Publications by authors named "Keith A Johnson"

100Publications

A physics-informed geometric learning model for pathological tau spread in Alzheimer's disease.

Med Image Comput Comput Assist Interv 2020 Oct 29;12267:418-427. Epub 2020 Sep 29.

University of Massachusetts Lowell, Lowell, MA, USA.

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October 2020

Defining the lowest threshold for amyloid-PET to predict future cognitive decline and amyloid accumulation.

Neurology 2020 Nov 16. Epub 2020 Nov 16.

From the Michelle E. Farrell, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US Shu Jiang, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis Aaron P. Schultz, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US Michael J. Properzi, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US Julie C.Price, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA J. Alex Becker, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Heidi I.L. Jacobs, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands Bernard J. Hanseeuw, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. Dorene M. Rentz, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA Victor L Villemagne, Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Australia. Kathryn V. Papp, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA Elizabeth C. Mormino, Department of Neuroscience, Stanford University, Palo Alto, CA, USA. Rebecca A. Betensky, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Department of Biostatistics, New York University School of Global Public Health, New York, NY, USA. Keith A. Johnson, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, Reisa A. Sperling, MD Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA. Rachel F. Buckley, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Center for Alzheimer Research and Treatment, Brigham and Womens Hospital, Boston, MA, USA, Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.

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November 2020

Attenuation correction using deep Learning and integrated UTE/multi-echo Dixon sequence: evaluation in amyloid and tau PET imaging.

Eur J Nucl Med Mol Imaging 2020 Oct 27. Epub 2020 Oct 27.

Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

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October 2020

The neurophysiology and seizure outcomes of late onset unexplained epilepsy.

Clin Neurophysiol 2020 Nov 19;131(11):2667-2672. Epub 2020 Sep 19.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MA, USA; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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November 2020

Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer's disease.

Neuroimage Clin 2020 2;28:102407. Epub 2020 Sep 2.

Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston 02114, MA, USA. Electronic address:

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September 2020

Multiple markers contribute to risk of progression from normal to mild cognitive impairment.

Neuroimage Clin 2020 28;28:102400. Epub 2020 Aug 28.

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA. Electronic address:

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August 2020

Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers.

Neurology 2020 09 1;95(10):e1312-e1321. Epub 2020 Jul 1.

From the Departments of Psychiatry (E.G.V., J.M., C.V.-C., A.A., J.S., Y.T.Q.), Neurology (A.P.S., D.R., R.S., K.A.J., Y.T.Q.), and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston; Grupo de Neurociencias (A.B., Y.B., F.L., Y.T.Q.), Universidad de Antioquia, Medellín, Colombia; Center for Alzheimer Research and Treatment (K.P., D.R., R.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Boston, MA; and Banner Alzheimer's Institute (P.N.T., E.M.R.), Phoenix, AZ.

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September 2020

Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study.

J Alzheimers Dis 2020 ;75(4):1437-1446

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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January 2020

MR-based PET attenuation correction using a combined ultrashort echo time/multi-echo Dixon acquisition.

Med Phys 2020 Jul 11;47(7):3064-3077. Epub 2020 May 11.

Department of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, 02114, USA.

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July 2020

The presubiculum links incipient amyloid and tau pathology to memory function in older persons.

Neurology 2020 05 9;94(18):e1916-e1928. Epub 2020 Apr 9.

From the Department of Radiology (H.I.L.J., A.P.S., K.A.J.), Division of Nuclear Medicine and Molecular Imaging, Department of Radiology (H.I.L.J., J.C.A., A.P.S., B.J.H., R.A.S.), The Athinoula A. Martinos Center for Biomedical Imaging, and Department of Neurology/Biostatistics (J.L., R.A.S., K.A.J.), Massachusetts General Hospital/Harvard Medical School, Boston; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands; Department of Neurology (B.J.H., R.A.E., K.V.P., D.M.R., R.A.S., K.A.J.), Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and Department of Neurology (B.J.H.), Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.

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May 2020

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals.

JAMA Neurol 2020 Jun;77(6):735-745

Alzheimer Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego.

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June 2020

Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults.

Neurobiol Aging 2020 09 7;93:124-130. Epub 2020 Mar 7.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital; Boston, MA, USA. Electronic address:

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September 2020

Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults.

JAMA Netw Open 2020 02 5;3(2):e200121. Epub 2020 Feb 5.

Division of Geriatric Psychiatry, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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February 2020

Topography of cortical thinning in the Lewy body diseases.

Neuroimage Clin 2020 31;26:102196. Epub 2020 Jan 31.

Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA. Electronic address:

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January 2020

Word retrieval across the biomarker-confirmed Alzheimer's disease syndromic spectrum.

Neuropsychologia 2020 03 10;140:107391. Epub 2020 Feb 10.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, 02115, USA; Center for Brain/Mind Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, 02129, USA.

