Karen Ocorr

Karen Ocorr

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Karen Ocorr

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The Functional Polymorphism R129W in the Gene Is Associated with Sporadic Tetralogy of Fallot in the Han Chinese Population.

Genet Test Mol Biomarkers 2019 Sep 6;23(9):601-609. Epub 2019 Aug 6.

State Key Lab of Development Biology of Freshwater Fish, Key Lab of MOE for Development Biology and Protein Chemistry, The Center for Heart Development, College of Life Sciences, Hunan Normal University, Changsha, China.

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http://dx.doi.org/10.1089/gtmb.2019.0085DOI Listing
September 2019

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.

Cell Rep 2018 03;22(10):2702-2715

Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242704PMC
March 2018

Reduced Cardiac Expression Mimics Long-Term Hypoxia-Induced Heart Defects in .

Circ Cardiovasc Genet 2017 10;10(5)

From the Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute (R.Z., S.M.W., K.O., R.B.) and Biomedical Sciences Graduate Program, School of Medicine, University of California at San Diego (R.Z.), La Jolla, CA.

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669044PMC
October 2017

Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.

PLoS Genet 2017 May 19;13(5):e1006786. Epub 2017 May 19.

Development, Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459509PMC
May 2017

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes.

PLoS One 2015 24;10(8):e0134620. Epub 2015 Aug 24.

Department of Life and Environmental Science, University of Bournemouth, Talbot Campus, Poole, Dorset BH12 5BB, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547745PMC
May 2016

SPARC-Dependent Cardiomyopathy in Drosophila.

Circ Cardiovasc Genet 2016 Apr 2;9(2):119-29. Epub 2016 Feb 2.

From the Department of Life and Environmental Science, University of Bournemouth, Dorset, United Kingdom (P.S.H.); and Proteomics Facility (K.M.) and Development, Aging, and Regeneration Program (R.B., K.O.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838489PMC
April 2016

Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis.

Rare Dis 2014 3;2(1):e968003. Epub 2014 Nov 3.

Department of Biology; Molecular Biology and Heart Institutes; San Diego State University; San Diego, CA USA; Development and Aging Program; Sanford-Burnham Institute for Medical Research; La Jolla, CA USA.

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http://dx.doi.org/10.4161/2167549X.2014.968003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755237PMC
March 2016

Cardiac responses to hypoxia and reoxygenation in Drosophila.

Am J Physiol Regul Integr Comp Physiol 2015 Dec 16;309(11):R1347-57. Epub 2015 Sep 16.

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California;

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http://dx.doi.org/10.1152/ajpregu.00164.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698404PMC
December 2015

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.

Hum Mol Genet 2015 Jul 19;24(13):3608-22. Epub 2015 Mar 19.

Departamento de Bioquímica, Facultad de Medicina, Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC and Centro de Investigación Biomédica en Red (CIBERER), c/ Arzobispo Morcillo s/n,Universidad Autónoma de Madrid, Madrid 28029, Spain, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid 28041, Spain

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http://dx.doi.org/10.1093/hmg/ddv106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459388PMC
July 2015

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Sci Transl Med 2015 Jun;7(292):292ra99

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Biomedical Sciences Program, University of California, San Diego, La Jolla, CA 92093, USA. Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa5843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507505PMC
June 2015

PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase.

Cell Rep 2015 Mar 5;10(9):1572-1584. Epub 2015 Mar 5.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560688PMC
March 2015

Enhanced assessment of contractile dynamics in Drosophila hearts.

Biotechniques 2015 Feb 1;58(2):77-80. Epub 2015 Feb 1.

Sanford-Burnham Medical Research Institute, La Jolla, CA.

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http://dx.doi.org/10.2144/000114255DOI Listing
February 2015

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.

PLoS Genet 2013 19;9(12):e1004024. Epub 2013 Dec 19.

Development and Aging Program, Sanford-Burnham Institute for Medical Research, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868535PMC
August 2014

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.

Aging Cell 2014 Jun 9;13(3):431-40. Epub 2014 Jan 9.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://doi.wiley.com/10.1111/acel.12193
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http://dx.doi.org/10.1111/acel.12193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032615PMC
June 2014

Methods to assess Drosophila heart development, function and aging.

Methods 2014 Jun 12;68(1):265-72. Epub 2014 Apr 12.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058868PMC
June 2014

ROS regulate cardiac function via a distinct paracrine mechanism.

