Publications by authors named "Khalida Aamir"

2 Publications

  • Page 1 of 1

High doses of Antisecretory Factor stop diarrhea fast without recurrence for six weeks post treatment.

Int J Infect Dis 2018 Jun 3;71:48-52. Epub 2018 Apr 3.

Institute of Biomedicine, Department of Clinical Bacteriology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Background: Diarrheal illnesses in young children cause morbidity and preventable deaths in developing countries. We evaluated two high doses of Salovum® [Antisecretory Factor] to treat diarrhea in young children and followed up for recurrence 6 weeks post treatment.

Methods: Forty children, 6-24 months old, admitted with acute diarrhea, to the Outpatient Department of Children's Hospital in Lahore, Pakistan were selected. The patients were randomly allocated to either Group A given 2 sachets, or to Group B, given 4 sachets. Each sachet contained 4gram of Salovum® and was mixed with Oral Rehydration Salt solution. This mixture was administered perorally within the first 30min of treatment. The trained nursing staff observed them for number of stools and consistency over every half hour for a total of 4hours. Follow up for 6 weeks was done daily by telephone, or visits by the mothers. The results demonstrate that Salovum provides a protective effect irrespective of the diarrhea causes.

Results: Group B, given 4 sachets of Salovum® showed improved fecal consistency in 80% of the children compared to 50% in Group A within 30minutes of treatment, p=0.004. The number of diarrheal stools decreased over this time from seven to one/two over 4hours in the two groups [p=0.234]. None of the children showed a recurrence of diarrhea over the follow up period.

Conclusion: Peroral high doses of Salovum® rapidly and safely counteract diarrhea in children followed by a diarrhea-free period of 6 weeks.
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http://dx.doi.org/10.1016/j.ijid.2018.03.015DOI Listing
June 2018

Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo-controlled, randomised study.

Acta Paediatr 2014 Jun 10;103(6):659-64. Epub 2014 Mar 10.

Children's Hospital and Institute of Child Health, Lahore, Pakistan.

Aim: We studied the response to high doses of egg yolk containing antisecretory factor (B221® , Salovum®) in young children with acute diarrhoea, presenting to the Children's Hospital, Lahore, Pakistan.

Methods: In a randomised, placebo-controlled trial, 36 children aged 7 to 60 months with acute diarrhoea of unknown aetiology, with mild-to-moderate dehydration, were randomised to the Salovum® or placebo groups. Initially, 16 grams of Salovum® or ordinary egg yolk (placebo) mixed in oral rehydration salts was given, followed by 8 g every 5 h until recovery. The number and consistency of stools were recorded.

Results: The two groups were comparable in age, gender, duration of diarrhoea, hydration and nutritional status, although the proportion with watery stools was higher in the Salovum® group (p = 0.04). Reduction in the frequency of stools was seen at 7 versus 18 h (p < 0.0001) and normalising of stool consistency was 10 versus 18 h, p < 0.03) in the Salovum® and placebo groups. The overall effect was 35 versus 70 h in the two groups (p = 0.001). No side effects were reported.

Conclusion: High doses of AF in the form of Salovum® effectively and safely reduce childhood diarrhoea of a likely broad aetiology.
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http://dx.doi.org/10.1111/apa.12581DOI Listing
June 2014
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