Karel Pacak

Karel Pacak

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Karel Pacak

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Exploring the link between tumour metabolism and succinate dehydrogenase deficiency: A F-FDOPA PET/CT study in head and neck paragangliomas.

Authors:
Thibaut Reichert Nicolas Fakhry Jean-Pierre Lavieille Vincent Amodru Frédéric Sebag Pauline Romanet Anderson Loundou Frédéric Castinetti Karel Pacak Marion Montava David Taïeb

Clin Endocrinol (Oxf) 2019 Dec 1;91(6):879-884. Epub 2019 Oct 1.

Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1111/cen.14086DOI Listing
December 2019

Pseudopheochromocytoma.

Authors:
Divya Mamilla Melissa K Gonzales Murray D Esler Karel Pacak

Endocrinol Metab Clin North Am 2019 Dec 18;48(4):751-764. Epub 2019 Sep 18.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver NICHD, NIH, Building 10, CRC, 1E-3140, 10 Center Drive, MSC-1109, Bethesda, MD 20892-1109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ecl.2019.08.004DOI Listing
December 2019

MicroRNA-210 May Be a Preoperative Biomarker of Malignant Pheochromocytomas and Paragangliomas.

Authors:
Samantha M Ruff Reed I Ayabe Parisa Malekzadeh Meghan L Good Michael M Wach Melissa K Gonzales Amit Tirosh Naris Nilubol Karel Pacak Electron Kebebew Dhaval Patel

J Surg Res 2019 Nov 27;243:1-7. Epub 2019 May 27.

Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Division of Surgical Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193028
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http://dx.doi.org/10.1016/j.jss.2019.04.086DOI Listing
November 2019

Synergistic Highly Potent Targeted Drug Combinations in Different Pheochromocytoma Models Including Human Tumor Cultures.

Authors:
Maria Fankhauser Nicole Bechmann Michael Lauseker Judith Goncalves Judith Favier Barbara Klink Doreen William Laura Gieldon Julian Maurer Gerald Spöttl Petra Rank Thomas Knösel Michael Orth Christian G Ziegler Elke Tatjana Aristizabal Prada German Rubinstein Martin Fassnacht Christine Spitzweg Ashley B Grossman Karel Pacak Felix Beuschlein Stefan R Bornstein Graeme Eisenhofer Christoph J Auernhammer Martin Reincke Svenja Nölting

Endocrinology 2019 Nov;160(11):2600-2617

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, LMU München, Munich, Germany.

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http://dx.doi.org/10.1210/en.2019-00410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795182PMC
November 2019

Some Considerations in Treating Malignant Head and Neck Paragangliomas.

Authors:
Abhishek Jha Naris Nilubol Karel Pacak

JAMA Otolaryngol Head Neck Surg 2019 Nov 14. Epub 2019 Nov 14.

Section on Medical Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jamaoto.2019.3444DOI Listing
November 2019

Prognostic and predictive value of nuclear imaging in endocrine oncology.

Authors:
Giorgio Treglia Bernard Goichot Luca Giovanella Elif Hindié Abhishek Jha Karel Pacak David Taïeb Thomas Walter Alessio Imperiale

Endocrine 2019 Nov 16. Epub 2019 Nov 16.

Biophysics and Nuclear Medicine, Hautepierre Hospital, University Hospitals of Strasbourg, Strasbourg University/FMTS, Strasbourg, France.

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http://dx.doi.org/10.1007/s12020-019-02131-4DOI Listing
November 2019

Coley's immunotherapy revived: Innate immunity as a link in priming cancer cells for an attack by adaptive immunity.

Authors:
Ondrej Uher Veronika Caisova Per Hansen Jan Kopecky Jindrich Chmelar Zhengping Zhuang Jan Zenka Karel Pacak

Semin Oncol 2019 Nov 6. Epub 2019 Nov 6.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, MD 20814, USA. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2019.10.004DOI Listing
November 2019

Current experts' views on precision nuclear medicine imaging of phaeochromocytoma and paraganglioma.

Authors:
David Taïeb Karel Pacak

Eur J Nucl Med Mol Imaging 2019 Oct 22;46(11):2223-2224. Epub 2019 Jul 22.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1E-3140, 10 Center Drive MSC-1109, Bethesda, MD, 20892-1109, USA.

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http://dx.doi.org/10.1007/s00259-019-04435-zDOI Listing
October 2019

Current Management of Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician in the Era of Precision Medicine.

Authors:
Svenja Nölting Martin Ullrich Jens Pietzsch Christian G Ziegler Graeme Eisenhofer Ashley Grossman Karel Pacak

Cancers (Basel) 2019 Oct 8;11(10). Epub 2019 Oct 8.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.3390/cancers11101505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827093PMC
October 2019

European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma.

Authors:
David Taïeb Rodney J Hicks Elif Hindié Benjamin A Guillet Anca Avram Pietro Ghedini Henri J Timmers Aaron T Scott Saeed Elojeimy Domenico Rubello Irène J Virgolini Stefano Fanti Sona Balogova Neeta Pandit-Taskar Karel Pacak

Eur J Nucl Med Mol Imaging 2019 Sep 29;46(10):2112-2137. Epub 2019 Jun 29.

Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00259-019-04398-1DOI Listing
September 2019

Surgical Resection of Pheochromocytomas and Paragangliomas is Associated with Lower Cholesterol Levels.

Authors:
Meghan L Good Parisa Malekzadeh Samantha M Ruff Shreya Gupta Amy Copeland Karel Pacak Naris Nilubol Electron Kebebew Dhaval Patel

World J Surg 2019 Sep 17. Epub 2019 Sep 17.

Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1007/s00268-019-05175-9DOI Listing
September 2019

Pheochromocytoma (PHEO) and Paraganglioma (PGL).

Authors:
Karel Pacak David Taïeb

Cancers (Basel) 2019 Sep 18;11(9). Epub 2019 Sep 18.

Department of Nuclear Medicine, La Timone University Hospital, European Center for Research in Medical Imaging, Aix-Marseille University, 13100 Marseille, France.

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http://dx.doi.org/10.3390/cancers11091391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769510PMC
September 2019

Characteristic CT features of pheochromocytomas - probability model calculation tool based on a multicentric study.

Authors:
Filip Ctvrtlik Zbynek Tudos Paulina Szasz Zuzana Sedlackova Igor Hartmann Jan Schovanek Zdenek Frysak Iva Macova Tomas Zelinka Milan Hora Eva Kocova Jaroslav Pacovsky Michal Krsek Viera Lehotska Emilia Mojtova Josef Molnar Vladimir Vanek Karel Pacak Jan Baxa

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Sep 23;163(3):212-219. Epub 2019 Sep 23.

