John Easton

John Easton

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John Easton

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Latent cellular analysis robustly reveals subtle diversity in large-scale single-cell RNA-seq data.

Nucleic Acids Res 2019 Dec;47(22):e143

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1093/nar/gkz826DOI Listing
December 2019

Nucleome Dynamics during Retinal Development.

Neuron 2019 Nov 4;104(3):512-528.e11. Epub 2019 Sep 4.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842117PMC
November 2019

RNAIndel: discovering somatic coding indels from tumor RNA-Seq data.

Bioinformatics 2019 Oct 8. Epub 2019 Oct 8.

Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz753DOI Listing
October 2019

Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping.

Nucleic Acids Res 2019 07;47(13):6699-6713

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1093/nar/gkz462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648894PMC
July 2019

Structure and evolution of double minutes in diagnosis and relapse brain tumors.

Acta Neuropathol 2019 01 28;137(1):123-137. Epub 2018 Sep 28.

Department of Computational Biology, St. Jude Children's Research Hospital, MS1135, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00401-018-1912-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338707PMC
January 2019

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.

Cancer Cell 2018 09 23;34(3):411-426.e19. Epub 2018 Aug 23.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158019PMC
September 2018

A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum.

Curr Biol 2018 09 13;28(18):2910-2920.e2. Epub 2018 Sep 13.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.07.062DOI Listing
September 2018

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping.

RNA 2018 08 29;24(8):1056-1066. Epub 2018 May 29.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1261/rna.065383.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049506PMC
August 2018

Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.

J Clin Oncol 2018 07 30;36(20):2078-2087. Epub 2018 May 30.

Zhaoming Wang, Carmen L. Wilson, John Easton, Andrew Thrasher, Heather Mulder, Dale J. Hedges, Shuoguo Wang, Michael C. Rusch, Michael N. Edmonson, Jennifer Q. Lanctot, Eric Caron, Kyla Shelton, Kelsey Currie, Matthew Lear, Aman Patel, Celeste Rosencrance, Ying Shao, Bhavin Vadodaria, Donald Yergeau, Yadav Sapkota, Russell J. Brooke, Wonjong Moon, Evadnie Rampersaud, Xiaotu Ma, Ti-Cheng Chang, Stephen V. Rice, Cynthia Pepper, Xin Zhou, Xiang Chen, Wenan Chen, Matthew J. Ehrhardt, Matthew J. Krasin, Rebecca M. Howell, Nicholas S. Phillips, Courtney Lewis, Deokumar Srivastava, Ching-Hon Pui, Chimene A. Kesserwan, Gang Wu, Kim E. Nichols, James R. Downing, Melissa M. Hudson, Yutaka Yasui, Leslie L. Robison, and Jinghui Zhang, St Jude Children's Research Hospital, Memphis, TN; Qi Liu, University of Alberta, Edmonton, Alberta, Canada; Shawn Levy, Angela Jones, and Braden Boone, HudsonAlpha Institute for Biotechnology, Huntsville, AL; and Rebecca M. Howell, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://ascopubs.org/doi/10.1200/JCO.2018.77.8589
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http://dx.doi.org/10.1200/JCO.2018.77.8589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036620PMC
July 2018

UMI-count modeling and differential expression analysis for single-cell RNA sequencing.

Genome Biol 2018 05 31;19(1):70. Epub 2018 May 31.

Department of Computational Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.

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https://genomebiology.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13059-018-1438-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984373PMC
May 2018

The genomic landscape of pediatric myelodysplastic syndromes.

Nat Commun 2017 11 16;8(1):1557. Epub 2017 Nov 16.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 342, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41467-017-01590-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691144PMC
November 2017

Genome-wide segregation of single nucleotide and structural variants into single cancer cells.

BMC Genomics 2017 Nov 25;18(1):906. Epub 2017 Nov 25.

Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1186/s12864-017-4286-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702214PMC
November 2017

Exome sequencing analysis of murine medulloblastoma models identifies WDR11 as a potential tumor suppressor in Group 3 tumors.

Oncotarget 2017 Sep 27;8(39):64685-64697. Epub 2017 Jul 27.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.18632/oncotarget.19642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630286PMC
September 2017

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.

Neuron 2017 May;94(3):550-568.e10

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508517PMC
May 2017

Germline Mutations in Predisposition Genes in Pediatric Cancer.

N Engl J Med 2015 Dec 18;373(24):2336-2346. Epub 2015 Nov 18.

