Dr. Jose Antonio Morales-Serna, PhD - Universidad del Papaloapan - Department of Chemistry

Dr. Jose Antonio Morales-Serna

PhD

Universidad del Papaloapan

Department of Chemistry

Tuxtepec, Oaxaca | Mexico

Main Specialties: Chemistry

Additional Specialties: Chemistry

ORCID logohttps://orcid.org/0000-0002-5204-772X


Top Author

Dr. Jose Antonio Morales-Serna, PhD - Universidad del Papaloapan - Department of Chemistry

Dr. Jose Antonio Morales-Serna

PhD

Introduction

2015-2017 Lecturer in Chemistry at Departamento de Química of the Universidad Autónoma Metropolitana-Iztapalapa, Mexico.
2013-2015 Newton International Fellowship, Royal Society. Postdoctoral position at University of Manchester. Advisor: Prof David A. Leigh,
2006-2009 PhD at Universidad Rovira i Virgili, Tarragona, Spain. Advisor: Prof Sergio Castillón.
2005-2006 Diploma of Advanced Studies (DEA) at Universidad Rovira i Virgili, Tarragona, Spain. Advisor: Prof Sergio Castillón.
1998-2000 MSc at Universidad Nacional Autónoma de México, México. Advisor: Dr. Jorge Cárdenas.
1992-1997 B.Sc. at Universidad Autónoma “Benito Juarez” de Oaxaca, México. Advisor: Prof Manuel Salmón.

Primary Affiliation: Universidad del Papaloapan - Tuxtepec, Oaxaca , Mexico

Specialties:

Additional Specialties:

Research Interests:

Education

Jan 2015
University of Manchester
Postdoc
Newton International Fellowship, The Royal Society, UK.
Jun 2009
Universitat Rovira i Virgili
PhD
Postgraduate Fellowship, Generalitat de Cataluña Spain and Fons Social Europeu (UE).
Jun 2003
Universidad Nacional Autonoma de Mexico
MSc
National Council on Science and Technology (Mexico-CONACyT) Fellowship.

Experience

Mar 2018 - Mar 2018
Universidad del Papaloapan - Campus Tuxtepec
Lecturer in Chemistry
Chemistry
Mar 2015 - Sep 2017
Universidad Autonoma Metropolitana Unidad Iztapalapa
Lecturer in Chemistry
Chemistry
Jan 2017
National System of Researchers, National Council of Science and Technology (CONACyT), Mexico, Level 2.
Fellow
Sep 2012 - Jan 2015
University of Manchester
Postdoctoral Position
School of Chemistry
Jan 2015
Newton International Alumni, Royal Society, UK.
Fellow
Jan 2014
National System of Researchers, National Council of Science and Technology (CONACyT), Mexico, Level 1.
Fellow
Jan 2013
Newton International Fellowship, Royal Society, UK.
Fellow

Publications

40Publications

97Reads

913Profile Views

15PubMed Central Citations

Guanidine-Catalyzed Reductive Amination of Carbon Dioxide with Silanes: Switching between Pathways and Suppressing Catalyst Deactivation.

ACS Catal. DOI: 10.1021/acscatal.7b04108

ACS Catalysis

A mechanistic investigation into the guanidine catalyzed reductive amination of CO2, using a combination of 1H, 29Si NMR, FT-IR, MS and GC profiling, is reported. Inexpensive and readily available N,N,N’,N’-tetramethylguanidine (TMG) was found to be an equally effective catalyst compared to more elaborate cyclic guanidines. Different catalytic pathways to formamide 2, aminal 4 and N-methylamine 3, were identified. A pathway to formamide product 2 dominates at 23 °C. Increasing the reaction temperature to 60 °C enables a competitive, higher energy pathway to 4 and 3, which requires direct reduction of CO2 with PhSiH3 to formoxysilane E. Reduction of aminal 4, in the presence of CO2 and the catalyst, led to formation of a 1 : 1 ratio of 2 and 3. The catalyst itself can be formylated under the reaction conditions, resulting in its deactivation. Thus, alkylated TMGs were found to be more stable and more active catalysts than TMG, leading to a successful organocatalyzed reductive functionalization of CO2 with silane at 0.1 mol% catalyst loading (TON = 805 and TOF = 33.5 h-1).

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March 2018
88 Reads

Glycosylation of stannyl ceramides promoted by modified montmorillonite in supercritical carbon dioxide.

