Karen Zwaenepoel

Multidisciplinary Oncologic Centre Antwerp [(MOCA)], Antwerp University Hospital, Edegem, Belgium; Center for Oncological Research (CORE), University of Antwerp, Wilrijk, Belgium.

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August 2020

Sensitive detection methods are key to identify secondary EGFR c.2369C>T p.(Thr790Met) in non-small cell lung cancer tissue samples.

BMC Cancer 2020 May 1;20(1):366. Epub 2020 May 1.

Department of Pathology, University of Groningen, University Medical Center Groningen (UMCG), Hanzeplein 1, PO Box 30001, 9700, RB, Groningen, the Netherlands.

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May 2020

The art of obtaining a high yield of cell-free DNA from urine.

Authors:

Elien Augustus Kaat Van Casteren Laure Sorber Peter van Dam Geert Roeyen Marc Peeters Alex Vorsters An Wouters Jo Raskin Christian Rolfo Karen Zwaenepoel Patrick Pauwels

PLoS One 2020 6;15(4):e0231058. Epub 2020 Apr 6.

Center for Oncological Research Antwerp (CORE), University of Antwerp (UA), Wilrijk, Belgium.

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July 2020

Clinical Performance of the Idylla MSI Test for a Rapid Assessment of the DNA Microsatellite Status in Human Colorectal Cancer.

Authors:

Karen Zwaenepoel Julie Holmgaard Duelund Koen De Winne Vincent Maes Christine Weyn Suzan Lambin Robina Dendooven Glenn Broeckx Torben Steiniche Patrick Pauwels

J Mol Diagn 2020 03 24;22(3):386-395. Epub 2019 Dec 24.

Laboratory of Pathological Anatomy, Antwerp University Hospital (UZA), Edegem, Belgium; Center for Oncological Research Antwerp (CORE), University of Antwerp, Wilrijk, Belgium.

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March 2020

Specialized Blood Collection Tubes for Liquid Biopsy: Improving the Pre-analytical Conditions.

Authors:

Laure Sorber Karen Zwaenepoel Julie Jacobs Koen De Winne Kaat Van Casteren Elien Augustus Filip Lardon Hans Prenen Marc Peeters Jan Van Meerbeeck Geert Roeyen Christian Rolfo Patrick Pauwels

Mol Diagn Ther 2020 02;24(1):113-124

Center for Oncological Research (CORE) Antwerp, University of Antwerp (UAntwerp), Universiteitsplein 1, 2610, Wilrijk, Belgium.

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February 2020

The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies.

Authors:

Nele Van Der Steen Karen Zwaenepoel Giulia Mazzaschi Rosa A Luirink Daan P Geerke Ken Op de Beeck Christophe Hermans Marcello Tiseo Paul Van Schil Filip Lardon Paul Germonpré Christian Rolfo Elisa Giovannetti Godefridus J Peters Patrick Pauwels

Molecules 2019 Dec 4;24(24). Epub 2019 Dec 4.

Center for Oncological Research, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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December 2019

Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method.

Authors:

Tal Flieswasser Valérie Camara-Clayette Alina Danu Jacques Bosq Vincent Ribrag Piotr Zabrocki Luc Van Rompaey Hans de Haard Karen Zwaenepoel Evelien Smits Patrick Pauwels Julie Jacobs

Cancers (Basel) 2019 Oct 22;11(10). Epub 2019 Oct 22.

Center for Oncological Research (CORE), University of Antwerp, 2610 Wilrijk, Belgium.

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October 2019

Desmoid tumors display a strong immune infiltration at the tumor margins and no PD-L1-driven immune suppression.

Authors:

Vasiliki Siozopoulou Elly Marcq Julie Jacobs Karen Zwaenepoel Christophe Hermans Jantine Brauns Siegrid Pauwels Clément Huysentruyt Martin Lammens Johan Somville Evelien Smits Patrick Pauwels

Cancer Immunol Immunother 2019 Oct 11;68(10):1573-1583. Epub 2019 Sep 11.

Center for Oncological Research, University of Antwerp, Antwerp, Belgium.

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October 2019

Circulating Cell-Free DNA and RNA Analysis as Liquid Biopsy: Optimal Centrifugation Protocol.

Authors:

Laure Sorber Karen Zwaenepoel Julie Jacobs Koen De Winne Sofie Goethals Pablo Reclusa Kaat Van Casteren Elien Augustus Filip Lardon Geert Roeyen Marc Peeters Jan Van Meerbeeck Christian Rolfo Patrick Pauwels

Cancers (Basel) 2019 Mar 30;11(4). Epub 2019 Mar 30.

Center for Oncological Research Antwerp (CORE), University of Antwerp (UAntwerp), 2610 Wilrijk, Belgium.

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March 2019

The prevalence of estrogen receptor-1 mutation in advanced breast cancer: The estrogen receptor one study (EROS1).

