Joshua D Rabinowitz

Joshua D Rabinowitz

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Joshua D Rabinowitz

Joshua D Rabinowitz

Publications by authors named "Joshua D Rabinowitz"

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100Publications

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The Tumor Metabolic Microenvironment: Lessons from Lactate.

Cancer Res 2019 Jun 6. Epub 2019 Jun 6.

Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, New Jersey.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3726DOI Listing
June 2019

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism.

Cell Rep 2019 Jun;27(11):3359-3370.e7

The Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.030DOI Listing
June 2019

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.

Cell Metab 2019 May 17. Epub 2019 May 17.

Institute for Diabetes, Obesity & Metabolism, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.05.005DOI Listing
May 2019

Serine Metabolism Supports Macrophage IL-1β Production.

Cell Metab 2019 Apr 14;29(4):1003-1011.e4. Epub 2019 Feb 14.

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447453PMC
April 2019

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.

Nat Metab 2019 Mar 11;1:404-415. Epub 2019 Mar 11.

Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489125PMC
March 2019

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids.

Cell Metab 2019 Feb 15;29(2):417-429.e4. Epub 2018 Nov 15.

Perelman School of Medicine, University of Pennsylvania, 3400 Civic Boulevard, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183064
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http://dx.doi.org/10.1016/j.cmet.2018.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365191PMC
February 2019

Peak Annotation and Verification Engine for Untargeted LC-MS Metabolomics.

Anal Chem 2019 Feb 10;91(3):1838-1846. Epub 2019 Jan 10.

Lewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b03132
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http://dx.doi.org/10.1021/acs.analchem.8b03132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501219PMC
February 2019

Minor Isozymes Tailor Yeast Metabolism to Carbon Availability.

mSystems 2019 Jan-Feb;4(1). Epub 2019 Feb 26.

Department of Chemistry, Princeton University, Princeton, New Jersey, USA.

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http://msystems.asm.org/lookup/doi/10.1128/mSystems.00170-18
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http://dx.doi.org/10.1128/mSystems.00170-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392091PMC
February 2019

Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase.

ACS Chem Biol 2018 10 4;13(10):3011-3020. Epub 2018 Oct 4.

Lewis Sigler Institute for Integrative Genomics , Princeton University , Princeton , New Jersey 08544 , United States.

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http://pubs.acs.org/doi/10.1021/acschembio.8b00804
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http://dx.doi.org/10.1021/acschembio.8b00804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466636PMC
October 2018

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Nat Med 2018 Sep;24(9):1482

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/s41591-018-0047-1DOI Listing
September 2018

5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination.

Mol Genet Metab 2018 09 15;125(1-2):118-126. Epub 2018 Jun 15.

Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183011
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http://dx.doi.org/10.1016/j.ymgme.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557438PMC
September 2018

Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle.

Mol Cell Endocrinol 2018 08 26;471:22-32. Epub 2017 May 26.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702591PMC
August 2018

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.

Cell 2018 08 26;174(4):831-842.e12. Epub 2018 Jul 26.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086765PMC
August 2018

An unexpected trigger for calorie burning in brown fat.

Nature 2018 08;560(7716):38-39

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http://dx.doi.org/10.1038/d41586-018-05619-7DOI Listing
August 2018

Four Key Steps Control Glycolytic Flux in Mammalian Cells.

Cell Syst 2018 Jul 27;7(1):49-62.e8. Epub 2018 Jun 27.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062487PMC
July 2018

Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.

J Neurochem 2018 06 16;145(5):362-373. Epub 2018 Apr 16.

Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.14319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288810PMC
June 2018

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.

Elife 2018 06 12;7. Epub 2018 Jun 12.

Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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https://elifesciences.org/articles/33246
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http://dx.doi.org/10.7554/eLife.33246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013257PMC
June 2018

Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Nat Med 2018 05 26;24(4):518-524. Epub 2018 Mar 26.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nm.4514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089616PMC
May 2018

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

Cell Metab 2018 May;27(5):1067-1080.e5

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Diabetes Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932087PMC
May 2018

Metabolomics and Isotope Tracing.

Cell 2018 05;173(4):822-837

Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Washington Rd, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034115PMC
May 2018

Ribosomes on the night shift.

Science 2018 05;360(6390):710-711

Department of Chemistry and Lewis-Sigler Institute, Princeton University, Princeton, NJ, USA.

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http://dx.doi.org/10.1126/science.aat7121DOI Listing
May 2018

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.

Cell Metab 2018 02 11;27(2):428-438.e5. Epub 2018 Jan 11.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803449PMC
February 2018

Mitochondrial translation requires folate-dependent tRNA methylation.

Nature 2018 02 24;554(7690):128-132. Epub 2018 Jan 24.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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http://www.nature.com/doifinder/10.1038/nature25460
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http://dx.doi.org/10.1038/nature25460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020024PMC
February 2018

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.

Cell Metab 2018 02;27(2):351-361.e3

Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131173072
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http://dx.doi.org/10.1016/j.cmet.2017.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032988PMC
February 2018

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors.

Antioxid Redox Signal 2018 Jan 19;28(3):167-179. Epub 2017 Jul 19.

Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University , Princeton, New Jersey.

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http://dx.doi.org/10.1089/ars.2017.7014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737638PMC
January 2018

PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.

Circ Res 2017 Dec 19;121(12):1370-1378. Epub 2017 Sep 19.

From the Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (L.X.L., F.D.); Corrigan Minehan Heart Center, Massachusetts General Hospital, Boston (L.X.L., F.D., M.C.C., S.D., A.R.); Division of Cardiovascular Disease, University of Alabama at Birmingham (G.C.R.); Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.Y., J.L., S.W., M.M., Z.A.); Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ (W.L., C.J., J.D.R.); and Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Germany (M.H., B.K.F.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722682PMC
December 2017

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Cell 2017 Dec 16;171(7):1545-1558.e18. Epub 2017 Nov 16.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920692PMC
December 2017

Glucose feeds the TCA cycle via circulating lactate.

Nature 2017 11 18;551(7678):115-118. Epub 2017 Oct 18.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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http://dx.doi.org/10.1038/nature24057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898814PMC
November 2017

An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate.

Anal Bioanal Chem 2017 Oct 10;409(25):5955-5964. Epub 2017 Aug 10.

Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.

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http://dx.doi.org/10.1007/s00216-017-0514-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737010PMC
October 2017

Chemical Basis for Deuterium Labeling of Fat and NADPH.

J Am Chem Soc 2017 10 4;139(41):14368-14371. Epub 2017 Oct 4.

Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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http://dx.doi.org/10.1021/jacs.7b08012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748894PMC
October 2017

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.

Am J Hum Genet 2017 Oct 21;101(4):489-502. Epub 2017 Sep 21.

Department of Genetics, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630162PMC
October 2017

A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae.

PLoS One 2017 17;12(5):e0176085. Epub 2017 May 17.

Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176085PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435139PMC
September 2017

Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.

Clin Cancer Res 2017 Sep 13;23(18):5639-5647. Epub 2017 Jun 13.

Abramson Cancer Center, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540110PMC
September 2017

mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.

Mol Cell 2017 Sep 14;67(6):936-946.e5. Epub 2017 Sep 14.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612669PMC
September 2017

Dynamic Control of dNTP Synthesis in Early Embryos.

Dev Cell 2017 08 20;42(3):301-308.e3. Epub 2017 Jul 20.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630127PMC
August 2017

Metabolite Spectral Accuracy on Orbitraps.

Anal Chem 2017 06 18;89(11):5940-5948. Epub 2017 May 18.

Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University , Washington Road, Princeton, New Jersey 08544, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b00396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748891PMC
June 2017

Metabolite Measurement: Pitfalls to Avoid and Practices to Follow.

Annu Rev Biochem 2017 06;86:277-304

Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, New Jersey 08544; email:

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http://dx.doi.org/10.1146/annurev-biochem-061516-044952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734093PMC
June 2017

One-Carbon Metabolism in Health and Disease.

Cell Metab 2017 01 15;25(1):27-42. Epub 2016 Sep 15.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353360PMC
January 2017

Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.

Cell Metab 2016 12 17;24(6):863-874. Epub 2016 Nov 17.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159233PMC
December 2016

Systems-level analysis of mechanisms regulating yeast metabolic flux.

Science 2016 10 27;354(6311). Epub 2016 Oct 27.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

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http://dx.doi.org/10.1126/science.aaf2786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414049PMC
October 2016

Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis.

ACS Chem Biol 2016 09 7;11(9):2420-7. Epub 2016 Jul 7.

Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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http://dx.doi.org/10.1021/acschembio.6b00290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317044PMC
September 2016

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.

Genes Dev 2016 08 11;30(15):1704-17. Epub 2016 Aug 11.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1101/gad.283416.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002976PMC
August 2016

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage.

Nat Chem Biol 2016 07 2;12(7):482-9. Epub 2016 May 2.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1038/nchembio.2077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912430PMC
July 2016

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

Cell Metab 2016 06 19;23(6):1140-1153. Epub 2016 May 19.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909566PMC
June 2016

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.

Cell Metab 2016 Jun 26;23(6):1154-1166. Epub 2016 May 26.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909537PMC
June 2016

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage.

Nat Chem Biol 2016 May 21;12(5):345-52. Epub 2016 Mar 21.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1038/nchembio.2047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891982PMC
May 2016

Partners in the Warburg effect.

Elife 2016 04 13;5:e15938. Epub 2016 Apr 13.

Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.

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http://dx.doi.org/10.7554/eLife.15938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841767PMC
April 2016

Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP.

Sci Rep 2016 04 25;6:24834. Epub 2016 Apr 25.

Dept. of Molecular Cell Biology, Weizmann Institute of Science, Rehovot Israel 76100.

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http://dx.doi.org/10.1038/srep24834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843011PMC
April 2016

Mitochondria and Cancer.

Mol Cell 2016 Mar;61(5):667-676

Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765160009
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http://dx.doi.org/10.1016/j.molcel.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779192PMC
March 2016

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.

Hypoxia (Auckl) 2016;4:15-27. Epub 2016 Mar 4.

