Publications by authors named "Jeffrey G Aaronson"

1 Publications

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Rapid HATU-mediated solution phase siRNA conjugation.

Bioconjug Chem 2011 Aug 11;22(8):1723-8. Epub 2011 Jul 11.

Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.
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August 2011