Authors:

Omar Najim Manon Huizing Konstantinos Papadimitriou Xuan Bich Trinh Patrick Pauwels Sofie Goethals Karen Zwaenepoel Kevin Peterson Joost Weyler Sevilay Altintas Peter van Dam Wiebren Tjalma

Cancer Treat Res Commun 2019 21;19:100123. Epub 2019 Feb 21.

Multidisciplinary Breast Clinic of Antwerp, University Hospital of Antwerp, Wilrijkstraat 10. Antwerp 2650, Belgium; Faculty of Medicine, University of Antwerp, Antwerp, Belgium; Unit of Gynecologic Oncology, Department of Obstetrics & Gynecology, University Hospital of Antwerp, Antwerp, Belgium.

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September 2019

Cell-Free DNA From Metastatic Pancreatic Neuroendocrine Tumor Patients Contains Tumor-Specific Mutations and Copy Number Variations.

Authors:

Gitta Boons Timon Vandamme Marc Peeters Matthias Beyens Ann Driessen Katrien Janssens Karen Zwaenepoel Geert Roeyen Guy Van Camp Ken Op de Beeck

Front Oncol 2018 1;8:467. Epub 2018 Nov 1.

Center for Oncological Research, University of Antwerp, Antwerp, Belgium.

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November 2018

Tumor-specific genetic variants can be detected in circulating cell-free DNA of malignant pleural mesothelioma patients.

Authors:

Marieke Hylebos Ken Op de Beeck Patrick Pauwels Karen Zwaenepoel Jan P van Meerbeeck Guy Van Camp

Lung Cancer 2018 10 21;124:19-22. Epub 2018 Jul 21.

Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43, 2650 Antwerp, Belgium; Center for Oncological Research, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

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October 2018

A Multicenter Study to Assess Mutational Status in Plasma: Focus on an Optimized Workflow for Liquid Biopsy in a Clinical Setting.

Cancers (Basel) 2018 Aug 27;10(9). Epub 2018 Aug 27.

Center for Oncological Research Antwerp (CORE), University of Antwerp, 2610 Wilrijk, Belgium.

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August 2018

Describing the Reportable Range Is Important for Reliable Treatment Decisions: A Multiple Laboratory Study for Molecular Tumor Profiling Using Next-Generation Sequencing.

Authors:

Véronique Tack Lien Spans Ed Schuuring Cleo Keppens Karen Zwaenepoel Patrick Pauwels Jeroen Van Houdt Elisabeth M C Dequeker

J Mol Diagn 2018 11 26;20(6):743-753. Epub 2018 Jul 26.

Biomedical Quality Assurance Research Unit, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium; Department of Medical Diagnostics, University Hospital Leuven, Leuven, Belgium. Electronic address:

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November 2018

Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation.

Authors:

Julie Jacobs Vanessa Deschoolmeester Karen Zwaenepoel Tal Flieswasser Christophe Deben Jolien Van den Bossche Christophe Hermans Christian Rolfo Marc Peeters Olivier De Wever Filip Lardon Vasiliki Siozopoulou Evelien Smits Patrick Pauwels

Oncoimmunology 2018;7(7):e1440167. Epub 2018 Mar 19.

Center for Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium.

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March 2018

Monitoring EGFR TKI resistance in real time using ddPCR-based liquid biopsy: a case report.

Authors:

Laure Sorber Karen Zwaenepoel An Wouters Annelies Janssens Birgitta Hiddinga Jan Van Meerbeeck Filip Lardon Patrick Pauwels Christian Rolfo

J Clin Pathol 2018 08 31;71(8):754-756. Epub 2018 May 31.

Phase I - Early Clinical Trials Unit - Oncology Department, Antwerp University Hospital (UZA), Edegem, Belgium.

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August 2018

A stitch in time saves nine: external quality assessment rounds demonstrate improved quality of biomarker analysis in lung cancer.

Authors:

Cleo Keppens Véronique Tack Nils 't Hart Lien Tembuyser Ales Ryska Patrick Pauwels Karen Zwaenepoel Ed Schuuring Florian Cabillic Luigi Tornillo Arne Warth Wilko Weichert Elisabeth Dequeker

Oncotarget 2018 Apr 17;9(29):20524-20538. Epub 2018 Apr 17.

University of Leuven, Department of Public Health and Primary Care, Biomedical Quality Assurance Research Unit, Leuven, Belgium.

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April 2018

Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade.

Authors:

Jorrit De Waele Elly Marcq Jonas Rm Van Audenaerde Jinthe Van Loenhout Christophe Deben Karen Zwaenepoel Erik Van de Kelft David Van der Planken Tomas Menovsky Johan Mj Van den Bergh Yannick Willemen Patrick Pauwels Zwi N Berneman Filip Lardon Marc Peeters An Wouters Evelien Lj Smits

Oncoimmunology 2018;7(3):e1407899. Epub 2017 Dec 12.

