Keyvan Karkouti

Keyvan Karkouti

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Keyvan Karkouti

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Fibrinogen Supplementation and Its Indications.

Semin Thromb Hemost 2019 Oct 1. Epub 2019 Oct 1.

Department of Anesthesia, Zurich University Children's Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1055/s-0039-1696946DOI Listing
October 2019

Transfusion-related Acute Lung Injury in the Perioperative Patient.

Anesthesiology 2019 Sep;131(3):693-715

From the Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Canada (M.J.M., J.W.S., W.M.K) Departments of Physiology and Anesthesia (M.J.M.) Pharmacology (J.W.S.) Laboratory Medicine-Pathobiology (C.C.-G.) Medicine-Division of Hematology (C.C.-G.) Anesthesia and Pain Management, University Health Network (K.K.) Physiology and Surgery (W.M.K.) University of Toronto, Toronto, Canada (C.C.-G.) Sickkids Department of Anesthesia and Pain Medicine (M.J.M.) Division of Hematology and Transfusion Medicine (R.K., J.W.S.), Lund University, Lund, Sweden Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands (R.K.) Departments of Laboratory Hematology (Blood Transfusion Laboratory), Laboratory Medicine Program (C.C.-G.) Medical Oncology and Hematology (C.C.-G.) University Health Network, Toronto, Canada (K.K.) Department of Clinical Pathology, Blood and Tissue Bank, Sunnybrook Health Sciences Centre, Toronto, Canada (C.C.-G.) Institute of Physiology, Charité University Berlin, Berlin, Germany (W.M.K.).

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http://dx.doi.org/10.1097/ALN.0000000000002687DOI Listing
September 2019

A regional massive hemorrhage protocol developed through a modified Delphi technique.

CMAJ Open 2019 Jul-Sep;7(3):E546-E561. Epub 2019 Sep 3.

Departments of Laboratory Medicine and Molecular Diagnostics (Callum, Chin, Viveiros), Surgery (Nathens, Nascimento), Emergency Services (McDonald), Critical Care Medicine (Adhikari) and Anesthesia (Margarido), Sunnybrook Health Sciences Centre; Departments of Laboratory Medicine and Pathobiology (Callum, Pendergrast, Skeate, Pavenski), Anesthesia (McVey, Karkouti, Alam, Margarido), Surgery (Nathens, Nascimento, Rizoli) and Paediatrics (Beno), University of Toronto; Division of Emergency Medicine (Yeh, Petrosoniak, McDonald, MacDonald), Department of Medicine, University of Toronto; Departments of Emergency Medicine (Petrosoniak), Surgery (Rizoli) and Laboratory Medicine (Sholzberg, Pavenski), St. Michael's Hospital; Department of Anesthesia and Pain Medicine (McVey, Skelton), The Hospital for Sick Children; Ontario Regional Blood Coordinating Network (Cope, Thompson, Collins, Owens); Department of Anesthesia and Pain Management (Karkouti), Sinai Health System, University Health Network, and Women's College Hospital, Toronto, Ont.; Department of Anesthesiology and Pain Medicine (Murto), Children's Hospital of Eastern Ontario; Department of Anesthesiology and Pain Medicine (Murto), University of Ottawa, Ottawa, Ont.; Paediatric Emergency Medicine (Beno), The Hospital for Sick Children; Department of Clinical Pathology (Pendergrast), University Health Network, Toronto, Ont.; Ornge Transport Medicine (McDonald, MacDonald), Mississauga, Ont.; Interdepartmental Division of Critical Care Medicine (Adhikari), University of Toronto; Department of Anesthesia (Alam, Arnold), North York General Hospital, Toronto, Ont.; McMaster Centre for Transfusion Research (Arnold, Pai, Zeller); Departments of Medicine (Pai, Zeller) and Pathology and Molecular Medicine (Pai), McMaster University, Hamilton, Ont.; Canadian Blood Services (Arnold, Skeate, White); St. Michael's Hospital (Barratt, Chaudhry, Harvey), Toronto, Ont.; Department of Surgery (Beckett), McGill University, Montréal, Que.; Canadian Forces Health Services (Beckett), Ottawa, Ont.; Sunnybrook Health Sciences Centre (Brenneman), Toronto, Ont.; General Surgery, Acute Care and Trauma (Lampron), The Ottawa Hospital; Departments of Surgery (Lampron), Medicine (Tinmouth) and Laboratory Medicine and Pathology (Tinmouth), Faculty of Medicine, University of Ottawa, Ottawa, Ont.; Trauma Program and Quality Assurance (McFarlan), St. Michael's Hospital, Toronto, Ont.; Departments of Pathology (Ruijs) and Surgery (Van Heest), William Osler Health Centre, Brampton, Ont.; Lakeridge Health Corporation (Syer), Oshawa, Ont.; Department of Critical Care (Theriault), Health Sciences North, Sudbury, Ont.; Division of Hematology (Tinmouth), The Ottawa Hospital; University of Ottawa Centre for Transfusion Research (Tinmouth), Ottawa Hospital Research Institute, Ottawa, Ont.; Canadian Blood Services (Zeller), Ancaster, Ont.

