Kevin Haigis

Kevin Haigis

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Kevin Haigis

Kevin Haigis

Publications by authors named "Kevin Haigis"

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69Publications

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Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.

Mol Cancer Res 2019 Sep 3;17(9):1828-1841. Epub 2019 Jun 3.

Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1154DOI Listing
September 2019

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.

Cell Syst 2019 Sep 11;9(3):258-270.e6. Epub 2019 Sep 11.

Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2019.07.006DOI Listing
September 2019

Tissue-specificity in cancer: The rule, not the exception.

Science 2019 Mar;363(6432):1150-1151

Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaw3472DOI Listing
March 2019

Computational translation of genomic responses from experimental model systems to humans.

PLoS Comput Biol 2019 01 10;15(1):e1006286. Epub 2019 Jan 10.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States of America.

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http://dx.plos.org/10.1371/journal.pcbi.1006286
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http://dx.doi.org/10.1371/journal.pcbi.1006286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343937PMC
January 2019

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Proc Natl Acad Sci U S A 2018 05 16;115(18):E4236-E4244. Epub 2018 Apr 16.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142;

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http://dx.doi.org/10.1073/pnas.1722020115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939099PMC
May 2018

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

PLoS Biol 2018 03 29;16(3):e2002417. Epub 2018 Mar 29.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2002417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892915PMC
March 2018

Brother's Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis.

Cell 2018 02;172(4):645-647

Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.019DOI Listing
February 2018

KRAS Alleles: The Devil Is in the Detail.

Authors:
Kevin M Haigis

Trends Cancer 2017 10 12;3(10):686-697. Epub 2017 Sep 12.

Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824632PMC
October 2017

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

Cell Rep 2017 07;20(2):427-438

Howard Hughes Medical Institute, Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA; Program in Virology, Harvard University Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553568PMC
July 2017

No back seat for a progression event-K-RAS as a therapeutic target in CRC.

Genes Dev 2017 02 17;31(4):333-335. Epub 2017 Mar 17.

Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1101/gad.297630.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358753PMC
February 2017

Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Sci Signal 2015 Dec 15;8(407):ra129. Epub 2015 Dec 15.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aac7235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812576PMC
December 2015

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Sci Rep 2015 Nov 13;5:16622. Epub 2015 Nov 13.

Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/srep16622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643219PMC
November 2015

Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells.

Stem Cell Res 2015 Jul 10;15(1):165-71. Epub 2015 Jun 10.

Cancer Research Institute, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061150007
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http://dx.doi.org/10.1016/j.scr.2015.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629819PMC
July 2015

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.

Stem Cells 2015 Jun;33(6):1998-2010

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/stem.1990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889217PMC
June 2015

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Nat Cell Biol 2015 Jun 25;17(6):804-15. Epub 2015 May 25.

Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/ncb3175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652934PMC
June 2015

Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers.

PLoS One 2013 12;8(12):e82982. Epub 2013 Dec 12.

Molecular Pathology Unit, Center for Cancer Research and Center for Systems Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082982PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861465PMC
March 2015

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.

Proc Natl Acad Sci U S A 2015 Jan 5;112(3):779-84. Epub 2015 Jan 5.

New York University Perlmutter Cancer Institute, New York University School of Medicine, New York, NY 10016;

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http://dx.doi.org/10.1073/pnas.1412811112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311840PMC
January 2015

ROS1 signaling regulates epithelial differentiation in the epididymis.

Endocrinology 2014 Sep 27;155(9):3661-73. Epub 2014 Jun 27.

Molecular Oncology Research Institute (H.J.J., S.W., D.P., A.C), Tufts Medical Center, Boston, Massachusetts 02111; Center for Cancer Research (K.L., A.C.), Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Program in Membrane Biology and Division of Nephrology and Center for Systems Biology (J.R., T.B.S., S.B.) and Molecular Pathology Unit (L.B.W., K.M.H.), Massachusetts General Hospital, Boston, Massachusetts 02114; Department of Pathology (R.T.B), Harvard Medical School, Boston, Massachusetts 02115; and Department of Neurosurgery and Program in Genetics (A.C), Tufts University School of Medicine, Boston, Massachusetts 02111.

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http://dx.doi.org/10.1210/en.2014-1341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138574PMC
September 2014

Strategies to achieve conditional gene mutation in mice.

Cold Spring Harb Protoc 2014 Apr 1;2014(4):339-49. Epub 2014 Apr 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://dx.doi.org/10.1101/pdb.top069807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142476PMC
April 2014

Whole-mount X-Gal staining of mouse tissues.

Cold Spring Harb Protoc 2014 Apr 1;2014(4):417-9. Epub 2014 Apr 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://www.cshprotocols.org/lookup/doi/10.1101/pdb.prot07345
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http://dx.doi.org/10.1101/pdb.prot073452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169236PMC
April 2014

Producing and concentrating lenti-Cre for mouse infections.