Synthesis 2018; 50(03): 593-598.

Synthesis

The direct glycosylation of ceramides in supercritical carbon dioxide (scCO2) successfully proceeded to produce β-glycolipids in high yield and with full stereoselectivity. The reaction is promoted by montmorillonite modified with a superacid (CF3SO3H). The value of this protocol was demonstrated in the efficient synthesis of isoglobotrihexosylceramide (iGB3).

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February 2018
9 Reads

Synthesis of 1,2,3-triazoles in the presence of mixed Mg/Fe oxides and their evaluation as corrosion inhibitors of API 5L X70 steel submerged in HCl.

RSC Adv. 2017; 7(40): 24736–24746.

RSC Adv.

In this work, the catalytic capacity of a Mg/Fe layered double hydroxide (LDH) and its mixed oxides to perform Huisgen cycloaddition was studied. The catalytic process was performed in the presence of sodium ascorbate, which was determinant for the success of the 1,3-cycloaddition. The obtained triazoles were evaluated as corrosion inhibitors using electrochemical impedance spectroscopy under static conditions, showing an inhibition efficiency higher than 95% at 50 ppm for some of the triazoles studied. According to the Langmuir isotherm, all the compounds synthesized and analysed exhibit a chemisorption process. Finally, the corrosion process when submerging a steel bar in 1 M HCl was studied using SEM-EDS. This experiment showed that the corrosion process decreases considerably in the presence of 50 ppm of the organic inhibitor.

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May 2017
9 Reads

Multicomponent synthesis of 4-aryl-NH-1,2,3-triazoles in the presence of Al-MCM-41 and sulfated zirconia.

Tetrahedron Lett. 2017; 58(28): 2690-2694.

Tetrahedron Lett.

The acid properties of Al-MCM-41 and sulfated zirconia were used to develop a strategy for the synthesis of 4-aryl-NH-1,2,3-triazoles via a multicomponent reaction involving various benzaldehydes, sodium azide and nitromethane. The efficiency of the process is analysed from the perspective of the difference in acids among the catalysts used.

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May 2017
10 Reads

Phosphinito palladium(II) complexes as catalysts for the synthesis of 1,3-enynes, aromatic alkynes and ynones.

RSC Adv. 2017; 7(16): 9780−9789.

RSC Adv.

An air-stable phosphinito palladium(II) complex (Ph1-Phoxide) has been found to be an efficient catalyst in the formation of C–C bonds. The coupling of terminal alkynes formed gem-1,3-enynes as the only reaction products. Aromatic alkynes can be synthesized from the coupling of terminal alkynes and haloaromatic compounds (Sonogashira coupling). The phosphinito palladium(II) complex also catalyses the coupling between acyl chlorides and terminal alkynes (Sonogashira coupling), furnishing ynones in excellent yields.

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February 2017
12 Reads

Evaluation of Fe3+ fixation into montmorillonite clay and its application in the polymerization of ethylenedioxythiophene.

RSC Adv. 2016; 6(98): 95879−95887.

RSC Adv.

Modification of natural montmorillonite can be achieved efficiently through Fe3+ fixation using solutions of Fe(ClO4)3 in NaClO4. An analysis of the process by a pseudo-second order model allowed us to establish that Fe3+ sorption into montmorillonite is a chemical process that involves an exchange of cations from the montmorillonite interstitial space between layers. The presence of Fe3+ on the interstitial space between layers was determinated by XPS (X-ray photoelectron spectroscopy). The oxidant properties of the modified montmorillonite were evaluated by the polymerisation of ethylenedioxythiophene (EDOT) to generate polyethylenedioxythiophene (PEDOT)–clay, which is a semiconductor material.

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October 2016
7 Reads

Cu–Al mixed oxide catalysts for azide–alkyne 1,3-cycloaddition in ethanol–water.

RSC Adv. 2016; 6(68): 63660−63666.

RSC Adv.

Cu(Al)O mixed oxides, which are obtained by the calcination of Cu–Al layered double hydroxide (LDH), promote the formation of 1,2,3-triazoles from an alkyne–azide cycloaddition reaction (Huisgen-type reaction) with excellent yields using an EtOH–H2O mixture as the solvent under microwave heating. The yield of the reaction is the result of both heterogeneous and homogeneous catalytic processes, as a consequence of capturing Cu(II) from the material by sodium ascorbate. Although the appropriate reaction conditions were employed (EtOH–H2O, 80 °C, MW, 10 min), the reconstruction of LDH by the so-called memory effect was not observed.