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http://dx.doi.org/10.9778/cmajo.20190042DOI Listing
September 2019

Comparison of Two Major Perioperative Bleeding Scores for Cardiac Surgery Trials: Universal Definition of Perioperative Bleeding in Cardiac Surgery and European Coronary Artery Bypass Grafting Bleeding Severity Grade.

Anesthesiology 2018 12;129(6):1092-1100

From the Department of Anesthesia and the Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada (J.B., D.N.W., K.K.) the Department of Anesthesia and Pain Management and the Peter Munk Cardiac Centre (D.N.W., K.K.) the Toronto General Research Institute (K.K.), Toronto General Hospital, University Health Network, Toronto, Ontario, Canada the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada (D.N.W.).

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http://dx.doi.org/10.1097/ALN.0000000000002179DOI Listing
December 2018

Point-of-care viscoelastic hemostatic testing in cardiac surgery patients: a systematic review and meta-analysis.

Can J Anaesth 2018 12 7;65(12):1333-1347. Epub 2018 Sep 7.

Department of Community Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.

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http://link.springer.com/10.1007/s12630-018-1217-9
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http://dx.doi.org/10.1007/s12630-018-1217-9DOI Listing
December 2018

Preventing and managing catastrophic bleeding during extracorporeal circulation.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):522-529

Department of Anesthesia, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/asheducation-2018.1.522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246010PMC
November 2018

In reply: Use of early postoperative serum creatinine elevation to identify acute kidney injury after cardiac surgery.

Authors:
Keyvan Karkouti

Can J Anaesth 2018 01 25;65(1):129-130. Epub 2017 Sep 25.

Department of Anesthesia and Institute of Health Policy Management and Evaluation, Peter Munk Cardiac Centre and the Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s12630-017-0980-3DOI Listing
January 2018

Early rise in postoperative creatinine for identification of acute kidney injury after cardiac surgery.

Can J Anaesth 2017 Aug 19;64(8):801-809. Epub 2017 May 19.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s12630-017-0899-8DOI Listing
August 2017

Losing sight of the precautionary principle.

Authors:
Keyvan Karkouti

Transfusion 2017 08;57(8):1854-1856

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/trf.14227DOI Listing
August 2017

Utilization and Effectiveness of Desmopressin Acetate After Cardiac Surgery Supplemented With Point-of-Care Hemostatic Testing: A Propensity-Score-Matched Analysis.

J Cardiothorac Vasc Anesth 2017 Jun 17;31(3):883-895. Epub 2016 Nov 17.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1053/j.jvca.2016.11.022DOI Listing
June 2017

Red Cell Transfusion-Associated Hemolysis in Cardiac Surgery: An Observational Cohort Study.

Anesth Analg 2017 06;124(6):1986-1991

From the *Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, and †Department of Clinical Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; ‡Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; §Centre for Innovation, Canadian Blood Services, Edmonton, Canada; ‖Department of Clinical Biochemistry, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada; and ¶Department of Surgery, Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1213/ANE.0000000000001807DOI Listing
June 2017

Point-of-Care Hemostatic Testing in Cardiac Surgery: A Stepped-Wedge Clustered Randomized Controlled Trial.

Circulation 2016 10 21;134(16):1152-1162. Epub 2016 Sep 21.

From Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, Canada (K.K.); Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, Canada (J.C.); Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Canada (D.N.W.); Division of Cardiac Surgery, Department of Surgery, Toronto General Hospital, University Health Network, University of Toronto, Canada (V.R.); Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada (M.C.); Department of Anesthesia and Perioperative Medicine, University of Manitoba, Winnipeg, Canada (H.P.G.); Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Canada (R.P.); Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care, University of Toronto, Canada (D.C.S.); and the Peter Munk Cardiac Centre, University Health Network, Toronto, Canada (K.K., D.N.W., V.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023956DOI Listing
October 2016

Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial.

Authors:
Alain Deschamps Richard Hall Hilary Grocott C David Mazer Peter T Choi Alexis F Turgeon Etienne de Medicis Jean S Bussières Christopher Hudson Summer Syed Doug Seal Stuart Herd Jean Lambert André Denault Alain Deschamps Alan Mutch Alexis Turgeon Andre Denault Andrea Todd Angela Jerath Ashraf Fayad Barry Finnegan Blaine Kent Brent Kennedy Brian H Cuthbertson Brian Kavanagh Brian Warriner Charles MacAdams Christian Lehmann Christine Fudorow Christopher Hudson Colin McCartney Dan McIsaac Daniel Dubois David Campbell David Mazer David Neilpovitz David Rosen Davy Cheng Dennis Drapeau Derek Dillane Diem Tran Dolores Mckeen Duminda Wijeysundera Eric Jacobsohn Etienne Couture Etienne de Medicis Fahad Alam Faraj Abdallah Fiona E Ralley Frances Chung Francois Lellouche Gary Dobson Genevieve Germain George Djaiani Ian Gilron Gregory Hare Gregory Bryson Hance Clarke Heather McDonald Helen Roman-Smith Hilary Grocott Homer Yang James Douketis James Paul Jean Beaubien Jean Bussières Jeremy Pridham J N Armstrong Joel Parlow John Murkin Jonathan Gamble Kaylene Duttchen Keyvan Karkouti Kim Turner Leyla Baghirzada Linda Szabo Manoj Lalu Marcin Wasowicz Michael Bautista Michael Jacka Michael Murphy Michael Schmidt Michaël Verret Michel-Antoine Perrault Nicolas Beaudet Norman Buckley Peter Choi Peter MacDougall Philip Jones Pierre Drolet Pierre Beaulieu Ravi Taneja Rene Martin Richard Hall Ronald George Rosa Chun Sarah McMullen Scott Beattie Sonia Sampson Stephen Choi Stephen Kowalski Stuart McCluskey Summer Syed Sylvain Boet Tim Ramsay Tarit Saha Thomas Mutter Tumul Chowdhury Vishal Uppal William Mckay

Anesthesiology 2016 Apr;124(4):826-36

From the Department of Anesthesiology (A. Deschamps, A. Denault) and Department of Intensive Care Medicine (A. Denault), Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada; Department of Anesthesiology and Critical Care Medicine, Queen Elizabeth II Health Science Centre, Dalhousie University, Halifax, Canada (R.H.); Department of Anesthesiology, University of Manitoba, St. Boniface Hospital, Winnipeg, Manitoba, Canada (H.G.); Department of Anesthesia, University of Toronto, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario, Canada (C.D.M.); Department of Anesthesiology Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada (P.T.C.); Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, and Population Health and Optimal Health Practices, CHU de Québec Research Center, CHU de Québec, Université Laval, Quebec City, Quebec, Canada (A.F.T.); Department of Anesthesiology, CHU de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, Canada (E.d.M.); Department of Anesthesiology, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Quebec, Canada (J.S.B.); Department of Anesthesiology, Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada (C.H.); Department of Anesthesiology, McMaster University, Hamilton, Ontario, Canada (S.S.); Department of Anesthesiology, Calgary Foothills Hospital, University of Calgary, Calgary, Alberta, Canada (D.S.); Department of Anesthesiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada (S.H.); and Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada (J.L.).Montreal Heart Institute, Montreal, QuébecUniversity of Manitoba, Winnipeg, ManitobaUniversité Laval, Québec, QuébecPh.D., Montreal Heart Institute, Montreal, Qu

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http://dx.doi.org/10.1097/ALN.0000000000001029DOI Listing
April 2016

Validity of Thromboelastometry for Rapid Assessment of Fibrinogen Levels in Heparinized Samples During Cardiac Surgery: A Retrospective, Single-center, Observational Study.