Department of Imaging Methods, University Hospital Pilsen and Faculty of Medicine in Pilsen, Charles University, Czech Republic.

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http://dx.doi.org/10.5507/bp.2019.047DOI Listing
September 2019

Molecular imaging and radionuclide therapy of paraganglioma and pheochromocytoma.

Authors:
David Taieb Abhishek Jha Giorgio Treglia Karel Pacak

Endocr Relat Cancer 2019 09 1. Epub 2019 Sep 1.

K Pacak, NICHD, NIH, Bethesda, 20817, United States.

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http://dx.doi.org/10.1530/ERC-19-0165DOI Listing
September 2019

Psychological impact of von Hippel-Lindau genetic screening in patients with a previous history of hemangioblastoma of the central nervous system.

Authors:
Claire Rochette Karine Baumstarck Hélène Canoni-Zattara Ahmad Esmaeel Abdullah Dominique Figarella-Branger Morgane Pertuit Anne Barlier Frédéric Castinetti Karel Pacak Philippe Metellus David Taïeb

J Psychosoc Oncol 2018 Sep-Oct;36(5):624-634. Epub 2018 May 15.

h Department of Nuclear Medicine , La Timone University Hospital & CERIMED & Inserm UMR1068 Marseille Cancerology Research Center, Institut Paoli-Calmettes, Aix-Marseille University , Marseille , France.

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http://dx.doi.org/10.1080/07347332.2018.1450320DOI Listing
August 2019

Long intergenic noncoding RNA profiles of pheochromocytoma and paraganglioma: A novel prognostic biomarker.

Authors:
Suman Ghosal Shaoli Das Ying Pang Melissa K Gonzales Thanh-Truc Huynh Yanqin Yang David Taieb Joakim Crona Uma T Shankavaram Karel Pacak

Int J Cancer 2019 Aug 30. Epub 2019 Aug 30.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/ijc.32654DOI Listing
August 2019

Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects.

Authors:
David Taïeb Henri Timmers Karel Pacak

Horm Metab Res 2019 Jul 4;51(7):414-418. Epub 2018 Apr 4.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1055/a-0586-3710DOI Listing
July 2019

Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease?

Authors:
Jenn Rachelle U Santos Alessandra Brofferio Bruna Viana Karel Pacak

Horm Metab Res 2019 Jul 18;51(7):458-469. Epub 2018 Sep 18.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0669-9556
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http://dx.doi.org/10.1055/a-0669-9556DOI Listing
July 2019

The 3PAs: An Update on the Association of Pheochromocytomas, Paragangliomas, and Pituitary Tumors.

Authors:
Paraskevi Xekouki Ana Brennand Ben Whitelaw Karel Pacak Constantine A Stratakis

Horm Metab Res 2019 Jul 1;51(7):419-436. Epub 2018 Oct 1.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0661-0341
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http://dx.doi.org/10.1055/a-0661-0341DOI Listing
July 2019

Gα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling.

Authors:
Min Chen Eric A Wilson Zhenzhong Cui Hui Sun Yogendra B Shrestha Brandon Podyma Christina H Le Benedetta Naglieri Karel Pacak Oksana Gavrilova Lee S Weinstein

Mol Metab 2019 Jul 12;25:142-153. Epub 2019 Apr 12.

Metabolic Diseases Branch, Bethesda, MD, 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601467PMC
July 2019

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.

Authors:
Sai P Pydi Shanu Jain Wesley Tung Yinghong Cui Lu Zhu Wataru Sakamoto Shalini Jain Brent S Abel Monica C Skarulis Jie Liu Thanh Huynh Karel Pacak Marc G Caron Oksana Gavrilova Toren Finkel Jürgen Wess

Nat Commun 2019 07 3;10(1):2936. Epub 2019 Jul 3.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, NIH-20892, USA.

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http://dx.doi.org/10.1038/s41467-019-11003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610117PMC
July 2019

Postoperative Management in Patients with Pheochromocytoma and Paraganglioma.

Authors:
Divya Mamilla Katherine A Araque Alessandra Brofferio Melissa K Gonzales James N Sullivan Naris Nilubol Karel Pacak

Cancers (Basel) 2019 07 3;11(7). Epub 2019 Jul 3.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers11070936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678461PMC
July 2019

Medullary Thyroid Carcinoma: An Update on Imaging.

Authors:
Sergiy V Kushchayev Yevgeniya S Kushchayeva Sri Harsha Tella Tetiana Glushko Karel Pacak Oleg M Teytelboym

J Thyroid Res 2019 7;2019:1893047. Epub 2019 Jul 7.

Department of Radiology, Mercy Catholic Medical Center, 1500 Lansdowne Ave, Darby, PA 19023, USA.

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http://dx.doi.org/10.1155/2019/1893047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642782PMC
July 2019

A high rate of modestly elevated plasma normetanephrine in a population referred for suspected PPGL when measured in a seated position.

Authors:
Jessica Boyd Alexander A Leung Hossein Sadrzadeh Christina Pamporaki Karel Pacak Timo Deutschbein Stephanie Fliedner Gregory A Kline

Eur J Endocrinol 2019 Jul 1. Epub 2019 Jul 1.

G Kline, Medicine/Endocrinology, University of Calgary Cumming School of Medicine, Calgary, Canada.

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https://eje.bioscientifica.com/view/journals/eje/181/3/EJE-1
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http://dx.doi.org/10.1530/EJE-19-0176DOI Listing
July 2019

Tumor multifocality with vagus nerve involvement as a phenotypic marker of SDHD mutation in patients with head and neck paragangliomas: A F-FDOPA PET/CT study.

Authors:
Vincent Amodru Pauline Romanet Ugo Scemama Marion Montava Nicolas Fakhry Frédéric Sebag Frédéric Castinetti Jean-Pierre Lavieille Anderson Loundou Arthur Varoquaux Anne Barlier Karel Pacak David Taïeb

Head Neck 2019 Jun 24;41(6):1565-1571. Epub 2018 Dec 24.

Department of Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1002/hed.25604DOI Listing
June 2019

A Previously Unrecognized Monocytic Component of Pheochromocytoma and Paraganglioma.

Authors:
Nada A Farhat James F Powers Annette Shepard-Barry Patricia Dahia Karel Pacak Arthur S Tischler

Endocr Pathol 2019 Jun;30(2):90-95

Department of Pathology and Laboratory Medicine, Tufts Medical Center, 800 Washington Street, Box 802, Boston, MA, 02111, USA.

