Joshua D Rabinowitz

Joshua D Rabinowitz

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Joshua D Rabinowitz

Joshua D Rabinowitz

Publications by authors named "Joshua D Rabinowitz"

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100Publications

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Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle.

Mol Cell Endocrinol 2018 Aug 26;471:22-32. Epub 2017 May 26.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:

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August 2018

Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions.

Nat Microbiol 2018 Aug 23;3(8):939-947. Epub 2018 Jul 23.

Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

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August 2018

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.

Cell 2018 Aug 26;174(4):831-842.e12. Epub 2018 Jul 26.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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August 2018

Four Key Steps Control Glycolytic Flux in Mammalian Cells.

Cell Syst 2018 Jul 27;7(1):49-62.e8. Epub 2018 Jun 27.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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July 2018

Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.

J Neurochem 2018 Jun 16;145(5):362-373. Epub 2018 Apr 16.

Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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June 2018

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.

Elife 2018 Jun 12;7. Epub 2018 Jun 12.

Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

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June 2018

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Nat Med 2018 Jun 12. Epub 2018 Jun 12.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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June 2018

5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination.

Mol Genet Metab 2018 Jun 15. Epub 2018 Jun 15.

Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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June 2018

Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Nat Med 2018 May 26;24(4):518-524. Epub 2018 Mar 26.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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May 2018

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

Cell Metab 2018 May;27(5):1067-1080.e5

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Diabetes Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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May 2018

Metabolomics and Isotope Tracing.

Cell 2018 May;173(4):822-837

Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Washington Rd, Princeton, NJ 08544, USA. Electronic address:

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May 2018

Ribosomes on the night shift.

Science 2018 05;360(6390):710-711

Department of Chemistry and Lewis-Sigler Institute, Princeton University, Princeton, NJ, USA.

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May 2018

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.

Cell Metab 2018 Feb 11;27(2):428-438.e5. Epub 2018 Jan 11.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:

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February 2018

Mitochondrial translation requires folate-dependent tRNA methylation.

Nature 2018 02 24;554(7690):128-132. Epub 2018 Jan 24.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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February 2018

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.

Cell Metab 2018 Feb;27(2):351-361.e3

Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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February 2018

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors.

Antioxid Redox Signal 2018 Jan 19;28(3):167-179. Epub 2017 Jul 19.

Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University , Princeton, New Jersey.

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January 2018

PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.

Circ Res 2017 Dec 19;121(12):1370-1378. Epub 2017 Sep 19.

From the Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (L.X.L., F.D.); Corrigan Minehan Heart Center, Massachusetts General Hospital, Boston (L.X.L., F.D., M.C.C., S.D., A.R.); Division of Cardiovascular Disease, University of Alabama at Birmingham (G.C.R.); Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.Y., J.L., S.W., M.M., Z.A.); Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ (W.L., C.J., J.D.R.); and Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Germany (M.H., B.K.F.).

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December 2017

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Cell 2017 Dec 16;171(7):1545-1558.e18. Epub 2017 Nov 16.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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December 2017

Glucose feeds the TCA cycle via circulating lactate.

Nature 2017 11 18;551(7678):115-118. Epub 2017 Oct 18.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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November 2017

An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate.

Anal Bioanal Chem 2017 Oct 10;409(25):5955-5964. Epub 2017 Aug 10.

Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA.

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October 2017

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate.

Nat Chem Biol 2017 Oct 7;13(10):1081-1087. Epub 2017 Aug 7.

Department of Chemistry, Princeton University, Princeton, New Jersey, USA.

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October 2017

Chemical Basis for Deuterium Labeling of Fat and NADPH.

J Am Chem Soc 2017 10 4;139(41):14368-14371. Epub 2017 Oct 4.

Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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October 2017

Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.

Am J Hum Genet 2017 Oct 21;101(4):489-502. Epub 2017 Sep 21.

Department of Genetics, The Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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October 2017

A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae.

PLoS One 2017 17;12(5):e0176085. Epub 2017 May 17.

Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America.

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September 2017

Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.

Clin Cancer Res 2017 Sep 13;23(18):5639-5647. Epub 2017 Jun 13.

Abramson Cancer Center, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.

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September 2017

mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.

Mol Cell 2017 Sep 14;67(6):936-946.e5. Epub 2017 Sep 14.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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September 2017

Dynamic Control of dNTP Synthesis in Early Embryos.

