Publications by authors named "Jussi Paananen"

65Publications

ThETA: transcriptome-driven efficacy estimates for gene-based TArget discovery.

Bioinformatics 2020 Aug;36(14):4214-4216

Institute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland.

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August 2020

Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium.

Mol Ther 2020 07 19;28(7):1731-1740. Epub 2020 Mar 19.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland; Heart Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland. Electronic address:

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July 2020

Publisher Correction: Prioritizing target-disease associations with novel safety and efficacy scoring methods.

Sci Rep 2020 Jan 31;10(1):1885. Epub 2020 Jan 31.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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January 2020

An omics perspective on drug target discovery platforms.

Brief Bioinform 2020 Dec;21(6):1937-1953

Institute of Biomedicine, University of Eastern Finland, Finland.

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December 2020

The Contribution of Staffing to Medication Administration Errors: A Text Mining Analysis of Incident Report Data.

J Nurs Scholarsh 2020 01 25;52(1):113-123. Epub 2019 Nov 25.

Professor, King's College London, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, London, UK.

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January 2020

Identifying risks areas related to medication administrations - text mining analysis using free-text descriptions of incident reports.

BMC Health Serv Res 2019 Nov 4;19(1):791. Epub 2019 Nov 4.

Centre for Medication Safety and Service Quality, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, / UCL School of Pharmacy, London, UK.

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November 2019

Random forest-based imputation outperforms other methods for imputing LC-MS metabolomics data: a comparative study.

BMC Bioinformatics 2019 Oct 11;20(1):492. Epub 2019 Oct 11.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, FI-70211, Kuopio, Finland.

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October 2019

Prioritizing target-disease associations with novel safety and efficacy scoring methods.

Sci Rep 2019 07 8;9(1):9852. Epub 2019 Jul 8.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.

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July 2019

Text Mining Method for Studying Medication Administration Incidents and Nurse-Staffing Contributing Factors: A Pilot Study.

Comput Inform Nurs 2019 Jul;37(7):357-365

Author Affiliations: Department of Nursing Science, University of Eastern Finland, Kuopio (Drs Härkänen and Vehviläinen-Julkunen); and Kuopio University Hospital (Dr Vehviläinen-Julkunen), Finland; Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, United Kingdom (Mr Murrells and Dr Rafferty); and Institute of Biomedicine, University of Eastern Finland, Kuopio (Dr Paananen).

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July 2019

Varanto: variant enrichment analysis and annotation.

Bioinformatics 2019 09;35(17):3154-3156

Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

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September 2019

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.

Acta Neuropathol Commun 2018 02 27;6(1):17. Epub 2018 Feb 27.

Epilepsy Research Laboratory, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FIN-70211, Kuopio, Finland.

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February 2018

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia.

Hypertension 2018 01 4;71(1):95-102. Epub 2017 Dec 4.

From Medical and Clinical Genetics, Helsinki University Hospital (T.K., S.U., M.M.K., H.L.), Obstetrics and Gynaecology, Helsinki University Hospital (M.M.K., S.H.), Abdominal Center, Nephrology, Helsinki University Hospital (I.T.), Clinical Chemistry and Hematology, Helsinki University Hospital (P.L.), Children's Hospital, Helsinki University Central Hospital (E.K.), Molecular Neurology Research Program (J.K.), and Institute for Molecular Medicine Finland, HiLIFE Unit (H.L.), University of Helsinki, Finland; Department of Obstetrics and Gynecology, South-Karelia Central Hospital, Lappeenranta, Finland (M.M.K.); Bioinformatics Center, University of Eastern Finland, Kuopio (J.P.); Department of Clinical Chemistry, University of Turku (K.P.), and Saske Screening Center, Turku University Central Hospital (K.P.), Finland; Eastern Finland Laboratory Centre, Kuopio (K.P., J.R.); Minerva Foundation Institute for Medical Research, Helsinki, Finland (I.T., P.L.); Chronic Disease Prevention Unit (E.K.) and Department of Government Services (A.P.), National Institute for Health and Welfare, Helsinki, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Finland (E.K., A.P.); Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden (J.K.); Folkhälsan Institute of Genetics, Helsinki, Finland (J.K.); Department of Medical and Molecular Genetics, King's College London, United Kingdom (J.K.); Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (K.K.); Faculty of Medicine and Life Sciences, University of Tampere, Finland (H.L.); and Department of Obstetrics and Gynecology, Tampere University Hospital, Finland (H.L.).

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January 2018

Decreased plasma β-amyloid in the Alzheimer's disease APP A673T variant carriers.

Ann Neurol 2017 Jul;82(1):128-132

Institute of Biomedicine University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland.

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July 2017

Common data elements and data management: Remedy to cure underpowered preclinical studies.

Epilepsy Res 2017 01 22;129:87-90. Epub 2016 Nov 22.

Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland. Electronic address:

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January 2017

Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44, and S100a4 as Treatment Targets.

Sci Rep 2016 08 17;6:31570. Epub 2016 Aug 17.

Epilepsy Research Laboratory, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FIN-70211 Kuopio, Finland.

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August 2016

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.

J Cell Sci 2016 06 15;129(11):2224-38. Epub 2016 Apr 15.

Institute of Biomedicine, School of Medicine, University of Eastern Finland, 70211 Kuopio, Finland Institute of Clinical Medicine - Neurology, School of Medicine, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland

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June 2016

The effects of a 2-year individualized and family-based lifestyle intervention on physical activity, sedentary behavior and diet in children.

Prev Med 2016 06 23;87:81-88. Epub 2016 Feb 23.

Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Electronic address:

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June 2016

Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study.

Pediatr Res 2016 05 12;79(5):684-8. Epub 2016 Jan 12.

Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.

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May 2016

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome.

Am J Clin Nutr 2015 Jan 19;101(1):228-39. Epub 2014 Nov 19.

From the Institute of Public Health and Clinical Nutrition (MK, J Paananen, VdM, US, J Pihlajamäki, KSP, and MU) and the Institute of Biomedicine (CC), University of Eastern Finland, Kuopio, Finland; the Institute of Clinical Medicine, Clinical Nutrition (US and J Pihlajamäki) and Research Unit (MU), Kuopio University Hospital, Kuopio, Finland; the Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo, Norway, and Akershus University College of Applied Sciences, Oslo, Norway (SMU and MM); the Department of Medicine (H7), Karolinska Institute, Stockholm, Sweden (ID, PA, ED, and ES); the Unit for Nutrition Research, University of Iceland and Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland (IG and IT); Biomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden (LC and BÅ); the Departments of Endocrinology (ML-O) and Clinical Nutrition (BÅ), Skåne University Hospital, Lund, Sweden; the Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden (FR and UR); the Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, and Medical Research Center, Oulu University Hospital, Oulu, Finland (MJS and JH); University of Copenhagen, Faculty of Science, Department of Human Nutrition, Copenhagen, Denmark (LOD); Institute of Biomedicine, University of Oulu, Oulu, Finland (K-HH); the Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark (KH and LB); and VTT Technical Research Centre of Finland, Espoo, Finland (KSP).

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January 2015

The postprandial plasma rye fingerprint includes benzoxazinoid-derived phenylacetamide sulfates.

J Nutr 2014 Jul 8;144(7):1016-22. Epub 2014 May 8.

Institute of Public Health and Clinical Nutrition and VTT Technical Research Centre of Finland, VTT, Espoo, Finland; and.

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July 2014

Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet).

PLoS One 2014 28;9(2):e90352. Epub 2014 Feb 28.

Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland ; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland.

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October 2014

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.

Diabetes 2013 Oct 8;62(10):3589-98. Epub 2013 Jul 8.

Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.

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October 2013

Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study.

Br J Nutr 2013 Nov 14;110(10):1856-65. Epub 2013 May 14.

Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, PO Box 1627, FI-70211 Kuopio, Finland.

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November 2013

Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population.

Neurosci Lett 2012 Apr 25;513(2):233-7. Epub 2012 Feb 25.

Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland.

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April 2012

Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study.

Br J Nutr 2012 Nov 23;108(10):1859-65. Epub 2012 Jan 23.

Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, PO Box 1627, FI-70211 Kuopio, Finland.

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November 2012

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

Amino Acids 2012 Feb 4;42(2-3):427-40. Epub 2011 Aug 4.

Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, 70211, Kuopio, Finland.

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February 2012

TAFFEL: Independent Enrichment Analysis of gene sets.

BMC Bioinformatics 2011 May 19;12:171. Epub 2011 May 19.

Department of Biosciences, University of Eastern Finland, PO Box 1627, FIN-70211 Kuopio, Finland.

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May 2011

Varietas: a functional variation database portal.

Database (Oxford) 2010 Jul 29;2010:baq016. Epub 2010 Jul 29.

Laboratory of Functional Genomics and Bioinformatics, Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences and Biocenter Finland, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio, Finland.

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July 2010

FORG3D: force-directed 3D graph editor for visualization of integrated genome scale data.

BMC Syst Biol 2009 Feb 24;3:26. Epub 2009 Feb 24.

A,I, Virtanen Institute of Molecular Sciences, University of Kuopio, Kuopio, Finland.

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February 2009

CROPPER: a metagene creator resource for cross-platform and cross-species compendium studies.

BMC Bioinformatics 2006 Sep 22;7:418. Epub 2006 Sep 22.

Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, Kuopio, Finland.

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September 2006

Analysis of microarray studies performed in the neurosciences.

J Mol Neurosci 2005 ;27(3):261-8

Department of Neuroscience, A. I. Virtanen Institute, Finland.

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February 2006