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June 2016
4 Reads

Reaction control in heterogeneous catalysis using montmorillonite: switching between acid catalysed and red-ox processes.

RSC Adv. 2016; 6(48): 42613−42617.

RSC Adv.

The use of montmorillonite, modified with a super-acid (CF3SO3H), in the presence of hydroquinone as a radical scavenger and under a nitrogen atmosphere, induced the formation of tetrasubstituted furans as the major product from benzoins. In the absence of a radical scavenger, the only products obtained were 1,2-diketones.

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April 2016
5 Reads

Synthesis of beta-nitrostyrenes in the presence of sulfated zirconia and secondary amines.

RSC Adv. 2015; 5(120): 99188–99192.

RSC Adv.

A simple and efficient protocol for the synthesis of β-nitrostyrenes has been achieved by the use of sulfated zirconia–secondary amine (piperidine, pyrrolidine, proline or prolinol) cooperative systems. The condensation of different aldehydes and nitromethane demonstrates the efficiency of this process, which does not require high-temperature reactivation for the reuse of the catalytic material.

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November 2015
4 Reads

A switchable [2]rotaxane asymmetric organocatalyst that utilizes an acyclic chiral secondary amine.

J Am Chem Soc. 2014 Apr 2;136(13):4905-8

J Am Chem Soc.

A rotaxane-based switchable asymmetric organocatalyst has been synthesized in which the change of the position of the macrocycle reveals or conceals an acyclic, yet still highly effective, chiral organocatalytic group. This allows control over both the rate and stereochemical outcome of a catalyzed asymmetric Michael addition.

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March 2014
8 Reads

Three new diarylbutane lignans from the resin of Bursera fagaroides.

Nat Prod Res 2013 30;27(9):824-9. Epub 2012 Jul 30.

Instituto de Química, Universidad Nacional Autónoma de México, México DF, México.

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http://dx.doi.org/10.1080/14786419.2012.708658DOI Listing
January 2014
5 Reads
2 Citations
0.920 Impact Factor

Synthesis of cycloveratrylene macrocycles and benzyl oligomers catalysed by bentonite under microwave/infrared and solvent-free conditions.

Molecules 2013 Oct 16;18(10):12820-44. Epub 2013 Oct 16.

Departamento de Ciencias Químicas, Campo 1, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Av 1o de Mayo s/n, Sta. Ma Las Torres, Cuautitlán Izcalli 54740, Estado de México, Mexico.

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http://dx.doi.org/10.3390/molecules181012820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269697PMC
October 2013
12 Reads
1 Citation
2.420 Impact Factor

Facile and efficient addition of terminal alkynes to benzotriazole esters: synthesis of D-erythro-sphingosine using ynones as the key intermediate.

Tetrahedron Lett. 2013; 54(52): 7111–7114.

Tetrahedron Lett.

From the perspective of synthesis, ynones are compounds of considerable interest because of their occurrence in a wide variety of biologically active molecules and as key synthetic intermediates. In this context, a facile and highly efficient synthesis of ynones was developed based on the high reactivity of benzotriazole esters formed in situ. Lithium acetylides can alkylate various carboxylic acids in yields ranging from 60% to 92%. To determine whether our methodology is useful for synthesising complex and biologically relevant molecules, we synthesise d-erythro-sphingosine in four steps and with 33% overall yield from l-serine.

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October 2013
9 Reads

Efficient activity of magnesium–aluminium hydrotalcite in the synthesis of amides.

RSC Adv. 2013; 3(45): 23046–23050.

RSC Adv.

The synthesis of amides by coupling benzotriazole esters and amines can be achieved conveniently in moderate to excellent yields (50–95%) using a commercial, synthesized, calcined or reconstructed Mg–Al hydrotalcite instead of one of the classic bases (tertiary amines). The experimental results demonstrated that commercial and synthesized hydrotalcite can be quantitatively recovered from the reaction by simple filtration and reused for a number of cycles and that the reconstructed hydrotalcite is the most active form for the amide bond formation. Finally, to test the scope of the protocol for the synthesis of biologically relevant molecules, the total synthesis of Sansalvamide A was carried out.

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September 2013
4 Reads

Photoproduction of H2O2 and hydroxyl radicals catalysed by natural and super acid-modified montmorillonite and its oxidative role in the peroxidation of lipids.