Departments of Computational Biology (J.Z., G.W., M.N.E., D.H., X.M., X.Z., M.R.W., X.C., M.R., A.P., J.B.B., S.W.), Oncology (M.F.W., T.A.G., R.B.M., S.H.-D., R.N., E.Q., A.G., A.S.P., C.-H.P., K.E.N.), and Pathology (T.A.G., M.R.W., S.A.S., D.W.E., C.-H.P., J.R.D.) and the Pediatric Cancer Genome Project (J.Z., M.F.W., G.W., M.N.E., T.A.G., J.E., X.M., D.A.Y., B.V., X.C., R.B.M., S.H.-D., R.N., E.Q., S.A.S., M.R., A.P., J.B.B., S.W., M.S.W., A.G., D.W.E., A.S.P., C.-H.P., K.E.N., J.R.D.), St. Jude Children's Research Hospital, Memphis, TN; and the Department of Genetics and McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis (L.D., E.R.M., R.K.W.).

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http://dx.doi.org/10.1056/NEJMoa1508054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734119PMC
December 2015

CONSERTING: integrating copy-number analysis with structural-variation detection.

Nat Methods 2015 Jun 4;12(6):527-30. Epub 2015 May 4.

1] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. [2] Pediatric Cancer Genome Project, St. Jude Children's Research Hospital and Washington University School of Medicine, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nmeth.3394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591043PMC
June 2015

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Keeping pace with EHS compliance management.

Authors:
John Easton

Occup Health Saf 2012 Jul;81(7):92-5

Medgate Inc., USA.

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July 2012

mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.

Mol Cell 2010 Nov;40(4):509-20

Center for Childhood Cancer, Nationwide Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004768PMC
November 2010

Linked metabolites: a tool for the construction of directed metabolic graphs.

Comput Biol Med 2010 Mar 6;40(3):340-9. Epub 2010 Feb 6.

School of Electronic, Electrical and Computer Engineering, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1016/j.compbiomed.2010.01.005DOI Listing
March 2010

Protection from rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling.

Cancer Res 2010 Mar 23;70(5):2000-9. Epub 2010 Feb 23.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003869PMC
March 2010

Metabolic changes in flatfish hepatic tumours revealed by NMR-based metabolomics and metabolic correlation networks.

J Proteome Res 2008 Dec;7(12):5277-85

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1021/pr800353tDOI Listing
December 2008

Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.

Mol Cell Biol 2007 May 26;27(9):3530-41. Epub 2007 Feb 26.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1128/MCB.00086-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899956PMC
May 2007

The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor.

J Neurochem 2006 May 29;97(3):834-45. Epub 2006 Mar 29.

Department of Molecular Pharmacology, St Jude Children's Research Hospital, North Lauderdale, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2006.03789.xDOI Listing
May 2006

IRS-1: auditing the effectiveness of mTOR inhibitors.

Cancer Cell 2006 Mar;9(3):153-5

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.02.027DOI Listing
March 2006

Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.

J Biol Chem 2005 Sep 11;280(36):31924-35. Epub 2005 Jul 11.

Department of Chemistry, Western Illinois University, Macomb 61455, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M507057200
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http://dx.doi.org/10.1074/jbc.M507057200DOI Listing
September 2005

Virtual docking approaches to protein kinase B inhibition.

J Med Chem 2005 Apr;48(7):2278-81

The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/jm048962uDOI Listing
April 2005

Therapeutic potential of target of rapamycin inhibitors.

Expert Opin Ther Targets 2004 Dec;8(6):551-64

St. Jude Childrens Research Hospital, Department of Molecular Pharmacology, 332 N. Lauderdale Street, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1517/14728222.8.6.551DOI Listing
December 2004

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.

J Biol Chem 2004 Aug 24;279(35):36490-6. Epub 2004 Jun 24.

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 Lauderdale, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1074/jbc.M401208200DOI Listing
August 2004

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1).

Mol Cell 2003 Jun;11(6):1491-501

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00180-1DOI Listing
June 2003

Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

Cancer Res 2003 Jan;63(2):364-74

Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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January 2003

Report of Diseases among the Poor of Glasgow, during the Months of Feb., March, and April, 1832.

Authors:
John A Easton

Glasgow Med J 1832 Nov;5(20):441

one of the Surgeons to the City Poor.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776378PMC
November 1832

Report of Diseases among the Poor of Glasgow, during the Months of May, June, and July, 1832.

Authors:
John A Easton

Glasgow Med J 1832 Nov;5(20):442-452

one of the Surgeons to the City Poor.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776388PMC
November 1832

Report of Diseases among the Poor of Glasgow, during the Winter Quarter of 1831-2.

Authors:
John Easton

Glasgow Med J 1832 May;5(18):232

District Surgeon.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776357PMC
May 1832

Report of Diseases among the Poor of Glasgow, during the Months of August, September, and October, 1831.

Authors:
John A Easton

Glasgow Med J 1832 Feb;5(17):97

one of the Surgeons to the City Poor.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776361PMC
February 1832