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http://dx.doi.org/10.1007/s12022-019-9575-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816458PMC
June 2019

Chiari Malformation Type 1 in -Associated Syndrome.

Authors:
Jared S Rosenblum Dominic Maggio Ying Pang Matthew A Nazari Melissa K Gonzales Ronald M Lechan James G Smirniotopoulos Zhengping Zhuang Karel Pacak John D Heiss

Int J Mol Sci 2019 Jun 10;20(11). Epub 2019 Jun 10.

Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/ijms20112819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600383PMC
June 2019

Optimizing Genetic Workup in Pheochromocytoma and Paraganglioma by Integrating Diagnostic and Research Approaches.

Authors:
Laura Gieldon Doreen William Karl Hackmann Winnie Jahn Arne Jahn Johannes Wagner Andreas Rump Nicole Bechmann Svenja Nölting Thomas Knösel Volker Gudziol Georgiana Constantinescu Jimmy Masjkur Felix Beuschlein Henri Jlm Timmers Letizia Canu Karel Pacak Mercedes Robledo Daniela Aust Evelin Schröck Graeme Eisenhofer Susan Richter Barbara Klink

Cancers (Basel) 2019 Jun 11;11(6). Epub 2019 Jun 11.

Institute for Clinical Genetics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

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http://dx.doi.org/10.3390/cancers11060809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627084PMC
June 2019

Eruption of Metastatic Paraganglioma After Successful Therapy with Lu/Y-DOTATOC and Lu-DOTATATE.

Authors:
Katherine I Wolf Abhishek Jha Anouk van Berkel Damian Wild Ingo Janssen Corina M Millo M J R Janssen Melissa K Gonzales Henri J K M Timmers Karel Pacak

Nucl Med Mol Imaging 2019 Jun 22;53(3):223-230. Epub 2019 Feb 22.

1Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 USA.

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http://dx.doi.org/10.1007/s13139-019-00579-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554376PMC
June 2019

More on Ivabradine in Tachycardia with Paraganglioma. Reply.

Authors:
Gelinemae Malaza Alessandra Brofferio Karel Pacak

N Engl J Med 2019 06;380(26):2590

National Institutes of Health, Bethesda, MD

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http://dx.doi.org/10.1056/NEJMc1905730DOI Listing
June 2019

Overexpression of a Neuronal Type Adenylyl Cyclase (Type 8) in Sinoatrial Node Markedly Impacts Heart Rate and Rhythm.

Authors:
Jack M Moen Michael G Matt Christopher Ramirez Kirill V Tarasov Khalid Chakir Yelena S Tarasova Yevgeniya Lukyanenko Kenta Tsutsui Oliver Monfredi Christopher H Morrell Syevda Tagirova Yael Yaniv Thanh Huynh Karel Pacak Ismayil Ahmet Edward G Lakatta

Front Neurosci 2019 18;13:615. Epub 2019 Jun 18.

Intramural Research Program, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fnins.2019.00615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591434PMC
June 2019

The Significant Reduction or Complete Eradication of Subcutaneous and Metastatic Lesions in a Pheochromocytoma Mouse Model after Immunotherapy Using Mannan-BAM, TLR Ligands, and Anti-CD40.

Authors:
Veronika Caisova Liping Li Garima Gupta Ivana Jochmanova Abhishek Jha Ondrej Uher Thanh-Truc Huynh Markku Miettinen Ying Pang Luma Abunimer Gang Niu Xiaoyuan Chen Hans Kumar Ghayee David Taïeb Zhengping Zhuang Jan Zenka Karel Pacak

Cancers (Basel) 2019 May 11;11(5). Epub 2019 May 11.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.3390/cancers11050654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562455PMC
May 2019

A Transgenic Mouse Model of Pacak⁻Zhuang Syndrome with An Gain-of-Function Mutation.

Authors:
Herui Wang Jing Cui Chunzhang Yang Jared S Rosenblum Qi Zhang Qi Song Ying Pang Francia Fang Mitchell Sun Pauline Dmitriev Mark R Gilbert Graeme Eisenhofer Karel Pacak Zhengping Zhuang

Cancers (Basel) 2019 May 14;11(5). Epub 2019 May 14.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers11050667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562734PMC
May 2019

Preoperative 18F-FDG PET/CT in Pheochromocytomas and Paragangliomas Allows for Precision Surgery.

Authors:
Pavel Nockel Mustapha El Lakis Apostolos Gaitanidis Roxanne Merkel Dhaval Patel Naris Nilubol Tamara Prodanov Karel Pacak Electron Kebebew

Ann Surg 2019 Apr;269(4):741-747

Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.

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http://dx.doi.org/10.1097/SLA.0000000000002671DOI Listing
April 2019

Nonmosaic somatic HIF2A mutations associated with late onset polycythemia-paraganglioma syndrome: Newly recognized subclass of polycythemia-paraganglioma syndrome.

Authors:
Ying Pang Garima Gupta Abhishek Jha Xupeng Yue Herui Wang Thanh-Truc Huynh Aiguo Li Liping Li Eva Baker Emily Chew Richard A Feelders Esther Korpershoek Zhengping Zhuang Chunzhang Yang Karel Pacak

Cancer 2019 Apr 15;125(8):1258-1266. Epub 2019 Jan 15.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cncr.31839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443474PMC
April 2019

Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells.

Authors:
Nicole Bechmann Isabel Poser Verena Seifert Christian Greunke Martin Ullrich Nan Qin Axel Walch Mirko Peitzsch Mercedes Robledo Karel Pacak Jens Pietzsch Susan Richter Graeme Eisenhofer

Cancers (Basel) 2019 Apr 28;11(5). Epub 2019 Apr 28.

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.

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http://dx.doi.org/10.3390/cancers11050594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562431PMC
April 2019

Gallbladder Paraganglioma Associated with Mutation: a Potential Pitfall on F-FDOPA PET Imaging.

Authors:
Zahraa Abdul Sater Abhishek Jha Adel Mandl Sheila K Mangelen Jorge A Carrasquillo Alexander Ling Melissa K Gonzales Osorio Lopes Abath Neto Markku Miettinen Karen T Adams Pavel Nockel Mustapha El Lakis Karel Pacak

Nucl Med Mol Imaging 2019 Apr 19;53(2):144-147. Epub 2019 Feb 19.

2Section on Medical Neuroendocrinology, Developmental Endocrine Oncology and Genetics Affinity Group, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Dr. MSC-1109, Bldg. 10, CRC, 1E-3140, Bethesda, MD 20892 USA.

