Leandro F Vendruscolo

Leandro F Vendruscolo

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Leandro F Vendruscolo

Leandro F Vendruscolo

Publications by authors named "Leandro F Vendruscolo"

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Utility of fentanyl vaccines: unique challenges posed by preventing opioid overdose and treating opioid use disorder.

Neuropsychopharmacology 2019 Sep 24;44(10):1675-1676. Epub 2019 May 24.

Neurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

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http://www.nature.com/articles/s41386-019-0418-4
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http://dx.doi.org/10.1038/s41386-019-0418-4DOI Listing
September 2019

Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.

J Neuroendocrinol 2019 Jul 16;31(7):e12663. Epub 2019 Jan 16.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1111/jne.12663DOI Listing
July 2019

Male and female mice develop escalation of heroin intake and dependence following extended access.

Neuropharmacology 2019 06 14;151:189-194. Epub 2019 Mar 14.

Neurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.03.019DOI Listing
June 2019

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala.

PLoS Biol 2019 Apr 16;17(4):e2006421. Epub 2019 Apr 16.

Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2006421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467366PMC
April 2019

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Sci Rep 2019 Feb 12;9(1):1841. Epub 2019 Feb 12.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41598-019-38549-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372697PMC
February 2019

Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood.

Neuropsychopharmacology 2018 12 27;43(13):2627-2635. Epub 2018 Feb 27.

Université Bordeaux, INCIA, UMR 5287, Bordeaux, F-33000, France.

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http://dx.doi.org/10.1038/s41386-018-0025-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224580PMC
December 2018

The Role of the Ghrelin System in Drug Addiction.

Int Rev Neurobiol 2017 18;136:89-119. Epub 2017 Sep 18.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, United States; Center for Alcohol and Addiction Studies, Brown University, Providence, RI, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2017.08.002DOI Listing
June 2018

Compulsive-Like Sufentanil Vapor Self-Administration in Rats.

Neuropsychopharmacology 2018 03 16;43(4):801-809. Epub 2017 Aug 16.

Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2017.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809787PMC
March 2018

Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST).

Psychopharmacology (Berl) 2017 Dec 6;234(23-24):3485-3498. Epub 2017 Oct 6.

Department of Immunology and Microbiology and Department ofNeuroscience, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/s00213-017-4732-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993421PMC
December 2017

Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors.

Psychoneuroendocrinology 2017 Oct 12;84:17-31. Epub 2017 Jun 12.

VA San Diego Healthcare System, San Diego, CA, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA; Department of Anesthesiology, University of California, San Diego, CA, USA.

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http://dx.doi.org/10.1016/j.psyneuen.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557646PMC
October 2017

Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking.

Curr Opin Behav Sci 2017 Feb 19;13:85-90. Epub 2016 Nov 19.

National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.cobeha.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461929PMC
February 2017

Sex, strain, and estrous cycle influences on alcohol drinking in rats.

Pharmacol Biochem Behav 2017 Jan 4;152:61-67. Epub 2016 Aug 4.

Neurobiology of Addiction Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755698PMC
January 2017

Divergent regulation of distinct glucocorticoid systems in alcohol dependence.

Alcohol 2015 Dec 30;49(8):811-6. Epub 2015 Apr 30.

National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.alcohol.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627854PMC
December 2015

Binge-like ingestion of a combination of an energy drink and alcohol leads to cognitive deficits and motivational changes.

Pharmacol Biochem Behav 2015 Sep 15;136:82-6. Epub 2015 Jul 15.

Department of Pharmacology, Universidade Federal de Santa Catarina, CCB, Bloco D, Setor J, Florianopolis, SC 88040-900, Brazil.

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https://linkinghub.elsevier.com/retrieve/pii/S00913057153003
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http://dx.doi.org/10.1016/j.pbb.2015.07.007DOI Listing
September 2015

DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.

J Neurosci 2015 Apr;35(15):6153-64

Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, SE-581 85 Linköping, Sweden, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-1108.

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http://dx.doi.org/10.1523/JNEUROSCI.4571-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397609PMC
April 2015

Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.