J Cardiothorac Vasc Anesth 2016 Jan 5;30(1):90-5. Epub 2015 May 5.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, Ont.

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http://dx.doi.org/10.1053/j.jvca.2015.04.030DOI Listing
January 2016

In Reply.

Anesthesiology 2015 Oct;123(4):975-6

Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada (K.K.).

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http://dx.doi.org/10.1097/ALN.0000000000000812DOI Listing
October 2015

Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis.

Anesthesiology 2015 Mar;122(3):560-70

From the Department of Anesthesia and Pain Management, and Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada (K.K.); Department of Anesthesia (S.A.M.), Department of Laboratory Medicine (R.S.), and Division of Cardiac Surgery, Department of Surgery (V.R.), Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada (J.C.); Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (J.F.); Department of Anesthesia, Université Paris-Diderot, Paris, France (T.T.); and Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada (D.R.).

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http://dx.doi.org/10.1097/ALN.0000000000000556DOI Listing
March 2015

Reliability of a point-of-care device for international normalized ratio testing during the three surgical phases of orthotopic liver transplantation: a retrospective observational study.

Can J Anaesth 2015 Mar 10;62(3):258-64. Epub 2015 Feb 10.

Hepatobiliary and Transplant Anesthesia, Toronto General Hospital, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s12630-014-0283-xDOI Listing
March 2015

Off-label use of recombinant activated factor VII in surgical and non-surgical patients at 16 Canadian hospitals from 2007 to 2010 (Canadian Registry Report).

Can J Anaesth 2014 Aug 3;61(8):727-35. Epub 2014 Jun 3.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, 3EN, Toronto, ON, M5G 2C4, Canada,

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http://dx.doi.org/10.1007/s12630-014-0184-zDOI Listing
August 2014

From the Journal archives: The red blood cell storage lesion: past, present, and future.

Authors:
Keyvan Karkouti

Can J Anaesth 2014 Jun 9;61(6):583-6. Epub 2014 Jan 9.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth St. 3EN, Toronto, ON, M5G 2C4, Canada,

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http://dx.doi.org/10.1007/s12630-013-0106-5DOI Listing
June 2014

Universal definition of perioperative bleeding in adult cardiac surgery.

J Thorac Cardiovasc Surg 2014 May 9;147(5):1458-1463.e1. Epub 2013 Dec 9.

Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00225223130130
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http://dx.doi.org/10.1016/j.jtcvs.2013.10.070DOI Listing
May 2014

Platelet dysfunction as measured by a point-of-care monitor is an independent predictor of high blood loss in cardiac surgery.

Anesth Analg 2014 Feb;118(2):257-63

From the Departments of *Anesthesia and Pain Management, †Laboratory Medicine, ‡Clinical Biochemistry, and §the Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, and ‖Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1213/ANE.0000000000000054DOI Listing
February 2014

Efficacy and safety of recombinant factor XIII on reducing blood transfusions in cardiac surgery: a randomized, placebo-controlled, multicenter clinical trial.

J Thorac Cardiovasc Surg 2013 Oct 29;146(4):927-39. Epub 2013 Jun 29.

Department of Anesthesia and the Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2013.04.044DOI Listing
October 2013

Hyperchloremia after noncardiac surgery is independently associated with increased morbidity and mortality: a propensity-matched cohort study.

Anesth Analg 2013 Aug 11;117(2):412-21. Epub 2013 Jun 11.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, 200 Elizabeth St., EN 3-405, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1213/ANE.0b013e318293d81eDOI Listing
August 2013

Starches for fluid therapy: is it time for a re-appraisal, or has the horse left the barn?

Can J Anaesth 2013 Jul 30;60(7):630-3. Epub 2013 Apr 30.

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http://dx.doi.org/10.1007/s12630-013-9949-zDOI Listing
July 2013

Relationship of erythrocyte transfusion with short- and long-term mortality in a population-based surgical cohort.

Anesthesiology 2012 Dec;117(6):1175-83

Department of Anesthesia, Toronto General Hospital, University Health Network, Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ALN.0b013e318271604eDOI Listing
December 2012

Use of clinically based troponin underestimates the cardiac injury in non-cardiac surgery: a single-centre cohort study in 51,701 consecutive patients.

