Lajos Pusztai

Lajos Pusztai

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Lajos Pusztai

Lajos Pusztai

Publications by authors named "Lajos Pusztai"

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Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer.

Sci Rep 2019 Oct 17;9(1):14934. Epub 2019 Oct 17.

Department of Internal Medicine, Section of Medical Oncology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41598-019-51453-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797726PMC
October 2019

Examining the cost-effectiveness of baseline left ventricular function assessment among breast cancer patients undergoing anthracycline-based therapy.

Breast Cancer Res Treat 2019 Jul 24;176(2):261-270. Epub 2019 Apr 24.

Cardiovascular Institute of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1007/s10549-019-05178-zDOI Listing
July 2019

Changing frameworks in treatment sequencing of triple-negative and HER2-positive, early-stage breast cancers.

Lancet Oncol 2019 Jul;20(7):e390-e396

Orlando Health, University of Florida Health Cancer Center, Orlando, FL, USA.

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http://dx.doi.org/10.1016/S1470-2045(19)30158-5DOI Listing
July 2019

Defining Risk of Late Recurrence in Early-Stage Estrogen Receptor-Positive Breast Cancer: Clinical Versus Molecular Tools.

J Clin Oncol 2019 Jun 3;37(16):1365-1369. Epub 2019 Apr 3.

1 Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1200/JCO.18.01933DOI Listing
June 2019

Immune microenvironment of triple-negative breast cancer in African-American and Caucasian women.

Breast Cancer Res Treat 2019 May 6;175(1):247-259. Epub 2019 Feb 6.

Breast Medical Oncology, Yale School of Medicine, Yale Cancer Center, 300 George St, Suite 120, Rm 133, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1007/s10549-019-05156-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666415PMC
May 2019

Immunotherapy and targeted therapy combinations in metastatic breast cancer.

Lancet Oncol 2019 Mar;20(3):e175-e186

Yale School of Medicine, Yale Cancer Center, New Haven, CT, USA.

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http://dx.doi.org/10.1016/S1470-2045(19)30026-9DOI Listing
March 2019

CD68, CD163, and matrix metalloproteinase 9 (MMP-9) co-localization in breast tumor microenvironment predicts survival differently in ER-positive and -negative cancers.

Breast Cancer Res 2018 12 17;20(1):154. Epub 2018 Dec 17.

Department of Pathology, Yale School of Medicine, 310 Cedar Street, P.O. Box 208023, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1186/s13058-018-1076-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298021PMC
December 2018

TQuest, A Web-Based Platform to Enable Precision Medicine by Linking a Tumor's Genetic Defects to Therapeutic Options.

JCO Clin Cancer Inform 2018 12;2:1-13

Peter Gershkovich, Joshua Knopf, Lajos Pusztai, Christos Hatzis, Yale School of Medicine, New Haven; James Platt, Biomantica, West Haven, CT; Marios K. Tasoulis, The Royal Marsden National Health Services Foundation Trust, London, United Kingdom; and Weiwei Shi, Origimed, Shanghai, China.

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http://dx.doi.org/10.1200/CCI.17.00120DOI Listing
December 2018

Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study.

Breast Cancer Res Treat 2018 Nov 30;172(1):105-112. Epub 2018 Jul 30.

Yale Cancer Center, Yale University School of Medicine, 333 Cedar St, PO Box 208032, New Haven, CT, 06520-8032, USA.

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http://dx.doi.org/10.1007/s10549-018-4895-7DOI Listing
November 2018

Incorporating Genomics Into the Care of Patients With Advanced Breast Cancer.

Am Soc Clin Oncol Educ Book 2018 May;38:56-64

From the University of Wisconsin Carbone Cancer Center, Madison, WI; Department of Medicine, Division of Hematology/Oncology, University of Wisconsin, Madison, WI; Yale Cancer Center, New Haven, CT; Princess Margaret Hospital, Calgary, ON, Canada; Princess Margaret Cancer Center, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/EDBK_200731DOI Listing
May 2018

Benefit of the addition of hormone therapy to neoadjuvant anthracycline-based chemotherapy for breast cancer: comparison of predicted and observed pCR.

