Oct 16.

Institute for Systems Biology, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41571-019-0273-6DOI Listing
March 2020

Blood metabolome predicts gut microbiome α-diversity in humans.

Nat Biotechnol 2019 10 2;37(10):1217-1228. Epub 2019 Sep 2.

Institute for Systems Biology, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41587-019-0233-9DOI Listing
October 2019

Blood Is a Window into Health and Disease.

Clin Chem 2019 10 6;65(10):1204-1206. Epub 2019 Jun 6.

Institute for Systems Biology, Seattle, WA;

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http://dx.doi.org/10.1373/clinchem.2018.299065DOI Listing
October 2019

Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders.

Cell Syst 2019 02 13;8(2):122-135.e7. Epub 2019 Feb 13.

Institute for Systems Biology, Seattle, WA, USA; Institute of Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.01.002DOI Listing
February 2019

A Blueprint for Systems Biology.

Clin Chem 2019 02 28;65(2):342-344. Epub 2018 Dec 28.

Institute for Systems Biology, Seattle, WA;

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.291
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http://dx.doi.org/10.1373/clinchem.2018.291062DOI Listing
February 2019

Reply to "Precision medicine in the clouds".

Nat Biotechnol 2018 08;36(8):680-682

Arivale, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nbt.4211DOI Listing
August 2018

Population-specific genetic modification of Huntington's disease in Venezuela.

PLoS Genet 2018 05 11;14(5):e1007274. Epub 2018 May 11.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965898PMC
May 2018

Taking Systems Medicine to Heart.

Circ Res 2018 04;122(9):1276-1289

From the Institute for Systems Biology, Seattle, WA (K.T., R.B., G.G., N.D.P., S.H., L.E.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926821PMC
April 2018

Lessons Learned as President of the Institute for Systems Biology (2000-2018).

Authors:
Leroy E Hood

Genomics Proteomics Bioinformatics 2018 02 2;16(1):1-9. Epub 2018 Mar 2.

Providence St. Joseph Health, Seattle, WA 98057, USA; Institute for Systems Biology, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000253PMC
February 2018

Human Gut Microbiota and Gastrointestinal Cancer.

Genomics Proteomics Bioinformatics 2018 02 21;16(1):33-49. Epub 2018 Feb 21.

Institute for Systems Biology, Seattle, WA 98109, USA; P4 Medicine Institute, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gpb.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000254PMC
February 2018

The building blocks of successful translation of proteomics to the clinic.

Curr Opin Biotechnol 2018 06 7;51:123-129. Epub 2018 Feb 7.

Institute for Systems Biology, Seattle, WA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2017.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091638PMC
June 2018

Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions.

Open Biol 2017 11;7(11)

Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China

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http://dx.doi.org/10.1098/rsob.170169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717345PMC
November 2017

Ultrafast Comparison of Personal Genomes via Precomputed Genome Fingerprints.

Front Genet 2017 26;8:136. Epub 2017 Sep 26.

Institute for Systems Biology, Seattle, WA, United States.

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http://dx.doi.org/10.3389/fgene.2017.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623000PMC
September 2017

The rs16906252:C>T SNP is not associated with increased overall survival or temozolomide response in a Han-Chinese glioma cohort.

PLoS One 2017 2;12(6):e0178842. Epub 2017 Jun 2.

Department of Medical Research and Development, Chang Gung Memorial Hospital-Linkou Medical Center, Taoyuan, Taiwan, Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178842PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456392PMC
September 2017

The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan.

Prog Cardiovasc Dis 2017 Mar - Apr;59(5):506-521. Epub 2016 Aug 18.

College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA; SARENA Clinic, Medical Center and Research Institute.

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http://dx.doi.org/10.1016/j.pcad.2016.08.002DOI Listing
June 2017

TGFβ-Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme.

Stem Cells 2016 09 4;34(9):2276-89. Epub 2016 Jul 4.

The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053103PMC
http://dx.doi.org/10.1002/stem.2411DOI Listing
September 2016

Opening a SWATH Window on Posttranslational Modifications: Automated Pursuit of Modified Peptides.

