Kiran Musunuru

Kiran Musunuru

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Kiran Musunuru

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Tunable and Reversible Substrate Stiffness Reveals a Dynamic Mechanosensitivity of Cardiomyocytes.

ACS Appl Mater Interfaces 2019 Jun 30;11(23):20603-20614. Epub 2019 May 30.

Department of Physics , Bryn Mawr College , Bryn Mawr , Pennsylvania 19010 , United States.

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http://dx.doi.org/10.1021/acsami.9b02446DOI Listing
June 2019

From Hypertrophy to Heart Failure: What Is New in Genetic Cardiomyopathies.

Curr Heart Fail Rep 2019 Jun 26. Epub 2019 Jun 26.

Division of Cardiovascular Medicine, Department of Medicine, and Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Cardiovascular Institute, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11897-019-00435-0DOI Listing
June 2019

Cardioprotective Effects of MTSS1 Enhancer Variants.

Circulation 2019 Apr;139(17):2073-2076

Division of Cardiovascular Medicine and Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (M.P.P., X.W., R.H., J.B., K.B.M., K.M., T.P.C.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510256PMC
April 2019

Genetics of Common, Complex Coronary Artery Disease.

Cell 2019 Mar;177(1):132-145

Broad Institute, Cambridge, MA 02142, USA; Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.02.015DOI Listing
March 2019

What do we do now?: Responding to claims of germline gene editing in humans.

Genet Med 2019 Mar 27. Epub 2019 Mar 27.

Department of Genetics and Stanford Center for Biomedical Ethics, Stanford School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41436-019-0492-3DOI Listing
March 2019

Challenges and advances of CRISPR-Cas9 genome editing in therapeutics.

Cardiovasc Res 2019 Feb;115(2):e12-e14

Division of Cardiology, Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/cvr/cvy300DOI Listing
February 2019

Scientists on the Spot: The future of genome editing in cardiovascular medicine.

Cardiovasc Res 2019 Feb;115(2):e20-e21

Cardiovascular Medicine and Genetics in the Perelman School of Medicine at the University of Pennsylvania, USA.

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http://dx.doi.org/10.1093/cvr/cvy302DOI Listing
February 2019

Functional Annotation of TNNT2 Variants of Uncertain Significance With Genome-Edited Cardiomyocytes.

Circulation 2018 Dec;138(24):2852-2854

Department of Medicine, Division of Cardiology and Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309910PMC
December 2018

Confirmation of Causal rs9349379- PHACTR1 Expression Quantitative Trait Locus in Human-Induced Pluripotent Stem Cell Endothelial Cells.

Circ Genom Precis Med 2018 10;11(10):e002327

Division of Cardiology and Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCGEN.118.002327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211814PMC
October 2018

Genetic and Chemical Screenings Identify HDAC3 as a Key Regulator in Hepatic Differentiation of Human Pluripotent Stem Cells.

Stem Cell Reports 2018 Jul 31;11(1):22-31. Epub 2018 May 31.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066908PMC
July 2018

Stem cell modeling of lipid genetics.

Authors:
Kiran Musunuru

Curr Opin Lipidol 2018 04;29(2):151-155

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http://dx.doi.org/10.1097/MOL.0000000000000490DOI Listing
April 2018

Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.

Circ Genom Precis Med 2018 04;11(4):e002178

Cardiovascular Institute, Department of Medicine (K.M.), Department of Genetics (K.M.), and Department of Pathology and Laboratory Medicine (F.S.L.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia. Department of Pediatrics (D.B.), Cardiovascular Institute (D.B., T.Q.), and Department of Medicine (T.Q.), Stanford University, CA. Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, MO (F.S.C.). St. Louis Children's Hospital, MO (F.S.C.). Pediatric Genomics Discovery Program, Department of Pediatrics and Genetics, Yale University School of Medicine, New Haven, CT (M.K.K.). Division of Cardiology, Department of Medicine, University of Washington, Seattle (S.L.). Department of Cardiovascular Sciences, University of South Florida Morsani College of Medicine, Tampa, FL (T.V.M.). Department of Pediatrics (I.P.M.), Department of Pathology (I.P.M.), and Department of Human Genetics (I.P.M.), The University of Chicago, IL. Division of Hematology/ Oncology, Boston Children's Hospital, MA (V.G.S.). Department of Pediatric Oncology, Dana-Farber Cancer Institute (V.G.S.) and Channing Division of Network Medicine, Brigham and Women's Hospital (E.K.S., X.Z.), Harvard Medical School, Boston. Broad Institute of MIT and Harvard, Cambridge, MA (V.G.S.). University of Colorado, Aurora (D.A.S.). Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (A.A.K.H., X.-z.J.L.).