J Cancer Res Clin Oncol 2018 Mar 17;144(3):601-606. Epub 2018 Jan 17.

Department of Obstetrics and Gynaecology, Tenon University Hospital, Paris, France.

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http://dx.doi.org/10.1007/s00432-017-2574-4DOI Listing
March 2018

Bidirectional Text Messaging to Monitor Endocrine Therapy Adherence and Patient-Reported Outcomes in Breast Cancer.

JCO Clin Cancer Inform 2017 11;1:1-10

Sarah S. Mougalian, Lianne N. Epstein, Erin W. Hofstatter, Michael P. DiGiovanna, Andrea L.M. Silber, Kerin Adelson, Lajos Pusztai, and Cary P. Gross, Yale Cancer Center, Yale University; Sarah S. Mougalian, Kerin Adelson, and Cary P. Gross, Yale Cancer Outcomes, Public Policy, and Effectiveness Research Center, Yale University, New Haven, CT; Ami P. Jhaveri, Lancaster General Health, Penn Medicine, Lancaster; Maysa Abu-Khalaf, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA; and Gang Han, Texas A&M University School of Public Health, College Station, TX.

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http://dx.doi.org/10.1200/CCI.17.00015DOI Listing
November 2017

Functional germline variants as potential co-oncogenes.

NPJ Breast Cancer 2017 22;3:46. Epub 2017 Nov 22.

Department of Medicine, Breast Medical Oncology, Yale School of Medicine, Yale University, New Haven, CT USA.

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http://dx.doi.org/10.1038/s41523-017-0051-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700137PMC
November 2017

Association of LN Evaluation with Survival in Women Aged 70 Years or Older With Clinically Node-Negative Hormone Receptor Positive Breast Cancer.

Ann Surg Oncol 2017 Oct 1;24(10):3073-3081. Epub 2017 Aug 1.

Department of Surgery, Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA.

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http://dx.doi.org/10.1245/s10434-017-5936-xDOI Listing
October 2017

Testing violations of the exponential assumption in cancer clinical trials with survival endpoints.

Biometrics 2017 06 26;73(2):687-695. Epub 2016 Sep 26.

Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, U.S.A.

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http://dx.doi.org/10.1111/biom.12590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093291PMC
June 2017

Immune Gene Expression Is Associated with Genomic Aberrations in Breast Cancer.

Cancer Res 2017 06 20;77(12):3317-3324. Epub 2017 Apr 20.

Breast Medical Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3478DOI Listing
June 2017

Bone Density Screening in Postmenopausal Women With Early-Stage Breast Cancer Treated With Aromatase Inhibitors.

J Oncol Pract 2017 05 7;13(5):e505-e515. Epub 2017 Mar 7.

Yale University School of Medicine; and Yale Cancer Outcomes Public Policy and Effectiveness Research (COPPER) Center, New Haven, CT.

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http://dx.doi.org/10.1200/JOP.2016.018341DOI Listing
May 2017

Long-Term Prognostic Risk After Neoadjuvant Chemotherapy Associated With Residual Cancer Burden and Breast Cancer Subtype.

J Clin Oncol 2017 Apr 30;35(10):1049-1060. Epub 2017 Jan 30.

W. Fraser Symmans, Caimiao Wei, Rebekah Gould, Xian Yu, Ya Zhang, Maheshwari Ramineni, Kelly Hunt, Thomas A. Buchholz, Vicente Valero, Aman U. Buzdar, Wei Yang, Abenaa M. Brewster, Stacy Moulder, and Gabriel N. Hortobagyi, University of Texas MD Anderson Cancer Center, Houston; Andrew Walls, Uniformed Services University of the Health Sciences, San Antonio, TX; Mei Liu, The General Hospital of People's Liberation Army, Beijing, China; Alex Bousamra, Allegheny General Hospital, Pittsburgh, PA; Bruno Sinn, Charite-Universitatsmedizin, Berlin, Germany; and Lajos Pusztai and Christos Hatzis, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1200/JCO.2015.63.1010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455352PMC
April 2017

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.

Nat Commun 2017 04 10;8:14929. Epub 2017 Apr 10.

National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 333 Haike Road, Shanghai 201210, China.