Mol Cell Proteomics 2016 Mar 24;15(3):1151-63. Epub 2015 Dec 24.

From the §Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M115.054478
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http://dx.doi.org/10.1074/mcp.M115.054478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813695PMC
March 2016

Developmental biologist Eric H. Davidson, 1937-2015.

Proc Natl Acad Sci U S A 2015 Nov 23;112(44):13423-5. Epub 2015 Oct 23.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125

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http://dx.doi.org/10.1073/pnas.1518876112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640791PMC
November 2015

Sequence-Level Analysis of the Major European Huntington Disease Haplotype.

Am J Hum Genet 2015 Sep 27;97(3):435-44. Epub 2015 Aug 27.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564985PMC
September 2015

Microarray based screening of peptide nano probes for HER2 positive tumor.

Anal Chem 2015 Aug 6;87(16):8367-72. Epub 2015 Aug 6.

§Institute for Systems Biology, 401 Terry Avenue North, Seattle, Washington 98109, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b01588DOI Listing
August 2015

Endogenous molecular-cellular hierarchical modeling of prostate carcinogenesis uncovers robust structure.

Prog Biophys Mol Biol 2015 Jan 3;117(1):30-42. Epub 2015 Feb 3.

Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2015.01.004DOI Listing
January 2015

Integrating big data and actionable health coaching to optimize wellness.

BMC Med 2015 Jan 9;13. Epub 2015 Jan 9.

Institute for Systems Biology, 401 Terry Avenue North, Seattle 98109, WA, USA.

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http://dx.doi.org/10.1186/s12916-014-0238-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288554PMC
January 2015

Whole-genome sequencing of the world's oldest people.

PLoS One 2014 12;9(11):e112430. Epub 2014 Nov 12.

Depts. of Developmental Biology and Genetics, Stanford University, Stanford, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112430PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229186PMC
July 2015

Rapid screening of peptide probes through in situ single-bead sequencing microarray.

Anal Chem 2014 Dec 14;86(23):11854-9. Epub 2014 Nov 14.

CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, China.

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http://dx.doi.org/10.1021/ac503454zDOI Listing
December 2014

Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury.

Biomarkers 2014 Nov 21;19(7):578-84. Epub 2014 Aug 21.

National Center for Nanoscience and Technology , Beijing , P.R. China .

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http://dx.doi.org/10.3109/1354750X.2014.951880DOI Listing
November 2014

Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging.

Anal Chem 2014 Sep 11;86(17):8857-64. Epub 2014 Aug 11.

National Center for Nanoscience and Technology , No. 11, Beiyitiao Zhongguancun, Beijing 100190, P. R. China.

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http://pubs.acs.org/doi/10.1021/ac5023056
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http://dx.doi.org/10.1021/ac5023056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151789PMC
September 2014

Realistic artificial DNA sequences as negative controls for computational genomics.

Nucleic Acids Res 2014 Jul 6;42(12):e99. Epub 2014 May 6.

Institute for Systems Biology, 401 Terry Ave. N, Seattle, WA 98109, USA

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http://dx.doi.org/10.1093/nar/gku356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081056PMC
July 2014

Protein-centric N-glycoproteomics analysis of membrane and plasma membrane proteins.

J Proteome Res 2014 Jun 1;13(6):2705-14. Epub 2014 May 1.

Department of Chemistry, Simon Fraser University , 8888 University Drive, Burnaby, British Columbia V5A1S6, Canada.

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http://dx.doi.org/10.1021/pr500187gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053080PMC
June 2014

P4 medicine needs P4 education.

Curr Pharm Des 2014 ;20(38):6071-2

Director, Area of Systems Medicine, IRCCS San Raffaele Pisana, Rome, Italy.

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http://dx.doi.org/10.2174/1381612820666140314145445DOI Listing
June 2015

An epigenetic biomarker panel for glioblastoma multiforme personalized medicine through DNA methylation analysis of human embryonic stem cell-like signature.

OMICS 2014 May 6;18(5):310-23. Epub 2014 Mar 6.

1 Department of Computer Science and Information Engineering, National Cheng Kung University , Tainan City, Taiwan .

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http://dx.doi.org/10.1089/omi.2013.0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012637PMC
May 2014

Demystifying disease, democratizing health care.