Can J Anaesth 2012 Nov 8;59(11):1013-22. Epub 2012 Sep 8.

Department of Anesthesia and Pain Management, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s12630-012-9782-9DOI Listing
November 2012

Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: an unblinded randomized pilot clinical trial.

Anesthesiology 2012 Mar;116(3):613-21

Department of Anesthesia and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ALN.0b013e3182475e39DOI Listing
March 2012

Managing clotting: a North American perspective.

Curr Opin Anaesthesiol 2012 Feb;25(1):74-9

Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia 30322, USA.

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http://pdfs.journals.lww.com/co-anesthesiology/2012/02000/Ma
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/ACO.0b013e32834ebd59DOI Listing
February 2012

Commentary: recombinant activated factor VII: the controversial conundrum regarding its off-label use.

Anesth Analg 2011 Oct 25;113(4):711-2. Epub 2011 Jul 25.

Department of Anesthesiology and Health Policy, Management, and Evaluation, Toronto General Hospital, 200 Elizabeth St., 3EN-402, Toronto, Ontario, Canada M5G 2C4.

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http://dx.doi.org/10.1213/ANE.0b013e318228c6a9DOI Listing
October 2011

Influence of erythrocyte transfusion on the risk of acute kidney injury after cardiac surgery differs in anemic and nonanemic patients.

Anesthesiology 2011 Sep;115(3):523-30

Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ALN.0b013e318229a7e8DOI Listing
September 2011

A hemorrhage of off-label use.

Ann Intern Med 2011 Sep;155(5):339; author reply 339-40

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http://dx.doi.org/10.7326/0003-4819-155-5-201109060-00023DOI Listing
September 2011

The safety of perioperative esmolol: a systematic review and meta-analysis of randomized controlled trials.

Anesth Analg 2011 Feb 2;112(2):267-81. Epub 2010 Dec 2.

Department of Anesthesia and Pain Management, University Health Network, of Toronto, Toronto, Ontario, M5G 2C4, Canada.

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http://dx.doi.org/10.1213/ANE.0b013e3182025af7DOI Listing
February 2011

The post-BART anti-fibrinolytic dilemma?

J Cardiothorac Vasc Anesth 2011 Feb;25(1):3-5

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http://dx.doi.org/10.1053/j.jvca.2010.11.018DOI Listing
February 2011

The influence of perioperative coagulation status on postoperative blood loss in complex cardiac surgery: a prospective observational study.

Anesth Analg 2010 Jun 30;110(6):1533-40. Epub 2010 Apr 30.

Department of Anesthesia, Toronto General Hospital, 200 Elizabeth St., EN3-402, Toronto, ON, Canada M5G 2C4.

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http://dx.doi.org/10.1213/ANE.0b013e3181db7991DOI Listing
June 2010

The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery.

Anesth Analg 2010 Jan 12;110(1):21-9. Epub 2009 Nov 12.

Department of Anesthesia, University of Toronto, and Toronto General Hospital, Toronto, ON, Canada M5G 2C4.

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http://dx.doi.org/10.1213/ANE.0b013e3181c0ea6dDOI Listing
January 2010

Acute surgical anemia influences the cardioprotective effects of beta-blockade: a single-center, propensity-matched cohort study.

Anesthesiology 2010 Jan;112(1):25-33

Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ALN.0b013e3181c5dd81DOI Listing
January 2010

The utility of thromboelastography for guiding recombinant activated factor VII therapy for refractory hemorrhage after cardiac surgery.

J Cardiothorac Vasc Anesth 2009 Dec 20;23(6):828-34. Epub 2009 May 20.

Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.jvca.2009.03.012DOI Listing
December 2009

Cryoprecipitate: the current state of knowledge.

Transfus Med Rev 2009 Jul;23(3):177-88

Sunnybrook Health Sciences Centre and University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.tmrv.2009.03.001DOI Listing
July 2009

N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery.

Crit Care Med 2009 Jun;37(6):1929-34

Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/CCM.0b013e31819ffed4DOI Listing
June 2009

The clinical utility of an index of global oxygenation for guiding red blood cell transfusion in cardiac surgery.

