Dr. Keith R Davis, Ph.D. - Indiana University - Director of Faculty Engagement, Innovation & Commercialization Office, Director, Biotechnology Program

Dr. Keith R Davis

Ph.D.

Indiana University

Director of Faculty Engagement, Innovation & Commercialization Office, Director, Biotechnology Program

Bloomington, Indiana | United States

Main Specialties: Biology, Biotechnology, Oncology

ORCID logohttps://orcid.org/0000-0002-7432-8610

Dr. Keith R Davis, Ph.D. - Indiana University - Director of Faculty Engagement, Innovation & Commercialization Office, Director, Biotechnology Program

Dr. Keith R Davis

Ph.D.

Introduction

Dr. Keith Davis serves as bothe the Director of Faculty Engagement in the Innovation & Commercialization Office and the Director of the Biotechnology Program. Keith joined IU in July, 2014. Keith has twenty-nine years of broad-based academic and industry experience in developing and managing research programs in biotechnology that utilize functional genomics and systems biology approaches for target discovery and accelerating R & D. More recently, his research has been in the areas of plant-made pharmaceutical R&D and translational research in cancer biology where he focuses on the development of the soy-derived peptide lunasin as an anticancer agent. Keith utilizes his experience to enhance IUB faculty participation in translational research and increasing the commercialization of faculty research discoveries by collaborating with industry partners and establishing new companies.

Prior to joining the JCITR, Keith was the founding Executive Director of the Owensboro Cancer Research Program, a satellite program of the University of Louisville James Graham Brown Cancer focused on using plant-based systems for the development of biologics for infectious disease and cancer, and Professor in the Department of Pharmacology and Toxicology. From July 1999 to June 2005, Keith worked at Icoria, Inc. (formerly Paradigm Genetics, Inc.), a biotechnology located in Research Triangle Park that utilized systems biology platforms for large R&D projects in both the agricultural biotechnology and health sectors. Keith served as Vice President, Agricultural Biotechnology at Icoria from April 2002 to June 2005 and led the transition team after his business unit was acquired by Monsanto. Before joining Icoria, Keith was a tenured Associate Professor in the Department of Plant Biology, the Ohio State University, where he also served as the Director of the campus-wide Plant Biotechnology Program.

Keith received a B.A. in Biology from Albion College, Albion, Michigan and a Ph.D. in Molecular, Cellular, and Developmental Biology from the University of Colorado, Boulder. He completed his postdoctoral training in the Department of Molecular Biology at Massachusetts General Hospital and the Department of Genetics, Harvard Medical School.

Primary Affiliation: Indiana University - Bloomington, Indiana , United States

Specialties:

Research Interests:

Education

Jan 1979 - Jan 1985
University of Colorado Boulder
Ph.D.
Molecular, Cellular & Developmental Biology
Jan 1975 - Jan 1979
Albion College
B.A.
Biology

Experience

Jul 2014
Indiana University Bloomington
Director of Faculty Engagement
Johnson Center for Innovation and Translational Research, Innovation and Commercialization Office

Publications

15Publications

178Reads

266Profile Views

200PubMed Central Citations

Development of the plant-derived peptide lunasin as an anticancer agent.

Curr Opin Pharmacol 2018 Aug 22;41:27-33. Epub 2018 May 22.

Biotechnology Program, Department of Biology, Indiana University, Bloomington, IN, USA; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2018.04.006DOI Listing
August 2018
68 Reads
4.595 Impact Factor

Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells.

Oncotarget 2016 Dec;7(51):84128-84141

Biotechnology Program, Indiana University, Bloomington, Indiana, USA.

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http://dx.doi.org/10.18632/oncotarget.11554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356649PMC
December 2016
40 Reads
5 Citations
6.360 Impact Factor

The potential of plants as a system for the development and production of human biologics.

F1000Res 2016 19;5. Epub 2016 May 19.