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http://dx.doi.org/10.1038/ncomms14929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394241PMC
April 2017

New Therapeutic Strategies for Triple-Negative Breast Cancer.

Oncology (Williston Park) 2017 02;31(2):130-7

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February 2017

Economic Impact of Routine Cavity Margins Versus Standard Partial Mastectomy in Breast Cancer Patients: Results of a Randomized Controlled Trial.

Ann Surg 2017 01;265(1):39-44

*Department of Surgery, Yale University †Yale Cancer Center ‡Yale Center for Outcomes Public Policy and Effectiveness Research §Department of Surgery, Thomas Jefferson University ¶Yale-New Haven Hospital ||Yale Center for Analytical Sciences **Department of Pathology, Yale University ††Department of Medicine, Yale University.

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http://dx.doi.org/10.1097/SLA.0000000000001799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605915PMC
January 2017

Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer.

Cancer Res 2017 01 21;77(2):566-578. Epub 2016 Nov 21.

Department of Internal Medicine, Section of Medical Oncology, Yale School of Medicine, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582957PMC
January 2017

Predictors of Chemosensitivity in Triple Negative Breast Cancer: An Integrated Genomic Analysis.

PLoS Med 2016 Dec 13;13(12):e1002193. Epub 2016 Dec 13.

Department of Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154510PMC
December 2016

Is precision medicine ready for use in breast cancer?

Authors:
Lajos Pusztai

Clin Adv Hematol Oncol 2016 Dec;14(12):964-966

Yale School of Medicine, Yale Cancer Center, New Haven, Connecticut.

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December 2016

Clinical Utility of Biomarker Tests in Decisions on Extended Endocrine Therapy.

J Clin Oncol 2016 11;34(32):3942-3943

Tara Sanft and Lajos Pusztai, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1200/JCO.2016.67.3285DOI Listing
November 2016

T-DM1 Activity in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancers That Received Prior Therapy With Trastuzumab and Pertuzumab.

J Clin Oncol 2016 10;34(29):3511-3517

Hannah Dzimitrowicz, Annette Hood, Osama Abdelghany, Christos Hatzis, and Lajos Pusztai, Yale University School of Medicine, New Haven, CT; Michael Berger and Craig Vargo, The James Cancer Hospital and Solove Research Institute at The Ohio State University, Columbus, OH; and Akshara Singareeka Raghavendra, Debu Tripathy, Vicente Valero, and Rashmi Murthy, MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.67.3624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075965PMC
October 2016

Tumor profiling and the incidentalome: patient decisions and risks.

Future Oncol 2015 12;11(24):3299-305. Epub 2015 Nov 12.

Section of Medical Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.2217/fon.15.260DOI Listing
September 2016

Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer.

Oncologist 2016 09 6;21(9):1063-78. Epub 2016 Jul 6.

Yale Cancer Center, School of Medicine, Yale University, New Haven, Connecticut, USA

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http://dx.doi.org/10.1634/theoncologist.2015-0369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016060PMC
September 2016

A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential core biopsies of primary, untreated breast cancer.

BMC Cancer 2016 Sep 22;16(1):745. Epub 2016 Sep 22.

Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Holcombe Boulevard, Houston, 77030, TX, USA.

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http://dx.doi.org/10.1186/s12885-016-2788-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034430PMC
September 2016

Standardization efforts enabling next-generation sequencing and microarray based biomarkers for precision medicine.

Biomark Med 2015 26;9(11):1265-72. Epub 2015 Oct 26.

Center for Pharmacogenomics & Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, China.

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http://dx.doi.org/10.2217/bmm.15.99DOI Listing
August 2016

The Influence of Host Factors on the Prognosis of Breast Cancer: Stroma and Immune Cell Components as Cancer Biomarkers.

Curr Cancer Drug Targets 2015 ;15(8):652-64

Department of Obstetrics and Gynecology, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.2174/156800961508151001101209DOI Listing
July 2016

Pembrolizumab in Patients With Advanced Triple-Negative Breast Cancer: Phase Ib KEYNOTE-012 Study.

J Clin Oncol 2016 07 2;34(21):2460-7. Epub 2016 May 2.