Sci Transl Med 2014 Feb;6(225):225ed5

Leroy Hood is President of the Institute for Systems Biology, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008665DOI Listing
February 2014

Relationship estimation from whole-genome sequence data.

PLoS Genet 2014 Jan 30;10(1):e1004144. Epub 2014 Jan 30.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907355PMC
January 2014

Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity.

Theranostics 2014 14;4(2):215-28. Epub 2014 Jan 14.

2. Institute for Systems Biology, 401 Terry Avenue N, Seattle, Washington 98109, USA.

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http://www.thno.org/v04p0215.htm
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http://dx.doi.org/10.7150/thno.7868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900804PMC
September 2014

Participatory medicine: a driving force for revolutionizing healthcare.

Genome Med 2013 23;5(12):110. Epub 2013 Dec 23.

European Institute for Systems Biology & Medicine, CNRS-ENS-UCBL, Université de Lyon, 50, Avenue Tony Garnier, 69007, Lyon, France.

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http://dx.doi.org/10.1186/gm514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978637PMC
May 2014

Optimal scaling of digital transcriptomes.

PLoS One 2013 6;8(11):e77885. Epub 2013 Nov 6.

Institute for Systems Biology, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077885PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819321PMC
August 2014

Systems approach to neurodegenerative disease biomarker discovery.

Annu Rev Pharmacol Toxicol 2014 23;54:457-81. Epub 2013 Oct 23.

Institute for Systems Biology, Seattle, Washington 98109; email: , , , , , ,

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http://dx.doi.org/10.1146/annurev-pharmtox-011613-135928DOI Listing
September 2014

The Human Genome Project: big science transforms biology and medicine.

Genome Med 2013 13;5(9):79. Epub 2013 Sep 13.

Institute for Systems Biology, 401 Terry Ave N., Seattle, WA 98109, USA.

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http://dx.doi.org/10.1186/gm483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066586PMC
August 2014

Every life has equal value.

Cell 2013 Sep;154(6):1178-9

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109-5234, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.08.046DOI Listing
September 2013

Multi-study integration of brain cancer transcriptomes reveals organ-level molecular signatures.

PLoS Comput Biol 2013 25;9(7):e1003148. Epub 2013 Jul 25.

Institute for Systems Biology, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723500PMC
February 2014

Systems biology and p4 medicine: past, present, and future.

Authors:
Leroy Hood

Rambam Maimonides Med J 2013 Apr 30;4(2):e0012. Epub 2013 Apr 30.

President, Institute for Systems Biology, Seattle, WA, USA.

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http://dx.doi.org/10.5041/RMMJ.10112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678833PMC
April 2013

An automated Teflon microfluidic peptide synthesizer.

Lab Chip 2013 Sep 8;13(17):3347-50. Epub 2013 Jul 8.

National Center for Nanoscience and Technology, No.11 ZhongGuanCun BeiYiTiao, 100190 Beijing, PR China.

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http://dx.doi.org/10.1039/c3lc50632kDOI Listing
September 2013

Interview with Leroy Hood.

Authors:
Leroy Hood

Bioanalysis 2013 Jun;5(12):1475-8

Institute for Systems Biology, Seattle, WA 98105, USA.

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http://dx.doi.org/10.4155/bio.13.119DOI Listing
June 2013

A Review of Computational Tools in microRNA Discovery.

Front Genet 2013 15;4:81. Epub 2013 May 15.

Institute for Systems Biology Seattle, WA, USA ; Pós-Graduaçao em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília Brasília, Brazil ; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília Brasília, Brazil.

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http://dx.doi.org/10.3389/fgene.2013.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654206PMC
May 2013

Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain.

Proc Natl Acad Sci U S A 2013 Feb 5;110(8):3095-100. Epub 2013 Feb 5.

Institute for Genomic Biology and Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.1222897110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581870PMC
February 2013

P4 medicine: how systems medicine will transform the healthcare sector and society.

Per Med 2013 ;10(6):565-576

Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

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http://dx.doi.org/10.2217/pme.13.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204402PMC
January 2013