Junke Zheng

Junke Zheng

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Junke Zheng

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Metabolic Regulations in Hematopoietic Stem Cells.

Adv Exp Med Biol 2019 ;1143:59-74

Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1007/978-981-13-7342-8_3DOI Listing
September 2019

Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.

Cell Metab 2019 04 20;29(4):950-965.e6. Epub 2018 Dec 20.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China; Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.11.013DOI Listing
April 2019

Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty.

EMBO J 2018 09 23;37(17). Epub 2018 Jul 23.

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

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http://dx.doi.org/10.15252/embj.201898984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120660PMC
September 2018

JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.

J Clin Invest 2018 05 26;128(5):1737-1751. Epub 2018 Mar 26.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1172/JCI93198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919829PMC
May 2018

PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.

Cell Rep 2018 05;23(5):1461-1475

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.140DOI Listing
May 2018

Hypothalamic-Pituitary-Gonadal Axis in Aging Men and Women: Increasing Total Testosterone in Aging Men.

Neuroendocrinology 2017 14;104(3):291-301. Epub 2016 May 14.

Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1159/000446656DOI Listing
May 2017

CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27 signaling.

Haematologica 2017 04 25;102(4):707-718. Epub 2017 Jan 25.

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, China

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http://dx.doi.org/10.3324/haematol.2016.151555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395111PMC
April 2017

CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling.

J Hematol Oncol 2016 11 17;9(1):124. Epub 2016 Nov 17.

Department of Hematology, Shanghai Tongji Hospital, Shanghai Tongji University School of Medicine, Shanghai, China; Hongqiao International Institute of Medicine,Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1186/s13045-016-0350-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114730PMC
November 2016

Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes.

J Pathol 2016 09;240(1):108-19

Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1002/path.4762DOI Listing
September 2016

ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.

Oncotarget 2016 Jun;7(25):38347-38358

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.18632/oncotarget.9520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122394PMC
June 2016

Inhibitory leukocyte immunoglobulin-like receptors in cancer development.

Sci China Life Sci 2015 Dec 14;58(12):1216-25. Epub 2015 Nov 14.

Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.

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http://dx.doi.org/10.1007/s11427-015-4925-1DOI Listing
December 2015

Novel source of human hematopoietic stem cells from peritoneal dialysis effluents.

Stem Cell Res 2015 Sep 16;15(2):299-304. Epub 2015 Jul 16.

Department of Bioengineering, University of Texas at Arlington, PO Box 19138, Arlington, TX 76019, United States; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2015.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600647PMC
September 2015

ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells.

Oncotarget 2015 Aug;6(25):21004-15

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.18632/oncotarget.4217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673246PMC
August 2015

Hypoxic metabolism in human hematopoietic stem cells.

Cell Biosci 2015 17;5:39. Epub 2015 Jul 17.

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China.

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http://dx.doi.org/10.1186/s13578-015-0020-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517642PMC
July 2015

Metabolic characterization of hematopoietic stem cells.

Methods Mol Biol 2014 ;1185:155-64

Department of Education, and Texas Institute of Biotechnology, Education and Research, North American University, 3203 N. Sam Houston Pkwy W, Houston, TX, 77038, USA,

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http://dx.doi.org/10.1007/978-1-4939-1133-2_10DOI Listing
March 2015

IGF-IR determines the fates of BCR/ABL leukemia.

J Hematol Oncol 2015 Feb 4;8. Epub 2015 Feb 4.

Taishan Scholar Immunology Program, Binzhou Medical University, 264003, Yantai, Shandong, China.

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http://dx.doi.org/10.1186/s13045-015-0106-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320836PMC
February 2015

Paired immunoglobulin-like receptor B regulates platelet activation.

Blood 2014 Oct 29;124(15):2421-30. Epub 2014 Jul 29.

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, and.

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http://dx.doi.org/10.1182/blood-2014-03-557645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192752PMC
October 2014

A motif in LILRB2 critical for Angptl2 binding and activation.

Blood 2014 Aug 4;124(6):924-35. Epub 2014 Jun 4.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX; Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-01-54
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http://dx.doi.org/10.1182/blood-2014-01-549162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126332PMC
August 2014

Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.

Blood 2014 Feb 2;123(7):992-1001. Epub 2014 Jan 2.

Department of Pathophysiology, Shanghai Universities E-Institute for Chemical Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

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http://dx.doi.org/10.1182/blood-2013-04-498469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924932PMC
February 2014

IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells.

J Hematol Oncol 2013 Oct 8;6(1):72. Epub 2013 Oct 8.

Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390, TX, USA.

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http://dx.doi.org/10.1186/1756-8722-6-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851819PMC
October 2013

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells.

Blood 2012 Dec 20;120(25):4963-72. Epub 2012 Sep 20.

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1182/blood-2012-05-432260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525021PMC
December 2012

A new chapter: hematopoietic stem cells are direct players in immunity.

Cell Biosci 2011 Oct 6;1:33. Epub 2011 Oct 6.

Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1186/2045-3701-1-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198676PMC
October 2011

IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells.

Blood 2011 Sep 5;118(12):3236-43. Epub 2011 Aug 5.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1182/blood-2011-01-331876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179393PMC
September 2011

Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.

Cell Stem Cell 2011 Aug;9(2):119-30

Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.stem.2011.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151486PMC
August 2011

Components of the hematopoietic compartments in tumor stroma and tumor-bearing mice.

PLoS One 2011 Mar 25;6(3):e18054. Epub 2011 Mar 25.

Department of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018054PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064668PMC
March 2011

Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche.

Blood 2011 Jan 19;117(2):470-9. Epub 2010 Oct 19.

Department of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1182/blood-2010-06-291716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031476PMC
January 2011

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

Cell Stem Cell 2010 Sep;7(3):380-90

Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.stem.2010.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159713PMC
September 2010

Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.

Leuk Res 2010 Aug 17;34(8):1107-9. Epub 2010 Mar 17.

Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9073, USA.

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http://dx.doi.org/10.1016/j.leukres.2010.02.029DOI Listing
August 2010

Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells.

Stem Cells 2008 Jun 27;26(6):1628-35. Epub 2008 Mar 27.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1634/stemcells.2008-0064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678056PMC
June 2008

Erasure of the paternal transcription program during spermiogenesis: the first step in the reprogramming of sperm chromatin for zygotic development.

Dev Dyn 2008 May;237(5):1463-76

Center for Developmental Biology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1002/dvdy.21499DOI Listing
May 2008

Potential treatment of liver-related disorders with in vitro expanded human liver precursors.

Differentiation 2007 Dec 9;75(10):928-38. Epub 2007 May 9.

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1111/j.1432-0436.2007.00184.xDOI Listing
December 2007

Differentiation of liver cells from human primordial germ cell-derived progenitors.

Differentiation 2007 Jun 5;75(5):350-9. Epub 2007 Feb 5.

Center for Developmental Biology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China.

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http://dx.doi.org/10.1111/j.1432-0436.2006.00151.xDOI Listing
June 2007

Nuclear reprogramming: the strategy used in normal development is also used in somatic cell nuclear transfer and parthenogenesis.

Cell Res 2007 Feb;17(2):135-50

Program for Graduation Studies, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://www.nature.com/articles/cr20072
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http://dx.doi.org/10.1038/cr.2007.2DOI Listing
February 2007

Nuclear reprogramming: the zygotic transcription program is established through an "erase-and-rebuild" strategy.

Cell Res 2007 Feb;17(2):117-34

Program for Graduation Studies, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/cr.2007.1DOI Listing
February 2007