Rita Nanda, University of Chicago, Chicago, IL; Laura Q.M. Chow, University of Washington, Seattle, WA; E. Claire Dees, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC; Raanan Berger, Sheba Medical Center, Tel Hashomer; Ravit Geva, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Shilpa Gupta, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Lajos Pusztai, Yale University School of Medicine, New Haven, CT; Kumudu Pathiraja, Gursel Aktan, Jonathan D. Cheng, and Vassiliki Karantza, Merck & Co., Kenilworth, NJ; and Laurence Buisseret, Université Libre de Bruxelles, Bruxelles, Belgium.

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http://dx.doi.org/10.1200/JCO.2015.64.8931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816000PMC
July 2016

Adaptive Randomization of Neratinib in Early Breast Cancer.

N Engl J Med 2016 Jul;375(1):11-22

From University of California, San Francisco (J.W.P., C.Y., L.J.V., N.M.H., M.B.B., A.J.C., M.M., J.L., S.E.D., G.L.H., L.J.E.), and QuantumLeap Healthcare Collaborative (M.P.), San Francisco, Buck Institute for Research and Aging, Novato (C.Y.), University of California, Davis, Davis (M.H.), University of California, San Diego, San Diego (A.M.W., R.S., T.H.), and University of Southern California, Los Angeles (D.T.) - all in California; Georgetown Lombardi Comprehensive Cancer Center, Washington, DC (M.C.L., C.I.); University of Minnesota, Minneapolis (D.Y., T.C.H.), and Mayo Clinic, Rochester (J.C.B.) - both in Minnesota; M.D. Anderson Cancer Center, Houston (W.F.S., L.P., S.L.M., D.A.B.), University of Texas Southwestern Medical Center, Dallas (D.M.E., B.B.H.), and Berry Consultants, Austin (A.S., D.A.B.) - all in Texas; Gemini Group, Ann Arbor, MI (J.P.); University of Pennsylvania, Philadelphia (A.D.); Oregon Health and Sciences University, Portland (S.Y.C., K.A.K.); Swedish Medical Center, Seattle (H.G.K.); University of Chicago (R.N.) and Loyola University (K.S.A.) - both in Chicago; Inova Fairfax Hospital, Falls Church, VA (K.K.E.); University of Denver, Denver (A.D.E.); Mayo Clinic, Scottsdale (D.W.N.), and University of Arizona, Tucson (J.E.L., R.K.V.) - both in Arizona; University of Kansas, Lawrence (Q.J.K.); and Emory University, Atlanta (W.C.W.).

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http://dx.doi.org/10.1056/NEJMoa1513750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259558PMC
July 2016

Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer.

N Engl J Med 2016 Jul;375(1):23-34

From University of California, San Francisco (UCSF) (H.S.R., C.Y., L.J.V., M.B.B., N.M.H., A.J.C., C.E., J.L., S.E.D., G.L.H., L.J.E.), and QuantumLeap Healthcare Collaborative (M.P.), San Francisco, Buck Institute for Research and Aging, Novato (C.Y.), University of California, Davis, Davis (M.H.), University of California San Diego, San Diego (A.M.W., R.S.), and University of Southern California, Los Angeles (D.T.) - all in California; University of Chicago (O.I.O., R.N.), and Loyola University (K.S.A.), Chicago; University of Pennsylvania, Philadelphia (A.D.); Gemini Group, Ann Arbor, MI (J.P.); University of Texas M.D. Anderson Cancer Center, Houston (W.F.S., L.P., S.L.M., D.A.B.), UT Southwestern Medical Center, Dallas (D.M.E., B.B.H.), and Berry Consultants, Austin (A.S., D.A.B.) - all in Texas; University of Minnesota, Minneapolis (D.Y.), and Mayo Clinic, Rochester (J.C.B., T.C.H.) - both in Minnesota; Swedish Medical Center, Seattle (H.G.K.); Georgetown Lombardi Comprehensive Cancer Center, Washington, DC (M.C.L., C.I.); University of Kansas, Lawrence (Q.J.K.); University of Arizona, Tucson (J.E.L., R.K.V.), and Mayo Clinic, Scottsdale (D.W.N.) - both in Arizona; Oregon Health and Sciences University, Portland (S.Y.C., K.A.K.); University of Denver, Denver (A.D.E.); Inova Fairfax Hospital, Falls Church, VA (K.K.E.); and Emory University, Atlanta (W.C.W.).

