Publications


TRPA1 channel participates in tacrolimus-induced pruritus in a chronic contact hypersensitivity murine model.
J Dermatol Sci 2018 Feb 31;89(2):207-209. Epub 2017 Oct 31.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, 139668, Singapore. Electronic address:

Requirement of MHC class I on radioresistant cells for granzyme B expression from CD8T cells in murine contact hypersensitivity.
J Dermatol Sci 2018 Feb 6. Epub 2018 Feb 6.
Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:

Barrier dysfunction in the skin allergy.
Allergol Int 2018 Jan 16;67(1):3-11. Epub 2017 Nov 16.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

Negative evidence of direct differentiation from bone-marrow cells to keratinocytes in normal and wounded skin using Keratin 5-specific reporter mice.
J Invest Dermatol 2018 Jan 10. Epub 2018 Jan 10.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:

Intravenous immunoglobulin treatment abrogates transplacental autoantibody transfer in a murine pemphigus model.
J Allergy Clin Immunol 2018 Jan 19. Epub 2018 Jan 19.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:

The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.
J Allergy Clin Immunol 2017 Dec 27. Epub 2017 Dec 27.
Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Ibaraki, Japan; Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, University of Tokyo, Tokyo, Japan; Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, Osaka University, Suita, Japan. Electronic address:

HLA-A*26 Is Correlated With Response to Nivolumab in Japanese Melanoma Patients.
J Invest Dermatol 2017 Nov 21;137(11):2443-2444. Epub 2017 Jul 21.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:


Efficacy of intravenous immunoglobulins for the treatment of mucous membrane pemphigoid-like epidermolysis bullosa acquisita.
Eur J Dermatol 2017 Oct;27(5):563-564
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore.

Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue.
J Allergy Clin Immunol 2017 Sep 21. Epub 2017 Sep 21.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

Receptor-interacting protein kinase 3 controls keratinocyte activation in a necroptosis-independent manner and promotes psoriatic dermatitis in mice.
J Allergy Clin Immunol 2017 Aug 23;140(2):619-622.e6. Epub 2017 Mar 23.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan. Electronic address:

Local inflammation exacerbates cutaneous manifestations in a murine autoimmune pemphigus model.
J Allergy Clin Immunol 2017 Jun 20;139(6):2026-2028.e5. Epub 2017 Jan 20.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

Alopecia areata: What's new in epidemiology, pathogenesis, diagnosis, and therapeutic options?
J Dermatol Sci 2017 Apr 11;86(1):3-12. Epub 2016 Oct 11.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Kawaguchi, Japan.

Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling.
J Allergy Clin Immunol 2017 Feb 1;139(2):562-571. Epub 2016 Oct 1.
Laboratory for Investigative Dermatology, Rockefeller University, New York, NY; Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Decreased Filaggrin Level May Lead to Sweat Duct Obstruction in Filaggrin Mutant Mice.
J Invest Dermatol 2017 Jan 31;137(1):248-251. Epub 2016 Aug 31.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.
J Invest Dermatol 2017 Jan 20;137(1):18-25. Epub 2016 Oct 20.
Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Advances in atopic dermatitis in 2015.
J Allergy Clin Immunol 2016 Dec;138(6):1548-1555
Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan.

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation.
Cell 2016 Sep;167(1):187-202.e17
Institute of Medical Biology, A(∗)STAR, Singapore 138632, Singapore; Institute of Molecular and Cellular Biology, A(∗)STAR, Singapore 138632, Singapore; Medical Genetics Department, Koç University School of Medicine, 34010 Istanbul, Turkey; Department of Paediatrics, National University of Singapore, Singapore 119228, Singapore. Electronic address:


Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march.
J Allergy Clin Immunol 2016 Aug 22;138(2):350-358.e1. Epub 2016 Jun 22.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

Novel insights into cutaneous immune systems revealed by in vivo imaging.
Allergol Int 2016 Jul 26;65(3):228-34. Epub 2016 Mar 26.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:


Dual CD4/CD8-positive Ichthyosiform Mycosis Fungoides with Lymph Node, Peripheral Blood and Cardiac Involvement: A Case Report.
Acta Derm Venereol 2016 May;96(4):564-6
Department of Dermatology, Kyoto University, Graduate School of Medicine, 54 Shogoin-Kawara, Sakyo-ku, Kyoto 606-8507, Japan.

Percutaneous exposure to high-dose hapten induces systemic immunosuppression through the inhibition of dendritic cell migration.
J Dermatol Sci 2016 Feb 28;81(2):136-40. Epub 2015 Nov 28.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, IMMUNOS Building #3-4, Biopolis 138648 Singapore; PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address:

Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2.
J Invest Dermatol 2016 Feb;136(2):416-24
Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address:

Identification and Characterization of a Recessive Missense Mutation p.P277L in SERPINB7 in Nagashima-Type Palmoplantar Keratosis.
J Invest Dermatol 2016 Jan;136(1):325-8
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; Keio-Maruho Laboratory of Skin Barriology, Keio University School of Medicine, Tokyo, Japan. Electronic address:

The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization.
J Allergy Clin Immunol 2015 Nov 1;136(5):1254-64. Epub 2015 Oct 1.
Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY; Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Atopic dermatitis-like skin lesions with IgE hyperproduction and pruritus in KFRS4/Kyo rats.
J Dermatol Sci 2015 Nov 21;80(2):116-23. Epub 2015 Sep 21.
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, Japan.

The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.
J Exp Med 2015 Oct 5;212(11):1901-19. Epub 2015 Oct 5.
Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan CREST, Japan Agency for Medical Research and Development (AMED) and Japan Science and Technology Agency (JST), Tokyo 100-0004, Japan

Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
J Exp Med 2015 Oct 5;212(11):1921-30. Epub 2015 Oct 5.
Department of Dermatology and Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto 606-8501, Japan PRESTO, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0076, Japan

PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division.
Cell Rep 2016 05 12;15(8):1615-23. Epub 2016 May 12.
Department of Microbiology & Immunology, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA. Electronic address:

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.
Immunity 2016 12;45(6):1299-1310
Laboratory of Vaccine Science, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan; Laboratory of Vaccine Design, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan. Electronic address:

Peripheral blood Th9 cells are a possible pharmacodynamic biomarker of nivolumab treatment efficacy in metastatic melanoma patients.
Oncoimmunology 2016 18;5(12):e1248327. Epub 2016 Oct 18.
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (ASTAR), Biopolis, Singapore.


Anti-Interleukin-31 Receptor A Antibody for Atopic Dermatitis.
N Engl J Med 2017 03;376(9):826-835
From the Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany (T.R., A.W.); the Department of Dermatology, Oregon Health and Science University, Portland (J.M.H.); the Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (M.F.), Tokyo Teishin Hospital (T.E.) and Chugai Pharmaceutical (R.M., H.Y.), Tokyo, the Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto (K.K.), and Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama (K.K.) - all in Japan; Jagiellonian University School of Medicine, Krakow (G.P.), Academic Health, Dermatology Clinic, Rzeszow (I.M.), and the Department of Histology and Embryology, Center for Biostructure, Medical University of Warsaw, Warsaw (R.G.) - all in Poland; and Chugai Pharma Europe, London (J.S.).

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