Transfusion 2009 Apr;49(4):682-8

Faculty of Medicine, Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1537-2995.2008.02022.xDOI Listing
April 2009

The pharmacokinetic profile of recombinant human erythropoietin is unchanged in patients undergoing cardiac surgery.

Eur J Clin Pharmacol 2009 Mar 30;65(3):273-9. Epub 2008 Oct 30.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Eaton North 3-405, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.1007/s00228-008-0575-6DOI Listing
March 2009

Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study.

Anesthesiology 2009 Mar;110(3):574-81

Department of Anesthesia, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ALN.0b013e31819878d3DOI Listing
March 2009

Acute kidney injury after cardiac surgery: focus on modifiable risk factors.

Circulation 2009 Feb 19;119(4):495-502. Epub 2009 Jan 19.

Department of Anesthesia and Health Policy, Management, and Evaluation, Toronto General Hospital, University of Toronto, 200 Elizabeth St, EN 3-402, Toronto, Ontario, Canada M5G 2C4.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.108.786913DOI Listing
February 2009

N-acetylcysteine to reduce renal failure after cardiac surgery: a systematic review and meta-analysis.

Can J Anaesth 2008 Dec;55(12):827-35

Department of Anesthesia and Pain Management, University Health Network, Toronto General Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/BF03034054DOI Listing
December 2008

Pro: The role of recombinant factor VIIa in cardiac surgery.

J Cardiothorac Vasc Anesth 2008 Oct 22;22(5):779-82. Epub 2008 Aug 22.

Department of Anesthesia, Toronto General Hospital, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1053/j.jvca.2008.07.012DOI Listing
October 2008

Technical report: analysis of citrated blood with thromboelastography: comparison with fresh blood samples.

Can J Anaesth 2008 May;55(5):284-9

Department of Anesthesia, Toronto General Hospital, University Health Network, and Department of Health Policy, Management and Evaluation, University of Toronto, 200 Elizabeth St., EN3-424, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1007/BF03017205DOI Listing
May 2008

The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery.

Transfusion 2008 Apr 10;48(4):666-72. Epub 2008 Jan 10.

Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1537-2995.2007.01590.xDOI Listing
April 2008

Does tight heart rate control improve beta-blocker efficacy? An updated analysis of the noncardiac surgical randomized trials.

Anesth Analg 2008 Apr;106(4):1039-48, table of contents

Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3-450 200 Elizabeth St., Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1213/ane.0b013e318163f6a9DOI Listing
April 2008

Risk factors for major complications after extrapleural pneumonectomy for malignant pleural mesothelioma.

Ann Thorac Surg 2008 Apr;85(4):1206-10

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.athoracsur.2007.11.065DOI Listing
April 2008

Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study.

Circulation 2008 Jan 2;117(4):478-84. Epub 2008 Jan 2.

Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada, M5G 2C4.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.718353DOI Listing
January 2008

Case report: transfusion-related acute lung injury (TRALI) - a clear and present danger.

Can J Anaesth 2007 Dec;54(12):1011-6

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/BF03016636DOI Listing
December 2007

Case 6--2007: massive intraoperative thrombosis and death after recombinant activated factor VII administration.

J Cardiothorac Vasc Anesth 2007 Dec;21(6):897-902

Department of Anesthesiology, Weill-Cornell Medical Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1053/j.jvca.2007.09.020DOI Listing
December 2007

Platelet transfusions as a risk factor in cardiac surgery.

Transfusion 2007 Sep;47(9):1739-40; author reply 1740

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http://dx.doi.org/10.1111/j.1537-2995.2007.01356.xDOI Listing
September 2007

A cluster-randomized controlled trial of a blood conservation algorithm in patients undergoing total hip joint arthroplasty.

Transfusion 2007 May;47(5):832-41

Robarts Research Institute, Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1537-2995.2007.01197.xDOI Listing
May 2007

Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery.

JAMA 2007 Apr;297(16):1801-9

Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jama.297.16.1801DOI Listing
April 2007

Perioperative hemostasis and thrombosis.

Can J Anaesth 2006 Dec;53(12):1260-2

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1007/BF03021588DOI Listing
December 2006

Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation.