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http://dx.doi.org/10.1007/s13139-018-0558-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473097PMC
April 2019

Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma.

Authors:
Susan Richter Laura Gieldon Ying Pang Mirko Peitzsch Thanh Huynh Rocio Leton Bruna Viana Tonino Ercolino Anastasios Mangelis Elena Rapizzi Mario Menschikowski Daniela Aust Matthias Kroiss Felix Beuschlein Volker Gudziol Henri Jlm Timmers Jacques Lenders Massimo Mannelli Alberto Cascon Karel Pacak Mercedes Robledo Graeme Eisenhofer Barbara Klink

Genet Med 2019 03 27;21(3):705-717. Epub 2018 Jul 27.

Institute for Clinical Genetics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1038/s41436-018-0106-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353556PMC
March 2019

New insights on the pathogenesis of paraganglioma and pheochromocytoma.

Authors:
Vitaly Kantorovich Karel Pacak

F1000Res 2018 20;7. Epub 2018 Sep 20.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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https://f1000research.com/articles/7-1500/v1
Publisher Site
http://dx.doi.org/10.12688/f1000research.14568.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173107PMC
March 2019

An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

Authors:
Terence K Lee Saravana Rk Murthy Niamh X Cawley Savita Dhanvantari Stephen M Hewitt Hong Lou Tracy Lau Stephanie Ma Thanh Huynh Robert A Wesley Irene O Ng Karel Pacak Ronnie T Poon Y Peng Loh

J Clin Invest 2019 Mar 18;130:1804. Epub 2019 Mar 18.

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http://dx.doi.org/10.1172/JCI128836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436901PMC
March 2019

Genotype-phenotype correlations in pheochromocytoma and paraganglioma.

Authors:
Joakim Crona Angela Lamarca Suman Ghosal Staffan Welin Britt Skogseid Karel Pacak

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

K Pacak, NICHD, NIH, Bethesda, 20817, United States.

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http://dx.doi.org/10.1530/ERC-19-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717695PMC
March 2019

Ivabradine in Catecholamine-Induced Tachycardia in a Patient with Paraganglioma.

Authors:
Gelinemae Malaza Alessandra Brofferio Frank Lin Karel Pacak

N Engl J Med 2019 03;380(13):1284-1286

National Institutes of Health, Bethesda, MD

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http://dx.doi.org/10.1056/NEJMc1817267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584758PMC
March 2019

Pheochromocytomas and Paragangliomas: From Genetic Diversity to Targeted Therapies.

Authors:
Ying Pang Yang Liu Karel Pacak Chunzhang Yang

Cancers (Basel) 2019 Mar 28;11(4). Epub 2019 Mar 28.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers11040436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521122PMC
March 2019

Metastatic Phaeochromocytoma: Spinning Towards More Promising Treatment Options.

Authors:
Svenja Nölting Ashley Grossman Karel Pacak

Exp Clin Endocrinol Diabetes 2019 Feb 20;127(2-03):117-128. Epub 2018 Sep 20.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

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February 2019

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Authors:
Martina Bajzikova Jaromira Kovarova Ana R Coelho Stepana Boukalova Sehyun Oh Katerina Rohlenova David Svec Sona Hubackova Berwini Endaya Kristyna Judasova Ayenachew Bezawork-Geleta Katarina Kluckova Laurent Chatre Renata Zobalova Anna Novakova Katerina Vanova Zuzana Ezrova Ghassan J Maghzal Silvia Magalhaes Novais Marie Olsinova Linda Krobova Yong Jin An Eliska Davidova Zuzana Nahacka Margarita Sobol Teresa Cunha-Oliveira Cristian Sandoval-Acuña Hynek Strnad Tongchuan Zhang Thanh Huynh Teresa L Serafim Pavel Hozak Vilma A Sardao Werner J H Koopman Miria Ricchetti Paulo J Oliveira Frantisek Kolar Mikael Kubista Jaroslav Truksa Katerina Dvorakova-Hortova Karel Pacak Robert Gurlich Roland Stocker Yaoqi Zhou Michael V Berridge Sunghyouk Park Lanfeng Dong Jakub Rohlena Jiri Neuzil

Cell Metab 2019 02 15;29(2):399-416.e10. Epub 2018 Nov 15.

Institute of Biotechnology, Czech Academy of Sciences, 252 50, Vestec, Prague-West, Czech Republic; School of Medical Science, Griffith University, Southport, QLD 4222, Australia. Electronic address:

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February 2019

A NECESSITY, NOT A SECOND THOUGHT: PRE-OPERATIVE ALPHA-ADRENOCEPTOR BLOCKADE IN PHEOCHROMOCYTOMA PATIENTS.

Authors:
Jenn Rachelle U Santos Katherine I Wolf Karel Pacak

Endocr Pract 2019 02;25(2):200-201

Senior Investigator, Chief, Section on Medical Neuroendocrinology, Professor of Medicine, NICHD, NIH, Building 10, CRC, Room 1E-3140, 10 Center Drive MSC-1109, Bethesda, MD 20892-1109, E-mail:

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http://dx.doi.org/10.4158/1934-2403-25.2.200DOI Listing
February 2019

Clinical, Diagnostic, and Treatment Characteristics of -Related Metastatic Pheochromocytoma and Paraganglioma.

Authors:
Abhishek Jha Kristine de Luna Charlene Ann Balili Corina Millo Cecilia Angela Paraiso Alexander Ling Melissa K Gonzales Bruna Viana Rami Alrezk Karen T Adams Isabel Tena Alice Chen Jiri Neuzil Margarita Raygada Electron Kebebew David Taieb M Sue O'Dorisio Thomas O'Dorisio Ali Cahid Civelek Constantine A Stratakis Leilani Mercado-Asis Karel Pacak

Front Oncol 2019 22;9:53. Epub 2019 Feb 22.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fonc.2019.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395427PMC
February 2019

Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies.

Authors:
Dominique Barbolosi Joakim Crona Raphaël Serre Karel Pacak David Taieb

PLoS One 2018 14;13(8):e0201303. Epub 2018 Aug 14.

INSERM UMR U1068, CNRS UMR 7258, Aix-Marseille University, Cancer Research Center of Marseille, Marseille, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091916PMC
January 2019

Radioguided Surgery With Gallium 68 Dotatate for Patients With Neuroendocrine Tumors.