Cell Rep 2014 Apr 20;7(1):35-44. Epub 2014 Mar 20.

Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164050PMC
April 2014

The role of pygopus in the differentiation of intracardiac valves in Drosophila.

Genesis 2014 Jan 21;52(1):19-28. Epub 2013 Nov 21.

The Center for Heart Development, Key Laboratory of MOE for Developmental Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China; Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037.

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http://dx.doi.org/10.1002/dvg.22724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142678PMC
January 2014

Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster.

PLoS One 2013 29;8(4):e62909. Epub 2013 Apr 29.

Development and Aging Program, Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639251PMC
November 2013

Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.

Circ Cardiovasc Genet 2013 Oct 17;6(5):472-80. Epub 2013 Sep 17.

Development and Aging Program, Sanford-Burnham Medical Research Institute, La Jolla, CA.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871875PMC
October 2013

In vivo cardiac reprogramming contributes to zebrafish heart regeneration.

Nature 2013 Jun 19;498(7455):497-501. Epub 2013 Jun 19.

Department of Medicine, Division of Cardiology, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature12322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090927PMC
June 2013

Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen.

PLoS Genet 2013 Jun 27;9(6):e1003597. Epub 2013 Jun 27.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1371/journal.pgen.1003597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694841PMC
June 2013

A Drosophila model of high sugar diet-induced cardiomyopathy.

PLoS Genet 2013 10;9(1):e1003175. Epub 2013 Jan 10.

Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1003175
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http://dx.doi.org/10.1371/journal.pgen.1003175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542070PMC
May 2013

The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model.

PLoS One 2011 25;6(7):e22579. Epub 2011 Jul 25.

Department of Biology, Molecular Biology Institute and Heart Institute, San Diego State University, San Diego, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022579PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143160PMC
December 2011

Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects.

PLoS Genet 2011 Nov 3;7(11):e1002344. Epub 2011 Nov 3.

Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207880PMC
November 2011

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.

Proc Natl Acad Sci U S A 2011 Jul 30;108(29):12024-9. Epub 2011 Jun 30.

Centre National de la Recherche Scientifique, Unité Propre de Recherche 9022, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67 084 Strasbourg Cedex, France.

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http://dx.doi.org/10.1073/pnas.1108926108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141999PMC
July 2011

Drosophila as a model to study cardiac aging.

Exp Gerontol 2011 May 3;46(5):326-30. Epub 2010 Dec 3.

Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.exger.2010.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079765PMC
May 2011

The effect of excess expression of GFP in a novel heart-specific green fluorescence zebrafish regulated by nppa enhancer at early embryonic development.

Mol Biol Rep 2011 Feb 10;38(2):793-9. Epub 2010 Apr 10.

The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, People's Republic of China.

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http://dx.doi.org/10.1007/s11033-010-0168-1DOI Listing
February 2011

Cloning and characterization of the cardiac-specific Lrrc10 promoter.

BMB Rep 2011 Feb;44(2):123-8

The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China.

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http://dx.doi.org/10.5483/BMBRep.2011.44.2.123DOI Listing
February 2011

Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.

Genes Dev 2011 Jan;25(2):189-200

Development and Aging Program, NASCR (Neuroscience, Aging, and Stem Cell Research) Center, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/gad.1992411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022264PMC
January 2011

SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.

BMB Rep 2010 May;43(5):355-61

The Center for Heart Development, Hunan Normal University, Changsha, Hunan, Peoples' Republic of China.

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http://dx.doi.org/10.5483/bmbrep.2010.43.5.355DOI Listing
May 2010

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.

Science 2010 Mar;327(5970):1223-8

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093-0723, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1182228
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http://dx.doi.org/10.1126/science.1182228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866632PMC
March 2010

Drug discovery through functional screening in the Drosophila heart.

Methods Mol Biol 2009 ;577:235-49

Burnham Institute for Medical Research, Del E. Webb Neuroscience, Aging and Stem Cell Research Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/978-1-60761-232-2_18DOI Listing
February 2010

KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1.

BMB Rep 2010 Jan;43(1):17-22

The Center For Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, Peoples' Republic of China.

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http://dx.doi.org/10.5483/bmbrep.2010.43.1.017DOI Listing
January 2010

Fluorescent labeling of Drosophila heart structures.

J Vis Exp 2009 Oct 13(32). Epub 2009 Oct 13.

Biology Department, San Diego State University, San Diego, CA, USA.

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http://dx.doi.org/10.3791/1423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164059PMC
October 2009

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.