Cold Spring Harb Protoc 2014 Mar 1;2014(3):304-6. Epub 2014 Mar 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://dx.doi.org/10.1101/pdb.prot073437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169239PMC
March 2014

In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation.

Cold Spring Harb Protoc 2014 Mar 1;2014(3):307-9. Epub 2014 Mar 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://dx.doi.org/10.1101/pdb.prot073445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169259PMC
March 2014

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.

Integr Biol (Camb) 2013 Nov 2;5(11):1355-65. Epub 2013 Oct 2.

Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1039/c3ib40062jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966991PMC
November 2013

HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.

Mol Cancer Res 2013 Sep 30;11(9):1072-7. Epub 2013 May 30.

Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, 149 13 Street, Charlestown, MA 02129.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0040-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778089PMC
September 2013

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.

Cancer Discov 2013 Sep 3;3(9):993-1001. Epub 2013 Jun 3.

1Department of Pediatrics and 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California; 3Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, 4Department of Biology, David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts; 5Department of Pathology, Institute for Genomics and Systems Biology, 6Ben May Department for Cancer Research, 7Section of Hematology/Oncology and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois; 8Department of Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan; and 9Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770749PMC
September 2013

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

PLoS Biol 2012 25;10(9):e1001393. Epub 2012 Sep 25.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463506PMC
June 2013

Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression.

Cancer Discov 2013 Mar 28;3(3):294-307. Epub 2012 Dec 28.

Molecular Pathology Unit, Center for Cancer Research and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129 , USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595397PMC
March 2013

BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.

PLoS One 2012 18;7(7):e41343. Epub 2012 Jul 18.

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399817PMC
January 2013

Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers.

Clin Cancer Res 2012 Sep 2;18(17):4753-63. Epub 2012 Jul 2.

Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, 450 Brookline Ave., Room JF-215C, Boston, MA 02215, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-3210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624899PMC
September 2012

Regulation of RAS oncogenicity by acetylation.

Proc Natl Acad Sci U S A 2012 Jul 18;109(27):10843-8. Epub 2012 Jun 18.

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.1201487109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390846PMC
July 2012

Cancers of the colon and rectum: identical or fraternal twins?

Cancer Discov 2012 Feb;2(2):117-21

Department of Radiation Oncology, Department of Medicine, and Molecular Pathology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0315DOI Listing
February 2012

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

Blood 2012 Jan 5;119(4):1032-5. Epub 2011 Dec 5.

Department of Pediatrics, University of California-San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1182/blood-2011-06-358960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271715PMC
January 2012

Regulating the regulator: post-translational modification of RAS.

Nat Rev Mol Cell Biol 2011 Dec 22;13(1):39-51. Epub 2011 Dec 22.

NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1038/nrm3255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879958PMC
December 2011

Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras.

Exp Cell Res 2011 Nov 17;317(19):2732-9. Epub 2011 Jun 17.

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.yexcr.2011.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192920PMC
November 2011

New insights into oncogenic stress.

Nat Genet 2011 Mar;43(3):177-8

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http://dx.doi.org/10.1038/ng0311-177DOI Listing
March 2011

In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs.

Sci Signal 2011 Mar 22;4(165):ra16. Epub 2011 Mar 22.

Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/scisignal.2001338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963028PMC
March 2011

Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.

Integr Biol (Camb) 2010 Apr 8;2(4):202-8. Epub 2010 Mar 8.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, 16-343, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/b925935jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687524PMC
April 2010

Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.

Mol Cells 2009 Oct 30;28(4):315-20. Epub 2009 Sep 30.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital and Department of Pathology, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1007/s10059-009-0143-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976423PMC
October 2009

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.

Nature 2008 Sep 14;455(7212):552-6. Epub 2008 Sep 14.

Laboratory of Molecular Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature07310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148807PMC
September 2008

Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question.

Genes Dev 2007 Feb;21(4):361-6

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1532107DOI Listing
February 2007

The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium.

J Biol Chem 2006 Jan 28;281(1):638-47. Epub 2005 Oct 28.

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M509053200
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http://dx.doi.org/10.1074/jbc.M509053200DOI Listing
January 2006

Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.

Proc Natl Acad Sci U S A 2004 Jun 21;101(26):9769-73. Epub 2004 Jun 21.

McArdle Laboratory for Cancer Research, 1400 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1073/pnas.0403338101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470749PMC
June 2004

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

Nat Genet 2003 Jan 25;33(1):33-9. Epub 2002 Nov 25.

McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin-Madison, 1400 University Avenue, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1038/ng1055DOI Listing
January 2003

Intestinal adenomas can develop with a stable karyotype and stable microsatellites.

Proc Natl Acad Sci U S A 2002 Jun 11;99(13):8927-31. Epub 2002 Jun 11.

McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA.

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http://www.pnas.org/content/99/13/8927.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.132275099
Publisher Site
http://dx.doi.org/10.1073/pnas.132275099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124400PMC
June 2002