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http://dx.doi.org/10.1056/NEJMoa1513749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259561PMC
July 2016

Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer.

Breast Cancer Res 2016 07 29;18(1):78. Epub 2016 Jul 29.

Department of Pathology, Yale School of Medicine, Yale University, 310 Cedar St., PO Box 208023, New Haven, CT, 06520-8023, USA.

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http://dx.doi.org/10.1186/s13058-016-0737-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966732PMC
July 2016

New Strategies in Breast Cancer: Immunotherapy.

Clin Cancer Res 2016 05 11;22(9):2105-10. Epub 2016 Feb 11.

Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.

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http://clincancerres.aacrjournals.org/content/early/2016/02/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-1315DOI Listing
May 2016

Patient preferences regarding incidental genomic findings discovered during tumor profiling.

Cancer 2016 May 11;122(10):1588-97. Epub 2016 Mar 11.

Section of Medical Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/cncr.29951DOI Listing
May 2016

[Immunotherapy opportunities in breast cancer].

Magy Onkol 2016 03 19;60(1):34-40. Epub 2015 Dec 19.

Radiológiai és Onkoterápiás Klinika, Semmelweis Egyetem, Budapest, Hungary.

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March 2016

miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer.

Cancer Res 2016 Feb 16;76(4):927-39. Epub 2015 Dec 16.

Institute for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755913PMC
February 2016

Uptake of exemestane chemoprevention in postmenopausal women at increased risk for breast cancer.

Eur J Cancer Prev 2016 Jan;25(1):3-8

aDepartmentof Medical Oncology, Yale Cancer Center, Yale School of Medicine bDepartment of Social and Behavioral Sciences, Yale School of Public Health, New Haven, Connecticut, USA cDepartment of Medical Oncology, Marmara University Pendik Training and Research Hospital, Marmara University School of Medicine, Ust Kaynarca, Istanbul, Turkey.

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http://dx.doi.org/10.1097/CEJ.0000000000000124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885537PMC
January 2016

Chemotherapy and the recurrence score--results as expected?

Authors:
Lajos Pusztai

Nat Rev Clin Oncol 2015 Dec 10;12(12):690-2. Epub 2015 Nov 10.

Yale Cancer Center, Yale School of Medicine, Section of Oncology, 300 George Street, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1038/nrclinonc.2015.191DOI Listing
December 2015

Racial Differences in the Use and Outcome of Neoadjuvant Chemotherapy for Breast Cancer: Results From the National Cancer Data Base.

J Clin Oncol 2015 Dec 23;33(36):4267-76. Epub 2015 Nov 23.

Brigid K. Killelea, Brandon Hayse, Sarah Mougalian, Nina R. Horowitz, Anees B. Chagpar, Lajos Pusztai, and Donald R. Lannin, Yale University School of Medicine; Brigid K. Killelea, Sarah Mougalian, Nina R. Horowitz, Anees B. Chagpar, Lajos Pusztai, and Donald R. Lannin, Yale Comprehensive Cancer Center; and Vicky Q. Yang and Shi-Yi Wang, Yale University School of Public Health, New Haven, CT.

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http://dx.doi.org/10.1200/JCO.2015.63.7801DOI Listing
December 2015

Predictive and Prognostic Value of the TauProtein in Breast Cancer.

Anticancer Res 2015 Oct;35(10):5179-84

Department of Breast and Gynaecological Surgery, Curie Institute, Versailles-St-Quentin-en-Yvelines University, Versailles, France EA 7285: "Clinics risks and security in women's health and perinatal health", Versailles-St-Quentin-en-Yvelines University, Versailles, France

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October 2015

A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.

Genome Med 2015 Oct 16;7:104. Epub 2015 Oct 16.

MTA TTK Lendület Cancer Biomarker Research Group, Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary.