Aging Cell 2009 Sep 9;8(5):542-52. Epub 2009 Jul 9.

Department of Internal Medicine/Institute of Gerontology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2009.00504.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832479PMC
September 2009

Semi-automated Optical Heartbeat Analysis of small hearts.

J Vis Exp 2009 Sep 16(31). Epub 2009 Sep 16.

Development and Aging Program, The Burnham Institute for Medical Research, USA.

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http://www.jove.com/index/Details.stp?ID=1435
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http://dx.doi.org/10.3791/1435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150057PMC
September 2009

Visualizing the beating heart in Drosophila.

J Vis Exp 2009 Sep 28(31). Epub 2009 Sep 28.

Development and Aging Program, The Burnham Institute for Medical Research.

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http://dx.doi.org/10.3791/1425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150055PMC
September 2009

Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies.

Dev Biol 2009 Apr 20;328(2):483-92. Epub 2009 Feb 20.

Development and Aging Program, NASCR Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060900128
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http://dx.doi.org/10.1016/j.ydbio.2009.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829972PMC
April 2009

Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.

Proc Natl Acad Sci U S A 2008 Dec 11;105(50):19833-8. Epub 2008 Dec 11.

Development and Aging Program, Del E. Webb Neuroscience, Aging and Stem Cell Research Center (NASCR), Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0808705105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605007PMC
December 2008

A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE.

Mol Cells 2008 Nov;26(5):443-53

The Center for Heart Development, Key Lab of Ministry of Education for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, Peoples' Republic of China.

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November 2008

ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway.

Mol Cell Biochem 2008 Mar 15;310(1-2):141-51. Epub 2007 Dec 15.

The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Hunan, Changsha 410081, PR China.

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http://dx.doi.org/10.1007/s11010-007-9674-4DOI Listing
March 2008

Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.

Aging Cell 2008 Mar 23;7(2):237-49. Epub 2008 Jan 23.

Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, Building 7, Room 7125, La Jolla, Ca 92037, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2008.00367.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840698PMC
March 2008

Drosophila aging 2006/2007.

Exp Gerontol 2008 Jan 3;43(1):5-10. Epub 2007 Dec 3.

Department of Anatomy and Neurobiology, Washington University, School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.exger.2007.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223272PMC
January 2008

The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.

J Exp Biol 2008 Jan;211(Pt 1):15-23

Development and Aging Program, Neuroscience, Aging and Stem Cell Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://jeb.biologists.org/content/jexbio/211/1/15.full.pdf
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http://jcs.biologists.org/content/joces/120/12/2066.full.pdf
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http://jeb.biologists.org/cgi/doi/10.1242/jeb.012435
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http://dx.doi.org/10.1242/jeb.012435DOI Listing
January 2008

ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway.

Biochem Biophys Res Commun 2007 Nov 10;363(4):895-900. Epub 2007 Sep 10.

The Center for Heart Development, Key Lab of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, 410081 Hunan, People's Republic of China.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0701905
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http://dx.doi.org/10.1016/j.bbrc.2007.08.180DOI Listing
November 2007

Genetic control of heart function and aging in Drosophila.

Trends Cardiovasc Med 2007 Jul;17(5):177-82

Burnham Institute for Medical Research, Program for Systems and Developmental Biology, Center for Neuroscienes and Aging, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S105017380700114
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http://dx.doi.org/10.1016/j.tcm.2007.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950717PMC
July 2007

Genetic variation for cardiac dysfunction in Drosophila.

PLoS One 2007 Jul 11;2(7):e601. Epub 2007 Jul 11.

Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000601PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913553PMC
July 2007

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.

Proc Natl Acad Sci U S A 2007 Mar 28;104(10):3943-8. Epub 2007 Feb 28.

Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0609278104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820688PMC
March 2007

Age-related cardiac disease model of Drosophila.

Mech Ageing Dev 2007 Jan 27;128(1):112-6. Epub 2006 Nov 27.

The Burnham Institute for Medical Research, Center for Neuroscience and Aging, 10901 North Torrey Pines Road, La Jolla, CA 92130, USA.

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http://dx.doi.org/10.1016/j.mad.2006.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850850PMC
January 2007

The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman.

Proc Natl Acad Sci U S A 2006 Aug 1;103(32):11999-2004. Epub 2006 Aug 1.

Del E. Webb Center for Neurosciences and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0603098103
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http://dx.doi.org/10.1073/pnas.0603098103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567687PMC
August 2006