Ludwig Institute for Cancer Research Ltd, Stockholm, Sweden; Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2147/HP.S96366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981084PMC
March 2016

Metabolic control of methylation and acetylation.

Curr Opin Chem Biol 2016 Feb 28;30:52-60. Epub 2015 Nov 28.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2015.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731252PMC
February 2016

RNA Futile Cycling in Model Persisters Derived from MazF Accumulation.

MBio 2015 Nov 17;6(6):e01588-15. Epub 2015 Nov 17.

Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA

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http://dx.doi.org/10.1128/mBio.01588-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659464PMC
November 2015

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.

Cancer Res 2015 Aug 25;75(16):3355-64. Epub 2015 Jun 25.

Department of Pathology and Translational Molecular Pathology, Sheikh Ahmad Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537812PMC
August 2015

Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.

Proc Natl Acad Sci U S A 2015 May 27;112(19):6116-21. Epub 2015 Apr 27.

Lewis-Sigler Institute for Integrative Genomics and Departments of Molecular Biology and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1506289112
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http://dx.doi.org/10.1073/pnas.1506289112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434743PMC
May 2015

Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication.

Cell Rep 2015 Mar 26;10(8):1375-85. Epub 2015 Feb 26.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354725PMC
March 2015

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

ACS Chem Biol 2015 Feb 18;10(2):510-6. Epub 2014 Nov 18.

Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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http://dx.doi.org/10.1021/cb500683cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340346PMC
February 2015

Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomics.

Anal Chem 2015 Feb 27;87(4):2273-81. Epub 2015 Jan 27.

Lewis Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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http://dx.doi.org/10.1021/ac504118yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354698PMC
February 2015

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate.

Cancer Metab 2014 11;2:23. Epub 2014 Dec 11.

Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544 USA.

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http://dx.doi.org/10.1186/2049-3002-2-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322440PMC
February 2015

ZMP: a master regulator of one-carbon metabolism.

Mol Cell 2015 Jan;57(2):203-4

The Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470396PMC
January 2015

Serine catabolism regulates mitochondrial redox control during hypoxia.

Cancer Discov 2014 Dec 3;4(12):1406-17. Epub 2014 Sep 3.

Cancer Biology and Genetics Program and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258153PMC
December 2014

Estrogen-related receptor α is required for efficient human cytomegalovirus replication.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5706-15. Epub 2014 Dec 15.

Departments of Molecular Biology and

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http://dx.doi.org/10.1073/pnas.1422361112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536PMC
December 2014

Enzyme clustering accelerates processing of intermediates through metabolic channeling.

Nat Biotechnol 2014 Oct 28;32(10):1011-8. Epub 2014 Sep 28.

1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1038/nbt.3018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666537PMC
October 2014

Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity.

Mol Cell 2014 Sep 28;55(6):916-930. Epub 2014 Aug 28.

Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, 08854. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169768PMC
September 2014

Autophagy is required for glucose homeostasis and lung tumor maintenance.

Cancer Discov 2014 Aug 29;4(8):914-27. Epub 2014 May 29.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey. Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125614PMC
August 2014

Quantitative flux analysis reveals folate-dependent NADPH production.

Nature 2014 Jun 4;510(7504):298-302. Epub 2014 May 4.

Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA.

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http://dx.doi.org/10.1038/nature13236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104482PMC
June 2014

Genetic basis of metabolome variation in yeast.

PLoS Genet 2014 Mar 6;10(3):e1004142. Epub 2014 Mar 6.

Departments of Human Genetics and Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California, United States of America; Howard Hughes Medical Institute, UCLA, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945093PMC
March 2014

Quantitation of cellular metabolic fluxes of methionine.

Anal Chem 2014 Feb 16;86(3):1583-91. Epub 2014 Jan 16.

Dept. of Computer Science, Technion - Israel Institute of Technology, Haifa 32000, Israel.

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http://dx.doi.org/10.1021/ac4032093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060246PMC
February 2014

Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny.

PLoS Pathog 2013 16;9(5):e1003333. Epub 2013 May 16.

Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656100PMC
December 2013

Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection.

Proc Natl Acad Sci U S A 2013 Dec 2;110(51):E5006-15. Epub 2013 Dec 2.

Departments of Molecular Biology and Chemistry, and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.

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http://dx.doi.org/10.1073/pnas.1321305110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870743PMC
December 2013

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.

Mol Syst Biol 2013 Dec 3;9:712. Epub 2013 Dec 3.

Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

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http://msb.embopress.org/cgi/doi/10.1038/msb.2013.65
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http://dx.doi.org/10.1038/msb.2013.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882799PMC
December 2013

Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.

Cell Rep 2013 Dec 19;5(6):1725-36. Epub 2013 Dec 19.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, QB3, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, San Francisco, CA 94158, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130072
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http://dx.doi.org/10.1016/j.celrep.2013.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007695PMC
December 2013

Pyrimidine homeostasis is accomplished by directed overflow metabolism.

Nature 2013 Aug 31;500(7461):237-41. Epub 2013 Jul 31.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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http://dx.doi.org/10.1038/nature12445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470420PMC
August 2013