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http://dx.doi.org/10.1161/CIRCGEN.118.002178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901889PMC
April 2018

How genome editing could be used in the treatment of cardiovascular diseases.

Authors:
Kiran Musunuru

Per Med 2018 03 2;15(2):67-69. Epub 2018 Feb 2.

Department of Medicine & Department of Genetics, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2217/pme-2017-0078DOI Listing
March 2018

Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3.

Circulation 2018 02;137(9):975-977

Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830171PMC
February 2018

From Genotype to Phenotype: A Primer on the Functional Follow-up of Genome-Wide Association Studies in Cardiovascular Disease.

Circ Genom Precis Med 2018 02 30;11(2). Epub 2018 Jan 30.

Division of Cardiovascular Medicine, Department of Medicine, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003539PMC
February 2018

CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia.

Arterioscler Thromb Vasc Biol 2018 01 24;38(1):12-18. Epub 2017 Aug 24.

From the Department of Medicine and Department of Genetics, Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/ATVBAHA.117.309326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832026PMC
January 2018

Interrogation of the Atherosclerosis-Associated (Sortilin 1) Locus With Primary Human Hepatocytes, Induced Pluripotent Stem Cell-Hepatocytes, and Locus-Humanized Mice.

Arterioscler Thromb Vasc Biol 2018 01 2;38(1):76-82. Epub 2017 Nov 2.

From the Cardiovascular Institute (X.W., E.E.P., D.J.R., K.M.), Department of Medicine (X.W., E.E.P., D.J.R., K.M.), and Department of Genetics (X.W., E.E.P., D.J.R., K.M.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; and Harvard Medical School, Boston, MA (A.R., D.T.P.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746470PMC
January 2018

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.

Atherosclerosis 2018 01 21;268:196-206. Epub 2017 Sep 21.

Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750127PMC
January 2018

Turning up the Heat with Therapeutic Epigenome Editing.

Cell Stem Cell 2018 01;22(1):10-11

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.12.013DOI Listing
January 2018

Exome-wide association study of plasma lipids in >300,000 individuals.