RSC Adv. 2013; 3(3): 937–944.

RSC Adv. 2013, 3, 937–944.

The reactivity of both natural montmorillonite and montmorillonite modified with super acids (CF3SO3H and HClO4) to generate hydrogen peroxide (H2O2) and hydroxyl radicals (˙OH) under both darkness and UV-light irradiation was investigated using EPR spin-trapping spectroscopy. We used the free-radical trapping action of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) to indicate the production of ˙OH from natural and modified clays. The recognition and characterisation of the formed DMPO–OH adduct established that super acid montmorillonites were able to generate hydroxyl radicals at 25 °C in the presence of O2 and H2O. When natural and acid montmorillonite were irradiated with UV light, hydroxyl radical generation was greater than under dark conditions. In addition, the peroxidation of lipids in biological matrices with natural and super acid montmorillonite was studied using a thiobarbituric acid reactive substances (TBARS) assay, which demonstrated that only ˙OH generated from the super acid montmorillonite induced the oxidative degradation of lipids. This study reports, for the first time, the generation of ˙OH and the peroxidation of lipids by a typical super acid-modified Mexican montmorillonite.

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November 2012
6 Reads

Characterization of modified fischer-tropsch catalysts promoted with alkaline metals for higher alcohol synthesis.

Catal. Lett. 2012; 142(3): 368–377.

Catal. Lett.

Two series of Cu/Co/Cr modified Fischer–Tropsch catalyst promoted with Zn or Mn and an alkaline metal (Me: Li, Na, K, Rb, Cs) were prepared by co-precipitation method and tested for high alcohol synthesis (HAS) at one hour on-stream and at two temperatures, 300 and 350 °C. The results indicate that the best selectivity toward high alcohols depends on temperature and catalysts composition and is obtained as follows: a) at 300 °C over catalysts without Zn and containing K, Na and Rb; b) at 350 °C over catalysts without Zn and containing K; c) at 350 °C over catalysts containing Zn as well as Li and Cs.

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March 2012
7 Reads

Synthesis of benzyl chlorides and cycloveratrylene macrocycles using benzylic alcohols under homogeneous catalysis by HCl/Dioxane.

Org. Commun. 2012; 5(2): 58–63.

Org. Commun.

The synthesis of benzyl chlorides, cyclic derivatives cyclotriveratrylene and cyclotripiperotrylene were carried out in using the HCl/dioxane system as a catalyst. The reaction proceeded with high selectivity and is sensitive to the number of alkyl and methoxy substituent on the aromatic ring.

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March 2012
6 Reads

Heck arylation of styrenes promoted by an air-stable phosphinito complex of palladium (II). Synthesis of resveratrol.

Synthesis 2012(3): 446-452

Synthesis

An air-stable phosphinito complex of palladium(II) was found to be an efficient catalyst in the Heck reaction of a variety of aryl halides and styrenes. Resveratrol was concisely synthesized in 63% overall yield; the reactions were performed under conventional and microwave heating.

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February 2012
8 Reads

The Heck reaction of allylic alcohols catalysed by an air-stable phosphinito complex of palladium (II).

Synthesis 2012(2): 272-282.

Synthesis

The Heck coupling of aryl bromides with primary and secondary allylic alcohols, performed in the presence of an air-stable­ phosphinito complex of palladium(II), produced the corresponding carbonyl compounds. Reactions with tertiary allylic alcohols under the same conditions generated the aromatic conjugated alcohols

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January 2012
16 Reads

Structure of salvioccidentalin, a diterpenoid with a rearranged neo-clerodane skeleton from Salvia occidentalis.

Molecules 2011 Oct 31;16(11):9109-15. Epub 2011 Oct 31.

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 México D. F., México.

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http://dx.doi.org/10.3390/molecules16119109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264670PMC
October 2011
7 Reads
1 Citation
2.420 Impact Factor

A new languidulane diterpenoid from Salvia mexicana var. mexicana.

Molecules 2011 Oct 21;16(10):8866-73. Epub 2011 Oct 21.

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 México D.F., México.

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http://dx.doi.org/10.3390/molecules16108866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264398PMC
October 2011
8 Reads
2.420 Impact Factor

Reduction of carboxylic acids using esters of benzotriazole as high reactivity intermediates.

Synthesis 2011(9): 1375-1382.