The Johnson Center for Innovation and Translational Research, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.12688/f1000research.8010.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876878PMC
June 2016
4 Reads
9 Citations

The soybean-derived peptide lunasin inhibits non-small cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein.

Oncotarget 2015 Mar;6(7):4649-62

Owensboro Cancer Research Program, Mitchell Memorial Cancer Center, Owensboro, Kentucky, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467105PMC
http://dx.doi.org/10.18632/oncotarget.3080DOI Listing
March 2015
5 Reads
7 Citations
6.360 Impact Factor

Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation.

Int J Mol Sci 2014 Dec 18;15(12):23705-24. Epub 2014 Dec 18.

Owensboro Cancer Research Program, Mitchell Memorial Cancer Center, Owensboro, KY 42303, USA.

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http://dx.doi.org/10.3390/ijms151223705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284788PMC
December 2014
4 Reads
5 Citations
2.862 Impact Factor

Ascorbic acid and a cytostatic inhibitor of glycolysis synergistically induce apoptosis in non-small cell lung cancer cells.

PLoS One 2013 11;8(6):e67081. Epub 2013 Jun 11.

Owensboro Cancer Research Program, Owensboro, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067081PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679078PMC
January 2014
5 Reads
10 Citations
3.234 Impact Factor

Ascorbic acid alleviates toxicity of paclitaxel without interfering with the anticancer efficacy in mice.

Nutr Res 2012 Nov 26;32(11):873-83. Epub 2012 Oct 26.

Department of Biomedical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

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http://dx.doi.org/10.1016/j.nutres.2012.09.011DOI Listing
November 2012
13 Reads
5 Citations
2.585 Impact Factor

Scalable purification and characterization of the anticancer lunasin peptide from soybean.

PLoS One 2012 13;7(4):e35409. Epub 2012 Apr 13.

James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326064PMC
August 2012
7 Reads
9 Citations
3.234 Impact Factor

Recombinant protein expression in Nicotiana.

Methods Mol Biol 2011 ;701:199-219

Owensboro Cancer Research Program, Owensboro, KY, USA.

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http://dx.doi.org/10.1007/978-1-61737-957-4_11DOI Listing
April 2011
4 Reads
11 Citations

C4 protein of Beet severe curly top virus is a pathomorphogenetic factor in Arabidopsis.

Plant Cell Rep 2010 Dec 20;29(12):1377-89. Epub 2010 Oct 20.

Department of Genetic Engineering, Sungkyunkwan University, Suwon, Korea.

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http://dx.doi.org/10.1007/s00299-010-0923-8DOI Listing
December 2010
3 Reads
7 Citations
3.071 Impact Factor

Identification of a promoter motif involved in Curtovirus sense-gene expression in transgenic Arabidopsis.

Mol Cells 2008 Aug 3;26(2):131-9. Epub 2008 Jul 3.

Department of Plant Cellular, The Ohio State University, Columbus, OH 43210, USA,

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August 2008
4 Reads
1 Citation
2.090 Impact Factor

Altered cell shapes, hyperplasia, and secondary growth in Arabidopsis caused by beet curly top geminivirus infection.

Mol Cells 2004 Feb;17(1):117-24

Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea.

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February 2004
4 Reads
3 Citations
2.090 Impact Factor

The beta-subunit of the Arabidopsis G protein negatively regulates auxin-induced cell division and affects multiple developmental processes.

Plant Cell 2003 Feb;15(2):393-409

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3280, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141209PMC
February 2003
3 Reads
98 Citations
9.340 Impact Factor

Ozone-induced ethylene production is dependent on salicylic acid, and both salicylic acid and ethylene act in concert to regulate ozone-induced cell death.

Plant J 2002 Nov;32(4):447-56

Paradigm Genetics, Inc., 108 Alexander Drive, Research Triangle Park, NC 27709, USA.

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November 2002
11 Reads
26 Citations
5.972 Impact Factor