Addict Biol 2015 Mar 13;20(2):275-84. Epub 2013 Dec 13.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/adb.12120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057367PMC
March 2015

Compulsive-like responding for opioid analgesics in rats with extended access.

Neuropsychopharmacology 2015 Jan 25;40(2):421-8. Epub 2014 Jul 25.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/npp.2014.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443956PMC
January 2015

Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction.

Psychopharmacology (Berl) 2014 Oct 13;231(19):3911-7. Epub 2014 Jun 13.

Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA, 92037, USA,

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http://dx.doi.org/10.1007/s00213-014-3623-1DOI Listing
October 2014

Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.

Addict Biol 2014 Sep 3;19(5):755-7. Epub 2013 May 3.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/adb.12059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872251PMC
September 2014

Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats.

Behav Brain Res 2014 Sep 7;271:171-6. Epub 2014 Jun 7.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, United States.

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http://dx.doi.org/10.1016/j.bbr.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216724PMC
September 2014

Hippocampal neurogenesis protects against cocaine-primed relapse.

Addict Biol 2014 Jul 24;19(4):562-74. Epub 2012 Dec 24.

Laboratoire de Neurobiologie et Psychotraumatologie, Université de Nice Sophia Antipolis, Nice, France; Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/adb.12019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620729PMC
July 2014

Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats.

Neuropsychopharmacology 2014 Jun 29;39(7):1722-31. Epub 2014 Jan 29.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/npp.2014.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023146PMC
June 2014

Operant alcohol self-administration in dependent rats: focus on the vapor model.

Alcohol 2014 May 1;48(3):277-86. Epub 2013 Nov 1.

Molecular and Cellular Neuroscience Department, Mouse Behavioral Assessment Core, The Scripps Research Institute, 10550 North Torrey Pines Road, MB18, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.alcohol.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007394PMC
May 2014

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats.

Psychopharmacology (Berl) 2014 Mar 13;231(5):929-37. Epub 2013 Nov 13.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA, 92037, USA,

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http://dx.doi.org/10.1007/s00213-013-3307-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945412PMC
March 2014

Addiction as a stress surfeit disorder.

Neuropharmacology 2014 Jan 6;76 Pt B:370-82. Epub 2013 Jun 6.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830720PMC
January 2014

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.

J Neurosci 2013 Dec;33(49):19384-92

Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037.

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http://dx.doi.org/10.1523/JNEUROSCI.1979-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850049PMC
December 2013

Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats.

Int J Neuropsychopharmacol 2013 Sep 16;16(8):1867-75. Epub 2013 Apr 16.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1017/S1461145713000308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880138PMC
September 2013

The NK1 receptor antagonist L822429 reduces heroin reinforcement.

Neuropsychopharmacology 2013 May 18;38(6):976-84. Epub 2012 Dec 18.

Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-1108, USA.

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http://dx.doi.org/10.1038/npp.2012.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629386PMC
May 2013

Dynamic vaccine blocks relapse to compulsive intake of heroin.

Proc Natl Acad Sci U S A 2013 May 6;110(22):9036-41. Epub 2013 May 6.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1219159110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670323PMC
May 2013

A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.

Sci Transl Med 2012 Aug;4(146):146ra110

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448552PMC
August 2012

Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism.

Neuropharmacology 2012 Feb 23;62(2):1142-51. Epub 2011 Nov 23.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2011.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262951PMC
February 2012

Developing a vaccine against multiple psychoactive targets: a case study of heroin.

CNS Neurol Disord Drug Targets 2011 Dec;10(8):865-75

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology and Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327724PMC
December 2011

A vaccine strategy that induces protective immunity against heroin.

J Med Chem 2011 Jul 30;54(14):5195-204. Epub 2011 Jun 30.

Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/jm200461mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142939PMC
July 2011

Escalation patterns of varying periods of heroin access.

Pharmacol Biochem Behav 2011 Jun 23;98(4):570-4. Epub 2011 Mar 23.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA92037, USA.