Synthesis

Herein, we describe a simple and practical protocol for the reduction of carboxylic acids via the in situ formation of hydroxy­benzotriazole esters followed by reaction with sodium borohydride to give the corresponding alcohols. The reaction proceeds with excellent yields in the presence of water.

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May 2011
6 Reads

Effects of bentonite on p-methoxybenzyl acetate: a theoretical model for oligomerization via an electrophilic-substitution mechanism.

Molecules 2011 Feb 21;16(2):1761-75. Epub 2011 Feb 21.

Instituto de Química de la Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria Coyoacán 04510, México, D.F., Mexico.

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http://dx.doi.org/10.3390/molecules16021761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259743PMC
February 2011
6 Reads
2.420 Impact Factor

Constituents of organic extracts of Cuphea hyssopifolia.

J. Mex. Chem. Soc. 2011; 55(1): 62-64.

J. Mex. Chem. Soc.

From the aerial part of Cuphea hyssopifolia (Lythraceae) diterpenes and flavonoids were isolated. The compounds were identified as: friedelan-3β-ol 1, ursolic acid 2, methyl gallate 3, quercetin 4, quercetin-3-O-α-rhamnopyranoside 5, 1,2,3,4,6-penta-O-galloyl-β-Dglucose 6 and manitol 7.

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January 2011
5 Reads

Using benzotriazole esters as a strategy in the esterification of tertiary alcohols.

Synthesis 2010(24): 4261-4267.

Synthesis

Benzotriazole esters formed in situ were found to be efficient intermediates in the esterification of tertiary alcohols using 4-(dimethylamino)pyridine (DMAP) as the base. These mild and basic reaction conditions allow the conversion of various substrates into esters in good yield.

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December 2010
5 Reads

Highly efficient macrolactonization of ω-hydroxy acids using benzotriazole esters: synthesis of Sansalvamide A.

Org Biomol Chem 2010 Nov 31;8(21):4940-8. Epub 2010 Aug 31.

Instituto de Química, Universidad Nacional Autónoma de México Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México D.F., México.

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http://dx.doi.org/10.1039/c0ob00161aDOI Listing
November 2010
12 Reads
3.562 Impact Factor

Oligomerization of 3,5-dimethyl benzyl alcohol promoted by clay: experimental and theoretical study.

Molecules 2010 Nov 11;15(11):8156-68. Epub 2010 Nov 11.

Instituto de Química de la Universidad Nacional Autónoma de México, Ciudad Universitaria Coyoacán, México, D.F., Mexico.

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http://dx.doi.org/10.3390/molecules15118156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259272PMC
November 2010
3 Reads
2.420 Impact Factor

Recent advances in the synthesis of sphingosine and phytosphingosine, molecules of biological significance.

Curr. Org. Chem. 2010; 14(20): 2483–2521.

Curr. Org. Chem

Due to the relevant biological role of sphingosines, ceramides and glycosyl ceramides, and the increasing demand of these compounds for biological evaluations, developing methods targeting sphingosine and phytosphingosine and derivatives have attracted the interest of researchers. The review initially presents the structural features of these compounds, presenting the different types of nomenclature of phytosphingosines, and the more relevant biological properties, as well as the biochemical synthesis. The synthetic procedures using products of the chiral pool, mainly carbohydrates and serine derivatives, are progressively shifted by asymmetric synthesis procedures, and particularly to those based on catalytic reactions. In this way, the review presents separately the synthetic procedures leading to sphingosine and phytosphingosine, and each case the synthesis based on the chiral pool are presented separately from the asymmetric synthesis. In this last case the methods are classified depending of the strategy used for inducing chirality, chiral auxiliary, chiral reagent or catalytic procedures, to which special attention is devoted. The syntheses are discussed in detail and reagents and yields for each step are provided. The review also rationalizes and integrates the different synthetic procedures from the point of view of construction the chiral fragment of these molecules.

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October 2010
6 Reads

Homoisoflavanones from Agave tequilana Weber.

Molecules 2010 May 4;15(5):3295-301. Epub 2010 May 4.

Instituto de Química, Universidad Nacional Autónoma de México Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México D.F., Mexico.

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http://dx.doi.org/10.3390/molecules15053295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263332PMC
May 2010
9 Reads
2 Citations
2.420 Impact Factor

Synthesis of hyperbranched beta-galceramide-containing dendritic polymers that bind HIV-1 rgp 120.

Eur. J. Org. Chem. 2010(14): 2657−2660.