Liver Transpl 2006 Nov;12(11):1584-93

Department of Anesthesia and Pain Management, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/lt.20868DOI Listing
November 2006

Case report: management of life-threatening oropharyngeal bleeding with recombinant factor VIIa.

Can J Anaesth 2006 Sep;53(9):881-4

Toronto General Hospital, University Health Network, Department of Anesthesia, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/BF03022830DOI Listing
September 2006

Prediction of massive blood transfusion in cardiac surgery.

Can J Anaesth 2006 Aug;53(8):781-94

University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3-402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1007/BF03022795DOI Listing
August 2006

Determinants of complications with recombinant factor VIIa for refractory blood loss in cardiac surgery.

Can J Anaesth 2006 Aug;53(8):802-9

University of Toronto, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1007/BF03022797DOI Listing
August 2006

Prognostic value of postoperative proteinuria in cardiac surgery: a pilot study.

Can J Anaesth 2006 May;53(5):500-6

University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3-402, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1007/BF03022624DOI Listing
May 2006

Platelet transfusions are not associated with increased morbidity or mortality in cardiac surgery.

Can J Anaesth 2006 Mar;53(3):279-87

Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/BF03022216DOI Listing
March 2006

Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia.

Can J Anaesth 2006 Jan;53(1):11-9

Toronto General Hospital, University Health Network, Department of Anesthesia, 3 Eaton North, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1007/BF03021522DOI Listing
January 2006

Improving the identification of patients at risk of postoperative renal failure after cardiac surgery.

Anesthesiology 2006 Jan;104(1):65-72

Department of Anesthesia, Toronto General Hospital and University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/00000542-200601000-00012DOI Listing
January 2006

Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery.

J Thorac Cardiovasc Surg 2005 Oct;130(4):1144

Division of Cardiovascular Surgery, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jtcvs.2005.05.049DOI Listing
October 2005

Erythropoietin is an effective clinical modality for reducing RBC transfusion in joint surgery.

Can J Anaesth 2005 Apr;52(4):362-8

Department of Anesthesia, Unversity Health Network, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/BF03016277DOI Listing
April 2005

Mild to moderate atheromatous disease of the thoracic aorta and new ischemic brain lesions after conventional coronary artery bypass graft surgery.

Stroke 2004 Sep 29;35(9):e356-8. Epub 2004 Jul 29.

Department of Anesthesiology, Toronto General Hospital, University Health Network, University of Toronto, Canada.

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http://dx.doi.org/10.1161/01.STR.0000138783.63858.62DOI Listing
September 2004

Calcium antagonists are associated with reduced mortality after cardiac surgery: a propensity analysis.

J Thorac Cardiovasc Surg 2004 Mar;127(3):755-62

Department of Anesthesia, University of Toronto, EN 3-453, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

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http://dx.doi.org/10.1016/s0022-5223(03)00695-0DOI Listing
March 2004

Acupressure wristbands for the prevention of postoperative nausea and vomiting in adults undergoing cardiac surgery.

J Cardiothorac Vasc Anesth 2004 Feb;18(1):68-71

Department of Anesthesia, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.jvca.2003.10.014DOI Listing
February 2004

Evaluating surrogate measures of renal dysfunction after cardiac surgery.

Anesth Analg 2003 May;96(5):1265-73, table of contents

Department of Anaesthesia, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1213/01.ane.0000056824.69668.33DOI Listing
May 2003

Pulmonary-artery catheters in high-risk surgical patients.

N Engl J Med 2003 May;348(20):2035-7; author reply 2035-7

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May 2003

Pro: Preoperative autologous blood donation has a role in cardiac surgery.

J Cardiothorac Vasc Anesth 2003 Feb;17(1):121-5

Department of Anesthesia and Perioperative Blood Conservation Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/jcan.2003.23DOI Listing
February 2003

Transfusion practices for elective orthopedic surgery.

CMAJ 2002 Feb;166(3):310-4

Department of Epidemiology and Biostatistics, London Clinical Trials Research Group, John P. Robarts Research Institute, Ont.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC99309PMC
February 2002

Learning fiberoptic intubation on a simple model transfers to the O.R.