Authors:
Dajiang J Liu Gina M Peloso Haojie Yu Adam S Butterworth Xiao Wang Anubha Mahajan Danish Saleheen Connor Emdin Dewan Alam Alexessander Couto Alves Philippe Amouyel Emanuele Di Angelantonio Dominique Arveiler Themistocles L Assimes Paul L Auer Usman Baber Christie M Ballantyne Lia E Bang Marianne Benn Joshua C Bis Michael Boehnke Eric Boerwinkle Jette Bork-Jensen Erwin P Bottinger Ivan Brandslund Morris Brown Fabio Busonero Mark J Caulfield John C Chambers Daniel I Chasman Y Eugene Chen Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu John M Connell Francesco Cucca L Adrienne Cupples Scott M Damrauer Gail Davies Ian J Deary George Dedoussis Joshua C Denny Anna Dominiczak Marie-Pierre Dubé Tapani Ebeling Gudny Eiriksdottir Tõnu Esko Aliki-Eleni Farmaki Mary F Feitosa Marco Ferrario Jean Ferrieres Ian Ford Myriam Fornage Paul W Franks Timothy M Frayling Ruth Frikke-Schmidt Lars G Fritsche Philippe Frossard Valentin Fuster Santhi K Ganesh Wei Gao Melissa E Garcia Christian Gieger Franco Giulianini Mark O Goodarzi Harald Grallert Niels Grarup Leif Groop Megan L Grove Vilmundur Gudnason Torben Hansen Tamara B Harris Caroline Hayward Joel N Hirschhorn Oddgeir L Holmen Jennifer Huffman Yong Huo Kristian Hveem Sehrish Jabeen Anne U Jackson Johanna Jakobsdottir Marjo-Riitta Jarvelin Gorm B Jensen Marit E Jørgensen J Wouter Jukema Johanne M Justesen Pia R Kamstrup Stavroula Kanoni Fredrik Karpe Frank Kee Amit V Khera Derek Klarin Heikki A Koistinen Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo Lakka Claudia Langenberg Anne Langsted Lenore J Launer Torsten Lauritzen David C M Liewald Li An Lin Allan Linneberg Ruth J F Loos Yingchang Lu Xiangfeng Lu Reedik Mägi Anders Malarstig Ani Manichaikul Alisa K Manning Pekka Mäntyselkä Eirini Marouli Nicholas G D Masca Andrea Maschio James B Meigs Olle Melander Andres Metspalu Andrew P Morris Alanna C Morrison Antonella Mulas Martina Müller-Nurasyid Patricia B Munroe Matt J Neville Jonas B Nielsen Sune F Nielsen Børge G Nordestgaard Jose M Ordovas Roxana Mehran Christoper J O'Donnell Marju Orho-Melander Cliona M Molony Pieter Muntendam Sandosh Padmanabhan Colin N A Palmer Dorota Pasko Aniruddh P Patel Oluf Pedersen Markus Perola Annette Peters Charlotta Pisinger Giorgio Pistis Ozren Polasek Neil Poulter Bruce M Psaty Daniel J Rader Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Stephen S Rich Paul M Ridker John D Rioux Neil R Robertson Dan M Roden Jerome I Rotter Igor Rudan Veikko Salomaa Nilesh J Samani Serena Sanna Naveed Sattar Ellen M Schmidt Robert A Scott Peter Sever Raquel S Sevilla Christian M Shaffer Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert V Smith Blair H Smith Sangeetha Somayajula Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kathleen E Stirrups Nathan Stitziel Konstantin Strauch Heather M Stringham Praveen Surendran Hayato Tada Alan R Tall Hua Tang Jean-Claude Tardif Kent D Taylor Stella Trompet Philip S Tsao Jaakko Tuomilehto Anne Tybjaerg-Hansen Natalie R van Zuydam Anette Varbo Tibor V Varga Jarmo Virtamo Melanie Waldenberger Nan Wang Nick J Wareham Helen R Warren Peter E Weeke Joshua Weinstock Jennifer Wessel James G Wilson Peter W F Wilson Ming Xu Hanieh Yaghootkar Robin Young Eleftheria Zeggini He Zhang Neil S Zheng Weihua Zhang Yan Zhang Wei Zhou Yanhua Zhou Magdalena Zoledziewska Joanna M M Howson John Danesh Mark I McCarthy Chad A Cowan Goncalo Abecasis Panos Deloukas Kiran Musunuru Cristen J Willer Sekar Kathiresan

Nat Genet 2017 Dec 30;49(12):1758-1766. Epub 2017 Oct 30.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146PMC
December 2017

Genome Editing: The Recent History and Perspective in Cardiovascular Diseases.

Authors:
Kiran Musunuru

J Am Coll Cardiol 2017 Dec;70(22):2808-2821

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and the Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742864PMC
December 2017

ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.

Dev Cell 2017 11 26;43(3):318-331.e5. Epub 2017 Oct 26.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Clinical Research Building, Room 463, 415 Curie Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687886PMC
November 2017

What Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine?

Circ Cardiovasc Genet 2017 10;10(5)

From the Cardiovascular Institute, Department of Medicine, and Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (K.M.); Department of Molecular Physiology and Biophysics, Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX (W.R.L.); and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (J.M.M.).

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http://circgenetics.ahajournals.org/lookup/doi/10.1161/CIRCG
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http://dx.doi.org/10.1161/CIRCGENETICS.117.001910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658039PMC
October 2017

Cardiovascular endocrinology: Is ANGPTL3 the next PCSK9?

Nat Rev Endocrinol 2017 09 14;13(9):503-504. Epub 2017 Jul 14.

Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5.830, Boston, Massachusetts 02114, USA; and at the Program in Medical and Population Genetics, Broad Institute, 75 Ames Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nrendo.2017.88DOI Listing
September 2017

In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing.

Arterioscler Thromb Vasc Biol 2017 09 27;37(9):1741-1747. Epub 2017 Jul 27.