Authors:
Mustapha El Lakis Andreas Gianakou Pavel Nockel Douglas Wiseman Amit Tirosh Martha A Quezado Dhaval Patel Naris Nilubol Karel Pacak Samira M Sadowski Electron Kebebew

JAMA Surg 2019 01;154(1):40-45

Department of Surgery, Stanford University, Stanford, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439858PMC
January 2019

WHY TAKE THE RISK? WE ONLY LIVE ONCE: THE DANGERS ASSOCIATED WITH NEGLECTING A PRE-OPERATIVE ALPHA ADRENOCEPTOR BLOCKADE IN PHEOCHROMOCYTOMA PATIENTS.

Authors:
Katherine I Wolf Jenn Rachelle U Santos Karel Pacak

Endocr Pract 2019 Jan 5;25(1):106-108. Epub 2018 Oct 5.

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http://journals.aace.com/doi/10.4158/EP-2018-0455
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478021PMC
January 2019

Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients.

Authors:
Bruna Calsina Maria Currás-Freixes Alexandre Buffet Tirso Pons Laura Contreras Rocío Letón Iñaki Comino-Méndez Laura Remacha María Calatayud Berta Obispo Antoine Martin Regis Cohen Susan Richter Judith Balmaña Esther Korpershoek Elena Rapizzi Timo Deutschbein Laurent Vroonen Judith Favier Ronald R de Krijger Martin Fassnacht Felix Beuschlein Henri J Timmers Graeme Eisenhofer Massimo Mannelli Karel Pacak Jorgina Satrústegui Cristina Rodríguez-Antona Laurence Amar Alberto Cascón Nicole Dölker Anne-Paule Gimenez-Roqueplo Mercedes Robledo

Genet Med 2018 12 16;20(12):1652-1662. Epub 2018 Jul 16.

Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/s41436-018-0068-7DOI Listing
December 2018

Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells.

Authors:
Susan Richter Vanessa D'Antongiovanni Serena Martinelli Nicole Bechmann Maria Riverso David M Poitz Karel Pacak Graeme Eisenhofer Massimo Mannelli Elena Rapizzi

Cell Tissue Res 2018 Dec 29;374(3):473-485. Epub 2018 Aug 29.

Department of Experimental and Clinical Medicine, University of Florence, Viale, Pieraccini 6, 50139, Florence, Italy.

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http://dx.doi.org/10.1007/s00441-018-2907-xDOI Listing
December 2018

RNA-Sequencing Analysis of Adrenocortical Carcinoma, Pheochromocytoma and Paraganglioma from a Pan-Cancer Perspective.

Authors:
Joakim Crona Samuel Backman Staffan Welin David Taïeb Per Hellman Peter Stålberg Britt Skogseid Karel Pacak

Cancers (Basel) 2018 Dec 15;10(12). Epub 2018 Dec 15.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Room 1E-3140, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers10120518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315481PMC
December 2018

Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol.

Authors:
Annie Y Park Paul M Plotsky Truyen D Pham Karel Pacak Brandi M Wynne Susan M Wall Yoskaly Lazo-Fernandez

Physiol Rep 2018 Nov;6(21):e13904

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

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http://doi.wiley.com/10.14814/phy2.13904
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234146PMC
November 2018

Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging.

Authors:
Rami Alrezk Andres Suarez Isabel Tena Karel Pacak

Front Endocrinol (Lausanne) 2018 27;9:515. Epub 2018 Nov 27.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fendo.2018.00515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277481PMC
November 2018

The role of GSK3 and its reversal with GSK3 antagonism in everolimus resistance.

Authors:
Elke Tatjana Aristizabal Prada Gerald Spöttl Julian Maurer Michael Lauseker Eva Jolanthe Koziolek Jörg Schrader Ashley Grossman Karel Pacak Felix Beuschlein Christoph Joseph Auernhammer Svenja Nölting

Endocr Relat Cancer 2018 10 12;25(10):893-908. Epub 2018 Jun 12.

Medizinische Klinik und Poliklinik IVInterdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM), Klinikum der Universität München (KUM), Ludwig-Maximilians-University, Munich, Germany

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https://erc.bioscientifica.com/view/journals/erc/25/10/ERC-1
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October 2018

Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy.

Authors:
Yanxin Lu Yang Liu Ying Pang Karel Pacak Chunzhang Yang

Pharmacol Ther 2018 08 3;188:168-175. Epub 2018 Apr 3.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067963PMC
August 2018

Molecular evaluation of a sporadic paraganglioma with concurrent IDH1 and ATRX mutations.

Authors:
Jing Zhang Jingjing Jiang Yu Luo Xiaomu Li Zhiqiang Lu Yujun Liu Jie Huang Yingyong Hou Ying Pang Mitchell Yee Fong Sun Tracy S Wang Douglas B Evans Karel Pacak Zhengping Zhuang Xin Gao

Endocrine 2018 08 30;61(2):216-223. Epub 2018 May 30.

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1007/s12020-018-1617-1DOI Listing
August 2018

Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.

Authors:
Irfan Jawed Margarita Velarde Roland Därr Katherine I Wolf Karen Adams Aradhana M Venkatesan Sanjeeve Balasubramaniam Marianne S Poruchynsky James C Reynolds Karel Pacak Tito Fojo

Cell Mol Neurobiol 2018 Jul 5;38(5):1099-1106. Epub 2018 Apr 5.

Medical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s10571-018-0579-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976545PMC
July 2018

Targeting NAD/PARP DNA Repair Pathway as a Novel Therapeutic Approach to -Mutated Cluster I Pheochromocytoma and Paraganglioma.

Authors:
Ying Pang Yanxin Lu Veronika Caisova Yang Liu Petra Bullova Thanh-Truc Huynh Yiqiang Zhou Di Yu Zdenek Frysak Igor Hartmann David Taïeb Karel Pacak Chunzhang Yang

Clin Cancer Res 2018 07 10;24(14):3423-3432. Epub 2018 Apr 10.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3406DOI Listing
July 2018

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints.

Authors:
Ayenachew Bezawork-Geleta He Wen LanFeng Dong Bing Yan Jelena Vider Stepana Boukalova Linda Krobova Katerina Vanova Renata Zobalova Margarita Sobol Pavel Hozak Silvia Magalhaes Novais Veronika Caisova Pavel Abaffy Ravindra Naraine Ying Pang Thiri Zaw Ping Zhang Radek Sindelka Mikael Kubista Steven Zuryn Mark P Molloy Michael V Berridge Karel Pacak Jakub Rohlena Sunghyouk Park Jiri Neuzil

Nat Commun 2018 06 7;9(1):2221. Epub 2018 Jun 7.