Dev Cell 2017 08 20;42(3):301-308.e3. Epub 2017 Jul 20.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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August 2017

Metabolite Spectral Accuracy on Orbitraps.

Anal Chem 2017 Jun 18;89(11):5940-5948. Epub 2017 May 18.

Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University , Washington Road, Princeton, New Jersey 08544, United States.

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June 2017

Metabolite Measurement: Pitfalls to Avoid and Practices to Follow.

Annu Rev Biochem 2017 06;86:277-304

Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, New Jersey 08544; email:

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June 2017

Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion.

Nat Med 2017 Feb 19;23(2):223-234. Epub 2016 Dec 19.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

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February 2017

One-Carbon Metabolism in Health and Disease.

Cell Metab 2017 Jan 15;25(1):27-42. Epub 2016 Sep 15.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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January 2017

Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.

Cell Metab 2016 Dec 17;24(6):863-874. Epub 2016 Nov 17.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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December 2016

Systems-level analysis of mechanisms regulating yeast metabolic flux.

Science 2016 10 27;354(6311). Epub 2016 Oct 27.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

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October 2016

Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis.

ACS Chem Biol 2016 09 7;11(9):2420-7. Epub 2016 Jul 7.

Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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September 2016

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.

Mol Cell 2016 09 25;63(5):811-26. Epub 2016 Aug 25.

Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA. Electronic address:

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September 2016

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.

Genes Dev 2016 08 11;30(15):1704-17. Epub 2016 Aug 11.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA.

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August 2016

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage.

Nat Chem Biol 2016 07 2;12(7):482-9. Epub 2016 May 2.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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July 2016

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.

Cell Metab 2016 06 19;23(6):1140-1153. Epub 2016 May 19.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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June 2016

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.

Cell Metab 2016 Jun 26;23(6):1154-1166. Epub 2016 May 26.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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June 2016

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage.

Nat Chem Biol 2016 May 21;12(5):345-52. Epub 2016 Mar 21.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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May 2016

Partners in the Warburg effect.

Elife 2016 04 13;5:e15938. Epub 2016 Apr 13.

Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.

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April 2016

Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP.

Sci Rep 2016 04 25;6:24834. Epub 2016 Apr 25.

Dept. of Molecular Cell Biology, Weizmann Institute of Science, Rehovot Israel 76100.

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April 2016

Mitochondria and Cancer.

Mol Cell 2016 Mar;61(5):667-676

Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

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March 2016

The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.

Hypoxia (Auckl) 2016;4:15-27. Epub 2016 Mar 4.

Ludwig Institute for Cancer Research Ltd, Stockholm, Sweden; Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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March 2016

Metabolic control of methylation and acetylation.

Curr Opin Chem Biol 2016 Feb 28;30:52-60. Epub 2015 Nov 28.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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February 2016

RNA Futile Cycling in Model Persisters Derived from MazF Accumulation.

MBio 2015 Nov 17;6(6):e01588-15. Epub 2015 Nov 17.

Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA

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November 2015

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.

Cancer Res 2015 Aug 25;75(16):3355-64. Epub 2015 Jun 25.

Department of Pathology and Translational Molecular Pathology, Sheikh Ahmad Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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August 2015

Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.

Proc Natl Acad Sci U S A 2015 May 27;112(19):6116-21. Epub 2015 Apr 27.

Lewis-Sigler Institute for Integrative Genomics and Departments of Molecular Biology and

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May 2015

Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication.

Cell Rep 2015 Mar 26;10(8):1375-85. Epub 2015 Feb 26.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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March 2015

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

ACS Chem Biol 2015 Feb 18;10(2):510-6. Epub 2014 Nov 18.

Lewis-Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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February 2015

Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomics.

Anal Chem 2015 Feb 27;87(4):2273-81. Epub 2015 Jan 27.

Lewis Sigler Institute for Integrative Genomics, Princeton University , Princeton, New Jersey 08544, United States.

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February 2015

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate.

Cancer Metab 2014 11;2:23. Epub 2014 Dec 11.

Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544 USA.

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February 2015

ZMP: a master regulator of one-carbon metabolism.

Mol Cell 2015 Jan;57(2):203-4

The Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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January 2015

Serine catabolism regulates mitochondrial redox control during hypoxia.