From the Cardiovascular Institute, Department of Medicine, and Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/ATVBAHA.117.309881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570639PMC
September 2017

The Hope and Hype of CRISPR-Cas9 Genome Editing: A Review.

Authors:
Kiran Musunuru

JAMA Cardiol 2017 08;2(8):914-919

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamacardio.2017.1713DOI Listing
August 2017

Treatment of Dyslipidemia Using CRISPR/Cas9 Genome Editing.

Curr Atheroscler Rep 2017 Jul;19(7):32

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s11883-017-0668-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832020PMC
July 2017

NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts†,‡.

Biol Reprod 2017 Apr;96(4):831-842

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1093/biolre/iox009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803763PMC
April 2017

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

J Am Coll Cardiol 2017 Apr 3;69(16):2054-2063. Epub 2017 Apr 3.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404817PMC
April 2017

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Cell Stem Cell 2017 04;20(4):547-557.e7

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.01.010DOI Listing
April 2017

Genome Editing for the Study of Cardiovascular Diseases.

Curr Cardiol Rep 2017 03;19(3):22

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s11886-017-0830-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969527PMC
March 2017

Genome editing in cardiovascular diseases.

Nat Rev Cardiol 2017 01 9;14(1):11-20. Epub 2016 Sep 9.

Cardiovascular Institute, Department of Medicine, and Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, 11-136 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Building 421, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrcardio.2016.139DOI Listing
January 2017

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Cell Rep 2016 12;17(12):3292-3304

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193246PMC
December 2016

Genome engineering tools for building cellular models of disease.

FEBS J 2016 09 22;283(17):3222-31. Epub 2016 Jun 22.

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://doi.wiley.com/10.1111/febs.13763
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http://dx.doi.org/10.1111/febs.13763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881911PMC
September 2016

Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing.

Arterioscler Thromb Vasc Biol 2016 07 26;36(7):1434-47. Epub 2016 May 26.

From the Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine (J.L.), Department of Biostatistics and Epidemiology (Y.H., M.L.), Department of Genetics, Perelman School of Medicine (B.C., K.M., D.J.R.), and Cardiovascular Institute, Department of Medicine, Perelman School of Medicine (M.G., W.L., K.M.), University of Pennsylvania, Philadelphia; Irving Institute for Clinical and Translational Research (M.P.R.) and Division of Cardiology, Department of Medicine (C.X., H.Z., M.P.R.), Columbia University Medical Center, New York, NY; and Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA (S.N., A.S.F.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919157PMC
July 2016

Improving Genomic Literacy Among Cardiovascular Practitioners via a Flipped-Classroom Workshop at a National Meeting.

Circ Cardiovasc Genet 2016 06;9(3):287-90

From the Cardiovascular Institute, Departments of Medicine and Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (K.M.); and Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston (R.L.H.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918462PMC
June 2016

CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo-Brief Report.

Arterioscler Thromb Vasc Biol 2016 05 3;36(5):783-6. Epub 2016 Mar 3.

From the Department of Stem Cell and Regenerative Biology, Harvard University, and Harvard Stem Cell Institute, Cambridge, MA (X.W., A.R., T.C., L.Q., K.M.); Harvard Medical School, Boston, MA (A.R., K.M.); Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China (Y.Z., Q.D.); Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (K.M.); and Broad Institute, Cambridge, MA (K.M.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850082PMC
May 2016

Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells.

Development 2016 05;143(9):1475-81

Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA

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http://dx.doi.org/10.1242/dev.132209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909860PMC
May 2016

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice.

Nat Biotechnol 2016 Mar 1;34(3):334-8. Epub 2016 Feb 1.

Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nbt.3469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786489PMC
March 2016

Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis.

Circ Res 2016 Feb;118(4):579-85

From the Department of Medicine, Harvard Medical School, Boston, MA (K.M., S.K.); Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (K.M.); Broad Institute of MIT and Harvard, Cambridge, MA (K.M., S.K.); and Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.115.30639
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.115.306398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762058PMC
February 2016

Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport--Brief Report.

Arterioscler Thromb Vasc Biol 2016 Jan 5;36(1):15-8. Epub 2015 Nov 5.