School of Medical Sciences, Griffith University, Southport, 4222, Qld, Australia.

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http://dx.doi.org/10.1038/s41467-018-04603-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992162PMC
June 2018

Superiority of Ga-DOTATATE over F-FDG and anatomic imaging in the detection of succinate dehydrogenase mutation (SDHx )-related pheochromocytoma and paraganglioma in the pediatric population.

Authors:
Abhishek Jha Alexander Ling Corina Millo Garima Gupta Bruna Viana Frank I Lin Peter Herscovitch Karen T Adams David Taïeb Adam R Metwalli W Marston Linehan Alessandra Brofferio Constantine A Stratakis Electron Kebebew Maya Lodish Ali Cahid Civelek Karel Pacak

Eur J Nucl Med Mol Imaging 2018 05 4;45(5):787-797. Epub 2017 Dec 4.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Dr., Bldg. 10, Room 1E-3140, Bethesda, MD, 20892, USA.

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http://link.springer.com/10.1007/s00259-017-3896-9
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707509PMC
May 2018

Molecular imaging and theranostic approaches in pheochromocytoma and paraganglioma.

Authors:
David Taïeb Karel Pacak

Cell Tissue Res 2018 05 15;372(2):393-401. Epub 2018 Feb 15.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00441-018-2791-4DOI Listing
May 2018

Prospective evaluation of Ga-DOTATATE PET/CT in limited disease neuroendocrine tumours and/or elevated serum neuroendocrine biomarkers.

Authors:
Sophie Gabriel Philippe Garrigue Laetitia Dahan Frédéric Castinetti Frédéric Sebag Karine Baumstark Cendrine Archange Abhishek Jha Karel Pacak Benjamin Guillet David Taïeb

Clin Endocrinol (Oxf) 2018 May 22. Epub 2018 May 22.

Department of Nuclear Medicine, La Timone & North University Hospital, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1111/cen.13745DOI Listing
May 2018

New Challenges in Nuclear Endocrinology.

Authors:
David Taïeb Rodney J Hicks Karel Pacak

J Nucl Med 2018 04 9;59(4):573-574. Epub 2017 Nov 9.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.2967/jnumed.117.199729DOI Listing
April 2018

18F-FDOPA PET/CT Imaging of MAX-Related Pheochromocytoma.

Authors:
David Taïeb Abhishek Jha Carole Guerin Ying Pang Karen T Adams Clara C Chen Pauline Romanet Philippe Roche Wassim Essamet Alexander Ling Martha M Quezado Frédéric Castinetti Fréderic Sebag Karel Pacak

J Clin Endocrinol Metab 2018 04;103(4):1574-1582

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1210/jc.2017-02324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276705PMC
April 2018

Successful Second-Line Metronomic Temozolomide in Metastatic Paraganglioma: Case Reports and Review of the Literature.

Authors:
Isabel Tena Garima Gupta Marcos Tajahuerce Marta Benavent Manuel Cifrián Alejandro Falcon María Fonfria Maribel Del Olmo Rosa Reboll Antonio Conde Francisca Moreno Julia Balaguer Adela Cañete Rosana Palasí Pilar Bello Alfredo Marco José Luis Ponce Juan Francisco Merino Antonio Llombart Alfredo Sanchez Karel Pacak

Clin Med Insights Oncol 2018 9;12:1179554918763367. Epub 2018 Apr 9.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1177/1179554918763367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922490PMC
April 2018

Prognostic Utility of Total Ga-DOTATATE-Avid Tumor Volume in Patients With Neuroendocrine Tumors.

Authors:
Amit Tirosh Georgios Z Papadakis Corina Millo Dima Hammoud Samira M Sadowski Peter Herscovitch Karel Pacak Stephen J Marx Lily Yang Pavel Nockel Jasmine Shell Patience Green Xavier M Keutgen Dhaval Patel Naris Nilubol Electron Kebebew

Gastroenterology 2018 03 16;154(4):998-1008.e1. Epub 2017 Nov 16.

Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847442PMC
March 2018

Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina.

Authors:
Herui Wang Matthew J Shepard Chao Zhang Lijin Dong Dyvon Walker Liliana Guedez Stanley Park Yujuan Wang Shida Chen Ying Pang Qi Zhang Chun Gao Wai T Wong Henry Wiley Karel Pacak Emily Y Chew Zhengping Zhuang Chi-Chao Chan

Cancer Res 2018 03 4;78(5):1266-1274. Epub 2018 Jan 4.

National Eye Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1718DOI Listing
March 2018

A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2 positive polycythemia vera: a case report.

Authors:
Ying Pang Garima Gupta Chunzhang Yang Herui Wang Thanh-Truc Huynh Ziedulla Abdullaev Svetlana D Pack Melanie J Percy Terence R J Lappin Zhengping Zhuang Karel Pacak

BMC Cancer 2018 03 13;18(1):286. Epub 2018 Mar 13.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s12885-018-4127-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850917PMC
March 2018

A Clinical Roadmap to Investigate the Genetic Basis of Pediatric Pheochromocytoma: Which Genes Should Physicians Think About?

Authors:
Bernardo Dias Pereira Tiago Nunes da Silva Ana Teresa Bernardo Rui César Henrique Vara Luiz Karel Pacak Luísa Mota-Vieira

Int J Endocrinol 2018 20;2018:8470642. Epub 2018 Mar 20.

Unidade de Genética e Patologia Moleculares, Hospital do Divino Espírito Santo de Ponta Delgada (EPER), Av. D. Manuel I, 9500-370 Ponta Delgada, Açores, Portugal.

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http://dx.doi.org/10.1155/2018/8470642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884154PMC
March 2018

Quantitative F-DOPA PET/CT in pheochromocytoma: the relationship between tumor secretion and its biochemical phenotype.

Authors:
Vincent Amodru Carole Guerin Sarkis Delcourt Pauline Romanet Anderson Loundou Bruna Viana Thierry Brue Frédéric Castinetti Frédéric Sebag Karel Pacak David Taïeb

Eur J Nucl Med Mol Imaging 2018 Feb 16;45(2):278-282. Epub 2017 Sep 16.

Department of Nuclear Medicine, La Timone University Hospital, European Center for Research in Medical Imaging, Aix-Marseille University, 264, rue Saint-Pierre, 13385, Marseille, France.

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http://link.springer.com/10.1007/s00259-017-3833-y
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February 2018

Small cell lung cancer tumors and preclinical models display heterogeneity of neuroendocrine phenotypes.