Center for Oncological Research, University of Antwerp, Wilrijk, Antwerp, Belgium.

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December 2017

Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy.

Authors:

Julie Jacobs Vanessa Deschoolmeester Christian Rolfo Karen Zwaenepoel Jolien Van den Bossche Christophe Deben Karen Silence Hans de Haard Christophe Hermans Sylvie Rottey Christel Vangestel Filip Lardon Evelien Smits Patrick Pauwels

Oncotarget 2017 Sep 23;8(43):74058-74067. Epub 2017 May 23.

Center for Oncological Research, University of Antwerp, Antwerp, 2610 Wilrijk, Belgium.

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September 2017

Prognostic markers in oropharyngeal squamous cell carcinoma: focus on CD70 and tumour infiltrating lymphocytes.

Authors:

Astrid De Meulenaere Tijl Vermassen Sandrine Aspeslagh Karen Zwaenepoel Philippe Deron Fréderic Duprez Sylvie Rottey Liesbeth Ferdinande

Pathology 2017 Jun 17;49(4):397-404. Epub 2017 Apr 17.

Department of Pathology, Ghent University Hospital, Ghent, Belgium.

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June 2017

CD70 and PD-L1 in anaplastic thyroid cancer - promising targets for immunotherapy.

Authors:

Karen Zwaenepoel Julie Jacobs Astrid De Meulenaere Karen Silence Evelien Smits Vasiliki Siozopoulou Esther Hauben Christian Rolfo Sylvie Rottey Patrick Pauwels

Histopathology 2017 Sep 16;71(3):357-365. Epub 2017 Jun 16.

Department of Pathology, Antwerp University Hospital, Edegem, Belgium.

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September 2017

Clinical performance evaluation of a sensitive, rapid low-throughput test for KRAS mutation analysis using formalin-fixed, paraffin-embedded tissue samples.

Authors:

Christine Weyn Sofie Van Raemdonck Robina Dendooven Vincent Maes Karen Zwaenepoel Suzan Lambin Patrick Pauwels

BMC Cancer 2017 02 16;17(1):139. Epub 2017 Feb 16.

Pathology Department, University Hospital Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium.

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February 2017

Prognostic and predictive aspects of the tumor immune microenvironment and immune checkpoints in malignant pleural mesothelioma.

Authors:

Elly Marcq Vasiliki Siozopoulou Jorrit De Waele Jonas van Audenaerde Karen Zwaenepoel Eva Santermans Niel Hens Patrick Pauwels Jan P van Meerbeeck Evelien L J Smits

Oncoimmunology 2017;6(1):e1261241. Epub 2016 Nov 28.

Center for Oncological Research, University of Antwerp, Antwerp, Belgium; Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.

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November 2016

A Comparison of Cell-Free DNA Isolation Kits: Isolation and Quantification of Cell-Free DNA in Plasma.

Authors:

Laure Sorber Karen Zwaenepoel Vanessa Deschoolmeester Geert Roeyen Filip Lardon Christian Rolfo Patrick Pauwels

J Mol Diagn 2017 01 17;19(1):162-168. Epub 2016 Nov 17.

Center for Oncological Research, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; Department of Pathology, Antwerp University Hospital, Edegem, Belgium. Electronic address:

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January 2017

CD70 Expression and Its Correlation with Clinicopathological Variables in Squamous Cell Carcinoma of the Head and Neck.

Authors:

Astrid De Meulenaere Tijl Vermassen Sandrine Aspeslagh Karen Zwaenepoel Philippe Deron Fréderic Duprez Liesbeth Ferdinande Sylvie Rottey

Pathobiology 2016 8;83(6):327-33. Epub 2016 Jul 8.

Department of Pathology, Antwerp University Hospital, Edegem, Belgium.

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March 2017

PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B″ subunit to regulate cell adhesion and migration.

Authors:

Veerle Janssens Karen Zwaenepoel Carine Rossé Marleen M R Petit Jozef Goris Peter J Parker

J Cell Sci 2016 Apr 4;129(8):1605-18. Epub 2016 Mar 4.

Francis Crick Institute, Protein Phosphorylation Laboratory, 44 Lincoln's Inn Fields, London WC2A 3PX, UK Division of Cancer Studies King's College London, Guy's Hospital Campus, Thomas Street, London SE1 9RT, UK

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April 2016

The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer.

Authors:

Christophe Deben An Wouters Ken Op de Beeck Jolien van Den Bossche Julie Jacobs Karen Zwaenepoel Marc Peeters Jan Van Meerbeeck Filip Lardon Christian Rolfo Vanessa Deschoolmeester Patrick Pauwels

Oncotarget 2015 Sep;6(26):22666-79

Center for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium.

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September 2015

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