Publications

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.
Cell Metab 2018 Feb 11;27(2):428-438.e5. Epub 2018 Jan 11.
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.
Circ Res 2017 Dec 19;121(12):1370-1378. Epub 2017 Sep 19.
From the Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (L.X.L., F.D.); Corrigan Minehan Heart Center, Massachusetts General Hospital, Boston (L.X.L., F.D., M.C.C., S.D., A.R.); Division of Cardiovascular Disease, University of Alabama at Birmingham (G.C.R.); Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.Y., J.L., S.W., M.M., Z.A.); Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ (W.L., C.J., J.D.R.); and Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Germany (M.H., B.K.F.).

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
Cell 2017 Dec 16;171(7):1545-1558.e18. Epub 2017 Nov 16.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.
Am J Hum Genet 2017 Oct 21;101(4):489-502. Epub 2017 Sep 21.
Department of Genetics, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.
Clin Cancer Res 2017 Sep 13;23(18):5639-5647. Epub 2017 Jun 13.
Abramson Cancer Center, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.


Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle.
Mol Cell Endocrinol 2017 May 26. Epub 2017 May 26.
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:

Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion.
Nat Med 2017 Feb 19;23(2):223-234. Epub 2016 Dec 19.
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.


Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.
Cell Metab 2016 Dec 17;24(6):863-874. Epub 2016 Nov 17.
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.
Hypoxia (Auckl) 2016;4:15-27. Epub 2016 Mar 4.
Ludwig Institute for Cancer Research Ltd, Stockholm, Sweden; Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.
Mol Cell 2016 Sep 25;63(5):811-26. Epub 2016 Aug 25.
Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA. Electronic address:

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
Cell Metab 2016 Aug;24(2):269-82
Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:


Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.
Cell Metab 2016 Jun 19;23(6):1140-1153. Epub 2016 May 19.
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.
Cell Metab 2016 Jun 26;23(6):1154-1166. Epub 2016 May 26.
Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:




Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.
Cancer Res 2015 Aug 25;75(16):3355-64. Epub 2015 Jun 25.
Department of Pathology and Translational Molecular Pathology, Sheikh Ahmad Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.


Serine catabolism regulates mitochondrial redox control during hypoxia.
Cancer Discov 2014 Dec 3;4(12):1406-17. Epub 2014 Sep 3.
Cancer Biology and Genetics Program and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Mol Cell 2014 Oct 18;56(2):205-18. Epub 2014 Sep 18.
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

Enzyme clustering accelerates processing of intermediates through metabolic channeling.
Nat Biotechnol 2014 Oct 28;32(10):1011-8. Epub 2014 Sep 28.
1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity.
Mol Cell 2014 Sep 28;55(6):916-930. Epub 2014 Aug 28.
Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, 08854. Electronic address:

Autophagy is required for glucose homeostasis and lung tumor maintenance.
Cancer Discov 2014 Aug 29;4(8):914-27. Epub 2014 May 29.
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey. Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey.

Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.
Cell Rep 2013 Dec 19;5(6):1725-36. Epub 2013 Dec 19.
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, QB3, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, San Francisco, CA 94158, USA. Electronic address:



Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
Nature 2013 May 12;497(7451):633-7. Epub 2013 May 12.
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016, USA.


Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.
Genes Dev 2016 08 11;30(15):1704-17. Epub 2016 Aug 11.
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA.


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