Authors:
Wei Zhang Luc Girard Yu-An Zhang Tomohiro Haruki Mahboubeh Papari-Zareei Victor Stastny Hans K Ghayee Karel Pacak Trudy G Oliver John D Minna Adi F Gazdar

Transl Lung Cancer Res 2018 Feb;7(1):32-49

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.21037/tlcr.2018.02.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835590PMC
February 2018

Preoperative genetic testing in pheochromocytomas and paragangliomas influences the surgical approach and the extent of adrenal surgery.

Authors:
Pavel Nockel Mustapha El Lakis Apostolos Gaitanidis Lily Yang Roxanne Merkel Dhaval Patel Naris Nilubol Tamara Prodanov Karel Pacak Electron Kebebew

Surgery 2018 01 7;163(1):191-196. Epub 2017 Nov 7.

Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, DC. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2017.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736453PMC
January 2018

Genomic Landscape of Pheochromocytoma and Paraganglioma.

Authors:
Ivana Jochmanova Karel Pacak

Trends Cancer 2018 01 26;4(1):6-9. Epub 2017 Nov 26.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819363PMC
January 2018

New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification.

Authors:
Joakim Crona David Taïeb Karel Pacak

Endocr Rev 2017 12;38(6):489-515

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health.

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http://dx.doi.org/10.1210/er.2017-00062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716829PMC
December 2017

The Evolving Role of Succinate in Tumor Metabolism: An F-FDG-Based Study.

Authors:
Philippe Garrigue Aurore Bodin-Hullin Laure Balasse Samantha Fernandez Wassim Essamet Françoise Dignat-George Karel Pacak Benjamin Guillet David Taïeb

J Nucl Med 2017 11 15;58(11):1749-1755. Epub 2017 Jun 15.

Aix-Marseille University, CERIMED, Marseille, France

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.117.192
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November 2017

New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.

Authors:
David Taïeb Karel Pacak

Trends Endocrinol Metab 2017 11 31;28(11):807-817. Epub 2017 Aug 31.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673583PMC
November 2017

HIF-2alpha: Achilles' heel of pseudohypoxic subtype paraganglioma and other related conditions.

Authors:
Sri Harsha Tella David Taïeb Karel Pacak

Eur J Cancer 2017 11 22;86:1-4. Epub 2017 Sep 22.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver NICHD, NIH, Building 10, CRC, Room 1E-3140, 10 Center Drive MSC-1109, Bethesda, MD 20892-1109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287501PMC
November 2017

Recurrent somatic mutations of in isolated cardiac myxoma.

Authors:
Jian He Mingju Sun Enyou Li Yingyong Hou Matthew J Shepard Di Chen Karel Pacak Changsong Wang Lei Guo Zhengping Zhuang Yang Liu

Oncotarget 2017 Nov 19;8(61):103968-103974. Epub 2017 Oct 19.

Scientific Research Center for Translational Medicine, Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://www.oncotarget.com/fulltext/21916
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http://dx.doi.org/10.18632/oncotarget.21916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732779PMC
November 2017

The microenvironment induces collective migration in -silenced mouse pheochromocytoma spheroids.

Authors:
Vanessa D'Antongiovanni Serena Martinelli Susan Richter Letizia Canu Daniele Guasti Tommaso Mello Paolo Romagnoli Karel Pacak Graeme Eisenhofer Massimo Mannelli Elena Rapizzi

Endocr Relat Cancer 2017 10;24(10):555-564

Department of Experimental and Clinical MedicineUniversity of Florence, Florence, Italy

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http://dx.doi.org/10.1530/ERC-17-0212DOI Listing
October 2017

Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice.

Authors:
Petra Bullova Antony Cougnoux Geena Marzouca Juraj Kopacek Karel Pacak

Endocrinology 2017 10;158(10):3097-3108

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1210/en.2017-00592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659682PMC
October 2017

PET Scans With 18F-Fluorodeoxyglucose to Diagnose Adrenal Tumors-Reply.

Authors:
David Taïeb Karel Pacak

JAMA 2017 10;318(16):1614-1615

Section on Medical Neuroendocrinology, National Institute of Child Health and Human Development, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jama.2017.13759DOI Listing
October 2017

Cardiometabolic risk factors and health behaviors in family caregivers.

Authors:
Alyson Ross Robert Shamburek Leslie Wehrlen Stephen D Klagholz Li Yang Elyssa Stoops Sharon L Flynn Alan T Remaley Karel Pacak Nonniekaye Shelburne Margaret F Bevans

PLoS One 2017 4;12(5):e0176408. Epub 2017 May 4.

Nursing Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417518PMC
September 2017

Functional Imaging Signature of Patients Presenting with Polycythemia/Paraganglioma Syndromes.

Authors:
Ingo Janssen Clara C Chen Zhenping Zhuang Corina M Millo Katherine I Wolf Alexander Ling Frank I Lin Karen T Adams Peter Herscovitch Richard A Feelders Antonio T Fojo David Taieb Electron Kebebew Karel Pacak

J Nucl Med 2017 08 23;58(8):1236-1242. Epub 2017 Mar 23.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

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http://dx.doi.org/10.2967/jnumed.116.187690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537614PMC
August 2017

SDHB-related pheochromocytoma and paraganglioma penetrance and genotype-phenotype correlations.

Authors:
Ivana Jochmanova Katherine I Wolf Kathryn S King Joan Nambuba Robert Wesley Victoria Martucci Margarita Raygada Karen T Adams Tamara Prodanov Antonio Tito Fojo Ivica Lazurova Karel Pacak

J Cancer Res Clin Oncol 2017 Aug 3;143(8):1421-1435. Epub 2017 Apr 3.

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, 1E-3140, Bethesda, MD, 20892-1109, USA.

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http://dx.doi.org/10.1007/s00432-017-2397-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505780PMC
August 2017

Mapping of human brown adipose tissue in lean and obese young men.

Authors:
Brooks P Leitner Shan Huang Robert J Brychta Courtney J Duckworth Alison S Baskin Suzanne McGehee Ilan Tal William Dieckmann Garima Gupta Gerald M Kolodny Karel Pacak Peter Herscovitch Aaron M Cypess Kong Y Chen

Proc Natl Acad Sci U S A 2017 08 24;114(32):8649-8654. Epub 2017 Jul 24.

Diabetes, Endocrinology, and Obesity Branch, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1705287114
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559032PMC
August 2017

Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha.