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http://dx.doi.org/10.1016/j.pbb.2011.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081940PMC
June 2011

[Comorbidity between attention deficit/hyperactivity disorder and substance use disorders: evidence from animal models].

Braz J Psychiatry 2011 Jun;33(2):203-8

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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June 2011

Reduced alcohol drinking in adult rats exposed to sucrose during adolescence.

Neuropharmacology 2010 Nov 17;59(6):388-94. Epub 2010 Jun 17.

CNRS-UMR5227, Université de Bordeaux 1&2, Bordeaux, France.

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http://dx.doi.org/10.1016/j.neuropharm.2010.05.015DOI Listing
November 2010

Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat-an animal model of attention deficit hyperactivity disorder.

Psychopharmacology (Berl) 2009 Aug 1;205(2):319-26. Epub 2009 May 1.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.

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http://dx.doi.org/10.1007/s00213-009-1542-3DOI Listing
August 2009

Drug reinforcement in a rat model of attention deficit/hyperactivity disorder--the Spontaneously Hypertensive Rat (SHR).

Curr Drug Abuse Rev 2009 May;2(2):177-83

Movement-Adaptation-Cognition, CNRS-UMR5227, Team Neuropsychopharmacology of Addiction, Université Victor Segalen Bordeaux 1 et 2, Bordeaux, France.

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May 2009

Anxious to drink: gabapentin normalizes GABAergic transmission in the central amygdala and reduces symptoms of ethanol dependence.

J Neurosci 2008 Sep;28(37):9087-9

Centre National de la Recherche Scientifique-Unité Mixte de Recherche 5227, Equipe Neuropsychopharmacologie de l'Addiction, Université Victor Segalen Bordeaux 1 et 2, 33076 Bordeaux, France.

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http://dx.doi.org/10.1523/JNEUROSCI.2928-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670924PMC
September 2008

Chronic methylphenidate treatment during adolescence increases anxiety-related behaviors and ethanol drinking in adult spontaneously hypertensive rats.

Behav Pharmacol 2008 Feb;19(1):21-7

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.

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http://dx.doi.org/10.1097/FBP.0b013e3282f3cfbeDOI Listing
February 2008

Two inbred rat strains contrasting for anxiety-related behaviors show similar levels of defensive responses to cat odor.

Behav Brain Funct 2007 Apr 13;3:17. Epub 2007 Apr 13.

Laboratório de Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

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http://behavioralandbrainfunctions.biomedcentral.com/article
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http://dx.doi.org/10.1186/1744-9081-3-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855343PMC
April 2007

Increased sensitivity to cocaine-induced analgesia in Spontaneously Hypertensive Rats (SHR).

Behav Brain Funct 2007 Feb 13;3. Epub 2007 Feb 13.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

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http://dx.doi.org/10.1186/1744-9081-3-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802084PMC
February 2007

Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats.

Life Sci 2005 Jun 4;77(6):693-706. Epub 2005 Mar 4.

Departamento de Ciências Farmacêuticas, Universidade Regional de Blumenau, FURB, R. São Paulo 2171, 89030-000, Blumenau-SC, Brasil.

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http://dx.doi.org/10.1016/j.lfs.2005.01.013DOI Listing
June 2005

Evaluation of the anxiolytic-like effect of NKP608, a NK1-receptor antagonist, in two rat strains that differ in anxiety-related behaviors.

Psychopharmacology (Berl) 2003 Nov 12;170(3):287-293. Epub 2003 Aug 12.

Laboratório de Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, 88.040-900, Florianópolis SC, Brazil.

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http://dx.doi.org/10.1007/s00213-003-1545-4DOI Listing
November 2003

Evaluation of Lewis and SHR rat strains as a genetic model for the study of anxiety and pain.

Behav Brain Res 2002 Feb;129(1-2):113-23

Laboratório de Genética do Comportamento, Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88.040-900, SC, Florianópolis, SC, Brazil.

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http://dx.doi.org/10.1016/s0166-4328(01)00337-0DOI Listing
February 2002