From the Department of Stem Cell and Regenerative Biology, Harvard University, and Harvard Stem Cell Institute, Cambridge, MA (R.M.G., T.B.M., C.A.C., K.M.); and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (R.M.G., K.M.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690765PMC
January 2016

(Pro)renin Receptor and LDL Clearance: An Old Player Joins A New Game.

Circ Res 2016 Jan;118(2):187-9

From the Department of Pediatrics, St Christopher's Hospital for Children, Philadelphia, PA (A.S.); Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA (K.M.); and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (K.M.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743896PMC
January 2016

Novel Genome-Editing Tools to Model and Correct Primary Immunodeficiencies.

Front Immunol 2015 21;6:250. Epub 2015 May 21.

Department of Stem Cell and Regenerative Biology, Harvard University , Cambridge, MA , USA.

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http://dx.doi.org/10.3389/fimmu.2015.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440404PMC
June 2015

Genome editing of a CArG element in the mouse genome establishes its role in gene expression.

Authors:
Kiran Musunuru

Arterioscler Thromb Vasc Biol 2015 Mar;35(3):496-7

From the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA; and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1161/ATVBAHA.115.305175DOI Listing
March 2015

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Cell Stem Cell 2014 Nov 6;15(5):643-52. Epub 2014 Nov 6.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269831PMC
November 2014

Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9.

J Clin Invest 2014 Oct 1;124(10):4154-61. Epub 2014 Oct 1.

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http://dx.doi.org/10.1172/JCI72992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191047PMC
October 2014

Personalized genomes and cardiovascular disease.

Authors:
Kiran Musunuru

Cold Spring Harb Perspect Med 2014 Sep 25;5(1):a014068. Epub 2014 Sep 25.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292073PMC
September 2014

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing.

Circ Res 2014 Aug 10;115(5):488-92. Epub 2014 Jun 10.

From the Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA (Q.D., S.-L.N., B.S.G., S.N.R., C.A.C., K.M.); Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity and Metabolism, and Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (A.S., K.M.P., D.J.R.); Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (K.M.); and Broad Institute, Cambridge, MA (C.A.C., K.M.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134749PMC
August 2014

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

Cell Stem Cell 2014 Jul;15(1):27-30

Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082799PMC
July 2014

The Stroke Genetics Network: living up to its potential.

Stroke 2013 Oct 10;44(10):2679. Epub 2013 Sep 10.

From the Department of Neurology and Stroke Program, Wayne State University, Detroit, MI (S.C.); and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (K.M.).

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October 2013

Identification of a growth factor that rejuvenates the heart.

Authors:
Kiran Musunuru

Circ Cardiovasc Genet 2013 Aug;6(4):435-6

Early Career Committee of the American Heart Association Functional Genomics and Translational Biology Council.

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August 2013

Genome editing of human pluripotent stem cells to generate human cellular disease models.

Authors:
Kiran Musunuru

Dis Model Mech 2013 Jul 10;6(4):896-904. Epub 2013 Jun 10.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.012054
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701209PMC
July 2013

Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations.

PLoS One 2012 7;7(12):e50198. Epub 2012 Dec 7.

Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517599PMC
May 2013

Enduring mystery of the chromosome 9p21.3 locus.

Authors:
Kiran Musunuru

Circ Cardiovasc Genet 2013 Apr;6(2):224-5

Early Career Committee of the American Heart Association Functional Genomics and Translational Biology Council.

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April 2013

Top advances in functional genomics and translational biology for 2012.

Circ Cardiovasc Genet 2013 Feb;6(1):132-4

Early Career Committee of the American Heart Association, Functional Genomics and Translational Biology Council, Dallas, TX, USA.