Cancer Discov 2014 Dec 3;4(12):1406-17. Epub 2014 Sep 3.

Cancer Biology and Genetics Program and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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December 2014

Estrogen-related receptor α is required for efficient human cytomegalovirus replication.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5706-15. Epub 2014 Dec 15.

Departments of Molecular Biology and

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December 2014

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

Mol Cell 2014 Oct 18;56(2):205-218. Epub 2014 Sep 18.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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October 2014

Enzyme clustering accelerates processing of intermediates through metabolic channeling.

Nat Biotechnol 2014 Oct 28;32(10):1011-8. Epub 2014 Sep 28.

1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

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October 2014

Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity.

Mol Cell 2014 Sep 28;55(6):916-930. Epub 2014 Aug 28.

Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, 08854. Electronic address:

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September 2014

Autophagy is required for glucose homeostasis and lung tumor maintenance.

Cancer Discov 2014 Aug 29;4(8):914-27. Epub 2014 May 29.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey. Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey.

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August 2014

Quantitative flux analysis reveals folate-dependent NADPH production.

Nature 2014 Jun 4;510(7504):298-302. Epub 2014 May 4.

Department of Chemistry and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA.

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June 2014

Genetic basis of metabolome variation in yeast.

PLoS Genet 2014 Mar 6;10(3):e1004142. Epub 2014 Mar 6.

Departments of Human Genetics and Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California, United States of America; Howard Hughes Medical Institute, UCLA, Los Angeles, California, United States of America.

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March 2014

Quantitation of cellular metabolic fluxes of methionine.

Anal Chem 2014 Feb 16;86(3):1583-91. Epub 2014 Jan 16.

Dept. of Computer Science, Technion - Israel Institute of Technology, Haifa 32000, Israel.

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February 2014

Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny.

PLoS Pathog 2013 16;9(5):e1003333. Epub 2013 May 16.

Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.

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December 2013

Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection.

Proc Natl Acad Sci U S A 2013 Dec 2;110(51):E5006-15. Epub 2013 Dec 2.

Departments of Molecular Biology and Chemistry, and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.

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December 2013

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.

Mol Syst Biol 2013 Dec 3;9:712. Epub 2013 Dec 3.

Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

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December 2013

Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.

Cell Rep 2013 Dec 19;5(6):1725-36. Epub 2013 Dec 19.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; California Institute for Quantitative Biosciences, QB3, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, San Francisco, CA 94158, USA. Electronic address:

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December 2013

Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux.

J Biol Chem 2013 Oct 12;288(43):31363-9. Epub 2013 Sep 12.

From the Lewis-Sigler Institute for Integrative Genomics and.

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October 2013

Pyrimidine homeostasis is accomplished by directed overflow metabolism.

Nature 2013 Aug 31;500(7461):237-41. Epub 2013 Jul 31.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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August 2013

Systems biology: metabolite turns master regulator.

Nature 2013 Aug 7;500(7462):283-4. Epub 2013 Aug 7.

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August 2013

Metabolism: Cancer mistunes methylation.

Nat Chem Biol 2013 May;9(5):293-4

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May 2013

Nucleotide degradation and ribose salvage in yeast.

Mol Syst Biol 2013 May 14;9:665. Epub 2013 May 14.

Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

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May 2013

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids.

Proc Natl Acad Sci U S A 2013 May 13;110(22):8882-7. Epub 2013 May 13.

Lewis-Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

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May 2013

Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation.

Mol Cell 2012 Oct 16;48(1):52-62. Epub 2012 Aug 16.

Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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October 2012

Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase.

J Virol 2012 Aug 23;86(15):8259-68. Epub 2012 May 23.

Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

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August 2012

Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells.

Science 2012 Jul 8;337(6093):470-3. Epub 2012 Jul 8.

Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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July 2012

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

Proc Natl Acad Sci U S A 2012 May 16;109(18):6904-9. Epub 2012 Apr 16.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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May 2012

Teaching the design principles of metabolism.

Nat Chem Biol 2012 May 17;8(6):497-501. Epub 2012 May 17.

Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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May 2012

Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase.

Nat Chem Biol 2012 Apr 22;8(6):562-8. Epub 2012 Apr 22.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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April 2012

RpoS proteolysis is controlled directly by ATP levels in Escherichia coli.

Genes Dev 2012 Mar;26(6):548-53

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

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March 2012