Eur. J. Org. Chem. 2010, 2657−2660.

We report the design, synthesis, and characterization of a series of water-soluble hyperbranched β-galceramide-containing dendritic. Polymers showing useful binding ability to HIV-1 rgp120 as demonstrated with surface plasmon resonance.

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April 2010
3 Reads

Efficient synthesis of beta-glycosphingolipids by reaction of stannylceramides with glycosyl iodides promoted by TBAI/AW 300 molecular sieves.

Eur. J. Org. Chem. 2009(23): 3849−3852.

Eur. J. Org. Chem.

TBAI and acid-washed molecular sieves efficiently promoted the glycosylation of stannylceramides with glycosyl iodides. This direct glycosylation reaction reduces the overall number of synthetic steps and provides rapid access to β-glycosphingolipids such as GalCer, β-lactosylceramide, and iGB3 in good yield and with complete chemo- and stereoselectivity.

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July 2009
7 Reads

Synthesis of D/L-erythro-sphingosine using a tethered aminohydroxylation reaction as the key step.

Synthesis 2009(5): 710-712

Synthesis

A diastereoselective synthesis of racemic d/l-erythro-sphingosine is described. The approach involves employing tethered­ aminohydroxylation (TA) to introduce the 2-amino and 3-hydroxy functions with required stereochemistry.

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March 2009
8 Reads

Asymmetric sulfur ylide based enantioselective synthesis of D-erythro-sphingosine.

Org Biomol Chem 2008 Dec 17;6(24):4502-4. Epub 2008 Oct 17.

Departamento de Química Analítica y Química Orgánica, Universitat Rovira i Virgili, C/Marcel.li Domingo s/n, 43007 Tarragona, Spain.

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http://dx.doi.org/10.1039/b814882aDOI Listing
December 2008
6 Reads
1 Citation
3.562 Impact Factor

Stannyl ceramides as efficient acceptors for synthesising beta-galactosyl ceramides.

Org Biomol Chem 2008 Oct 13;6(20):3831-6. Epub 2008 Aug 13.

Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/Marceli.li Domingo s/n, 43007, Tarragona, Spain.

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http://dx.doi.org/10.1039/b809570aDOI Listing
October 2008
9 Reads
2 Citations
3.562 Impact Factor

Direct and efficient glycosylation protocol for synthesizing beta-glycolipids: Application to the synthesis of KRN7000.

Eur. J. Org. Chem. 2008(11): 1851–1854.

Eur. J. Org. Chem.

Herein we describe a simple and practical protocol for accessing the biologically active galactosyl ceramide KRN7000 and other α-glycolipids with excellent yield and stereoselectivity by using per-O-silylated galactosyl iodide and stannyl ethers as glycosylation partners. This direct glycosylation reaction reduces the overall number of steps and provides rapid access to biologically important α-galactosyl ceramide derivatives.

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April 2008
6 Reads

Highly efficient and stereoselective synthesis of beta-glycolipids.

Org Biomol Chem 2008 Feb 11;6(3):443-6. Epub 2007 Dec 11.

Departamento de Química Analítica y Química Orgánica, Universitat Rovira i Virgili, C/Marcel.li Domingo s/n, 43007 Tarragona, Spain.

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http://dx.doi.org/10.1039/b718521aDOI Listing
February 2008
6 Reads
2 Citations
3.562 Impact Factor

Recent advances in the glycosylation of sphingosines and ceramides.

Carbohydr Res 2007 Sep 11;342(12-13):1595-612. Epub 2007 Apr 11.

Departament de Química Analítica i Química Orgànica, Facultat de Química, Universitat Rovira i Virgili, C/Marcelí Domingo s/n, 43005 Tarragona, Spain.

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http://dx.doi.org/10.1016/j.carres.2007.03.028DOI Listing
September 2007
6 Reads
4 Citations
1.930 Impact Factor

The first example of macrolactonization of ω-hydroxy acids catalized by calcined Mg–Al hydrotalcite.

Arkivoc 2005(vi): 428–435.

Arkivoc

Calcined Mg-Al Hydrotalcites x = 0.20, 0.27, 0.33 proved effective catalysts for the lactonization of 10, 12, 15, and 16 hydroxy acid benzotriazole esters to their correspondent macrolactones. This new methodology was used for the lactonization step in the synthesis of Sansalvamide A.

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October 2005
10 Reads