Authors:
Chao Zhang Chunzhang Yang Michael J Feldman Herui Wang Ying Pang Dominic M Maggio Dongwang Zhu Cody L Nesvick Pauline Dmitriev Petra Bullova Prashant Chittiboina Roscoe O Brady Karel Pacak Zhengping Zhuang

Oncotarget 2017 Aug 23;8(34):56110-56125. Epub 2017 May 23.

Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.18125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593548PMC
August 2017

PheoSeq: A Targeted Next-Generation Sequencing Assay for Pheochromocytoma and Paraganglioma Diagnostics.

Authors:
Maria Currás-Freixes Elena Piñeiro-Yañez Cristina Montero-Conde María Apellániz-Ruiz Bruna Calsina Veronika Mancikova Laura Remacha Susan Richter Tonino Ercolino Natalie Rogowski-Lehmann Timo Deutschbein María Calatayud Sonsoles Guadalix Cristina Álvarez-Escolá Cristina Lamas Javier Aller Julia Sastre-Marcos Conxi Lázaro Juan C Galofré Ana Patiño-García Amparo Meoro-Avilés Judith Balmaña-Gelpi Paz De Miguel-Novoa Milagros Balbín Xavier Matías-Guiu Rocío Letón Lucía Inglada-Pérez Rafael Torres-Pérez Juan M Roldán-Romero Cristina Rodríguez-Antona Stephanie M J Fliedner Giuseppe Opocher Karel Pacak Esther Korpershoek Ronald R de Krijger Laurent Vroonen Massimo Mannelli Martin Fassnacht Felix Beuschlein Graeme Eisenhofer Alberto Cascón Fátima Al-Shahrour Mercedes Robledo

J Mol Diagn 2017 07 25;19(4):575-588. Epub 2017 May 25.

Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre, Madrid, Spain; Biomedical Research Networking Center on Rare Diseases (CIBERER), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500830PMC
July 2017

A Large Adrenal Tumor With Marked 18F-Fluorodeoxyglucose Uptake.

Authors:
David Taïeb Frédéric Sebag Karel Pacak

JAMA 2017 Jul;318(1):84-85

Eunice Kennedy Shriver National Institute of Child Health & Human Development, Section on Medical Neuroendocrinology, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jama.2017.6326DOI Listing
July 2017

Metanephrines for Evaluating Palpitations and Flushing.

Authors:
Fady Hannah-Shmouni Karel Pacak Constantine A Stratakis

JAMA 2017 Jul;318(4):385-386

Section on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jama.2017.5926DOI Listing
July 2017

Emerging role of dopamine in neovascularization of pheochromocytoma and paraganglioma.

Authors:
Thamara E Osinga Thera P Links Robin P F Dullaart Karel Pacak Anouk N A van der Horst-Schrivers Michiel N Kerstens Ido P Kema

FASEB J 2017 06 6;31(6):2226-2240. Epub 2017 Mar 6.

Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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http://dx.doi.org/10.1096/fj.201601131RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434646PMC
June 2017

PRECISION MEDICINE IN ADRENAL DISORDERS: THE NEXT GENERATION.

Authors:
Hans K Ghayee Aaron I Vinik Karel Pacak

Endocr Pract 2017 Jun 23;23(6):672-679. Epub 2017 Mar 23.

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http://journals.aace.com/doi/10.4158/EP161716.RA
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June 2017

PRECISION MEDICINE: AN UPDATE ON GENOTYPE/BIOCHEMICAL PHENOTYPE RELATIONSHIPS IN PHEOCHROMOCYTOMA/PARAGANGLIOMA PATIENTS.

Authors:
Garima Gupta Karel Pacak

Endocr Pract 2017 Jun 23;23(6):690-704. Epub 2017 Mar 23.

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http://dx.doi.org/10.4158/EP161718.RADOI Listing
June 2017

Accuracy of recommended sampling and assay methods for the determination of plasma-free and urinary fractionated metanephrines in the diagnosis of pheochromocytoma and paraganglioma: a systematic review.

Authors:
Roland Därr Matthias Kuhn Christoph Bode Stefan R Bornstein Karel Pacak Jacques W M Lenders Graeme Eisenhofer

Endocrine 2017 Jun 12;56(3):495-503. Epub 2017 Apr 12.

Department of Medicine ΙΙI, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany.

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http://dx.doi.org/10.1007/s12020-017-1300-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297899PMC
June 2017

Association between neuroendocrine tumors biomarkers and primary tumor site and disease type based on total Ga-DOTATATE-Avid tumor volume measurements.

Authors:
Amit Tirosh Georgios Z Papadakis Corina Millo Samira M Sadowski Peter Herscovitch Karel Pacak Stephen J Marx Lily Yang Pavel Nockel Jasmine Shell Patience Green Xavier M Keutgen Dhaval Patel Naris Nilubol Electron Kebebew

Eur J Endocrinol 2017 May;176(5):575-582

Endocrine Oncology BranchNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1530/EJE-16-1079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430160PMC
May 2017

Characteristics of Pediatric vs Adult Pheochromocytomas and Paragangliomas.

Authors:
Christina Pamporaki Barbora Hamplova Mirko Peitzsch Aleksander Prejbisz Felix Beuschlein Henri J L M Timmers Martin Fassnacht Barbara Klink Maya Lodish Constantine A Stratakis Angela Huebner Stephanie Fliedner Mercedes Robledo Richard O Sinnott Andrzej Januszewicz Karel Pacak Graeme Eisenhofer

J Clin Endocrinol Metab 2017 Apr;102(4):1122-1132

Departments of Medicine ΙΙI and.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2016-3829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460722PMC
April 2017

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway.

Authors:
Ying Pang Chunzhang Yang Jan Schovanek Herui Wang Petra Bullova Veronika Caisova Garima Gupta Katherine I Wolf Gregg L Semenza Zhengping Zhuang Karel Pacak

Oncotarget 2017 Apr;8(14):22313-22324

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.16224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410225PMC
April 2017

Paraganglioma of the organ of Zuckerkandl associated with a somatic α mutation: A case report.

Authors:
Ahmad Esmaeel Abdullah Carole Guerin Alessio Imperiale Anne Barlier Stéphanie Battini Morgane Pertuit Philippe Roche Wassim Essamet Bernard Vaisse Karel Pacak Fréderic Sebag David Taïeb

Oncol Lett 2017 Mar 12;13(3):1083-1086. Epub 2017 Jan 12.

Department of Nuclear Medicine, La Timone University Hospital, European Center for Research in Medical Imaging, Aix-Marseille University, 13385 Marseille Cedex 5, France.

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http://dx.doi.org/10.3892/ol.2017.5599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403169PMC
March 2017