Kevin Qian

Kevin Qian

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Kevin Qian

Kevin Qian

Publications by authors named "Kevin Qian"

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16Publications

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Transcriptional regulation of -GlcNAc homeostasis is disrupted in pancreatic cancer.

J Biol Chem 2018 Sep 23;293(36):13989-14000. Epub 2018 Jul 23.

From the Program in Integrative Cell Signaling and Neurobiology of Metabolism and

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http://dx.doi.org/10.1074/jbc.RA118.004709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130940PMC
September 2018

Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation.

Genes Dev 2017 08 13;31(16):1655-1665. Epub 2017 Sep 13.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1101/gad.305441.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647936PMC
August 2017

Protein O-GlcNAcylation: emerging mechanisms and functions.

Nat Rev Mol Cell Biol 2017 07 10;18(7):452-465. Epub 2017 May 10.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1038/nrm.2017.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667541PMC
July 2017

Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms.

PLoS One 2014 8;9(4):e93965. Epub 2014 Apr 8.

Departments of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, United States of America; Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093965PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979711PMC
January 2015

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.

Cell Metab 2012 Aug;16(2):226-37

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480732PMC
August 2012

New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site.

Bioorg Med Chem Lett 2007 Aug 18;17(15):4242-7. Epub 2007 May 18.

Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceutical, Inc., 900 Ridgebury Road, Ridgefield, CT 0687, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.05.042DOI Listing
August 2007

Discovery and optimization of p38 inhibitors via computer-assisted drug design.

J Med Chem 2007 Aug 20;50(17):4016-26. Epub 2007 Jul 20.

Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., Research and Development Center, Ridgefield, Connecticut 06877, USA.

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http://dx.doi.org/10.1021/jm070415wDOI Listing
August 2007

Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase.

Bioorg Med Chem Lett 2006 Dec 28;16(24):6316-20. Epub 2006 Sep 28.

Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.09.014DOI Listing
December 2006

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase.

J Biol Chem 2005 Feb 3;280(7):6130-7. Epub 2004 Nov 3.

Departments of Medicinal Chemistry and Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals, Inc., Research and Development, 175 Briar Ridge Rd., Ridgefield, CT 06877, USA.

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http://dx.doi.org/10.1074/jbc.M409123200DOI Listing
February 2005

Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jan 2;61(Pt 1):96-9. Epub 2004 Dec 2.

Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals Inc., Research and Development, Ridgefield, CT 06877, USA.

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http://dx.doi.org/10.1107/S1744309104029963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952393PMC
January 2005