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http://dx.doi.org/10.1186/s13073-015-0228-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609150PMC
October 2015

Clinical nomogram to predict bone-only metastasis in patients with early breast carcinoma.

Br J Cancer 2015 Sep 22;113(7):1003-9. Epub 2015 Sep 22.

Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/bjc.2015.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651124PMC
September 2015

Use of neoadjuvant chemotherapy for patients with stage I to III breast cancer in the United States.

Cancer 2015 Aug 22;121(15):2544-52. Epub 2015 Apr 22.

Cancer Outcomes, Public Policy, and Effectiveness Research Center, Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut.

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http://doi.wiley.com/10.1002/cncr.29348
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http://dx.doi.org/10.1002/cncr.29348DOI Listing
August 2015

Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer.

J Natl Cancer Inst 2015 Aug 19;107(8). Epub 2015 May 19.

: Department of Pathology (DECH, KAS, DLR) and Medical Oncology (LP), Yale University School of Medicine, New Haven, CT; Attikon University Hospital, Athens, Greece (AP); Translational Research Section, Hellenic Cooperative Oncology Group, Data Office, Athens, Greece (KTK); Department of Medical Oncology, "Papageorgiou" Hospital (KTK, GF), Department of Pathology (VK), and Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research (VK, GF), Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.

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http://jnci.oxfordjournals.org/content/107/8/djv136.full.pdf
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djv136
Publisher Site
http://dx.doi.org/10.1093/jnci/djv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554192PMC
August 2015

A Randomized, Controlled Trial of Cavity Shave Margins in Breast Cancer.

N Engl J Med 2015 Aug 30;373(6):503-10. Epub 2015 May 30.

From the Departments of Surgery (A.B.C., B.K.K., M.B., K.S., D.R.L., N.R.H.), Pathology (V.B., M.H.), and Medicine (L.P.), Yale Cancer Center (A.B.C., B.K.K., M.B., K.S., F.L., X.Y., D.R.L., L.P., N.R.H.), and Yale Center for Analytical Sciences (F.L., X.Y.), Yale University School of Medicine, New Haven, CT; and the Department of Surgery, Thomas Jefferson University, Philadelphia (T.N.T.).

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http://dx.doi.org/10.1056/NEJMoa1504473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584380PMC
August 2015

CCR 20th Anniversary Commentary: Divide and Conquer-Breast Cancer Subtypes and Response to Therapy.

Clin Cancer Res 2015 Aug;21(16):3575-7

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-3121DOI Listing
August 2015

Neoadjuvant chemotherapy for breast cancer increases the rate of breast conservation: results from the National Cancer Database.

J Am Coll Surg 2015 Jun 26;220(6):1063-9. Epub 2015 Feb 26.

Department of Surgery, Yale University School of Medicine, and Yale Comprehensive Cancer Center, New Haven, CT 06520.

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https://linkinghub.elsevier.com/retrieve/pii/S10727515150014
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http://dx.doi.org/10.1016/j.jamcollsurg.2015.02.011DOI Listing
June 2015

Dynamic classification using case-specific training cohorts outperforms static gene expression signatures in breast cancer.

Int J Cancer 2015 May 11;136(9):2091-8. Epub 2014 Oct 11.

MTA TTK Lendület Cancer Biomarker Research Group, Budapest, Hungary; 2nd Department of Pediatrics, Semmelweis University Budapest, 1094, Budapest, Tűzoltó utca 7-9, Hungary; MTA-SE Pediatrics and Nephrology Research Group, Bókay u. 53, H-1083, Budapest, Hungary.

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http://doi.wiley.com/10.1002/ijc.29247
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http://dx.doi.org/10.1002/ijc.29247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354298PMC
May 2015

Functional polymorphisms in cancer.

Oncoscience 2015 20;2(2):73-4. Epub 2015 Feb 20.

Department of Molecular, Cellular and Developmental Biology, Yale University, CT, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381696PMC
http://dx.doi.org/10.18632/oncoscience.129DOI Listing
April 2015

Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer.

BMC Genomics 2014 Oct 8;15:876. Epub 2014 Oct 8.

Department of Internal Medicine, Yale School of Medicine, Yale Cancer Center, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1186/1471-2164-15-876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197225PMC
October 2014