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March 2020

Somatic symptoms are associated with Insomnia disorder but not Obstructive Sleep Apnoea or Hypersomnolence in traumatic brain injury.

NeuroRehabilitation 2019 ;45(3):409-418

CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, NSW, Australia.

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March 2020

Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults.

Neuroimage Clin 2019 18;24:102097. Epub 2019 Nov 18.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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September 2020

PET Image Deblurring and Super-Resolution with an MR-Based Joint Entropy Prior.

IEEE Trans Comput Imaging 2019 Dec 25;5(4):530-539. Epub 2019 Apr 25.

Department of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA; Massachusetts General Hospital, Boston, MA, 02114, USA.

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December 2019

Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden.

Neuroimage Clin 2020 22;26:102052. Epub 2019 Oct 22.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

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October 2019

Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [F]MK6240 in human subjects.

Eur J Nucl Med Mol Imaging 2019 Sep 22;46(10):2099-2111. Epub 2019 Jul 22.

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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September 2019

Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults.

Am J Geriatr Psychiatry 2019 11 10;27(11):1247-1256. Epub 2019 May 10.

Division of Geriatric Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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November 2019

Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease.

Neurology 2019 07 26;93(5):e476-e484. Epub 2019 Jun 26.

From the Departments of Neurology (J.S., R.Y., K.A.J., T.G.-I., J.H.G., S.N.G.), Pathology (N.C., M.F.), and Radiology (S.K., A.S., K.A.J.), Massachusetts General Hospital, Boston.

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July 2019

Multi-Modal Signatures of Tau Pathology, Neuronal Fiber Integrity, and Functional Connectivity in Traumatic Brain Injury.

J Neurotrauma 2019 12 1;36(23):3233-3243. Epub 2019 Aug 1.

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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December 2019

Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults.

Neurobiol Aging 2019 09 16;81:38-46. Epub 2019 May 16.

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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September 2019

A longitudinal model for tau aggregation in Alzheimer's disease based on structural connectivity.

Inf Process Med Imaging 2019 22;11492:384-393. Epub 2019 May 22.

Department of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, USA.

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May 2019

Tired and lack focus? Insomnia increases distractibility.

J Health Psychol 2019 Apr 22:1359105319842927. Epub 2019 Apr 22.

1 CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, NSW, Australia.

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April 2019

Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid.

Neurobiol Aging 2019 06 7;78:178-185. Epub 2019 Mar 7.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Gordon Center for Medical Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

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June 2019

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue.

Acta Neuropathol Commun 2019 03 11;7(1):37. Epub 2019 Mar 11.

Department of Neurology, Massachusetts General Hospital, WACC, Suite 715, 15th Parkman St., Boston, MA, 02114, USA.

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March 2019

Regional tau pathology and loneliness in cognitively normal older adults.

Transl Psychiatry 2018 12 18;8(1):282. Epub 2018 Dec 18.

Department of Psychiatry, Division of Geriatric Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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December 2018

Correction: Association of anxiety with subcortical amyloidosis in cognitively normal older adults.

Mol Psychiatry 2020 Oct;25(10):2644

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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October 2020

Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.

J Neurosci 2019 01 27;39(3):548-556. Epub 2018 Nov 27.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.

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January 2019

Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers.

Neuroimage 2019 02 17;186:446-454. Epub 2018 Nov 17.

Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. Electronic address:

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February 2019

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex.

Nat Med 2018 12 29;24(12):1910-1918. Epub 2018 Oct 29.

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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December 2018

Amyloid-associated increases in longitudinal report of subjective cognitive complaints.

Alzheimers Dement (N Y) 2018 6;4:444-449. Epub 2018 Sep 6.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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September 2018

Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.

Proc Natl Acad Sci U S A 2018 10 17;115(40):10160-10165. Epub 2018 Sep 17.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129.

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October 2018

Association of anxiety with subcortical amyloidosis in cognitively normal older adults.

Mol Psychiatry 2020 10 16;25(10):2599-2607. Epub 2018 Aug 16.

Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

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October 2020

Threshold regression to accommodate a censored covariate.

Biometrics 2018 12 22;74(4):1261-1270. Epub 2018 Jun 22.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, U.S.A.

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December 2018

PET staging of amyloidosis using striatum.

Alzheimers Dement 2018 10 21;14(10):1281-1292. Epub 2018 May 21.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, Charlestown, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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October 2018

PET imaging of tau protein targets: a methodology perspective.

Brain Imaging Behav 2019 Apr;13(2):333-344

Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, USA.

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April 2019

Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults.

Cereb Cortex 2019 03;29(3):1251-1262

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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March 2019

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.

Nat Neurosci 2018 03 5;21(3):424-431. Epub 2018 Feb 5.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

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March 2018

Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults.

Am J Psychiatry 2018 06 12;175(6):530-537. Epub 2018 Jan 12.