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February 2013

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

Authors:
Folkert W Asselbergs Yiran Guo Erik P A van Iperen Suthesh Sivapalaratnam Vinicius Tragante Matthew B Lanktree Leslie A Lange Berta Almoguera Yolande E Appelman John Barnard Jens Baumert Amber L Beitelshees Tushar R Bhangale Yii-Der Ida Chen Tom R Gaunt Yan Gong Jemma C Hopewell Toby Johnson Marcus E Kleber Taimour Y Langaee Mingyao Li Yun R Li Kiang Liu Caitrin W McDonough Matthijs F L Meijs Rita P S Middelberg Kiran Musunuru Christopher P Nelson Jeffery R O'Connell Sandosh Padmanabhan James S Pankow Nathan Pankratz Suzanne Rafelt Ramakrishnan Rajagopalan Simon P R Romaine Nicholas J Schork Jonathan Shaffer Haiqing Shen Erin N Smith Sam E Tischfield Peter J van der Most Jana V van Vliet-Ostaptchouk Niek Verweij Kelly A Volcik Li Zhang Kent R Bailey Kristian M Bailey Florianne Bauer Jolanda M A Boer Peter S Braund Amber Burt Paul R Burton Sarah G Buxbaum Wei Chen Rhonda M Cooper-Dehoff L Adrienne Cupples Jonas S deJong Christian Delles David Duggan Myriam Fornage Clement E Furlong Nicole Glazer John G Gums Claire Hastie Michael V Holmes Thomas Illig Susan A Kirkland Mika Kivimaki Ronald Klein Barbara E Klein Charles Kooperberg Kandice Kottke-Marchant Meena Kumari Andrea Z LaCroix Laya Mallela Gurunathan Murugesan Jose Ordovas Willem H Ouwehand Wendy S Post Richa Saxena Hubert Scharnagl Pamela J Schreiner Tina Shah Denis C Shields Daichi Shimbo Sathanur R Srinivasan Ronald P Stolk Daniel I Swerdlow Herman A Taylor Eric J Topol Elina Toskala Joost L van Pelt Jessica van Setten Salim Yusuf John C Whittaker A H Zwinderman Sonia S Anand Anthony J Balmforth Gerald S Berenson Connie R Bezzina Bernhard O Boehm Eric Boerwinkle Juan P Casas Mark J Caulfield Robert Clarke John M Connell Karen J Cruickshanks Karina W Davidson Ian N M Day Paul I W de Bakker Pieter A Doevendans Anna F Dominiczak Alistair S Hall Catharina A Hartman Christian Hengstenberg Hans L Hillege Marten H Hofker Steve E Humphries Gail P Jarvik Julie A Johnson Bernhard M Kaess Sekar Kathiresan Wolfgang Koenig Debbie A Lawlor Winfried März Olle Melander Braxton D Mitchell Grant W Montgomery Patricia B Munroe Sarah S Murray Stephen J Newhouse N Charlotte Onland-Moret Neil Poulter Bruce Psaty Susan Redline Stephen S Rich Jerome I Rotter Heribert Schunkert Peter Sever Alan R Shuldiner Roy L Silverstein Alice Stanton Barbara Thorand Mieke D Trip Michael Y Tsai Pim van der Harst Ellen van der Schoot Yvonne T van der Schouw W M Monique Verschuren Hugh Watkins Arthur A M Wilde Bruce H R Wolffenbuttel John B Whitfield G Kees Hovingh Christie M Ballantyne Cisca Wijmenga Muredach P Reilly Nicholas G Martin James G Wilson Daniel J Rader Nilesh J Samani Alex P Reiner Robert A Hegele John J P Kastelein Aroon D Hingorani Philippa J Talmud Hakon Hakonarson Clara C Elbers Brendan J Keating Fotios Drenos

Am J Hum Genet 2012 Nov 11;91(5):823-38. Epub 2012 Oct 11.

Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487124PMC
November 2012

Functional evaluation of genetic variation in complex human traits.

Hum Mol Genet 2012 Oct 29;21(R1):R18-23. Epub 2012 Aug 29.

Department of Stem Cell and Regenerative Biology, Harvard University, Sherman Fairchild Biochemistry Bldg 160, 7 Divinity Ave., Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1093/hmg/dds363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459642PMC
October 2012

Transforming growth factor β2 mutations and familial thoracic aortic aneurysms.

Authors:
Kiran Musunuru

Circ Cardiovasc Genet 2012 Oct;5(5):593-4

Early Career Committee of the American Heart Association Functional Genomics and Translational Biology Council, Harvard University, Cambridge, MA 02138, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.112.964
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October 2012

Induction of cardiomyocytes from cardiac fibroblasts.

Authors:
Kiran Musunuru

Circ Cardiovasc Genet 2012 Aug;5(4):481-2

Early Career Committee of the American Heart Association Functional Genomics and Translational Biology Council.

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August 2012