Authors:
Viren Naik Edward Matsumoto Patricia Houston Stanley Hamstra Raymond Yeung Joseph Mallon Terry Martire Rhonda M Zwack David C Campbell Terrance W Breen Ray W Yip Jean-Denis Roy Michel Girard Pierre Drolet Joanne Guay Rafik S Bolis Kenneth LeDez J T Balatbat J Mukherji M J Ali J Carroll J M Karski S Sui D C H Cheng Robert Banner Raymond Yip James Zondervan Vance Chow Dean McMillan Judy Fisher Ralph Lattermann Franco Carli Linda Wykes Thomas Schricker Louise Mazza Franco Carli Gerard Danjoux David Thomas Pamela H Lennox Cynthia Henderson Lynn Martin G W E Mitchell Himat Vaghadia Rajive Jassal Ian R Thomson Robert J Hudson Glenn McGuire Pirjo Manninen Hossam El-Beheiry Andres Lozano Richard Wennberg David P Archer Tim K K Tang Ian R Staveley David H Goldstein Elizabeth G VanDenKerkhof Richard I Hall Graeme M Rocker J P O'Connor Jacquelyn I Dunham Frederick S Mikelberg Gordana Dulovic Kathryn L Jenkins Robin Correa David T Wong Glenn P McGuire A A Fayad J Paul H Yang C Sawchuk Karen A Brown Jason H T Bates Robert Edington Jeremy Pridham Jayanta Mukherji Jacek M Karski Joselito Balatbat Jo Carroll Rosa Chun Davy Ch Cheng J Karski R DeBrouwere M Mathieu J Carroll C Feindel D Cheng Michel Clairoux Stéphane Coutu Stuart A McCluskey Keyvan Karkouti Mohammed Ghannam Michael Jewett Raja Rampersaud Terry Yau Ian Quirt Edmund D Carver P Kim Mark W Crawford G Allen Finley Lynn M Breau Patrick J McGrath Carol Camfield Peter H K Mak Theresa W C Hui Michael G Irwin Franco Carli Judith Trudel Paul Belliveau Nancy Mayo Michelle L Clunie Lesley-Ann L Crone Linda J Klassen Raymond W Yip Bernard Hubert Marek Radomski Gilbert Blaise Paolo M Renzi Marie-Claude Paradis René Martin Michel Parent Pierre Parent Daniel Gagnon Jean-Pierre Tétrault Atul J Prabhu Beverly K Philip Patrick P Higgins Hannah J Blanshard Stéphanie van Rensselaer Frances F Chung Valerie B Caraiscos John F MacDonald Beverley A Orser Markus Schreiber Michael Georgieff Fengling Jin Frances Chung Doris Tong Joseph L Reiz Zoltan Harsanyi Paula C Miceli Andrew C Darke Jean-Sébastien Roy Jacques St-Pierre Peter H Norman M Denise Daley Kim E Turner Joel L Parlow Deborah A Tod Nicole D Avery Pierre C Nicole Claude A Trépanier Martin R Lessard Sylvie Marcoux Dean A Cowie Adrian W Gelb J Kevin Shoemaker Roger Baskett Ben C Lim Ayoub Dangor Pamela J Morgan Doreen Cleave-Hogg D John Doyle Robert Byrick Dusanka Filipovi Fred Cashin Michelle Chiu Toby J Kemp Gregory L Bryson Mark J Cleland Edward T Crosby Tokuya Harioka Koichiro Nomura Norioki Ando Naoyuki Ikegami Toshiki Aoki J Roger Maltby Michael T Beriault Neil C Watson David J Liepert Gordon H Fick J Roger Maltby David Liepert Atul J Prabhu Robin K Correa David T Wong Frances Chung Tom Goyagi Anish Bhardwaj Patricia D Hum Richard D Traystman Jeffrey R Kirsch Daniel T Bainbridge Madhav Swaminathan Brian J McCreath George Djaiani Hilary P Grocott Fergal Day Jacek Karski George Djaiani Jens Tan Davy Cheng Pamela J Wake Mohamed Ali Jacek Karski Sam Sui Craig Guenther John Mullen Michael Bentley Arvind Koshal Barry Finegan William Murtha Michael J Fredrickson Igor A Luginbuehl Bruno Bissonnette Jeff T Granton Hugh Platt R A Craen

Can J Anaesth 2001 Jun;48(Suppl 1):A2-A50

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http://dx.doi.org/10.1007/BF03028184DOI Listing
June 2001