From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston; the Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston; the Division of Geriatric Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Mass.; the Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neurosciences, Université Catholique de Louvain, Brussels; the Department of Psychiatry, the Department of Neurology, and the Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.

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June 2018

Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals.

Neuroimage Clin 2018 31;17:388-396. Epub 2017 Oct 31.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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June 2018

Flortaucipir tau PET imaging in semantic variant primary progressive aphasia.

J Neurol Neurosurg Psychiatry 2018 10 6;89(10):1024-1031. Epub 2017 Oct 6.

Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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October 2018

Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging.

Neuroimage Clin 2017 25;15:408-414. Epub 2017 May 25.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Athinoula A. Martinos Center for Biomedical Imaging and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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March 2018

Functional network integrity presages cognitive decline in preclinical Alzheimer disease.

Neurology 2017 Jul 7;89(1):29-37. Epub 2017 Jun 7.

From the Florey Institutes of Neuroscience and Mental Health (R.F.B.), Melbourne; Melbourne School of Psychological Science (R.F.B.), University of Melbourne, Australia; Department of Neurology (R.F.B., A.P.S., K.V.P., B.J.H., G.M., D.M.R., K.A.J., R.A.S., J.P.C.), Athinoula A. Martinos Center for Biomedical Imaging (A.P.S., T.H., B.J.H., J.S., K.A.J.) and Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging (J.S., K.A.J.), Department of Radiology, Massachusetts General Hospital; Harvard Medical School (R.F.B., A.P.S., T.H., K.V.P., B.J.H., G.M., D.M.R., K.A.J., R.A.S., J.P.C.); Center for Alzheimer Research and Treatment, Department of Neurology (K.V.P., G.M., D.M.R., K.A.J., R.A.S., J.P.C.), Brigham and Women's Hospital, Boston, MA: and Department of Psychiatry (E.E.S.), University of Texas Southwestern Medical Center, Dallas.

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July 2017

Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex.

JAMA Neurol 2017 07;74(7):813-820

Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts4Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts5Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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July 2017

The association between tau PET and retrospective cortical thinning in clinically normal elderly.

Neuroimage 2017 08 22;157:612-622. Epub 2017 May 22.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, 149/10.008 13th Street, Charlestown, MA 02129, USA.

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August 2017

Neuroimaging markers associated with maintenance of optimal memory performance in late-life.

Neuropsychologia 2017 06 1;100:164-170. Epub 2017 May 1.

Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States; Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.

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June 2017

Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease.

Am J Geriatr Psychiatry 2017 Jul 4;25(7):683-693. Epub 2017 Jan 4.

Center of Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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July 2017

Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease.

Neuropsychologia 2017 05 3;99:343-349. Epub 2017 Apr 3.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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May 2017

Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden.

Neurology 2017 May 5;88(18):1759-1767. Epub 2017 Apr 5.

From the Department of Neurology (P.V., B.H., C.E.M., K.A.J., D.M.R., K.A.H., R.A.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Athinoula A. Martinos Center for Biomedical Imaging (P.V., B.H., K.A.J., R.A.S.), Department of Psychiatry (P.V., B.H., K.A.J., R.A.S.), and Department of Radiology (B.H., K.A.J.), Division of Molecular Imaging and Nuclear Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown; Center for Alzheimer Research and Treatment (P.V., R.E.A., G.A.M., K.A.J., D.M.R., R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; and Berenson-Allen Center for Noninvasive Brain Stimulation and Division for Cognitive Neurology (A.P.-L.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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May 2017

Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain.

Alzheimers Dement 2017 Nov 30;13(11):1261-1269. Epub 2017 Mar 30.

Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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November 2017

Cued memory decline in biomarker-defined preclinical Alzheimer disease.

Neurology 2017 Apr 10;88(15):1431-1438. Epub 2017 Mar 10.

From the Center for Alzheimer Research and Treatment (K.V.P., D.M.R., R.E.A., K.A.J., R.A.S.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School; Department of Neurology (D.M.R., E.C.M., A.P.S., K.A.J., R.A.S.), Department of Psychiatry (Y.Q.), and Division of Nuclear Medicine and Molecular Imaging (K.A.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; and Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Massachusetts General Hospital, Charlestown.

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April 2017

Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.

Ann Neurol 2017 Apr 6;81(4):583-596. Epub 2017 Apr 6.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, Charlestown, MA.

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April 2017

Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β.

Alzheimers Dement 2017 Sep 28;13(9):1004-1012. Epub 2017 Feb 28.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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September 2017

Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease.

JAMA Neurol 2017 04;74(4):427-436

Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown2Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown.

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April 2017

Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study.

J R Stat Soc Ser C Appl Stat 2017 27;66(2):313-328. Epub 2016 Jun 27.

Harvard T.H. Chan School of Public Health, Boston, USA.

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June 2016